Concepts of Artificial Intelligence for Computer-Assisted Drug Discovery
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Published in Chemical reviews (25.09.2019)
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Zhong, Lei, Li, Yueshan, Xiong, Liang, Wang, Wenjing, Wu, Ming, Yuan, Ting, Yang, Wei, Tian, Chenyu, Miao, Zhuang, Wang, Tianqi, Yang, Shengyong
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Published in Signal transduction and targeted therapy (31.05.2021)
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Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
Cheng, Yuan, He, Cai, Wang, Manni, Ma, Xuelei, Mo, Fei, Yang, Shengyong, Han, Junhong, Wei, Xiawei
Published in Signal transduction and targeted therapy (17.12.2019)
Published in Signal transduction and targeted therapy (17.12.2019)
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Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition
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Published in Cell research (01.12.2021)
Published in Cell research (01.12.2021)
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Structure of the human gonadotropin-releasing hormone receptor GnRH1R reveals an unusual ligand binding mode
Yan, Wei, Cheng, Lin, Wang, Wei, Wu, Chao, Yang, Xin, Du, Xiaozhe, Ma, Liang, Qi, Shiqian, Wei, Yuquan, Lu, Zhiliang, Yang, Shengyong, Shao, Zhenhua
Published in Nature communications (20.10.2020)
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Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response
Wei, Xiawei, Shao, Bin, He, Zhiyao, Ye, Tinghong, Luo, Min, Sang, Yaxiong, Liang, Xiao, Wang, Wei, Luo, Shuntao, Yang, Shengyong, Zhang, Shuang, Gong, Changyang, Gou, Maling, Deng, Hongxing, Zhao, Yinglan, Yang, Hanshuo, Deng, Senyi, Zhao, Chengjian, Yang, Li, Qian, Zhiyong, Li, Jiong, Sun, Xun, Han, Jiahuai, Jiang, Chengyu, Wu, Min, Zhang, Zhirong
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Published in Cell research (01.02.2015)
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Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3–Gi signaling complexes
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Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor
Li, Yueshan, Zhang, Liting, Wang, Yifei, Zou, Jun, Yang, Ruicheng, Luo, Xinling, Wu, Chengyong, Yang, Wei, Tian, Chenyu, Xu, Haixing, Wang, Falu, Yang, Xin, Li, Linli, Yang, Shengyong
Published in Nature communications (12.11.2022)
Published in Nature communications (12.11.2022)
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Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes
Xiao, Peng, Yan, Wei, Gou, Lu, Zhong, Ya-Ni, Kong, Liangliang, Wu, Chao, Wen, Xin, Yuan, Yuan, Cao, Sheng, Qu, Changxiu, Yang, Xin, Yang, Chuan-Cheng, Xia, Anjie, Hu, Zhenquan, Zhang, Qianqian, He, Yong-Hao, Zhang, Dao-Lai, Zhang, Chao, Hou, Gui-Hua, Liu, Huanxiang, Zhu, Lizhe, Fu, Ping, Yang, Shengyong, Rosenbaum, Daniel M., Sun, Jin-Peng, Du, Yang, Zhang, Lei, Yu, Xiao, Shao, Zhenhua
Published in Cell (18.02.2021)
Published in Cell (18.02.2021)
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The bromodomain protein BRD4 positively regulates necroptosis via modulating MLKL expression
Xiong, Yu, Li, Linli, Zhang, Liting, Cui, Yangyang, Wu, Chengyong, Li, Hui, Chen, Kai, Yang, Qiuyuan, Xiang, Rong, Hu, Yiguo, Huang, Shile, Wei, Yuquan, Yang, Shengyong
Published in Cell death and differentiation (01.10.2019)
Published in Cell death and differentiation (01.10.2019)
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Crystal structure of SARS-CoV-2 nsp10/nsp16 2′-O-methylase and its implication on antiviral drug design
Lin, Sheng, Chen, Hua, Ye, Fei, Chen, Zimin, Yang, Fanli, Zheng, Yue, Cao, Yu, Qiao, Jingxin, Yang, Shengyong, Lu, Guangwen
Published in Signal transduction and targeted therapy (29.07.2020)
Published in Signal transduction and targeted therapy (29.07.2020)
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Non-classical ferroptosis inhibition by a small molecule targeting PHB2
Yang, Wei, Mu, Bo, You, Jing, Tian, Chenyu, Bin, Huachao, Xu, Zhiqiang, Zhang, Liting, Ma, Ronggang, Wu, Ming, Zhang, Guo, Huang, Chong, Li, Linli, Shao, Zhenhua, Dai, Lunzhi, Désaubry, Laurent, Yang, Shengyong
Published in Nature communications (03.12.2022)
Published in Nature communications (03.12.2022)
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Discovery of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer
Luo, Xinling, Yang, Ruicheng, Li, Yueshan, Zhang, Liting, Yang, Shengyong, Li, Linli
Published in Bioorganic & medicinal chemistry letters (01.07.2022)
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HDAC inhibitors improve CRISPR-Cas9 mediated prime editing and base editing
Liu, Nan, Zhou, Lifang, Lin, Guifeng, Hu, Yun, Jiao, Yaoge, Wang, Yanhong, Liu, Jingming, Yang, Shengyong, Yao, Shaohua
Published in Molecular therapy. Nucleic acids (13.09.2022)
Published in Molecular therapy. Nucleic acids (13.09.2022)
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Targeting Pin1 by inhibitor API‐1 regulates microRNA biogenesis and suppresses hepatocellular carcinoma development
Pu, Wenchen, Li, Jiao, Zheng, Yuanyuan, Shen, Xianyan, Fan, Xin, Zhou, Jian‐Kang, He, Juan, Deng, Yulan, Liu, Xuesha, Wang, Chun, Yang, Shengyong, Chen, Qiang, Liu, Lunxu, Zhang, Guolin, Wei, Yu‐Quan, Peng, Yong
Published in Hepatology (Baltimore, Md.) (01.08.2018)
Published in Hepatology (Baltimore, Md.) (01.08.2018)
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Predicting transcriptional responses to novel chemical perturbations using deep generative model for drug discovery
Qi, Xiaoning, Zhao, Lianhe, Tian, Chenyu, Li, Yueyue, Chen, Zhen-Lin, Huo, Peipei, Chen, Runsheng, Liu, Xiaodong, Wan, Baoping, Yang, Shengyong, Zhao, Yi
Published in Nature communications (26.10.2024)
Published in Nature communications (26.10.2024)
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Jumonji domain‐containing protein 6 protein and its role in cancer
Yang, Jing, Chen, Siyuan, Yang, Yanfei, Ma, Xuelei, Shao, Bin, Yang, Shengyong, Wei, Yuquan, Wei, Xiawei
Published in Cell proliferation (01.02.2020)
Published in Cell proliferation (01.02.2020)
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Capsule Networks Showed Excellent Performance in the Classification of hERG Blockers/Nonblockers
Wang, Yiwei, Huang, Lei, Jiang, Siwen, Wang, Yifei, Zou, Jun, Fu, Hongguang, Yang, Shengyong
Published in Frontiers in pharmacology (28.01.2020)
Published in Frontiers in pharmacology (28.01.2020)
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