Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies
Koblish, Holly, Li, Yun-Long, Shin, Niu, Hall, Leslie, Wang, Qian, Wang, Kathy, Covington, Maryanne, Marando, Cindy, Bowman, Kevin, Boer, Jason, Burke, Krista, Wynn, Richard, Margulis, Alex, Reuther, Gary W, Lambert, Que T, Dostalik Roman, Valerie, Zhang, Ke, Feng, Hao, Xue, Chu-Biao, Diamond, Sharon, Hollis, Greg, Yeleswaram, Swamy, Yao, Wenqing, Huber, Reid, Vaddi, Kris, Scherle, Peggy
Published in PloS one (21.06.2018)
Published in PloS one (21.06.2018)
Get full text
Journal Article
Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist
Zheng, Changsheng, Cao, Ganfeng, Xia, Michael, Feng, Hao, Glenn, Joseph, Anand, Rajan, Zhang, Ke, Huang, Taisheng, Wang, Anlai, Kong, Ling, Li, Mei, Galya, Laurine, Hughes, Robert O., Devraj, Rajesh, Morton, Phillip A., Rogier, D. Joseph, Covington, Maryanne, Baribaud, Fred, Shin, Niu, Scherle, Peggy, Diamond, Sharon, Yeleswaram, Swamy, Vaddi, Kris, Newton, Robert, Hollis, Greg, Friedman, Steven, Metcalf, Brian, Xue, Chu-Biao
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Published in Bioorganic & medicinal chemistry letters (01.03.2011)
Get full text
Journal Article
Pharmacological characterization of INCB3344, a small molecule antagonist of human CCR2
Shin, Niu, Baribaud, Frédéric, Wang, Kathy, Yang, Genjie, Wynn, Rich, Covington, Maryanne B., Feldman, Patricia, Gallagher, Karen B., Leffet, Lynn M., Lo, Yvonne Y., Wang, Anlai, Xue, Chu-Biao, Newton, Robert C., Scherle, Peggy A.
Published in Biochemical and biophysical research communications (18.09.2009)
Published in Biochemical and biophysical research communications (18.09.2009)
Get full text
Journal Article
Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist
Xue, Chu-Biao, Feng, Hao, Cao, Ganfeng, Huang, Taisheng, Glenn, Joseph, Anand, Rajan, Meloni, David, Zhang, Ke, Kong, Lingquan, Wang, Anlai, Zhang, Yingxin, Zheng, Changsheng, Xia, Michael, Chen, Lihua, Tanaka, Hiroyuki, Han, Qi, Robinson, D. J, Modi, Dilip, Storace, Lou, Shao, Lixin, Sharief, Vaqar, Li, Mei, Galya, Laurine G, Covington, Maryanne, Scherle, Peggy, Diamond, Sharon, Emm, Tom, Yeleswaram, Swamy, Contel, Nancy, Vaddi, Kris, Newton, Robert, Hollis, Greg, Friedman, Steven, Metcalf, Brian
Published in ACS medicinal chemistry letters (09.06.2011)
Published in ACS medicinal chemistry letters (09.06.2011)
Get full text
Journal Article
Preclinical characterization of itacitinib (INCB039110), a novel selective inhibitor of JAK1, for the treatment of inflammatory diseases
Covington, Maryanne, He, Xin, Scuron, Monika, Li, Jun, Collins, Robert, Juvekar, Ashish, Shin, Niu, Favata, Margaret, Gallagher, Karen, Sarah, Sarala, Xue, Chu-biao, Peel, Michael, Burke, Krista, Oliver, Julian, Fay, Brittany, Yao, Wenqing, Huang, Taisheng, Scherle, Peggy, Diamond, Sharon, Newton, Robert, Zhang, Yan, Smith, Paul
Published in European journal of pharmacology (15.10.2020)
Published in European journal of pharmacology (15.10.2020)
Get full text
Journal Article
The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies
Stubbs, Matthew C, Burn, Timothy C, Sparks, Richard, Maduskuie, Thomas, Diamond, Sharon, Rupar, Mark, Wen, Xiaoming, Volgina, Alla, Zolotarjova, Nina, Waeltz, Paul, Favata, Margaret, Jalluri, Ravi, Liu, Huiqing, Liu, Xuesong Mike, Li, Jun, Collins, Robert, Falahatpisheh, Nikoo, Polam, Padmaja, DiMatteo, Darlise, Feldman, Patricia, Dostalik, Valerie, Thekkat, Pramod, Gardiner, Christine, He, Xin, Li, Yanlong, Covington, Maryanne, Wynn, Richard, Ruggeri, Bruce, Yeleswaram, Swamy, Xue, Chu-Biao, Yao, Wenqing, Combs, Andrew P, Huber, Reid, Hollis, Gregory, Scherle, Peggy, Liu, Phillip C C
Published in Clinical cancer research (01.01.2019)
Published in Clinical cancer research (01.01.2019)
Get full text
Journal Article
INCB050465 (Parsaclisib), a Novel Next-Generation Inhibitor of Phosphoinositide 3‑Kinase Delta (PI3Kδ)
Yue, Eddy W, Li, Yun-Long, Douty, Brent, He, Chunhong, Mei, Song, Wayland, Brian, Maduskuie, Thomas, Falahatpisheh, Nikoo, Sparks, Richard B, Polam, Padmaja, Zhu, Wenyu, Glenn, Joseph, Feng, Hao, Zhang, Ke, Li, Yanlong, He, Xin, Katiyar, Kamna, Covington, Maryanne, Feldman, Patricia, Shin, Niu, Wang, Kathy He, Diamond, Sharon, Li, Yu, Koblish, Holly K, Hall, Leslie, Scherle, Peggy, Yeleswaram, Swamy, Xue, Chu-Biao, Metcalf, Brian, Combs, Andrew P, Yao, Wenqing
Published in ACS medicinal chemistry letters (14.11.2019)
Published in ACS medicinal chemistry letters (14.11.2019)
Get full text
Journal Article
Aggrecanase: A Target for the Design of Inhibitors of Cartilage Degradation
ARNER, ELIZABETH C., PRATTA, MICHAEL A., DECICCO, CARL P., XUE, CHU-BIAO, NEWTON, ROBERT C., TRZASKOS, JAMES M., MAGOLDA, RONALD L., TORTERELLA, MICKY D.
Published in Annals of the New York Academy of Sciences (01.06.1999)
Published in Annals of the New York Academy of Sciences (01.06.1999)
Get full text
Journal Article
Discovery and Pharmacological Characterization of a Novel Rodent-Active CCR2 Antagonist, INCB3344
Brodmerkel, Carrie M, Huber, Reid, Covington, Maryanne, Diamond, Sharon, Hall, Leslie, Collins, Robert, Leffet, Lynn, Gallagher, Karen, Feldman, Patricia, Collier, Paul, Stow, Mark, Gu, Xiaomei, Baribaud, Frederic, Shin, Niu, Thomas, Beth, Burn, Tim, Hollis, Greg, Yeleswaram, Swamy, Solomon, Kim, Friedman, Steve, Wang, Anlai, Xue, Chu Biao, Newton, Robert C, Scherle, Peggy, Vaddi, Kris
Published in The Journal of immunology (1950) (15.10.2005)
Published in The Journal of immunology (1950) (15.10.2005)
Get full text
Journal Article
Identification and characterization of INCB9471, an allosteric noncompetitive small-molecule antagonist of C-C chemokine receptor 5 with potent inhibitory activity against monocyte migration and HIV-1 infection
Shin, Niu, Solomon, Kim, Zhou, Naiming, Wang, Kathy He, Garlapati, Vasudha, Thomas, Beth, Li, Yanlong, Covington, Maryanne, Baribaud, Frederic, Erickson-Viitanen, Susan, Czerniak, Phil, Contel, Nancy, Liu, Phillip, Burn, Timothy, Hollis, Gregory, Yeleswaram, Swamy, Vaddi, Kris, Xue, Chu-Biao, Metcalf, Brian, Friedman, Steve, Scherle, Peggy, Newton, Robert
Published in The Journal of pharmacology and experimental therapeutics (01.07.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2011)
Get full text
Journal Article
Discovery of INCB3344, a potent, selective and orally bioavailable antagonist of human and murine CCR2
Xue, Chu-Biao, Wang, Anlai, Meloni, David, Zhang, Ke, Kong, Ling, Feng, Hao, Glenn, Joseph, Huang, Taisheng, Zhang, Yingxin, Cao, Ganfeng, Anand, Rajan, Zheng, Changsheng, Xia, Michael, Han, Qi, Robinson, D.J., Storace, Lou, Shao, Lixin, Li, Mei, Brodmerkel, Carrie M., Covington, Maryanne, Scherle, Peggy, Diamond, Sharon, Yeleswaram, Swamy, Vaddi, Kris, Newton, Robert, Hollis, Greg, Friedman, Steven, Metcalf, Brian
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Get full text
Journal Article
Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)
Sheppeck, James E., Gilmore, John L., Tebben, Andrew, Xue, Chu-Biao, Liu, Rui-Qin, Decicco, Carl P., Duan, James J.-W.
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Get full text
Journal Article
Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist
Xue, Chu-Biao, Wang, Anlai, Han, Qi, Zhang, Yingxin, Cao, Ganfeng, Feng, Hao, Huang, Taisheng, Zheng, Changsheng, Xia, Michael, Zhang, Ke, Kong, Lingquan, Glenn, Joseph, Anand, Rajan, Meloni, David, Robinson, D. J, Shao, Lixin, Storace, Lou, Li, Mei, Hughes, Robert O, Devraj, Rajesh, Morton, Philip A, Rogier, D. Joseph, Covington, Maryanne, Scherle, Peggy, Diamond, Sharon, Emm, Tom, Yeleswaram, Swamy, Contel, Nancy, Vaddi, Kris, Newton, Robert, Hollis, Greg, Metcalf, Brian
Published in ACS medicinal chemistry letters (08.12.2011)
Published in ACS medicinal chemistry letters (08.12.2011)
Get full text
Journal Article
Discovery of ((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methanone, PF-4254196, a CCR2 antagonist with an improved cardiovascular profile
Hughes, Robert O, Rogier, D.J, Devraj, Rajesh, Zheng, Changsheng, Cao, Ganfeng, Feng, Hao, Xia, Michael, Anand, Rajan, Xing, Li, Glenn, Joseph, Zhang, Ke, Covington, Maryanne, Morton, Philip A, Hutzler, J. Matthew, Davis, John W., II, Scherle, Peggy, Baribaud, Fred, Bahinski, Anthony, Mo, Zun-Li, Newton, Robert, Metcalf, Brian, Xue, Chu-Biao
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Get full text
Journal Article
Discovery of β-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors
Duan, James J.-W., Chen, Lihua, Lu, Zhonghui, Xue, Chu-Biao, Liu, Rui-Qin, Covington, Maryanne B., Qian, Mingxin, Wasserman, Zelda R., Vaddi, Krishna, Christ, David D., Trzaskos, James M., Newton, Robert C., Decicco, Carl P.
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
Get full text
Journal Article
Design and synthesis of novel CCR2 antagonists: Investigation of non-aryl/heteroaryl binding motifs
Trujillo, John I., Huang, Wei, Hughes, Robert O., Joseph Rogier, D., Turner, Steven R., Devraj, Rajesh, Morton, Philip A., Xue, Chu-Biao, Chao, Ganfeng, Covington, Maryanne B., Newton, Robert C., Metcalf, Brian
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Get full text
Journal Article
Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)
Sheppeck, James E., Gilmore, John L., Yang, Anle, Chen, Xiao-Tao, Xue, Chu-Biao, Roderick, John, Liu, Rui-Qin, Covington, Maryanne B., Decicco, Carl P., Duan, James J.-W.
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
Get full text
Journal Article
Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity
Xue, Chu-Biao, Chen, Lihua, Cao, Ganfeng, Zhang, Ke, Wang, Anlai, Meloni, David, Glenn, Joseph, Anand, Rajan, Xia, Michael, Kong, Ling, Huang, Taisheng, Feng, Hao, Zheng, Changsheng, Li, Mei, Galya, Laurine, Zhou, Jiacheng, Shin, Niu, Baribaud, Fredric, Solomon, Kim, Scherle, Peggy, Zhao, Bitao, Diamond, Sharon, Emm, Tom, Keller, Douglas, Contel, Nancy, Yeleswaram, Swamy, Vaddi, Kris, Hollis, Gregory, Newton, Robert, Friedman, Steven, Metcalf, Brian
Published in ACS medicinal chemistry letters (09.12.2010)
Published in ACS medicinal chemistry letters (09.12.2010)
Get full text
Journal Article