Cross-species chromatin interactions drive transcriptional rewiring in Epstein–Barr virus–positive gastric adenocarcinoma
Okabe, Atsushi, Huang, Kie Kyon, Matsusaka, Keisuke, Fukuyo, Masaki, Xing, Manjie, Ong, Xuewen, Hoshii, Takayuki, Usui, Genki, Seki, Motoaki, Mano, Yasunobu, Rahmutulla, Bahityar, Kanda, Teru, Suzuki, Takayoshi, Rha, Sun Young, Ushiku, Tetsuo, Fukayama, Masashi, Tan, Patrick, Kaneda, Atsushi
Published in Nature genetics (01.09.2020)
Published in Nature genetics (01.09.2020)
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Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer
Huang, Kie Kyon, Ramnarayanan, Kalpana, Zhu, Feng, Srivastava, Supriya, Xu, Chang, Tan, Angie Lay Keng, Lee, Minghui, Tay, Suting, Das, Kakoli, Xing, Manjie, Fatehullah, Aliya, Alkaff, Syed Muhammad Fahmy, Lim, Tony Kiat Hon, Lee, Jonathan, Ho, Khek Yu, Rozen, Steven George, Teh, Bin Tean, Barker, Nick, Chia, Chung King, Khor, Christopher, Ooi, Choon Jin, Fock, Kwong Ming, So, Jimmy, Lim, Wee Chian, Ling, Khoon Lin, Ang, Tiing Leong, Wong, Andrew, Rao, Jaideepraj, Rajnakova, Andrea, Lim, Lee Guan, Yap, Wai Ming, Teh, Ming, Yeoh, Khay Guan, Tan, Patrick
Published in Cancer cell (08.01.2018)
Published in Cancer cell (08.01.2018)
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Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity
Ooi, Wen Fong, Xing, Manjie, Xu, Chang, Yao, Xiaosai, Ramlee, Muhammad Khairul, Lim, Mei Chee, Cao, Fan, Lim, Kevin, Babu, Deepak, Poon, Lai-Fong, Lin Suling, Joyce, Qamra, Aditi, Irwanto, Astrid, Qu Zhengzhong, James, Nandi, Tannistha, Lee-Lim, Ai Ping, Chan, Yang Sun, Tay, Su Ting, Lee, Ming Hui, Davies, James O. J., Wong, Wai Keong, Soo, Khee Chee, Chan, Weng Hoong, Ong, Hock Soo, Chow, Pierce, Wong, Chow Yin, Rha, Sun Young, Liu, Jianjun, Hillmer, Axel M., Hughes, Jim R., Rozen, Steve, Teh, Bin Tean, Fullwood, Melissa Jane, Li, Shang, Tan, Patrick
Published in Nature communications (28.09.2016)
Published in Nature communications (28.09.2016)
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VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma
Yao, Xiaosai, Tan, Jing, Lim, Kevin Junliang, Koh, Joanna, Ooi, Wen Fong, Li, Zhimei, Huang, Dachuan, Xing, Manjie, Chan, Yang Sun, Qu, James Zhengzhong, Tay, Su Ting, Wijaya, Giovani, Lam, Yue Ning, Hong, Jing Han, Lee-Lim, Ai Ping, Guan, Peiyong, Ng, Michelle Shu Wen, He, Cassandra Zhengxuan, Lin, Joyce Suling, Nandi, Tannistha, Qamra, Aditi, Xu, Chang, Myint, Swe Swe, Davies, James O J, Goh, Jian Yuan, Loh, Gary, Tan, Bryan C, Rozen, Steven G, Yu, Qiang, Tan, Iain Bee Huat, Cheng, Christopher Wai Sam, Li, Shang, Chang, Kenneth Tou En, Tan, Puay Hoon, Silver, David Lawrence, Lezhava, Alexander, Steger, Gertrud, Hughes, Jim R, Teh, Bin Tean, Tan, Patrick
Published in Cancer discovery (01.11.2017)
Published in Cancer discovery (01.11.2017)
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HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis
Yan, TingDong, Ooi, Wen Fong, Qamra, Aditi, Cheung, Alice, Ma, DongLiang, Sundaram, Gopinath Meenakshi, Xu, Chang, Xing, Manjie, Poon, LaiFong, Wang, Jing, Loh, Yan Ping, Ho, Jess Hui Jie, Ng, Joscelyn Jun Quan, Ramlee, Muhammad Khairul, Aswad, Luay, Rozen, Steve G., Ghosh, Sujoy, Bard, Frederic A., Sampath, Prabha, Tergaonkar, Vinay, Davies, James O. J., Hughes, Jim R., Goh, Eyleen, Bi, Xuezhi, Fullwood, Melissa Jane, Tan, Patrick, Li, Shang
Published in Nature communications (08.01.2018)
Published in Nature communications (08.01.2018)
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Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer
Nargund, Amrita M, Xu, Chang, Mandoli, Amit, Okabe, Atsushi, Chen, Gao Bin, Huang, Kie Kyon, Sheng, Taotao, Yao, Xiaosai, Teo, Jia Ming Nickolas, Sundar, Raghav, Kok, Yee Jiun, See, Yi Xiang, Xing, Manjie, Li, Zhimei, Yong, Chern Han, Anand, Aparna, A I, Zul Fazreen, Poon, Lai Fong, Ng, Michelle Shu Wen, Koh, Javier Yu Peng, Ooi, Wen Fong, Tay, Su Ting, Ong, Xuewen, Tan, Angie Lay Keng, Grabsch, Heike I, Fullwood, Melissa J, Teh, Tean Bin, Bi, Xuezhi, Kaneda, Atsushi, Li, Shang, Tan, Patrick
Published in Cancer research (Chicago, Ill.) (18.07.2022)
Published in Cancer research (Chicago, Ill.) (18.07.2022)
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Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation
Padmanabhan, Nisha, Kyon, Huang Kie, Boot, Arnoud, Lim, Kevin, Srivastava, Supriya, Chen, Shuwen, Wu, Zhiyuan, Lee, Hyung-Ok, Mukundan, Vineeth T, Chan, Charlene, Chan, Yarn Kit, Xuewen, Ong, Pitt, Jason J, Isa, Zul Fazreen Adam, Xing, Manjie, Lee, Ming Hui, Tan, Angie Lay Keng, Ting, Shamaine Ho Wei, Luftig, Micah A, Kappei, Dennis, Kruger, Warren D, Bian, Jinsong, Ho, Ying Swan, Teh, Ming, Rozen, Steve George, Tan, Patrick
Published in Genome Biology (01.06.2021)
Published in Genome Biology (01.06.2021)
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Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements
Muratani, Masafumi, Deng, Niantao, Ooi, Wen Fong, Lin, Suling Joyce, Xing, Manjie, Xu, Chang, Qamra, Aditi, Tay, Su Ting, Malik, Simeen, Wu, Jeanie, Lee, Ming Hui, Zhang, Shenli, Tan, Luke Lin Chuen, Chua, Huihoon, Wong, Wai Keong, Ong, Hock Soo, Ooi, London Lucien, Chow, Pierce Kah-How, Chan, Weng Hoong, Soo, Khee Chee, Goh, Liang Kee, Rozen, Steve, Teh, Bin Tean, Yu, Qiang, Ng, Huck Hui, Tan, Patrick
Published in Nature communications (10.07.2014)
Published in Nature communications (10.07.2014)
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Epigenomic Promoter Alterations Amplify Gene Isoform and Immunogenic Diversity in Gastric Adenocarcinoma
Qamra, Aditi, Xing, Manjie, Padmanabhan, Nisha, Kwok, Jeffrey Jun Ting, Zhang, Shenli, Xu, Chang, Leong, Yan Shan, Lee Lim, Ai Ping, Tang, Qianqao, Ooi, Wen Fong, Suling Lin, Joyce, Nandi, Tannistha, Yao, Xiaosai, Ong, Xuewen, Lee, Minghui, Tay, Su Ting, Keng, Angie Tan Lay, Gondo Santoso, Erna, Ng, Cedric Chuan Young, Ng, Alvin, Jusakul, Apinya, Smoot, Duane, Ashktorab, Hassan, Rha, Sun Young, Yeoh, Khay Guan, Peng Yong, Wei, Chow, Pierce K H, Chan, Weng Hoong, Ong, Hock Soo, Soo, Khee Chee, Kim, Kyoung-Mee, Wong, Wai Keong, Rozen, Steven G, Teh, Bin Tean, Kappei, Dennis, Lee, Jeeyun, Connolly, John, Tan, Patrick
Published in Cancer discovery (01.06.2017)
Published in Cancer discovery (01.06.2017)
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Author Correction: Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation
Padmanabhan, Nisha, Kyon, Huang Kie, Boot, Arnoud, Lim, Kevin, Srivastava, Supriya, Chen, Shuwen, Wu, Zhiyuan, Lee, Hyung-Ok, Mukundan, Vineeth T., Chan, Charlene, Chan, Yarn Kit, Xuewen, Ong, Pitt, Jason J., Isa, Zul Fazreen Adam, Xing, Manjie, Lee, Ming Hui, Tan, Angie Lay Keng, Ting, Shamaine Ho Wei, Luftig, Micah A., Kappei, Dennis, Kruger, Warren D., Bian, Jinsong, Ho, Ying Swan, Teh, Ming, Rozen, Steve George, Tan, Patrick
Published in Genome Biology (17.06.2021)
Published in Genome Biology (17.06.2021)
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Integrative epigenomic and high-throughput functional enhancer profiling reveals determinants of enhancer heterogeneity in gastric cancer
Sheng, Taotao, Ho, Shamaine Wei Ting, Ooi, Wen Fong, Xu, Chang, Xing, Manjie, Padmanabhan, Nisha, Huang, Kie Kyon, Ma, Lijia, Ray, Mohana, Guo, Yu Amanda, Sim, Ngak Leng, Anene-Nzelu, Chukwuemeka George, Chang, Mei Mei, Razavi-Mohseni, Milad, Beer, Michael A, Foo, Roger Sik Yin, Sundar, Raghav, Chan, Yiong Huak, Tan, Angie Lay Keng, Ong, Xuewen, Skanderup, Anders Jacobsen, White, Kevin P, Jha, Sudhakar, Tan, Patrick
Published in Genome medicine (11.10.2021)
Published in Genome medicine (11.10.2021)
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Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor
Xu, Xun, Hou, Yong, Yin, Xuyang, Bao, Li, Tang, Aifa, Song, Luting, Li, Fuqiang, Tsang, Shirley, Wu, Kui, Wu, Hanjie, He, Weiming, Zeng, Liang, Xing, Manjie, Wu, Renhua, Jiang, Hui, Liu, Xiao, Cao, Dandan, Guo, Guangwu, Hu, Xueda, Gui, Yaoting, Li, Zesong, Xie, Wenyue, Sun, Xiaojuan, Shi, Min, Cai, Zhiming, Wang, Bin, Zhong, Meiming, Li, Jingxiang, Lu, Zuhong, Gu, Ning, Zhang, Xiuqing, Goodman, Laurie, Bolund, Lars, Wang, Jian, Yang, Huanming, Kristiansen, Karsten, Dean, Michael, Li, Yingrui, Wang, Jun
Published in Cell (02.03.2012)
Published in Cell (02.03.2012)
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Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities
Ho, Shamaine Wei Ting, Sheng, Taotao, Xing, Manjie, Ooi, Wen Fong, Xu, Chang, Sundar, Raghav, Huang, Kie Kyon, Li, Zhimei, Kumar, Vikrant, Ramnarayanan, Kalpana, Zhu, Feng, Srivastava, Supriya, Isa, Zul Fazreen Bin Adam, Anene-Nzelu, Chukwuemeka George, Razavi-Mohseni, Milad, Shigaki, Dustin, Ma, Haoran, Tan, Angie Lay Keng, Ong, Xuewen, Lee, Ming Hui, Tay, Su Ting, Guo, Yu Amanda, Huang, Weitai, Li, Shang, Beer, Michael A., Foo, Roger Sik Yin, Teh, Ming, Skanderup, Anders Jacobsen, Teh, Bin Tean, Tan, Patrick
Published in Gut (01.02.2023)
Published in Gut (01.02.2023)
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Epigenetic promoter alterations in GI tumour immune-editing and resistance to immune checkpoint inhibition
Sundar, Raghav, Huang, Kie-Kyon, Kumar, Vikrant, Ramnarayanan, Kalpana, Demircioglu, Deniz, Her, Zhisheng, Ong, Xuewen, Bin Adam Isa, Zul Fazreen, Xing, Manjie, Tan, Angie Lay-Keng, Tai, David Wai Meng, Choo, Su Pin, Zhai, Weiwei, Lim, Jia Qi, Das Thakur, Meghna, Molinero, Luciana, Cha, Edward, Fasso, Marcella, Niger, Monica, Pietrantonio, Filippo, Lee, Jeeyun, Jeyasekharan, Anand D, Qamra, Aditi, Patnala, Radhika, Fabritius, Arne, De Simone, Mark, Yeong, Joe, Ng, Cedric Chuan Young, Rha, Sun Young, Narita, Yukiya, Muro, Kei, Guo, Yu Amanda, Skanderup, Anders Jacobsen, So, Jimmy Bok Yan, Yong, Wei Peng, Chen, Qingfeng, Göke, Jonathan, Tan, Patrick
Published in Gut (01.07.2022)
Published in Gut (01.07.2022)
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Integrated paired-end enhancer profiling and whole-genome sequencing reveals recurrent CCNE1 and IGF2 enhancer hijacking in primary gastric adenocarcinoma
Ooi, Wen Fong, Nargund, Amrita M, Lim, Kevin Junliang, Zhang, Shenli, Xing, Manjie, Mandoli, Amit, Lim, Jing Quan, Ho, Shamaine Wei Ting, Guo, Yu, Yao, Xiaosai, Lin, Suling Joyce, Nandi, Tannistha, Xu, Chang, Ong, Xuewen, Lee, Minghui, Tan, Angie Lay-Keng, Lam, Yue Ning, Teo, Jing Xian, Kaneda, Atsushi, White, Kevin P, Lim, Weng Khong, Rozen, Steven G, Teh, Bin Tean, Li, Shang, Skanderup, Anders J, Tan, Patrick
Published in Gut (01.06.2020)
Published in Gut (01.06.2020)
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Journal Article
HNF4α pathway mapping identifies wild-type IDH1 as a targetable metabolic node in gastric cancer
Xu, Chang, Ooi, Wen Fong, Qamra, Aditi, Tan, Jing, Chua, Benjamin Yan-Jiang, Ho, Shamaine Wei Ting, Das, Kakoli, Adam Isa, Zul Fazreen, Li, Zhimei, Yao, Xiaosai, Yan, Tingdong, Xing, Manjie, Huang, Kie Kyon, Lin, Joyce Suling, Nandi, Tannistha, Tay, Su Ting, Lee, Ming Hui, Tan, Angie Lay Keng, Ong, Xuewen, Ashktorab, Hassan, Smoot, Duane, Li, Shang, Ng, Shyh-Chang, Teh, Bin Tean, Tan, Patrick
Published in Gut (01.02.2020)
Published in Gut (01.02.2020)
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Journal Article
Correction: Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer
Nargund, Amrita M, Xu, Chang, Mandoli, Amit, Okabe, Atsushi, Chen, Gao Bin, Huang, Kie Kyon, Sheng, Taotao, Yao, Xiaosai, Teo, Jia Ming Nickolas, Sundar, Raghav, Kok, Yee Jiun, See, Yi Xiang, Xing, Manjie, Li, Zhimei, Yong, Chern Han, Anand, Aparna, Bin Adam Isa, Zul Fazreen, Poon, Lai Fong, Ng, Michelle Shu Wen, Koh, Javier Yu Peng, Ooi, Wen Fong, Tay, Su Ting, Ong, Xuewen, Tan, Angie Lay Keng, Smoot, Duane T, Ashktorab, Hassan, Grabsch, Heike I, Fullwood, Melissa J, Teh, Bin Tean, Bi, Xuezhi, Kaneda, Atsushi, Li, Shang, Tan, Patrick
Published in Cancer research (Chicago, Ill.) (02.03.2023)
Published in Cancer research (Chicago, Ill.) (02.03.2023)
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Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer
Xing, Manjie, Ooi, Wen Fong, Tan, Jing, Qamra, Aditi, Lee, Po-Hsien, Li, Zhimei, Xu, Chang, Padmanabhan, Nisha, Lim, Jing Quan, Guo, Yu Amanda, Yao, Xiaosai, Amit, Mandoli, Ng, Ley Moy, Sheng, Taotao, Wang, Jing, Huang, Kie Kyon, Anene-Nzelu, Chukwuemeka George, Ho, Shamaine Wei Ting, Ray, Mohana, Ma, Lijia, Fazzi, Gregorio, Lim, Kevin Junliang, Wijaya, Giovani Claresta, Zhang, Shenli, Nandi, Tannistha, Yan, Tingdong, Chang, Mei Mei, Das, Kakoli, Isa, Zul Fazreen Adam, Wu, Jeanie, Poon, Polly Suk Yean, Lam, Yue Ning, Lin, Joyce Suling, Tay, Su Ting, Lee, Ming Hui, Tan, Angie Lay Keng, Ong, Xuewen, White, Kevin, Rozen, Steven George, Beer, Michael, Foo, Roger Sik Yin, Grabsch, Heike Irmgard, Skanderup, Anders Jacobsen, Li, Shang, Teh, Bin Tean, Tan, Patrick
Published in The Journal of clinical investigation (01.06.2020)
Published in The Journal of clinical investigation (01.06.2020)
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Journal Article
Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer
Xing, Manjie, Ooi, Wen Fong, Tan, Jing, Qamra, Aditi, Lee, Po-Hsien, Li, Zhimei, Xu, Chang, Padmanabhan, Nisha, Lim, Jing Quan, Guo, Yu Amanda, Yao, Xiaosai, Amit, Mandoli, Ng, Ley Moy, Sheng, Taotao, Wang, Jing, Huang, Kie Kyon, Anene-Nzelu, Chukwuemeka George, Ho, Shamaine Wei Ting, Ray, Mohana, Ma, Lijia, Fazzi, Gregorio, Lim, Kevin Junliang, Wijaya, Giovani Claresta, Zhang, Shenli, Nandi, Tannistha, Yan, Tingdong, Chang, Mei Mei, Das, Kakoli, Adam, Zul Fazreen, Wu, Isa Jeanie, Poon, Polly Suk Yean, Lam, Yue Ning, Lin, Joyce Suling, Tay, Su Ting, Lee, Ming Hui, Tan, Angie Lay Keng, Ong, Xuewen, White, Kevin, Rozen, Steven George, Beer, Michael, Foo, Roger Sik Yin, Grabsch, Heike Irmgard, Skanderup, Anders Jacobsen, Li, Shang, Teh, Bin Tean, Tan, Patrick
Published in The Journal of clinical investigation (01.06.2020)
Published in The Journal of clinical investigation (01.06.2020)
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