A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
Sonoiki, Ebere, Ng, Caroline L., Lee, Marcus C. S., Guo, Denghui, Zhang, Yong-Kang, Zhou, Yasheen, Alley, M. R. K., Ahyong, Vida, Sanz, Laura M., Lafuente-Monasterio, Maria Jose, Dong, Chen, Schupp, Patrick G., Gut, Jiri, Legac, Jenny, Cooper, Roland A., Gamo, Francisco-Javier, DeRisi, Joseph, Freund, Yvonne R., Fidock, David A., Rosenthal, Philip J.
Published in Nature communications (06.03.2017)
Published in Nature communications (06.03.2017)
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Linking phenotype to kinase: identification of a novel benzoxaborole hinge-binding motif for kinase inhibition and development of high-potency rho kinase inhibitors
Akama, Tsutomu, Dong, Chen, Virtucio, Charlotte, Sullivan, David, Zhou, Yasheen, Zhang, Yong-Kang, Rock, Fernando, Freund, Yvonne, Liu, Liang, Bu, Wei, Wu, Anne, Fan, Xiao-Qing, Jarnagin, Kurt
Published in The Journal of pharmacology and experimental therapeutics (01.12.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2013)
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Chalcones and flavonoids as anti-tuberculosis agents
LIN, Yuh-Meei, YASHEEN ZHOU, FLAVIN, Michael T, ZHOU, Li-Ming, WEIGUO NIE, CHEN, Fa-Ching
Published in Bioorganic & medicinal chemistry (01.08.2002)
Published in Bioorganic & medicinal chemistry (01.08.2002)
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Discovery of an orally bioavailable isoxazoline benzoxaborole (AN8030) as a long acting animal ectoparasiticide
Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Zhou, Yasheen, Akama, Tsutomu, Bu, Wei, White, W. Hunter, Defauw, Jean M., Winkle, Joseph R., Balko, Terry W., Guo, Shenghai, Xue, Jian, Cao, Jianxin, Zou, Wuxin
Published in Bioorganic & medicinal chemistry letters (01.12.2015)
Published in Bioorganic & medicinal chemistry letters (01.12.2015)
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Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles
Zhang, Yong-Kang, Plattner, Jacob J., Freund, Yvonne R., Easom, Eric E., Zhou, Yasheen, Ye, Long, Zhou, Huchen, Waterson, David, Gamo, Francisco-Javier, Sanz, Laura M., Ge, Min, Li, Zhiya, Li, Lingchao, Wang, Hailong, Cui, Han
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
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Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease
Ding, Charles Z., Zhang, Yong-Kang, Li, Xianfeng, Liu, Yang, Zhang, Suoming, Zhou, Yasheen, Plattner, Jacob J., Baker, Stephen J., Liu, Liang, Duan, Maosheng, Jarvest, Richard L., Ji, Jingjing, Kazmierski, Wieslaw M., Tallant, Matthew D., Wright, Lois L., Smith, Gary K., Crosby, Renae M., Wang, Amy A., Ni, Zhi-Jie, Zou, Wuxin, Wright, Jon
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
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Discovery of novel P3-oxo inhibitor of hepatitis C virus NS3/4A serine protease
Duan, Maosheng, Kazmierski, Wieslaw, Crosby, Renae, Gartland, Margaret, Ji, Jinjing, Tallant, Matt, Wang, Amy, Hamatake, Robert, Wright, Lois, Wu, Min, Zhang, Yong-Kang, Ding, Charles Z., Li, Xianfeng, Liu, Yang, Zhang, Suoming, Zhou, Yasheen, Plattner, Jacob J., Baker, Stephen J.
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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Methylenedioxy- and ethylenedioxy-fused indolocarbazoles: potent human topoisomerase I inhibitors and antitumor agents
Zembower, David E, Xie, Yongping, Koohang, Ali, Kuffel, Mary J, Ames, Matthew M, Zhou, Yasheen, Mishra, Rama, Mar, Aye Aye, Flavin, Michael T, Xu, Ze-Qi
Published in Anti-cancer agents in medicinal chemistry (01.11.2012)
Published in Anti-cancer agents in medicinal chemistry (01.11.2012)
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Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)‑3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)‑ol (GSK656)
Li, Xianfeng, Hernandez, Vincent, Rock, Fernando L, Choi, Wai, Mak, Yvonne S. L, Mohan, Manisha, Mao, Weimin, Zhou, Yasheen, Easom, Eric E, Plattner, Jacob J, Zou, Wuxin, Pérez-Herrán, Esther, Giordano, Ilaria, Mendoza-Losana, Alfonso, Alemparte, Carlos, Rullas, Joaquín, Angulo-Barturen, Iñigo, Crouch, Sabrinia, Ortega, Fátima, Barros, David, Alley, M. R. K
Published in Journal of medicinal chemistry (12.10.2017)
Published in Journal of medicinal chemistry (12.10.2017)
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Design and synthesis of highly constrained factor Xa inhibitors: amidine-Substituted bis(benzoyl)- [1,3]-diazepan-2-ones and bis(benzylidene)-bis( gem-dimethyl)cycloketones
Cui, Jian, Crich, David, Wink, Donald, Lam, Matthew, Rheingold, Arnold L, Case, David A, Fu, WenTao, Zhou, Yasheen, Rao, Mohan, Olson, Arthur J, Johnson, Michael E
Published in Bioorganic & medicinal chemistry (05.08.2003)
Published in Bioorganic & medicinal chemistry (05.08.2003)
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Treatment of Skin Inflammation with Benzoxaborole Phosphodiesterase Inhibitors: Selectivity, Cellular Activity, and Effect on Cytokines Associated with Skin Inflammation and Skin Architecture Changes
Dong, Chen, Virtucio, Charlotte, Zemska, Olga, Baltazar, Grober, Zhou, Yasheen, Baia, Diogo, Jones-Iatauro, Shannon, Sexton, Holly, Martin, Shamra, Dee, Joshua, Mak, Yvonne, Meewan, Maliwan, Rock, Fernando, Akama, Tsutomu, Jarnagin, Kurt
Published in The Journal of pharmacology and experimental therapeutics (01.09.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2016)
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Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase
Palencia, Andrés, Li, Xianfeng, Bu, Wei, Choi, Wai, Ding, Charles Z, Easom, Eric E, Feng, Lisa, Hernandez, Vincent, Houston, Paul, Liu, Liang, Meewan, Maliwan, Mohan, Manisha, Rock, Fernando L, Sexton, Holly, Zhang, Suoming, Zhou, Yasheen, Wan, Baojie, Wang, Yuehong, Franzblau, Scott G, Woolhiser, Lisa, Gruppo, Veronica, Lenaerts, Anne J, O'Malley, Theresa, Parish, Tanya, Cooper, Christopher B, Waters, M Gerard, Ma, Zhenkun, Ioerger, Thomas R, Sacchettini, James C, Rullas, Joaquín, Angulo-Barturen, Iñigo, Pérez-Herrán, Esther, Mendoza, Alfonso, Barros, David, Cusack, Stephen, Plattner, Jacob J, Alley, M R K
Published in Antimicrobial agents and chemotherapy (01.10.2016)
Published in Antimicrobial agents and chemotherapy (01.10.2016)
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Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center
Freund, Yvonne R., Akama, Tsutomu, Alley, M.R.K., Antunes, Joana, Dong, Chen, Jarnagin, Kurt, Kimura, Richard, Nieman, James A., Maples, Kirk R., Plattner, Jacob J., Rock, Fernando, Sharma, Rashmi, Singh, Rajeshwar, Sanders, Virginia, Zhou, Yasheen
Published in FEBS letters (21.09.2012)
Published in FEBS letters (21.09.2012)
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Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria
HERNANDEZ, Vincent, CREPIN, Thibaut, MEEWAN, Maliwan, MOHAN, Manisha, WEIMIN MAO, ROCK, Fernando L, SEXTON, Holly, SHEORAN, Anita, YANCHEN ZHANG, ZHANG, Yong-Kang, ZHOU, Yasheen, NIEMAN, James A, PALENCIA, Andrés, MAHIPAL REDDY ANUGULA, EL MEHDI KERAMANE, SAVARIRAJ, Kingsley, SHEKHAR REDDY, D, SHARMA, Rashmi, SUBEDI, Rajendra, SINGH, Rajeshwar, O'LEARY, Ann, SIMON, Nerissa L, DE MARSH, Peter L, CUSACK, Stephen, MUSHTAQ, Shazad, WARNER, Marina, LIVERMORE, David M, ALLEY, M. R. K, PLATTNER, Jacob J, AKAMA, Tsutomu, BAKER, Stephen J, WEI BU, LISA FENG, FREUND, Yvonne R, LIANG LIU
Published in Antimicrobial Agents and Chemotherapy (01.03.2013)
Published in Antimicrobial Agents and Chemotherapy (01.03.2013)
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Exploring boron applications in modern agriculture: A structure-activity relationship study of a novel series of multi-substitution benzoxaboroles for identification of potential fungicides
Liu, Chunliang, Steere, Luke, McGregor, Cari, Frederick, Brittany H., Pastoor, Timothy, Zhou, Yasheen, Liu, C. Tony, Cai, Yan, Zhou, Haibo, Xu, Musheng, Wang, Jiangong, Kim, Sang Hu, Whitesell, Luke, Cowen, Leah E., Zhang, Yong-Kang
Published in Bioorganic & medicinal chemistry letters (01.07.2021)
Published in Bioorganic & medicinal chemistry letters (01.07.2021)
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Inhibiting Protein Prenylation with Benzoxaboroles to Target Fungal Plant Pathogens
Kim, Sang Hu, Liu, Chunliang, Zhou, Yasheen, Zhang, Yong-Kang, McGregor, Cari, Steere, Luke, Frederick, Brittany H, Liu, C. Tony, Whitesell, Luke, Cowen, Leah E
Published in ACS chemical biology (17.07.2020)
Published in ACS chemical biology (17.07.2020)
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Inhibiting C‑4 Methyl Sterol Oxidase with Novel Diazaborines to Target Fungal Plant Pathogens
Kim, Sang Hu, Steere, Luke, Zhang, Yong-Kang, McGregor, Cari, Hahne, Chris, Zhou, Yasheen, Liu, Chunliang, Cai, Yan, Zhou, Haibo, Chen, Xuefei, Puumala, Emily, Duncan, Dustin, Wright, Gerard D., Liu, C. Tony, Whitesell, Luke, Cowen, Leah E.
Published in ACS chemical biology (17.06.2022)
Published in ACS chemical biology (17.06.2022)
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Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model
Robertson, Gregory T, Ektnitphong, Victoria A, Scherman, Michael S, McNeil, Matthew B, Dennison, Devon, Korkegian, Aaron, Smith, Anthony J, Halladay, Jason, Carter, David S, Xia, Yi, Zhou, Yasheen, Choi, Wai, Berry, Pamela W, Mao, Weimin, Hernandez, Vincent, Alley, M R K, Parish, Tanya, Lenaerts, Anne J
Published in Antimicrobial agents and chemotherapy (01.04.2019)
Published in Antimicrobial agents and chemotherapy (01.04.2019)
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The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis
Korkegian, Aaron, O'Malley, Theresa, Xia, Yi, Zhou, Yasheen, Carter, David S., Sunde, Bjorn, Flint, Lindsay, Thompson, Dean, Ioerger, Thomas R., Sacchettini, Jim, Alley, M.R.K., Parish, Tanya
Published in Tuberculosis (Edinburgh, Scotland) (01.01.2018)
Published in Tuberculosis (Edinburgh, Scotland) (01.01.2018)
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AN2728, a new boron-based topical anti-inflammatory agent, inhibits phosphodiesterase 4 (IRC4P.611)
Freund, Yvonne, Dong, Chen, Virtucio-Frates, Charlotte, Rock, Fernando, Mak, Yvonne, Zhou, Yasheen, Zane, Lee, Jarnagin, Kurt
Published in The Journal of immunology (1950) (01.05.2015)
Published in The Journal of immunology (1950) (01.05.2015)
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