Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53
Martinez-Zapien, Denise, Ruiz, Francesc Xavier, Poirson, Juline, Mitschler, André, Ramirez, Juan, Forster, Anne, Cousido-Siah, Alexandra, Masson, Murielle, Pol, Scott Vande, Podjarny, Alberto, Travé, Gilles, Zanier, Katia
Published in Nature (London) (28.01.2016)
Published in Nature (London) (28.01.2016)
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Validation of surface plasmon resonance screening of a diverse chemical library for the discovery of protein tyrosine phosphatase 1b binders
Zeder-Lutz, Gabrielle, Choulier, Laurence, Besse, Marie, Cousido-Siah, Alexandra, Figueras, Francesc Xavier Ruiz, Didier, Bruno, Jung, Marie-Louise, Podjarny, Alberto, Altschuh, Danièle
Published in Analytical biochemistry (15.02.2012)
Published in Analytical biochemistry (15.02.2012)
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Journal Article
X-ray structure of the V301L aldo–keto reductase 1B10 complexed with NADP+ and the potent aldose reductase inhibitor fidarestat: Implications for inhibitor binding and selectivity
Ruiz, Francesc Xavier, Cousido-Siah, Alexandra, Mitschler, André, Farrés, Jaume, Parés, Xavier, Podjarny, Alberto
Published in Chemico-biological interactions (25.02.2013)
Published in Chemico-biological interactions (25.02.2013)
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Journal Article
Structure-Based Design of Covalent SARS-CoV-2 Papain-like Protease Inhibitors
Tan, Bin, Liang, Xueying, Ansari, Ahmadullah, Jadhav, Prakash, Tan, Haozhou, Li, Kan, Ruiz, Francesc Xavier, Arnold, Eddy, Deng, Xufang, Wang, Jun
Published in Journal of medicinal chemistry (05.11.2024)
Published in Journal of medicinal chemistry (05.11.2024)
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Journal Article
Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model
Tan, Bin, Zhang, Xiaoming, Ansari, Ahmadullah, Jadhav, Prakash, Tan, Haozhou, Li, Kan, Chopra, Ashima, Ford, Alexandra, Chi, Xiang, Ruiz, Francesc Xavier, Arnold, Eddy, Deng, Xufang, Wang, Jun
Published in Science (American Association for the Advancement of Science) (29.03.2024)
Published in Science (American Association for the Advancement of Science) (29.03.2024)
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Structures, functions and adaptations of the human LINE-1 ORF2 protein
Baldwin, Eric T., van Eeuwen, Trevor, Hoyos, David, Zalevsky, Arthur, Tchesnokov, Egor P., Sánchez, Roberto, Miller, Bryant D., Di Stefano, Luciano H., Ruiz, Francesc Xavier, Hancock, Matthew, Işik, Esin, Mendez-Dorantes, Carlos, Walpole, Thomas, Nichols, Charles, Wan, Paul, Riento, Kirsi, Halls-Kass, Rowan, Augustin, Martin, Lammens, Alfred, Jestel, Anja, Upla, Paula, Xibinaku, Kera, Congreve, Samantha, Hennink, Maximiliaan, Rogala, Kacper B., Schneider, Anna M., Fairman, Jennifer E., Christensen, Shawn M., Desrosiers, Brian, Bisacchi, Gregory S., Saunders, Oliver L., Hafeez, Nafeeza, Miao, Wenyan, Kapeller, Rosana, Zaller, Dennis M., Sali, Andrej, Weichenrieder, Oliver, Burns, Kathleen H., Götte, Matthias, Rout, Michael P., Arnold, Eddy, Greenbaum, Benjamin D., Romero, Donna L., LaCava, John, Taylor, Martin S.
Published in Nature (London) (01.02.2024)
Published in Nature (London) (01.02.2024)
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Journal Article
The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition
Fanfrlík, Jindřich, Ruiz, Francesc X, Kadlčíková, Aneta, Řezáč, Jan, Cousido-Siah, Alexandra, Mitschler, André, Haldar, Susanta, Lepšík, Martin, Kolář, Michal H, Majer, Pavel, Podjarny, Alberto D, Hobza, Pavel
Published in ACS chemical biology (17.07.2015)
Published in ACS chemical biology (17.07.2015)
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Cryo-EM structure of the HIV-1 Pol polyprotein provides insights into virion maturation
Harrison, Jerry Joe E K, Passos, Dario Oliveira, Bruhn, Jessica F, Bauman, Joseph D, Tuberty, Lynda, DeStefano, Jeffrey J, Ruiz, Francesc Xavier, Lyumkis, Dmitry, Arnold, Eddy
Published in Science advances (08.07.2022)
Published in Science advances (08.07.2022)
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Journal Article
Aldo–keto reductases in retinoid metabolism: Search for substrate specificity and inhibitor selectivity
Porté, Sergio, Xavier Ruiz, F., Giménez, Joan, Molist, Iago, Alvarez, Susana, Domínguez, Marta, Alvarez, Rosana, de Lera, Angel R., Parés, Xavier, Farrés, Jaume
Published in Chemico-biological interactions (25.02.2013)
Published in Chemico-biological interactions (25.02.2013)
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Journal Article
X-ray structures of Aldose Reductase and AKR1B10 with the lead inhibitor JF0064
Ruiz, Francesc Xavier, Cousido-Siah, Alexandra, Mitschler, André, Porté, Sergio, de la Fuente, Jesús, Terwesten, Felix, Klebe, Gerhard, Farrés, Jaume, Parés, Xavier, Podjarny, Alberto
Published in Acta crystallographica. Section A, Foundations and advances (05.08.2014)
Published in Acta crystallographica. Section A, Foundations and advances (05.08.2014)
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Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase
Crespo, Isidro, Giménez-Dejoz, Joan, Porté, Sergio, Cousido-Siah, Alexandra, Mitschler, André, Podjarny, Alberto, Pratsinis, Harris, Kletsas, Dimitris, Parés, Xavier, Ruiz, Francesc X., Metwally, Kamel, Farrés, Jaume
Published in European journal of medicinal chemistry (25.05.2018)
Published in European journal of medicinal chemistry (25.05.2018)
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New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM
Fadel, Firas, Zhao, Yuguang, Cachau, Raul, Cousido-Siah, Alexandra, Ruiz, Francesc X., Harlos, Karl, Howard, Eduardo, Mitschler, Andre, Podjarny, Alberto
Published in Acta crystallographica. Section D, Biological crystallography. (01.07.2015)
Published in Acta crystallographica. Section D, Biological crystallography. (01.07.2015)
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Discovery of (R)‑2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury
Van Zandt, Michael C, Whitehouse, Darren L, Golebiowski, Adam, Ji, Min Koo, Zhang, Mingbao, Beckett, R. Paul, Jagdmann, G. Erik, Ryder, Todd R, Sheeler, Ryan, Andreoli, Monica, Conway, Bruce, Mahboubi, Keyvan, D’Angelo, Gerard, Mitschler, Andre, Cousido-Siah, Alexandra, Ruiz, Francesc X, Howard, Eduardo I, Podjarny, Alberto D, Schroeter, Hagen
Published in Journal of medicinal chemistry (28.03.2013)
Published in Journal of medicinal chemistry (28.03.2013)
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Journal Article
IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors
Cousido-Siah, Alexandra, Ruiz, Francesc X, Fanfrlík, Jindřich, Giménez-Dejoz, Joan, Mitschler, André, Kamlar, Martin, Veselý, Jan, Ajani, Haresh, Parés, Xavier, Farrés, Jaume, Hobza, Pavel, Podjarny, Alberto D
Published in ACS chemical biology (21.10.2016)
Published in ACS chemical biology (21.10.2016)
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Journal Article
Design of SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model
Tan, Bin, Zhang, Xiaoming, Ansari, Ahmadullah, Jadhav, Prakash, Tan, Haozhou, Li, Kan, Chopra, Ashima, Ford, Alexandra, Chi, Xiang, Ruiz, Francesc Xavier, Arnold, Eddy, Deng, Xufang, Wang, Jun
Published in bioRxiv : the preprint server for biology (03.12.2023)
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Published in bioRxiv : the preprint server for biology (03.12.2023)
Journal Article
Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008
Ruiz, Francesc X., Crespo, Isidro, Álvarez, Susana, Porté, Sergio, Giménez-Dejoz, Joan, Cousido-Siah, Alexandra, Mitschler, André, de Lera, Ángel R., Parés, Xavier, Podjarny, Alberto, Farrés, Jaume
Published in Chemico-biological interactions (01.10.2017)
Published in Chemico-biological interactions (01.10.2017)
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