Harnessing the power of IVIVE-PBPK to explore potential discordance between local gut vs systemic bioequivalence in health and disease: the case of budesonide in crohn’s disease
Han, Chunyan, Chirumamilla, Siri Kalyan, Sun, Tiancheng, Xu, Mandy, Bois, Frederic, Rostami-Hodjegan, Amin
Published in Drug metabolism and pharmacokinetics (01.04.2024)
Published in Drug metabolism and pharmacokinetics (01.04.2024)
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Journal Article
Implementation of combined approaches to quantify plasma protein binding of bRo5 compounds
Li, Na, Taylor, Simon, Davoren, Jennifer, Diner, Colin, Wang, Yi, Han, Chunyan, Jiao, Xingjin, Xu, Mandy, Thorarensen, Atli
Published in Drug metabolism and pharmacokinetics (01.04.2024)
Published in Drug metabolism and pharmacokinetics (01.04.2024)
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Journal Article
Understanding Discordance between In Vitro Dissolution, Local Gut and Systemic Bioequivalence of Budesonide in Healthy and Crohn’s Disease Patients through PBPK Modeling
Han, Chunyan, Sun, Tiancheng, Chirumamilla, Siri Kalyan, Bois, Frederic Y, Xu, Mandy, Rostami-Hodjegan, Amin
Published in Pharmaceutics (30.08.2023)
Published in Pharmaceutics (30.08.2023)
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Journal Article
Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models
Gardner, Iain, Xu, Mandy, Han, Chunyan, Wang, Yi, Jiao, Xingjin, Jamei, Masoud, Khalidi, Hiba, Kilford, Peter, Neuhoff, Sibylle, Southall, Roz, Turner, David B., Musther, Helen, Jones, Barry, Taylor, Simon
Published in Xenobiotica (03.08.2022)
Published in Xenobiotica (03.08.2022)
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Journal Article
Time dependent inhibition of P450 by phenelzine in human liver microsomes
Xu, Mandy, Wang, Yu, Yuan, Cui, Li, Danxi, Harris, Stephen
Published in Drug metabolism and pharmacokinetics (01.01.2018)
Published in Drug metabolism and pharmacokinetics (01.01.2018)
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