An inhibitor of oxidative phosphorylation exploits cancer vulnerability
Molina, Jennifer R., Sun, Yuting, Protopopova, Marina, Gera, Sonal, Bandi, Madhavi, Bristow, Christopher, McAfoos, Timothy, Morlacchi, Pietro, Ackroyd, Jeffrey, Agip, Ahmed-Noor A., Al-Atrash, Gheath, Asara, John, Bardenhagen, Jennifer, Carrillo, Caroline C., Carroll, Christopher, Chang, Edward, Ciurea, Stefan, Cross, Jason B., Czako, Barbara, Deem, Angela, Daver, Naval, de Groot, John Frederick, Dong, Jian-Wen, Feng, Ningping, Gao, Guang, Gay, Jason, Do, Mary Geck, Greer, Jennifer, Giuliani, Virginia, Han, Jing, Han, Lina, Henry, Verlene K., Hirst, Judy, Huang, Sha, Jiang, Yongying, Kang, Zhijun, Khor, Tin, Konoplev, Sergej, Lin, Yu-Hsi, Liu, Gang, Lodi, Alessia, Lofton, Timothy, Ma, Helen, Mahendra, Mikhila, Matre, Polina, Mullinax, Robert, Peoples, Michael, Petrocchi, Alessia, Rodriguez-Canale, Jaime, Serreli, Riccardo, Shi, Thomas, Smith, Melinda, Tabe, Yoko, Theroff, Jay, Tiziani, Stefano, Xu, Quanyun, Zhang, Qi, Muller, Florian, DePinho, Ronald A., Toniatti, Carlo, Draetta, Giulio F., Heffernan, Timothy P., Konopleva, Marina, Jones, Philip, Di Francesco, M. Emilia, Marszalek, Joseph R.
Published in Nature medicine (01.07.2018)
Published in Nature medicine (01.07.2018)
Get full text
Journal Article
Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials
Yap, Timothy A., Daver, Naval, Mahendra, Mikhila, Zhang, Jixiang, Kamiya-Matsuoka, Carlos, Meric-Bernstam, Funda, Kantarjian, Hagop M., Ravandi, Farhad, Collins, Meghan E., Francesco, Maria Emilia Di, Dumbrava, Ecaterina E., Fu, Siqing, Gao, Sisi, Gay, Jason P., Gera, Sonal, Han, Jing, Hong, David S., Jabbour, Elias J., Ju, Zhenlin, Karp, Daniel D., Lodi, Alessia, Molina, Jennifer R., Baran, Natalia, Naing, Aung, Ohanian, Maro, Pant, Shubham, Pemmaraju, Naveen, Bose, Prithviraj, Piha-Paul, Sarina A., Rodon, Jordi, Salguero, Carolina, Sasaki, Koji, Singh, Anand K., Subbiah, Vivek, Tsimberidou, Apostolia M., Xu, Quanyun A., Yilmaz, Musa, Zhang, Qi, Li, Yuan, Bristow, Christopher A., Bhattacharjee, Meenakshi B., Tiziani, Stefano, Heffernan, Timothy P., Vellano, Christopher P., Jones, Philip, Heijnen, Cobi J., Kavelaars, Annemieke, Marszalek, Joseph R., Konopleva, Marina
Published in Nature medicine (2023)
Published in Nature medicine (2023)
Get full text
Journal Article
Phase I Study of the Combination of Sorafenib and Temsirolimus in Patients with Metastatic Melanoma
DAVIES, Michael A, FOX, Patricia S, SHA HUANG, WANLENG DENG, NG, Chaan S, GUPTA, Sanjay, WENBIN LIU, DANCEY, Janet E, WRIGHT, John J, BASSETT, Roland L, HWU, Patrick, KIM, Kevin B, PAPADOPOULOS, Nicholas E, BEDIKIAN, Agop Y, HWU, Wen-Jen, LAZAR, Alexander J, PRIETO, Victor G, CULOTTA, Kirk S, MADDEN, Timothy L, QUANYUN XU
Published in Clinical cancer research (15.02.2012)
Published in Clinical cancer research (15.02.2012)
Get full text
Journal Article
Drug compatibility with new polyolefin infusion solution containers
Trissel, Lawrence A, Xu, Quanyun A, Baker, Mary
Published in American journal of health-system pharmacy (01.12.2006)
Published in American journal of health-system pharmacy (01.12.2006)
Get full text
Journal Article
Physical and chemical stability of palonosetron hydrochloride with dacarbazine and with methylprednisolone sodium succinate during simulated y-site administration
Trissel, Lawrence A, Zhang, Yanping, Xu, Quanyun A
Published in International journal of pharmaceutical compounding (01.05.2006)
Get full text
Published in International journal of pharmaceutical compounding (01.05.2006)
Journal Article
Compatibility and stability of linezolid injection admixed with three quinolone antibiotics
Zhang, Y, Xu, Q A, Trissel, L A, Williams, K Y
Published in The Annals of pharmacotherapy (01.09.2000)
Published in The Annals of pharmacotherapy (01.09.2000)
Get more information
Journal Article
Abstract 3277: IACS-9779, a development candidate that inhibits 2,3-dioxygenase (IDO) activity by blocking heme incorporation into IDO apoenzyme
Mseeh, Faika, Hamilton, Matthew M., Marszalek, Joseph R., Rogers, Norma E., Parker, Connor A., Yu, Simon S., Liu, Zhen, Reyna, Naphtali J., McAfoos, Timothy, Virgin-Downey, Brett W., Leonard, Paul G., Cross, Jason B., Feng, Ningping, Harris, Angela L., Zuniga, Andy M., Mikule, Keith, Tremblay, Martin, Jiang, Yongying, Mahendra, Mikhila, Pang, Jihai, Wu, Qi, Xu, Quanyun, Heffernan, Timothy P., Jones, Philip, Lewis, Richard T.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article
Abstract 3229: IACS-16559, a CBP/P300 bromodomain inhibitor for the treatment of specific AML subsets
Zanca, Ciro, Soth, Michael, Gao, Guang, Gay, Jason, Feng, Ningping, Bristow, Christopher, Le, Kang, Xu, Quanyun, Nguyen, Phuong, Jiang, Yongying, Perry, Teresa, Mseeh, Faika, Leonard, Paul, Cross, Jason, Giuliani, Virginia, Marszalek, Joe, Jones, Philip, Heffernan, Tim
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Get full text
Journal Article
Phase I trial of IACS-010759 (IACS), a potent, selective inhibitor of complex I of the mitochondrial electron transport chain, in patients (pts) with advanced solid tumors
Yap, Timothy A, Rodon Ahnert, Jordi, Piha-Paul, Sarina Anne, Fu, Siqing, Janku, Filip, Karp, Daniel D., Naing, Aung, Ileana Dumbrava, Ecaterina Elena, Pant, Shubham, Subbiah, Vivek, Tsimberidou, Apostolia Maria, Hong, David S., Rose, Kelsey Meagan, Xu, Quanyun, Vellano, Christopher P., Mahendra, Mikhila, Jones, Philip, Di Francesco, Maria Emilia, Marszalek, Joseph R., Meric-Bernstam, Funda
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
Get full text
Journal Article
Abstract LB-071: Discovery of an imidazopyridine series of potent human IDO1 inhibitors with robust target engagement in a preclinical tumor model
Petrocchi, Alessia, Reyna, Naphtali J., Mseeh, Faika, Parker, Connor A., Yu, Simon, Xu, Quanyun, Feng, Ningping, Leonard, Paul, Rogers, Norma, Cross, Jason B., Harris, Angela L., Jiang, Yongying, Khor, Tin Oo, Mahendra, Mikhila G., Pang, Jihai, Wu, Qi, Zuniga, Andy M., McAfoos, Timothy, Hamilton, Matthew M., Marszalek, Joe R., Mikule, Keith, Vancutsem, Paul, Wilcoxen, Keith, Tremblay, Martin, Jones, Philip, Lewis, Richard T.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Abstract 4971: IACS-010759, a novel inhibitor of complex I in Phase I clinical development to target OXPHOS dependent tumors
Molina, Jennifer, Bandi, Madhavi, Bardenhagen, Jennifer, Bristow, Christopher, Carroll, Christopher, Chang, Edward, Cross, Jason, Daver, Naval, Feng, Ningping, Gay, Jason, Do, Mary Geck, Greer, Jennifer, Han, Jing, Hirst, Judy, Huang, Sha, Jiang, Yongying, Kang, Zhijun, Konopleva, Marina, Liu, Gang, Ma, Helen, Matre, Polina, McAfoos, Timothy, Meric-Bernstam, Funda, Morlacchi, Pietro, Muller, Florian, Protopopova, Marina, Smith, Melinda, Sonal, Sonal, Sun, Yuting, Theroff, Jay, Viale, Andrea, Xu, Quanyun, Toniatti, Carlo, Draetta, Giulio, Jones, Philip, Francesco, M. Emilia Di, Marszalek, Joseph R.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article