Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways
Tan, Xin, Xu, Aizhang, Zhao, Tuo, Zhao, Qin, Zhang, Jun, Fan, Cuihong, Deng, Yulin, Freywald, Andrew, Genth, Harald, Xiang, Jim
Published in Scientific reports (28.02.2018)
Published in Scientific reports (28.02.2018)
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DDX41 is required for cGAS-STING activation against DNA virus infection
Singh, Ravi Shankar, Vidhyasagar, Venkatasubramanian, Yang, Shizhuo, Arna, Ananna Bhadra, Yadav, Manisha, Aggarwal, Aanchal, Aguilera, Alexya N., Shinriki, Satoru, Bhanumathy, Kalpana Kalyanasundaram, Pandey, Kannupriya, Xu, Aizhang, Rapin, Noreen, Bosch, Mark, DeCoteau, John, Xiang, Jim, Vizeacoumar, Franco J., Zhou, Yan, Misra, Vikram, Matsui, Hirotaka, Ross, Susan R., Wu, Yuliang
Published in Cell reports (Cambridge) (24.05.2022)
Published in Cell reports (Cambridge) (24.05.2022)
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Distinct roles but cooperative effect of TLR3/9 agonists and PD-1 blockade in converting the immunotolerant microenvironment of irreversible electroporation-ablated tumors
Babikr, Fatma, Wan, Jiangbo, Xu, Aizhang, Wu, Zhaojia, Ahmed, Shahid, Freywald, Andrew, Chibbar, Rajni, Wu, Yue, Moser, Michael, Groot, Gary, Zhang, Wenjun, Zhang, Bing, Xiang, Jim
Published in Cellular & molecular immunology (01.12.2021)
Published in Cellular & molecular immunology (01.12.2021)
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TLR9 agonist enhances radiofrequency ablation-induced CTL responses, leading to the potent inhibition of primary tumor growth and lung metastasis
Xu, Aizhang, Zhang, Lifeng, Yuan, Jingying, Babikr, Fatma, Freywald, Andrew, Chibbar, Rajni, Moser, Michael, Zhang, Wenjun, Zhang, Bing, Fu, Zhaoying, Xiang, Jim
Published in Cellular & molecular immunology (01.10.2019)
Published in Cellular & molecular immunology (01.10.2019)
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Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-κB and ERK1/2 Pathways
Zhao, Tuo, Li, Rong, Tan, Xin, Zhang, Jun, Fan, Cuihong, Zhao, Qin, Deng, Yulin, Xu, Aizhang, Lukong, Kiven Erique, Genth, Harald, Xiang, Jim
Published in International journal of molecular sciences (08.07.2018)
Published in International journal of molecular sciences (08.07.2018)
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Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway
Wang, Rong, Xu, Aizhang, Zhang, Xueying, Wu, Jie, Freywald, Andrew, Xu, Jianqing, Xiang, Jim
Published in Cellular & molecular immunology (01.06.2017)
Published in Cellular & molecular immunology (01.06.2017)
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Enhanced suppression of polyclonal CD8+25+ regulatory T cells via exosomal arming of antigen‐specific peptide/MHC complexes
Mu, Chuanyong, Zhang, Xueshu, Wang, Lu, Xu, Aizhang, Ahmed, Khawaja Ashfaque, Pang, Xueqin, Chibbar, Rajni, Freywald, Andrew, Huang, Jianan, Zhu, Yehan, Xiang, Jim
Published in Journal of leukocyte biology (01.05.2017)
Published in Journal of leukocyte biology (01.05.2017)
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The Energy Sensor AMPKα1 Is Critical in Rapamycin-Inhibition of mTORC1-S6K-Induced T-cell Memory
Ara, Anjuman, Xu, Aizhang, Ahmed, Khawaja Ashfaque, Leary, Scot C, Islam, Md Fahmid, Wu, Zhaojia, Chibbar, Rajni, Xiang, Jim
Published in International journal of molecular sciences (21.12.2021)
Published in International journal of molecular sciences (21.12.2021)
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The Critical Role of AMPKα1 in Regulating Autophagy and Mitochondrial Respiration in IL-15-Stimulated mTORC1Weak Signal-Induced T Cell Memory: An Interplay between Yin (AMPKα1) and Yang (mTORC1) Energy Sensors in T Cell Differentiation
Ara, Anjuman, Wu, Zhaojia, Xu, Aizhang, Ahmed, Khawaja Ashfaque, Leary, Scot C., Islam, Md. Fahmid, Chibbar, Rajni, Wu, Yue, Xiang, Jim
Published in International journal of molecular sciences (23.08.2022)
Published in International journal of molecular sciences (23.08.2022)
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Design and synthesis of affinity ligands and relation of their structure with adsorption of proteins
Ye, Long, Xu, Aizhang, Cheng, Chao, Zhang, Li, Huo, Chenxi, Huang, Feiyun, Xu, Hong, Li, Rongxiu
Published in Journal of separation science (01.11.2011)
Published in Journal of separation science (01.11.2011)
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Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis
Yu, Ziqi, Dong, Xue, Song, Mei, Xu, Aizhang, He, Qing, Li, Huilin, Ouyang, Wen, Chouchane, Lotfi, Ma, Xiaojing
Published in International journal of cancer (15.02.2024)
Published in International journal of cancer (15.02.2024)
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Heterologous human/rat HER2-specific exosome-targeted T cell vaccine stimulates potent humoral and CTL responses leading to enhanced circumvention of HER2 tolerance in double transgenic HLA-A2/HER2 mice
Xie, Yufeng, Wu, Jie, Xu, Aizhang, Ahmeqd, Shahid, Sami, Amer, Chibbar, Rajni, Freywald, Andrew, Zheng, Changyu, Xiang, Jim
Published in Vaccine (07.03.2018)
Published in Vaccine (07.03.2018)
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Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKα1-ULK1-ATG7 Pathways
Xu, Aizhang, Leary, Scot C, Islam, Md Fahmid, Wu, Zhaojia, Bhanumathy, Kalpana Kalyanasundaram, Ara, Anjuman, Chibbar, Rajni, Fleywald, Andrew, Ahmed, Khawaja Ashfaque, Xiang, Jim
Published in The Journal of immunology (1950) (01.01.2022)
Published in The Journal of immunology (1950) (01.01.2022)
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Potent immunotherapy against well-established thymoma using adoptively transferred transgene IL-6-engineered dendritic cell-stimulated CD8+ T-cells with prolonged survival and enhanced cytotoxicity
Kalyanasundaram Bhanumathy, Kalpana, Zhang, Bei, Xie, Yufeng, Xu, Aizhang, Tan, Xin, Xiang, Jim
Published in The journal of gene medicine (01.08.2015)
Published in The journal of gene medicine (01.08.2015)
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CD40 agonist converting CTL exhaustion via the activation of the mTORC1 pathway enhances PD-1 antagonist action in rescuing exhausted CTLs in chronic infection
Xu, Aizhang, Wang, Rong, Freywald, Andrew, Stewart, Kristoffor, Tikoo, Suresh, Xu, Jianqing, Zheng, Changyu, Xiang, Jim
Published in Biochemical and biophysical research communications (11.03.2017)
Published in Biochemical and biophysical research communications (11.03.2017)
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IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia
Xu, Aizhang, Bhanumathy, Kalpana Kalyanasundaram, Wu, Jie, Ye, Zhenmin, Freywald, Andrew, Leary, Scot C, Li, Rongxiu, Xiang, Jim
Published in Cell & bioscience (06.05.2016)
Published in Cell & bioscience (06.05.2016)
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