The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer
Yan, Shunfei, Xuan, Jiachen, Brajanovski, Natalie, Tancock, Madeleine R C, Madhamshettiwar, Piyush B, Simpson, Kaylene J, Ellis, Sarah, Kang, Jian, Cullinane, Carleen, Sheppard, Karen E, Hannan, Katherine M, Hannan, Ross D, Sanij, Elaine, Pearson, Richard B, Chan, Keefe T
Published in British journal of cancer (02.02.2021)
Published in British journal of cancer (02.02.2021)
Get full text
Journal Article
The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function
Koltowska, Katarzyna, Okuda, Kazuhide S, Gloger, Marleen, Rondon-Galeano, Maria, Mason, Elizabeth, Xuan, Jiachen, Dudczig, Stefanie, Chen, Huijun, Arnold, Hannah, Skoczylas, Renae, Bower, Neil I, Paterson, Scott, Lagendijk, Anne Karine, Baillie, Gregory J, Leshchiner, Ignaty, Simons, Cas, Smith, Kelly A, Goessling, Wolfram, Heath, Joan K, Pearson, Richard B, Sanij, Elaine, Schulte-Merker, Stefan, Hogan, Benjamin M
Published in Nature cell biology (01.11.2021)
Published in Nature cell biology (01.11.2021)
Get full text
Journal Article
CX-5461 can destabilize replication forks in PARP inhibitor-resistant models of ovarian cancer
Xuan, Jiachen, Pearson, Richard B., Sanij, Elaine
Published in Molecular & cellular oncology (01.11.2020)
Published in Molecular & cellular oncology (01.11.2020)
Get full text
Journal Article
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer
Sanij, Elaine, Hannan, Katherine M, Xuan, Jiachen, Yan, Shunfei, Ahern, Jessica E, Trigos, Anna S, Brajanovski, Natalie, Son, Jinbae, Chan, Keefe T, Kondrashova, Olga, Lieschke, Elizabeth, Wakefield, Matthew J, Frank, Daniel, Ellis, Sarah, Cullinane, Carleen, Kang, Jian, Poortinga, Gretchen, Nag, Purba, Deans, Andrew J, Khanna, Kum Kum, Mileshkin, Linda, McArthur, Grant A, Soong, John, Berns, Els M J J, Hannan, Ross D, Scott, Clare L, Sheppard, Karen E, Pearson, Richard B
Published in Nature communications (26.05.2020)
Published in Nature communications (26.05.2020)
Get full text
Journal Article
Abstract PR13: Inhibition of RNA polymerase I transcription activates targeted DNA damage response and enhances the efficacy of PARP inhibitors in high-grade serous ovarian cancer
Sanij, Elaine, Hannan, Katherine, Xuan, Jiachen, Yan, Shunfei, Ahern, Jessica A., Trigos, Anna S., Brajanovski, Natalie, Son, Jinbae, Chan, Keefe T., Kondrashova, Olga, Lieschke, Elizabeth, Wakefield, Matthew J., Ellis, Sarah, Cullinane, Carleen, Poortinga, Gretchen, Khanna, Kum Kum, Mileshkin, Linda, McArthur, Grant A., Soong, John, Berns, Els M., Hannan, Ross D., Scott, Clare L., Sheppard, Karen E., Pearson, Richard B.
Published in Clinical cancer research (01.07.2020)
Published in Clinical cancer research (01.07.2020)
Get full text
Journal Article