Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS
Nagata, Tetsuya, Dwyer, Chrissa A., Yoshida-Tanaka, Kie, Ihara, Kensuke, Ohyagi, Masaki, Kaburagi, Hidetoshi, Miyata, Haruka, Ebihara, Satoe, Yoshioka, Kotaro, Ishii, Takashi, Miyata, Kanjiro, Miyata, Kenichi, Powers, Berit, Igari, Tomoko, Yamamoto, Syunsuke, Arimura, Naoto, Hirabayashi, Hideki, Uchihara, Toshiki, Hara, Rintaro Iwata, Wada, Takeshi, Bennett, C. Frank, Seth, Punit P., Rigo, Frank, Yokota, Takanori
Published in Nature biotechnology (01.12.2021)
Published in Nature biotechnology (01.12.2021)
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Journal Article
Enhanced pulmonary absorption of poorly soluble itraconazole by micronized cocrystal dry powder formulations
Karashima, Masatoshi, Sano, Noriyasu, Yamamoto, Syunsuke, Arai, Yuta, Yamamoto, Katsuhiko, Amano, Nobuyuki, Ikeda, Yukihiro
Published in European journal of pharmaceutics and biopharmaceutics (01.06.2017)
Published in European journal of pharmaceutics and biopharmaceutics (01.06.2017)
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Journal Article
Advanced translational PBPK model for transferrin receptor-mediated drug delivery to the brain
Sato, Sho, Liu, Siyu, Goto, Akihiko, Yoneyama, Tomoki, Okita, Koki, Yamamoto, Syunsuke, Hirabayashi, Hideki, Iwasaki, Shinji, Kusuhara, Hiroyuki
Published in Journal of controlled release (01.05.2023)
Published in Journal of controlled release (01.05.2023)
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Journal Article
Impact of P-Glycoprotein on Intestinal Absorption of an Inhibitor of Apoptosis Protein Antagonist in Rats: Mechanisms of Nonlinear Pharmacokinetics and Food Effects
Yamamoto, Syunsuke, Kosugi, Yohei, Hirabayashi, Hideki, Moriwaki, Toshiya
Published in Pharmaceutical research (01.10.2018)
Published in Pharmaceutical research (01.10.2018)
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Journal Article
Corrigendum to “Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration” [Drug Metabol Pharmacokinet 41 (2021) 100408]
Ding, Ning, Yamamoto, Syunsuke, Chisaki, Ikumi, Nakayama, Miyu, Matsumoto, Shin-ichi, Hirabayashi, Hideki
Published in Drug metabolism and pharmacokinetics (01.08.2024)
Published in Drug metabolism and pharmacokinetics (01.08.2024)
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Journal Article
Heteroduplex oligonucleotide technology boosts oligonucleotide splice switching activity of morpholino oligomers in a Duchenne muscular dystrophy mouse model
Hasegawa, Juri, Nagata, Tetsuya, Ihara, Kensuke, Tanihata, Jun, Ebihara, Satoe, Yoshida-Tanaka, Kie, Yanagidaira, Mitsugu, Ohara, Masahiro, Sasaki, Asuka, Nakayama, Miyu, Yamamoto, Syunsuke, Ishii, Takashi, Iwata-Hara, Rintaro, Naito, Mitsuru, Miyata, Kanjiro, Sakaue, Fumika, Yokota, Takanori
Published in Nature communications (26.09.2024)
Published in Nature communications (26.09.2024)
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Journal Article
Quantitative PCR methodology with a volume-based unit for the sophisticated cellular kinetic evaluation of chimeric antigen receptor T cells
Yamamoto, Syunsuke, Matsumoto, Shin-ichi, Goto, Akihiko, Ugajin, Miyuki, Nakayama, Miyu, Moriya, Yuu, Hirabayashi, Hideki
Published in Scientific reports (21.10.2020)
Published in Scientific reports (21.10.2020)
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Journal Article
Preferential delivery of lipid-ligand conjugated DNA/RNA heteroduplex oligonucleotide to ischemic brain in hyperacute stage
Li, Fuying, Ichinose, Keiko, Ishibashi, Satoru, Yamamoto, Syunsuke, Iwasawa, Eri, Suzuki, Motohiro, Yoshida-Tanaka, Kie, Yoshioka, Kotaro, Nagata, Tetsuya, Hirabayashi, Hideki, Mogushi, Kaoru, Yokota, Takanori
Published in Molecular therapy (05.04.2023)
Published in Molecular therapy (05.04.2023)
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Journal Article
Direct Drug Delivery of Low-Permeable Compounds to the Central Nervous System Via Intranasal Administration in Rats and Monkeys
Iwasaki, Shinji, Yamamoto, Syunsuke, Sano, Noriyasu, Tohyama, Kimio, Kosugi, Yohei, Furuta, Atsutoshi, Hamada, Teruki, Igari, Tomoko, Fujioka, Yasushi, Hirabayashi, Hideki, Amano, Nobuyuki
Published in Pharmaceutical research (01.05.2019)
Published in Pharmaceutical research (01.05.2019)
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Journal Article
Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration
Ding, Ning, Yamamoto, Syunsuke, Chisaki, Ikumi, Nakayama, Miyu, Matsumoto, Shin-ichi, Hirabayashi, Hideki
Published in Drug metabolism and pharmacokinetics (01.12.2021)
Published in Drug metabolism and pharmacokinetics (01.12.2021)
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Journal Article
Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation
Miyakawa, Shuuichi, Sakuma, Hiroyuki, Warude, Dnyaneshwar, Asanuma, Satomi, Arimura, Naoto, Yoshihara, Tomoki, Tavares, Daniel, Hata, Akito, Ida, Koh, Hori, Yuri, Okuzono, Yuumi, Yamamoto, Syunsuke, Iida, Koichi, Shimizu, Hisao, Kondo, Shinichi, Sato, Shuji
Published in Frontiers in neuroscience (15.12.2020)
Published in Frontiers in neuroscience (15.12.2020)
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Journal Article
Multisite evaluation of nonclinical biodistribution study in cell therapy products
Kamiyama, Yoshiteru, Fujita, Eriko, Yamamoto, Syunsuke, Nakayama, Miyu, Hanada, Takeshi, Arimura, Yukiko, Suzuki, Yoshiyuki, Ito, Masahiko, Koga, Yoshiyuki, Asano, Yuya, Yatsuda, Yukinori, Sato, Yoji
Published in Drug metabolism and pharmacokinetics (01.04.2024)
Published in Drug metabolism and pharmacokinetics (01.04.2024)
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Journal Article
Identification and Functional Characterization of Rat Riboflavin Transporter 2
Yamamoto, Syunsuke, Inoue, Katsuhisa, Ohta, Kin-ya, Fukatsu, Rui, Maeda, Jun-ya, Yoshida, Yukihiro, Yuasa, Hiroaki
Published in Journal of biochemistry (Tokyo) (01.04.2009)
Published in Journal of biochemistry (Tokyo) (01.04.2009)
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Journal Article
Functional Characteristics of the Human Ortholog of Riboflavin Transporter 2 and Riboflavin-Responsive Expression of Its Rat Ortholog in the Small Intestine Indicate Its Involvement in Riboflavin Absorption
Fujimura, Misaki, Yamamoto, Syunsuke, Murata, Tomoaki, Yasujima, Tomoya, Inoue, Katsuhisa, Ohta, Kin-ya, Yuasa, Hiroaki
Published in The Journal of nutrition (01.10.2010)
Published in The Journal of nutrition (01.10.2010)
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Journal Article
A novel and selective melanin-concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet-induced obese rodent models
Kawata, Yayoi, Okuda, Shoki, Hotta, Natsu, Igawa, Hideyuki, Takahashi, Masashi, Ikoma, Minoru, Kasai, Shizuo, Ando, Ayumi, Satomi, Yoshinori, Nishida, Mayumi, Nakayama, Masaharu, Yamamoto, Syunsuke, Nagisa, Yasutaka, Takekawa, Shiro
Published in European journal of pharmacology (05.02.2017)
Published in European journal of pharmacology (05.02.2017)
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Journal Article
Biodistribution studies for cell therapy products: Current status and issues
Kamiyama, Yoshiteru, Naritomi, Yoichi, Moriya, Yuu, Yamamoto, Syunsuke, Kitahashi, Tsukasa, Maekawa, Toshihiko, Yahata, Masahiro, Hanada, Takeshi, Uchiyama, Asako, Noumaru, Akari, Koga, Yoshiyuki, Higuchi, Tomoaki, Ito, Masahiko, Komatsu, Hiroyuki, Miyoshi, Sosuke, Kimura, Sadaaki, Umeda, Nobuhiro, Fujita, Eriko, Tanaka, Naoko, Sugita, Taku, Takayama, Satoru, Kurogi, Akihiko, Yasuda, Satoshi, Sato, Yoji
Published in Regenerative therapy (01.12.2021)
Published in Regenerative therapy (01.12.2021)
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Journal Article