Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation
Gamazon, Eric R., Segrè, Ayellet V., van de Bunt, Martijn, Wen, Xiaoquan, Xi, Hualin S., Hormozdiari, Farhad, Ongen, Halit, Konkashbaev, Anuar, Derks, Eske M., Aguet, François, Quan, Jie, Nicolae, Dan L., Eskin, Eleazar, Kellis, Manolis, Getz, Gad, McCarthy, Mark I., Dermitzakis, Emmanouil T., Cox, Nancy J., Ardlie, Kristin G.
Published in Nature genetics (01.07.2018)
Published in Nature genetics (01.07.2018)
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Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
Jaffe, Andrew E., Straub, Richard E., Shin, Joo Heon, Tao, Ran, Gao, Yuan, Collado-Torres, Leonardo, Kam-Thong, Tony, Xi, Hualin S., Quan, Jie, Chen, Qiang, Colantuoni, Carlo, Ulrich, William S., Maher, Brady J., Deep-Soboslay, Amy, Cross, Alan J., Brandon, Nicholas J., Leek, Jeffrey T., Hyde, Thomas M., Kleinman, Joel E., Weinberger, Daniel R.
Published in Nature neuroscience (01.08.2018)
Published in Nature neuroscience (01.08.2018)
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Roadmap for the use of base editors to decipher drug mechanism of action
Aparicio-Prat, Estel, Yan, Dong, Mariotti, Marco, Bassik, Michael, Hess, Gaelen, Fortin, Jean-Philippe, Weston, Andrea, Xi, Hualin S, Stanton, Robert
Published in PloS one (21.09.2021)
Published in PloS one (21.09.2021)
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Transcriptomic RNAseq drug screen in cerebrocortical cultures: toward novel neurogenetic disease therapies
Hadwen, Jeremiah, Schock, Sarah, Mears, Alan, Yang, Robert, Charron, Philippe, Zhang, Liying, Xi, Hualin S, MacKenzie, Alex
Published in Human molecular genetics (15.09.2018)
Published in Human molecular genetics (15.09.2018)
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Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia
Park, Gun-Hoo, Noh, Haneul, Shao, Zhicheng, Ni, Peiyan, Qin, Yiren, Liu, Dongxin, Beaudreault, Cameron P., Park, Joy S., Abani, Chiderah P., Park, James M., Le, Derek T., Gonzalez, Sasha Z., Guan, Youxin, Cohen, Bruce M., McPhie, Donna L., Coyle, Joseph T., Lanz, Thomas A., Xi, Hualin S., Yin, Changhong, Huang, Weihua, Kim, Hae-Young, Chung, Sangmi
Published in Nature neuroscience (01.11.2020)
Published in Nature neuroscience (01.11.2020)
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Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia
Malik, Manasi, Chiles, 3rd, Joe, Xi, Hualin S, Medway, Christopher, Simpson, James, Potluri, Shobha, Howard, Dianna, Liang, Ying, Paumi, Christian M, Mukherjee, Shubhabrata, Crane, Paul, Younkin, Steven, Fardo, David W, Estus, Steven
Published in Human molecular genetics (15.06.2015)
Published in Human molecular genetics (15.06.2015)
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BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders
Schubert, Christian R., O’Donnell, Patricio, Quan, Jie, Wendland, Jens R., Xi, Hualin S., Winslow, Ashley R., Domenici, Enrico, Essioux, Laurent, Kam-Thong, Tony, Airey, David C., Calley, John N., Collier, David A., Wang, Hong, Eastwood, Brian, Ebert, Philip, Liu, Yushi, Nisenbaum, Laura, Ruble, Cara, Scherschel, James E., Smith, Ryan Matthew, Qian, Hui-Rong, Merchant, Kalpana, Didriksen, Michael, Matsumoto, Mitsuyuki, Saito, Takeshi, Brandon, Nicholas J., Cross, Alan J., Wang, Qi, Manji, Husseini, Kolb, Hartmuth, Furey, Maura, Drevets, Wayne C., Shin, Joo Heon, Jaffe, Andrew E., Jia, Yankai, Straub, Richard E., Deep-Soboslay, Amy, Hyde, Thomas M., Kleinman, Joel E., Weinberger, Daniel R.
Published in Neuron (Cambridge, Mass.) (16.12.2015)
Published in Neuron (Cambridge, Mass.) (16.12.2015)
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Journal Article
Translating Human Genetics into Novel Treatment Targets for Schizophrenia
Schubert, Christian R., Xi, Hualin S., Wendland, Jens R., O’Donnell, Patricio
Published in Neuron (Cambridge, Mass.) (05.11.2014)
Published in Neuron (Cambridge, Mass.) (05.11.2014)
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Improving genetic diagnosis in Mendelian disease with transcriptome sequencing
Cummings, Beryl B, Marshall, Jamie L, Tukiainen, Taru, Lek, Monkol, Donkervoort, Sandra, Foley, A Reghan, Bolduc, Veronique, Waddell, Leigh B, Sandaradura, Sarah A, O'Grady, Gina L, Estrella, Elicia, Reddy, Hemakumar M, Zhao, Fengmei, Weisburd, Ben, Karczewski, Konrad J, O'Donnell-Luria, Anne H, Birnbaum, Daniel, Sarkozy, Anna, Hu, Ying, Gonorazky, Hernan, Claeys, Kristl, Joshi, Himanshu, Bournazos, Adam, Oates, Emily C, Ghaoui, Roula, Davis, Mark R, Laing, Nigel G, Topf, Ana, Kang, Peter B, Beggs, Alan H, North, Kathryn N, Straub, Volker, Dowling, James J, Muntoni, Francesco, Clarke, Nigel F, Cooper, Sandra T, Bönnemann, Carsten G, MacArthur, Daniel G
Published in Science translational medicine (19.04.2017)
Published in Science translational medicine (19.04.2017)
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Investigating the neuroimmunogenic architecture of schizophrenia
Birnbaum, R, Jaffe, A E, Chen, Q, Shin, J H, Kleinman, J E, Hyde, T M, Weinberger, D R
Published in Molecular psychiatry (01.05.2018)
Published in Molecular psychiatry (01.05.2018)
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Cell type specific genetic regulation of gene expression across human tissues
Kim-Hellmuth, Sarah, Aguet, Francois, Oliva, Meritxell, Munoz-Aguirre, Manuel, Wucher, Valentin, Silva Kasela, Castel, Stephane E, Hamel, Andrew, Vinuela, Ana, Roberts, Amy L, Serghei Mangul, Wen, Xiaoquan, Wang, Gao, Barbeira, Alvaro, Garrido-Martin, Diego, Nadel, Brian, Zou, Yuxin, Bonazzola, Rodrigo, Quan, Jie, Brown, Andrew, Martinez-Perez, Angel, Soria, Jose Manuel, The Gtex Consortium, Getz, Gad, Dermitzakis, Emmanouil, Small, Kerrin S, Stephens, Matthew, Xi, Hualin S, Im, Hae Kyung, Guigo, Roderic, Segre, Ayellet, Stranger, Barbara, Ardlie, Kristin, Lappalainen, Tuuli
Published in bioRxiv (17.10.2019)
Published in bioRxiv (17.10.2019)
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Activated microglia cause metabolic disruptions in developmental cortical interneuron that persist in schizophrenia-patient-derived interneurons
Park, Gun-Hoo, Noh, Haneul, Shao, Zhicheng, Ni, Peiyan, Qin, Yiren, Liu, Dongxin, Beaudreault, Cameron P., Park, Joy S., Abani, Chiderah P., Park, James M., Le, Derek T., Gonzalez, Sasha Z., Guan, Youxin, Cohen, Bruce M., McPhie, Donna L., Coyle, Joseph T., Lanz, Thomas A., Xi, Hualin S, Yin, Changhong, Huang, Weihua, Kim, Hae-Young, Chung, Sangmi
Published in Nature neuroscience (23.10.2020)
Published in Nature neuroscience (23.10.2020)
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Journal Article
Potassium channel gene associations with joint processing speed and white matter impairments in schizophrenia
Bruce, H. A., Kochunov, P., Paciga, S. A., Hyde, C. L., Chen, X., Xie, Z., Zhang, B., Xi, H. S., O'Donnell, P., Whelan, C., Schubert, C. R., Bellon, A., Ament, S. A., Shukla, D. K., Du, X., Rowland, L. M., O'Neill, H., Hong, L. E.
Published in Genes, brain and behavior (01.06.2017)
Published in Genes, brain and behavior (01.06.2017)
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Profiling microglia from AD donors and non-demented elderly in acute human post-mortem cortical tissue
Alsema, Astrid M, Jiang, Qiong, Kracht, Laura, Gerrits, Emma, Dubbelaar, Marissa L, Miedema, Anneke, Brouwer, Nieske, Woodbury, Maya, Wachter, Astrid, Xi, Hualin S, Moeller, Thomas, Biber, Knut P, Kooistra, Susanne M, Boddeke, Erik Hwgm, Eggen, Bart Jl
Published in bioRxiv (19.03.2020)
Published in bioRxiv (19.03.2020)
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A systematic survey of human tissue-specific gene expression and splicing reveals new opportunities for therapeutic target identification and evaluation
Yang, Robert Y, Quan, Jie, Sodaie, Reza, Aguet, Francois, Segre, Ayellet V, Allen, John A, Lanz, Thomas A, Reinhart, Veronica, Crawford, Matthew, Hasson, Samuel, Consortium, Gtex, Ardlie, Kristin G, Guigo, Roderic, Xi, Hualin S
Published in bioRxiv (30.04.2018)
Published in bioRxiv (30.04.2018)
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Developmental And Genetic Regulation Of The Human Cortex Transcriptome In Schizophrenia
Jaffe, Andrew E, Straub, Richard E, Shin, Joo Heon, Tao, Ran, Gao, Yuan, Leonardo Collado Torres, Kam-Thong, Tony, Xi, Hualin S, Quan, Jie, Chen, Qiang, Colantuoni, Carlo, Ulrich, William S, Maher, Brady J, Deep-Soboslay, Amy, The Brainseq Consortium, Cross, Alan, Brandon, Nicholas J, Leek, Jeffrey T, Hyde, Thomas M, Kleinman, Joel E, Weinberger, Daniel R
Published in bioRxiv (22.11.2017)
Published in bioRxiv (22.11.2017)
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