Novel reporters of mitochondria‐associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis
Sakai, Shohei, Watanabe, Seiji, Komine, Okiru, Sobue, Akira, Yamanaka, Koji
Published in The FASEB journal (01.07.2021)
Published in The FASEB journal (01.07.2021)
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Journal Article
A Seeding Reaction Recapitulates Intracellular Formation of Sarkosyl-insoluble Transactivation Response Element (TAR) DNA-binding Protein-43 Inclusions
Furukawa, Yoshiaki, Kaneko, Kumi, Watanabe, Shoji, Yamanaka, Koji, Nukina, Nobuyuki
Published in The Journal of biological chemistry (27.05.2011)
Published in The Journal of biological chemistry (27.05.2011)
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Journal Article
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction
Konishi, Hiroyuki, Okamoto, Takayuki, Hara, Yuichiro, Komine, Okiru, Tamada, Hiromi, Maeda, Mitsuyo, Osako, Fumika, Kobayashi, Masaaki, Nishiyama, Akira, Kataoka, Yosky, Takai, Toshiyuki, Udagawa, Nobuyuki, Jung, Steffen, Ozato, Keiko, Tamura, Tomohiko, Tsuda, Makoto, Yamanaka, Koji, Ogi, Tomoo, Sato, Katsuaki, Kiyama, Hiroshi
Published in The EMBO journal (16.11.2020)
Published in The EMBO journal (16.11.2020)
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Journal Article
Mitochondria‐associated membrane collapse is a common pathomechanism in SIGMAR1‐ and SOD1‐linked ALS
Watanabe, Seiji, Ilieva, Hristelina, Tamada, Hiromi, Nomura, Hanae, Komine, Okiru, Endo, Fumito, Jin, Shijie, Mancias, Pedro, Kiyama, Hiroshi, Yamanaka, Koji
Published in EMBO molecular medicine (01.12.2016)
Published in EMBO molecular medicine (01.12.2016)
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Journal Article
Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis
Watanabe, Seiji, Horiuchi, Mai, Murata, Yuri, Komine, Okiru, Kawade, Noe, Sobue, Akira, Yamanaka, Koji
Published in Neurobiology of disease (01.04.2023)
Published in Neurobiology of disease (01.04.2023)
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Journal Article
Aggresome formation and liquid–liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43
Watanabe, Seiji, Inami, Hidekazu, Oiwa, Kotaro, Murata, Yuri, Sakai, Shohei, Komine, Okiru, Sobue, Akira, Iguchi, Yohei, Katsuno, Masahisa, Yamanaka, Koji
Published in Cell death & disease (23.10.2020)
Published in Cell death & disease (23.10.2020)
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Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease
Sobue, Akira, Komine, Okiru, Hara, Yuichiro, Endo, Fumito, Mizoguchi, Hiroyuki, Watanabe, Seiji, Murayama, Shigeo, Saito, Takashi, Saido, Takaomi C, Sahara, Naruhiko, Higuchi, Makoto, Ogi, Tomoo, Yamanaka, Koji
Published in Acta neuropathologica communications (05.01.2021)
Published in Acta neuropathologica communications (05.01.2021)
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Stagnation of glymphatic interstitial fluid flow and delay in waste clearance in the SOD1-G93A mouse model of ALS
Hirose, Mikako, Asano, Mito, Watanabe-Matsumoto, Saori, Yamanaka, Koji, Abe, Yoichiro, Yasui, Masato, Tokuda, Eiichi, Furukawa, Yoshiaki, Misawa, Hidemi
Published in Neuroscience research (01.10.2021)
Published in Neuroscience research (01.10.2021)
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Journal Article
Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS
Israelson, Adrian, Arbel, Nir, Da Cruz, Sandrine, Ilieva, Hristelina, Yamanaka, Koji, Shoshan-Barmatz, Varda, Cleveland, Don W.
Published in Neuron (Cambridge, Mass.) (26.08.2010)
Published in Neuron (Cambridge, Mass.) (26.08.2010)
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Journal Article
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
Yamanaka, Koji, Cleveland, Don W, Chun, Seung Joo, Boillee, Severine, Fujimori-Tonou, Noriko, Yamashita, Hirofumi, Gutmann, David H, Takahashi, Ryosuke, Misawa, Hidemi
Published in Nature neuroscience (01.03.2008)
Published in Nature neuroscience (01.03.2008)
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Astrocyte-derived TGF-β1 accelerates disease progression in ALS mice by interfering with the neuroprotective functions of microglia and T cells
Endo, Fumito, Komine, Okiru, Fujimori-Tonou, Noriko, Katsuno, Masahisa, Jin, Shijie, Watanabe, Seiji, Sobue, Gen, Dezawa, Mari, Wyss-Coray, Tony, Yamanaka, Koji
Published in Cell reports (Cambridge) (28.04.2015)
Published in Cell reports (Cambridge) (28.04.2015)
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