Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors
Bhattacharya, Samit K., Aspnes, Gary E., Bagley, Scott W., Boehm, Markus, Brosius, Arthur D., Buckbinder, Leonard, Chang, Jeanne S., Dibrino, Joseph, Eng, Heather, Frederick, Kosea S., Griffith, David A., Griffor, Matthew C., Guimarães, Cristiano R.W., Guzman-Perez, Angel, Han, Seungil, Kalgutkar, Amit S., Klug-McLeod, Jacquelyn, Garcia-Irizarry, Carmen, Li, Jianke, Lippa, Blaise, Price, David A., Southers, James A., Walker, Daniel P., Wei, Liuqing, Xiao, Jun, Zawistoski, Michael P., Zhao, Xumiao
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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Journal Article
Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution
Wendt, Michael D, Rockway, Todd W, Geyer, Andrew, McClellan, William, Weitzberg, Moshe, Zhao, Xumiao, Mantei, Robert, Nienaber, Vicki L, Stewart, Kent, Klinghofer, Vered, Giranda, Vincent L
Published in Journal of medicinal chemistry (15.01.2004)
Published in Journal of medicinal chemistry (15.01.2004)
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The discovery of highly selective erbB2 (Her2) inhibitors for the treatment of cancer
Lippa, Blaise, Kauffman, Goss S., Arcari, Joel, Kwan, Tricia, Chen, Jinshan, Hungerford, William, Bhattacharya, Samit, Zhao, Xumiao, Williams, Courtney, Xiao, Jun, Pustilnik, Leslie, Su, Chunyan, Moyer, James D., Ma, Ling, Campbell, Mary, Steyn, Stefanus
Published in Bioorganic & medicinal chemistry letters (01.06.2007)
Published in Bioorganic & medicinal chemistry letters (01.06.2007)
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Journal Article
Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties
Bruncko, Milan, McClellan, William J., Wendt, Michael D., Sauer, Daryl R., Geyer, Andrew, Dalton, Christopher R., Kaminski, Michele A., Weitzberg, Moshe, Gong, Jane, Dellaria, Joseph F., Mantei, Robert, Zhao, Xumiao, Nienaber, Vicki L., Stewart, Kent, Klinghofer, Vered, Bouska, Jennifer, Rockway, Todd W., Giranda, Vincent L.
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
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Journal Article
Interaction with the S1β-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors
WENDT, Michael D, GEYER, Andrew, GIRANDA, Vincent L, MCCLELLAN, William J, ROCKWAY, Todd W, WEITZBERG, Moshe, XUMIAO ZHAO, MANTEI, Robert, STEWART, Kent, NIENABER, Vicki, KLINGHOFER, Vered
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
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Journal Article
Interaction with the S1β-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors
Wendt, Michael D., Geyer, Andrew, McClellan, William J., Rockway, Todd W., Weitzberg, Moshe, Zhao, Xumiao, Mantei, Robert, Stewart, Kent, Nienaber, Vicki, Klinghofer, Vered, Giranda, Vincent L.
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
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Journal Article
Structure-directed discovery of potent non-peptidic inhibitors of human urokinase that access a novel binding subsite
Nienaber, Vicki L, Davidson, Donald, Edalji, Rohinton, Giranda, Vincent L, Klinghofer, Vered, Henkin, Jack, Magdalinos, Peter, Mantei, Robert, Merrick, Sean, Severin, Jean M, Smith, Richard A, Stewart, Kent, Walter, Karl, Wang, Jieyi, Wendt, Michael, Weitzberg, Moshe, Zhao, Xumiao, Rockway, Todd
Published in Structure (London) (15.05.2000)
Published in Structure (London) (15.05.2000)
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Journal Article
SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
Luzzio, Michael Joseph, Xiao, Jun, Hayward, Matthew Merrill, Hulford, Catherine Angela, Autry, Christopher Lowell, Zhao, Xumiao, Nelson, Kendra Louise, Bhattacharya, Samit Kumar, Freeman-Cook, Kevin Daniel
Year of Publication 04.04.2024
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Year of Publication 04.04.2024
Patent
Species Specificity of Amidine-Based Urokinase Inhibitors
Klinghofer, Vered, Stewart, Kent, McGonigal, Tom, Smith, Richard, Sarthy, Aparna, Nienaber, Vicki, Butler, Chris, Dorwin, Sarah, Richardson, Paul, Weitzberg, Moshe, Wendt, Mike, Rockway, Todd, Zhao, Xumiao, Hulkower, Keren I, Giranda, Vincent L
Published in Biochemistry (Easton) (07.08.2001)
Published in Biochemistry (Easton) (07.08.2001)
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Journal Article
SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
Luzzio, Michael Joseph, Xiao, Jun, Hayward, Matthew Merrill, Hulford, Catherine Angela, Autry, Christopher Lowell, Zhao, Xumiao, Nelson, Kendra Louise, Bhattacharya, Samit Kumar, Freeman-Cook, Kevin Daniel
Year of Publication 11.08.2022
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Year of Publication 11.08.2022
Patent
SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
Luzzio, Michael Joseph, Xiao, Jun, Hayward, Matthew Merrill, Hulford, Catherine Angela, Autry, Christopher Lowell, Zhao, Xumiao, Nelson, Kendra Louise, Bhattacharya, Samit Kumar, Freeman-Cook, Kevin Daniel
Year of Publication 02.01.2020
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Year of Publication 02.01.2020
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Immobilized thymine chromatography–mass spectrometry of oligonucleotides
van Breemen, Richard B, Tan, Yecheng, Lai, Jacob, Huang, Chao-Ran, Zhao, Xumiao
Published in Journal of Chromatography A (08.05.1998)
Published in Journal of Chromatography A (08.05.1998)
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Journal Article
Sulfonyl amide derivatives for the treatment of abnormal cell growth
Luzzio, Michael Joseph, Xiao, Jun, Hayward, Matthew Merrill, Hulford, Catherine Angela, Autry, Christopher Lowell, Nelson, Kendra Louise, Zhao, Xumiao, Bhattacharya, Samit Kumar, Freeman-Cook, Kevin Daniel
Year of Publication 28.06.2018
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Year of Publication 28.06.2018
Patent
Sulfonyl amide derivatives for the treatment of abnormal cell growth
Luzzio, Michael Joseph, Xiao, Jun, Hayward, Matthew Merrill, Hulford, Catherine Angela, Autry, Christopher Lowell, Nelson, Kendra Louise, Zhao, Xumiao, Bhattacharya, Samit Kumar, Freeman-Cook, Kevin Daniel
Year of Publication 08.03.2018
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Year of Publication 08.03.2018
Patent