Search Results - "YABUKI MASATO" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells

A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells

by Ishikawa, Yoshinori, Gamo, Kanae, Yabuki, Masato, Takagi, Shinji, Toyoshima, Kosei, Nakayama, Kazuhide, Nakayama, Akiko, Morimoto, Megumi, Miyashita, Hitoshi, Dairiki, Ryo, Hikichi, Yukiko, Tomita, Naoki, Tomita, Daisuke, Imamura, Shinichi, Iwatani, Misa, Kamada, Yusuke, Matsumoto, Satoru, Hara, Ryujiro, Nomura, Toshiyuki, Tsuchida, Ken, Nakamura, Kazuhide
Published in Molecular cancer therapeutics (01.02.2017)

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Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy

Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy

by Shibata, Akira, Kuno, Masako, Adachi, Ryutaro, Sato, Yosuke, Hattori, Harumi, Matsuda, Atsushi, Okuzono, Yuumi, Igaki, Keiko, Tominari, Yusuke, Takagi, Terufumi, Yabuki, Masato, Okaniwa, Masanori
Published in PloS one (24.10.2017)

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Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2‑a]pyrazine Scaffold as a Novel Proline Mimetic

Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2‑a]pyrazine Scaffold as a Novel Proline Mimetic

by Hashimoto, Kentaro, Saito, Bunnai, Miyamoto, Naoki, Oguro, Yuya, Tomita, Daisuke, Shiokawa, Zenyu, Asano, Moriteru, Kakei, Hiroyuki, Taya, Naohiro, Kawasaki, Masanori, Sumi, Hiroyuki, Yabuki, Masato, Iwai, Kenichi, Yoshida, Sei, Yoshimatsu, Mie, Aoyama, Kazunobu, Kosugi, Yohei, Kojima, Takashi, Morishita, Nao, Dougan, Douglas R, Snell, Gyorgy P, Imamura, Shinichi, Ishikawa, Tomoyasu
Published in Journal of medicinal chemistry (14.02.2013)

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Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists

Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists

by Asano, Moriteru, Hashimoto, Kentaro, Saito, Bunnai, Shiokawa, Zenyu, Sumi, Hiroyuki, Yabuki, Masato, Yoshimatsu, Mie, Aoyama, Kazunobu, Hamada, Teruki, Morishita, Nao, Dougan, Douglas R., Mol, Clifford D., Yoshida, Sei, Ishikawa, Tomoyasu
Published in Bioorganic & medicinal chemistry (15.09.2013)

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Discovery of a Selective Kinase Inhibitor (TAK-632) Targeting Pan-RAF Inhibition: Design, Synthesis, and Biological Evaluation of C‑7-Substituted 1,3-Benzothiazole Derivatives

Discovery of a Selective Kinase Inhibitor (TAK-632) Targeting Pan-RAF Inhibition: Design, Synthesis, and Biological Evaluation of C‑7-Substituted 1,3-Benzothiazole Derivatives

by Okaniwa, Masanori, Hirose, Masaaki, Arita, Takeo, Yabuki, Masato, Nakamura, Akito, Takagi, Terufumi, Kawamoto, Tomohiro, Uchiyama, Noriko, Sumita, Akihiko, Tsutsumi, Shunichirou, Tottori, Tsuneaki, Inui, Yoshitaka, Sang, Bi-Ching, Yano, Jason, Aertgeerts, Kathleen, Yoshida, Sei, Ishikawa, Tomoyasu
Published in Journal of medicinal chemistry (22.08.2013)

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T-3256336, a novel and orally available small molecule IAP antagonist, induced tumor cell death via induction of systemic TNF alpha production

T-3256336, a novel and orally available small molecule IAP antagonist, induced tumor cell death via induction of systemic TNF alpha production

by Sumi, Hiroyuki, Inazuka, Masakazu, Hashimoto, Kentaro, Ishikawa, Tomoyasu, Yoshida, Sei, Yabuki, Masato
Published in Biochemical and biophysical research communications (14.10.2016)

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An inhibitor of apoptosis protein antagonist T-3256336 potentiates the antitumor efficacy of the Nedd8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924)

An inhibitor of apoptosis protein antagonist T-3256336 potentiates the antitumor efficacy of the Nedd8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924)

by Sumi, Hiroyuki, Inazuka, Masakazu, Morimoto, Megumi, Hibino, Ryosuke, Hashimoto, Kentaro, Ishikawa, Tomoyasu, Kuida, Keisuke, Smith, Peter G., Yoshida, Sei, Yabuki, Masato
Published in Biochemical and biophysical research communications (18.11.2016)

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Design and Synthesis of Novel DFG-Out RAF/Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Inhibitors. 1. Exploration of [5,6]-Fused Bicyclic Scaffolds

Design and Synthesis of Novel DFG-Out RAF/Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Inhibitors. 1. Exploration of [5,6]-Fused Bicyclic Scaffolds

by Okaniwa, Masanori, Hirose, Masaaki, Imada, Takashi, Ohashi, Tomohiro, Hayashi, Youko, Miyazaki, Tohru, Arita, Takeo, Yabuki, Masato, Kakoi, Kazuyo, Kato, Juran, Takagi, Terufumi, Kawamoto, Tomohiro, Yao, Shuhei, Sumita, Akihiko, Tsutsumi, Shunichirou, Tottori, Tsuneaki, Oki, Hideyuki, Sang, Bi-Ching, Yano, Jason, Aertgeerts, Kathleen, Yoshida, Sei, Ishikawa, Tomoyasu
Published in Journal of medicinal chemistry (12.04.2012)

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Gene Signature-Based Approach Identified MEK1/2 as a Potential Target Associated With Relapse After Anti-TNFα Treatment for Crohn's Disease

Gene Signature-Based Approach Identified MEK1/2 as a Potential Target Associated With Relapse After Anti-TNFα Treatment for Crohn's Disease

by Gamo, Kanae, Okuzono, Yuumi, Yabuki, Masato, Ochi, Takashi, Sugimura, Kyoko, Sato, Yosuke, Sagara, Masaki, Hayashi, Hiroki, Ishimura, Yoshimasa, Nishimoto, Yutaka, Murakawa, Yusuke, Shiokawa, Zenyu, Gotoh, Masayuki, Miyazaki, Takahiro, Ebisuno, Yukihiko
Published in Inflammatory bowel diseases (18.05.2018)

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Gene Signature-Based Approach Identified MEK1/2 as a Potential Target Associated With Relapse After Anti-TNF[alpha] Treatment for Crohn's Disease

Gene Signature-Based Approach Identified MEK1/2 as a Potential Target Associated With Relapse After Anti-TNF[alpha] Treatment for Crohn's Disease

by Gamo, Kanae, Okuzono, Yuumi, Yabuki, Masato, Ochi, Takashi, Sugimura, Kyoko, Sato, Yosuke, Sagara, Masaki, Hayashi, Hiroki, Ishimura, Yoshimasa, Nishimoto, Yutaka, Murakawa, Yusuke, Shiokawa, Zenyu, Gotoh, Masayuki, Miyazaki, Takahiro, Ebisuno, Yukihiko
Published in Inflammatory bowel diseases (01.06.2018)

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Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells

Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells

by Shiokawa, Zenyu, Hashimoto, Kentaro, Saito, Bunnai, Oguro, Yuya, Sumi, Hiroyuki, Yabuki, Masato, Yoshimatsu, Mie, Kosugi, Yohei, Debori, Yasuyuki, Morishita, Nao, Dougan, Douglas R., Snell, Gyorgy P., Yoshida, Sei, Ishikawa, Tomoyasu
Published in Bioorganic & medicinal chemistry (15.12.2013)

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Antitumor activity and pharmacodynamic biomarkers of a novel and orally available small-molecule antagonist of inhibitor of apoptosis proteins

Antitumor activity and pharmacodynamic biomarkers of a novel and orally available small-molecule antagonist of inhibitor of apoptosis proteins

by Sumi, Hiroyuki, Yabuki, Masato, Iwai, Kenichi, Morimoto, Megumi, Hibino, Ryosuke, Inazuka, Masakazu, Hashimoto, Kentaro, Kosugi, Yohei, Aoyama, Kazunobu, Yamamoto, Shunsuke, Yoshimatsu, Mie, Yamasaki, Hideki, Tozawa, Ryuichi, Ishikawa, Tomoyasu, Yoshida, Sei
Published in Molecular cancer therapeutics (01.02.2013)

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Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives

Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives

by Hirose, Masaaki, Okaniwa, Masanori, Miyazaki, Tohru, Imada, Takashi, Ohashi, Tomohiro, Tanaka, Yuta, Arita, Takeo, Yabuki, Masato, Kawamoto, Tomohiro, Tsutsumi, Shunichirou, Sumita, Akihiko, Takagi, Terufumi, Sang, Bi-Ching, Yano, Jason, Aertgeerts, Kathleen, Yoshida, Sei, Ishikawa, Tomoyasu
Published in Bioorganic & medicinal chemistry (15.09.2012)

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Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption

Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption

by Okaniwa, Masanori, Imada, Takashi, Ohashi, Tomohiro, Miyazaki, Tohru, Arita, Takeo, Yabuki, Masato, Sumita, Akihiko, Tsutsumi, Shunichirou, Higashikawa, Keiko, Takagi, Terufumi, Kawamoto, Tomohiro, Inui, Yoshitaka, Yoshida, Sei, Ishikawa, Tomoyasu
Published in Bioorganic & medicinal chemistry (01.08.2012)

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Journal Article

Abstract C255: Discovery of TAK-632: A selective kinase inhibitor of pan-RAF with potent antitumor activity against BRAF and NRAS mutant melanomas

Abstract C255: Discovery of TAK-632: A selective kinase inhibitor of pan-RAF with potent antitumor activity against BRAF and NRAS mutant melanomas

by Okaniwa, Masanori, Hirose, Masaaki, Arita, Takeo, Yabuki, Masato, Nakamura, Akito, Takagi, Terufumi, Kawamoto, Tomohiro, Uchiyama, Noriko, Sumita, Akihiko, Tsutsumi, Shunichirou, Tottori, Tsuneaki, Inui, Yoshitaka, Sang, Bi-Ching, Yano, Jason, Aertgeerts, Kathleen, Yoshida, Sei, Ishikawa, Tomoyasu
Published in Molecular cancer therapeutics (01.11.2013)

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Journal Article

Ser super(46) phosphorylation of p53 is not always sufficient to induce apoptosis: multiple mechanisms of regulation of p53-dependent apoptosis

Ser super(46) phosphorylation of p53 is not always sufficient to induce apoptosis: multiple mechanisms of regulation of p53-dependent apoptosis

by Kurihara, Akira, Nagoshi, Hirokazu, Yabuki, Masato, Okuyama, Ryuhei, Obinata, Masuo, Ikawa, Shuntaro
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.07.2007)

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Ser46 phosphorylation of p53 is not always sufficient to induce apoptosis: multiple mechanisms of regulation of p53‐dependent apoptosis

Ser46 phosphorylation of p53 is not always sufficient to induce apoptosis: multiple mechanisms of regulation of p53‐dependent apoptosis

by Kurihara, Akira, Nagoshi, Hirokazu, Yabuki, Masato, Okuyama, Ryuhei, Obinata, Masuo, Ikawa, Shuntaro
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.07.2007)

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Journal Article

Ser 46 phosphorylation of p53 is not always sufficient to induce apoptosis: multiple mechanisms of regulation of p53‐dependent apoptosis

Ser 46 phosphorylation of p53 is not always sufficient to induce apoptosis: multiple mechanisms of regulation of p53‐dependent apoptosis

by Kurihara, Akira, Nagoshi, Hirokazu, Yabuki, Masato, Okuyama, Ryuhei, Obinata, Masuo, Ikawa, Shuntaro
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.07.2007)

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Journal Article

LOAD BALANCER AND PROGRAM

LOAD BALANCER AND PROGRAM

by YABUKI MASATO, OWADA TOSHIYUKI
Year of Publication 19.10.2006

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Patent

JP2857842B

JP2857842B

by YABUKI MASATO
Year of Publication 17.02.1999

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Patent