Transcription inactivation through local refolding of the RNA polymerase structure
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Published in Nature (15.01.2009)
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Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase
Lira, Ricardo, Xiang, Alan X., Doundoulakis, Thomas, Biller, William T., Agrios, Konstantinos A., Simonsen, Klaus B., Webber, Stephen E., Sisson, Wes, Aust, Robert M., Shah, Amit M., Showalter, Richard E., Banh, Virginia N., Steffy, Kevin R., Appleman, James R.
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Published in Bioorganic & medicinal chemistry letters (15.12.2007)
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Strategic Diastereoselective C1 Functionalization in the Aza-Rocaglamide Scaffold toward Natural Product-Inspired eIF4A Inhibitors
Nilewski, Christian, Michels, Theodore D, Xiang, Alan X, Packard, Garrick K, Sprengeler, Paul A, Eam, Boreth, Fish, Sarah, Thompson, Peggy A, Wegerski, Christopher J, Ernst, Justin T, Reich, Siegfried H
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Published in Organic letters (21.08.2020)
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1-Aminomethyl SAR in a novel series of flavagline-inspired eIF4A inhibitors: Effects of amine substitution on cell potency and in vitro PK properties
Nilewski, Christian, Michels, Theodore D., Packard, Garrick K., Xiang, Alan X., Sprengeler, Paul A., Eam, Boreth, Fish, Sarah, Thompson, Peggy A., Wegerski, Christopher J., Nevarez, Andres, Clarine, Jeff, Sperry, Samuel, Ernst, Justin T., Reich, Siegfried H.
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Discovery of ANA975: An Oral Prodrug of the TLR-7 Agonist Isatoribine
Xiang, Alan X., Webber, Stephen E., Kerr, Bradley M., Rueden, Erik J., Lennox, Joseph R., Haley, Gregory J., Wang, Tingmin, Ng, John S., Herbert, Mark R., Clark, David L., Banh, Virginia N., Li, Wei, Fletcher, Simon P., Steffy, Kevin R., Bartkowski, Darian M., Kirkovsky, Leonid I., Bauman, Lisa A., Averett, Devron R.
Published in Nucleosides, nucleotides & nucleic acids (26.11.2007)
Published in Nucleosides, nucleotides & nucleic acids (26.11.2007)
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Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase
RUEBSAM, Frank, MURPHY, Douglas E, BLAZEL, Julie K, SUN HEE KIM, YUEFEN ZHOU, QING HAN, KISSINGER, Charles R, WEBBER, Stephen E, SHOWALTER, Richard E, SHAH, Amit M, TSAN, Mei, PATEL, Rupal A, TRAN, Chinh V, THOMPSON, Peggy A, LEBRUN, Laurie A, HOU, Huiying J, KAMRAN, Ruhi, SERGEEVA, Maria V, BARTKOWSKI, Darian M, NOLAN, Thomas G, NORRIS, Daniel A, KHANDURINA, Julia, BROOKS, Jennifer, LI, Lian-Sheng, OKAMOTO, Ellen, KIRKOVSKY, Leo, JINGJING ZHAO, DRAGOVICH, Peter S, MCGUIRE, Helen M, XIANG, Alan X, ZHONGXIANG SUN, AYIDA, Benjamin K
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
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Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[ b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase
Kim, Sun Hee, Tran, Martin T., Ruebsam, Frank, Xiang, Alan X., Ayida, Benjamin, McGuire, Helen, Ellis, David, Blazel, Julie, Tran, Chinh V., Murphy, Douglas E., Webber, Stephen E., Zhou, Yuefen, Shah, Amit M., Tsan, Mei, Showalter, Richard E., Patel, Rupal, Gobbi, Alberto, LeBrun, Laurie A., Bartkowski, Darian M., Nolan, Thomas G., Norris, Daniel A., Sergeeva, Maria V., Kirkovsky, Leo, Zhao, Qiang, Han, Qing, Kissinger, Charles R.
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
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5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase
Ruebsam, Frank, Tran, Chinh V, Li, Lian-Sheng, Kim, Sun Hee, Xiang, Alan X, Zhou, Yuefen, Blazel, Julie K, Sun, Zhongxiang, Dragovich, Peter S, Zhao, Jingjing, McGuire, Helen M, Murphy, Douglas E, Tran, Martin T, Stankovic, Nebojsa, Ellis, David A, Gobbi, Alberto, Showalter, Richard E, Webber, Stephen E, Shah, Amit M, Tsan, Mei, Patel, Rupal A, Lebrun, Laurie A, Hou, Huiying J, Kamran, Ruhi, Sergeeva, Maria V, Bartkowski, Darian M, Nolan, Thomas G, Norris, Daniel A, Kirkovsky, Leo
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
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5,5'- and 6,6'-Dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase
ELLIS, David A, BLAZEL, Julie K, WEBBER, Stephen E, QIANG ZHAO, QING HAN, KISSINGER, Charles R, LARDY, Matthew, GOBBI, Alberto, SHOWALTER, Richard E, SHAH, Amit M, TSAN, Mei, PATEL, Rupal A, TRAN, Chinh V, LEBRUN, Laurie A, KAMRAN, Ruhi, BARTKOWSKI, Darian M, NOLAN, Thomas G, NORRIS, Daniel A, SERGEEVA, Maria V, KIRKOVSKY, Leo, RUEBSAM, Frank, MURPHY, Douglas E, LI, Lian-Sheng, JINGJING ZHAO, YUEFEN ZHOU, MCGUIRE, Helen M, XIANG, Alan X
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
Published in Bioorganic & medicinal chemistry letters (01.11.2009)
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Synthetic Studies on Borrelidin: Enantioselective Synthesis of the C1−C12 Fragment
Vong, Binh G, Abraham, Sunny, Xiang, Alan X, Theodorakis, Emmanuel A
Published in Organic letters (15.05.2003)
Published in Organic letters (15.05.2003)
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4-(1,1-Dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase
ELLIS, David A, BLAZEL, Julie K, LI, Lian-Sheng, YUEFEN ZHOU, QING HAN, KISSINGER, Charles R, SHOWALTER, Richard E, LARDY, Matthew, SHAH, Amit M, TSAN, Mei, PATEL, Rupal, LEBRUN, Laurie A, WEBBER, Stephen E, KAMRAN, Ruhi, BARTKOWSKI, Darian M, NOLAN, Thomas G, NORRIS, Daniel A, SERGEEVA, Maria V, KIRKOVSKY, Leo, TRAN, Chinh V, DRAGOVICH, Peter S, ZHONGXIANG SUN, RUEBSAM, Frank, MCGUIRE, Helen M, XIANG, Alan X, JINGJING ZHAO
Published in Bioorganic & medicinal chemistry letters (15.08.2008)
Published in Bioorganic & medicinal chemistry letters (15.08.2008)
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MNK 억제제의 결정질 형태
XIANG ALAN X, WILSON JO ANN Z, SPERRY SAMUEL, WEBBER STEPHEN E, SPRENGELER PAUL A, REICH SIEGFRIED H, BORER BENNETT C, ERNST JUSTIN T
Year of Publication 19.08.2021
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Year of Publication 19.08.2021
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EIF4E-억제 4-옥소-3,4-디히드로피리도[3,4-D]피리미딘 화합물
NILEWSKI CHRISTIAN, PACKARD GARRICK KENNETH, MICHELS THEO, SPRENGELER PAUL A, MUKAIYAMA TAKASUKE, URKALAN KAVERI, ERNST JUSTIN T, XIANG ALAN X, SHAGHAFI MIKE, SPERRY SAMUEL, GRUBBS ALAN, REICH SIEGFRIED H, TRAN CHINH VIET
Year of Publication 13.05.2022
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Year of Publication 13.05.2022
Patent
Myxopyronin B analogs as inhibitors of RNA polymerase, synthesis and biological evaluation
DOUNDOULAKIS, Thomas, XIANG, Alan X, SIMONSEN, Klaus B, LIRA, Ricardo, AGRIOS, Konstantinos A, WEBBER, Stephen E, SISSON, Wes, AUST, Robert M, SHAH, Amit M, SHOWALTER, Richard E, APPLEMAN, James R
Published in Bioorganic & medicinal chemistry letters (15.11.2004)
Published in Bioorganic & medicinal chemistry letters (15.11.2004)
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Total Synthesis of Clerocidin via a Novel, Enantioselective Homoallenylboration Methodology
Xiang, Alan X, Watson, Donald A, Ling, Taotao, Theodorakis, Emmanuel A
Published in Journal of organic chemistry (02.10.1998)
Published in Journal of organic chemistry (02.10.1998)
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Design, synthesis, and evaluation of N-aroyloxy-2-thiopyridones as DNA photocleaving reagents
Blom, Petra, Xiang, Alan X., Kao, David, Theodorakis, Emmanuel A.
Published in Bioorganic & medicinal chemistry (01.05.1999)
Published in Bioorganic & medicinal chemistry (01.05.1999)
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Enantioselective Total Synthesis of Avarol and Avarone
Ling, Taotao, Xiang, Alan X., Theodorakis, Emmanuel A.
Published in Angewandte Chemie International Edition (18.10.1999)
Published in Angewandte Chemie International Edition (18.10.1999)
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Efficient synthesis of (1 R,2 S) and (1 S,2 R)-2-aminocyclopentanecarboxylic acid ethyl ester derivatives in enantiomerically pure form
Dragovich, Peter S., Murphy, Douglas E., Dao, Kimkim, Kim, Sun Hee, Li, Lian-Sheng, Ruebsam, Frank, Sun, Zhongxiang, Tran, Chinh V., Xiang, Alan X., Zhou, Yuefen
Published in Tetrahedron: asymmetry (12.12.2008)
Published in Tetrahedron: asymmetry (12.12.2008)
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