Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
YANG, Dun-Sheng, STAVRIDES, Philip, PAWLIK, Monika, PETERHOFF, Corrinne M, YANG, Austin J, WILSON, Donald A, GEORGE-HYSLOP, Peter St, WESTAWAY, David, MATHEWS, Paul M, LEVY, Efrat, CUERVO, Ana M, NIXON, Ralph A, MOHAN, Panaiyur S, KAUSHIK, Susmita, KUMAR, Asok, OHNO, Masuo, SCHMIDT, Stephen D, WESSON, Daniel, BANDYOPADHYAY, Urmi, YING JIANG
Published in Brain (London, England : 1878) (01.01.2011)
Published in Brain (London, England : 1878) (01.01.2011)
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Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits
YANG, Dun-Sheng, STAVRIDES, Philip, NIXON, Ralph A, SAITO, Mitsuo, KUMAR, Asok, RODRIGUEZ-NAVARRO, Jose A, PAWLIK, Monika, CHUNFENG HUO, WALKLEY, Steven U, SAITO, Mariko, CUERVO, Ana M
Published in Brain (London, England : 1878) (01.12.2014)
Published in Brain (London, England : 1878) (01.12.2014)
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Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration
Jiang, Ying, Alam, John J., Gomperts, Stephen N., Maruff, Paul, Lemstra, Afina W., Germann, Ursula A., Stavrides, Philip H., Darji, Sandipkumar, Malampati, Sandeep, Peddy, James, Bleiwas, Cynthia, Pawlik, Monika, Pensalfini, Anna, Yang, Dun-Sheng, Subbanna, Shivakumar, Basavarajappa, Balapal S., Smiley, John F., Gardner, Amanda, Blackburn, Kelly, Chu, Hui-May, Prins, Niels D., Teunissen, Charlotte E., Harrison, John E., Scheltens, Philip, Nixon, Ralph A.
Published in Nature communications (21.09.2022)
Published in Nature communications (21.09.2022)
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Transgenic expression of a ratiometric autophagy probe specifically in neurons enables the interrogation of brain autophagy in vivo
Lee, Ju-Hyun, Rao, Mala V., Yang, Dun-Sheng, Stavrides, Philip, Im, Eunju, Pensalfini, Anna, Huo, Chunfeng, Sarkar, Pallabi, Yoshimori, Tamotsu, Nixon, Ralph A.
Published in Autophagy (04.03.2019)
Published in Autophagy (04.03.2019)
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Neuronal Apoptosis and Autophagy Cross Talk in Aging PS/APP Mice, a Model of Alzheimer's Disease
Yang, Dun-Sheng, Kumar, Asok, Stavrides, Philip, Peterson, Jesse, Peterhoff, Corrine M, Pawlik, Monika, Levy, Efrat, Cataldo, Anne M, Nixon, Ralph A
Published in The American journal of pathology (01.09.2008)
Published in The American journal of pathology (01.09.2008)
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Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis
Yang, Dun-Sheng, Stavrides, Philip, Mohan, Panaiyur S., Kaushik, Susmita, Kumar, Asok, Ohno, Masuo, Schmidt, Stephen D., Wesson, Daniel W., Bandyopadhyay, Urmi, Jiang, Ying, Pawlik, Monika, Peterhoff, Corrinne M., Yang, Austin J., Wilson, Donald A., St. George-Hyslop, Peter, Westaway, David, Mathews, Paul M., Levy, Efrat, Cuervo, Ana Maria, Nixon, Ralph A.
Published in Autophagy (01.07.2011)
Published in Autophagy (01.07.2011)
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Marked Calpastatin (CAST) Depletion in Alzheimer's Disease Accelerates Cytoskeleton Disruption and Neurodegeneration: Neuroprotection by CAST Overexpression
Rao, Mala V, Mohan, Panaiyur S, Peterhoff, Corrinne M, Yang, Dun-Sheng, Schmidt, Stephen D, Stavrides, Philip H, Campbell, Jabbar, Chen, Yuanxin, Jiang, Ying, Paskevich, Peter A, Cataldo, Anne M, Haroutunian, Vahram, Nixon, Ralph A
Published in The Journal of neuroscience (19.11.2008)
Published in The Journal of neuroscience (19.11.2008)
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Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques
Lee, Ju-Hyun, Yang, Dun-Sheng, Goulbourne, Chris N., Im, Eunju, Stavrides, Philip, Pensalfini, Anna, Chan, Han, Bouchet-Marquis, Cedric, Bleiwas, Cynthia, Berg, Martin J., Huo, Chunfeng, Peddy, James, Pawlik, Monika, Levy, Efrat, Rao, Mala, Staufenbiel, Mathias, Nixon, Ralph A.
Published in Nature neuroscience (01.06.2022)
Published in Nature neuroscience (01.06.2022)
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Elevation of GM2 ganglioside during ethanol-induced apoptotic neurodegeneration in the developing mouse brain
Saito, Mitsuo, Chakraborty, Goutam, Shah, Relish, Mao, Rui-Fen, Kumar, Asok, Yang, Dun-Sheng, Dobrenis, Kostantin, Saito, Mariko
Published in Journal of neurochemistry (01.05.2012)
Published in Journal of neurochemistry (01.05.2012)
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Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease
Xue, Xue, Wang, Li-Rong, Sato, Yutaka, Jiang, Ying, Berg, Martin, Yang, Dun-Sheng, Nixon, Ralph A, Liang, Xing-Jie
Published in Nano letters (10.09.2014)
Published in Nano letters (10.09.2014)
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Mature Glycosylation and Trafficking of Nicastrin Modulate Its Binding to Presenilins
Yang, Dun-Sheng, Tandon, Anurag, Chen, Fusheng, Yu, Gang, Yu, Haung, Arawaka, Shigeki, Hasegawa, Hiroshi, Duthie, Monika, Schmidt, Stephen D, Ramabhadran, Triprayer V, Nixon, Ralph A, Mathews, Paul M, Gandy, Samuel E, Mount, Howard T J, St George-Hyslop, Peter, Fraser, Paul E
Published in The Journal of biological chemistry (02.08.2002)
Published in The Journal of biological chemistry (02.08.2002)
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Autophagy and neuronal cell death in neurological disorders
Nixon, Ralph A, Yang, Dun-Sheng
Published in Cold Spring Harbor perspectives in biology (01.10.2012)
Published in Cold Spring Harbor perspectives in biology (01.10.2012)
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Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons
Lie, Pearl P.Y., Yang, Dun-Sheng, Stavrides, Philip, Goulbourne, Chris N., Zheng, Ping, Mohan, Panaiyur S., Cataldo, Anne M., Nixon, Ralph A.
Published in Cell reports (Cambridge) (27.04.2021)
Published in Cell reports (Cambridge) (27.04.2021)
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Autophagy is a novel pathway for neurofilament protein degradation in vivo
Rao, Mala V., Darji, Sandipkumar, Stavrides, Philip H., Goulbourne, Chris N., Kumar, Asok, Yang, Dun-Sheng, Yoo, Lang, Peddy, James, Lee, Ju-Hyun, Yuan, Aidong, Nixon, Ralph A.
Published in Autophagy (03.04.2023)
Published in Autophagy (03.04.2023)
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Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice
Yang, Dun-Sheng, Stavrides, Philip, Kumar, Asok, Jiang, Ying, Mohan, Panaiyur S, Ohno, Masuo, Dobrenis, Kostantin, Davidson, Cristin D, Saito, Mitsuo, Pawlik, Monika, Huo, Chunfeng, Walkley, Steven U, Nixon, Ralph A
Published in Human molecular genetics (01.03.2017)
Published in Human molecular genetics (01.03.2017)
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