Design and Synthesis of Orexin 1 Receptor-Selective Agonists
Iio, Keita, Hashimoto, Kao, Nagumo, Yasuyuki, Amezawa, Mao, Hasegawa, Taisei, Yamamoto, Naoshi, Kutsumura, Noriki, Takeuchi, Katsuhiko, Ishikawa, Yukiko, Yamamoto, Hikari, Tokuda, Akihisa, Sato, Tetsu, Uchida, Yasuo, Inoue, Asuka, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi, Saitoh, Tsuyoshi
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
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Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring
Iio, Keita, Saitoh, Tsuyoshi, Ohshita, Ryuichiro, Hino, Tsubasa, Amezawa, Mao, Takayama, Yoshiaki, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (15.03.2022)
Published in Bioorganic & medicinal chemistry letters (15.03.2022)
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Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton
Hino, Tsubasa, Saitoh, Tsuyoshi, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
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Journal Article
Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in d-nor-nalfurafine derivatives
Katoh, Koki, Kutsumura, Noriki, Yamamoto, Naoshi, Nagumo, Yasuyuki, Saitoh, Tsuyoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
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Synthesis of unnatural morphinan compounds to induce itch-like behaviors in mice: Towards the development of MRGPRX2 selective ligands
Iio, Keita, Kutsumura, Noriki, Nagumo, Yasuyuki, Saitoh, Tsuyoshi, Tokuda, Akihisa, Hashimoto, Kao, Yamamoto, Naoshi, Kise, Ryoji, Inoue, Asuka, Mizoguchi, Hirokazu, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (15.01.2022)
Published in Bioorganic & medicinal chemistry letters (15.01.2022)
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Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors
Katoh, Koki, Yamamoto, Naoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Tanimura, Ryuji, Saitoh, Tsuyoshi, Nagumo, Yasuyuki, Kutsumura, Noriki, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
Published in Bioorganic & medicinal chemistry letters (01.03.2022)
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Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library
Saitoh, Tsuyoshi, Amezawa, Mao, Horiuchi, Jumpei, Nagumo, Yasuyuki, Yamamoto, Naoshi, Kutsumura, Noriki, Ohshita, Ryuichiro, Tokuda, Akihisa, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Hasegawa, Emi, Sakurai, Takeshi, Uchida, Yasuo, Sato, Tetsu, Gouda, Hiroaki, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi
Published in European journal of medicinal chemistry (05.10.2022)
Published in European journal of medicinal chemistry (05.10.2022)
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The application of a specific morphinan template to the synthesis of galanthamine
Yamamoto, Naoshi, Okada, Takahiro, Harada, Yukimasa, Kutsumura, Noriki, Imaide, Satomi, Saitoh, Tsuyoshi, Fujii, Hideaki, Nagase, Hiroshi
Published in Tetrahedron (28.09.2017)
Published in Tetrahedron (28.09.2017)
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Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group
Saitoh, Tsuyoshi, Seki, Kazunori, Nakajima, Ryo, Yamamoto, Naoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (01.02.2020)
Published in Bioorganic & medicinal chemistry letters (01.02.2020)
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Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity
Saitoh, Tsuyoshi, Seki, Kazunori, Nakajima, Ryo, Yamamoto, Naoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Tanimura, Ryuji, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
Published in Bioorganic & medicinal chemistry letters (15.09.2019)
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ZnCl2-Promoted Intramolecular Hetero-Diels–Alder Reaction of o-Alkynylphenylcarbodiimides for Synthesis of Dihydrodibenzo[b,g][1,8]naphthyridines
Kutsumura, Noriki, Koyama, Yasuaki, Tateno, Kotaro, Yamamoto, Naoshi, Nagase, Hiroshi, Saito, Takao
Published in Chemical & pharmaceutical bulletin (01.09.2016)
Published in Chemical & pharmaceutical bulletin (01.09.2016)
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Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity
Ohrui, Sayaka, Yamamoto, Naoshi, Saitoh, Tsuyoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Watanabe, Yurie, Hayakawa, Daichi, Gouda, Hiroaki, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry letters (15.02.2018)
Published in Bioorganic & medicinal chemistry letters (15.02.2018)
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Journal Article
Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring
Yamamoto, Naoshi, Ohrui, Sayaka, Okada, Takahiro, Saitoh, Tsuyoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Watanabe, Yurie, Hayakawa, Daichi, Gouda, Hiroaki, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Bioorganic & medicinal chemistry (15.04.2019)
Published in Bioorganic & medicinal chemistry (15.04.2019)
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Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti- Plasmodium falciparum Activities
Kutsumura, Noriki, Koyama, Yasuaki, Saitoh, Tsuyoshi, Yamamoto, Naoshi, Nagumo, Yasuyuki, Miyata, Yoshiyuki, Hokari, Rei, Ishiyama, Aki, Iwatsuki, Masato, Otoguro, Kazuhiko, Ōmura, Satoshi, Nagase, Hiroshi
Published in Molecules (Basel, Switzerland) (02.03.2020)
Published in Molecules (Basel, Switzerland) (02.03.2020)
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A NOVEL REARRANGEMENT REACTION OF MORPHINAN TO ARYLMORPHAN SKELETONS AND THE PHARMACOLOGIES OF ARYLMORPHAN DERIVATIVES
Yata, Masahiro, Kutsumura, Noriki, Nagumo, Yasuyuki, Yamamoto, Naoshi, Saitoh, Tsuyoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Yanagisawa, Masashi, Nagase, Hiroshi
Published in Heterocycles (01.04.2019)
Published in Heterocycles (01.04.2019)
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FORMAL SYNTHESIS OF SCELETIUM ALKALOIDS, (+/-)-MESEMBRINE AND (+/-)-MESEMBRANOL
Honda, Toshio, Arai, Hironobu, Yamamoto, Naoshi, Takahashi, Kazunori
Published in Heterocycles (01.01.2012)
Published in Heterocycles (01.01.2012)
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Journal Article
Synthesis of (−)-Homogalanthamine from Naltrexone
Yamamoto, Naoshi, Fujii, Hideaki, Imaide, Satomi, Hirayama, Shigeto, Nemoto, Toru, Inokoshi, Junji, Tomoda, Hiroshi, Nagase, Hiroshi
Published in Journal of organic chemistry (01.04.2011)
Published in Journal of organic chemistry (01.04.2011)
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Journal Article
Synthesis of a Stable Iminium Salt and Propellane Derivatives
Nagase, Hiroshi, Yamamoto, Naoshi, Nemoto, Toru, Yoza, Kenji, Kamiya, Kenshu, Hirono, Shuichi, Momen, Shinobu, Izumimoto, Naoki, Hasebe, Ko, Mochizuki, Hidenori, Fujii, Hideaki
Published in Journal of organic chemistry (17.10.2008)
Published in Journal of organic chemistry (17.10.2008)
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Synthesis of opioid ligands having oxabicyclo[2.2.2]octane and oxabicyclo[2.2.1]heptane skeletons
Nagase, Hiroshi, Watanabe, Akio, Nemoto, Toru, Yamamoto, Naoshi, Osa, Yumiko, Sato, Noriko, Yoza, Kenji, Kai, Toshitsugu
Published in Tetrahedron letters (02.04.2007)
Published in Tetrahedron letters (02.04.2007)
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Journal Article
Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5‑trioxazatriquinane skeleton
Amezawa, Mao, Yamamoto, Naoshi, Nagumo, Yasuyuki, Kutsumura, Noriki, Ishikawa, Yukiko, Yanagisawa, Masashi, Nagase, Hiroshi, Saitoh, Tsuyoshi
Published in Bioorganic & medicinal chemistry letters (15.02.2023)
Published in Bioorganic & medicinal chemistry letters (15.02.2023)
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