SPH3643: A novel cyclin‐dependent kinase 4/6 inhibitor with good anticancer efficacy and strong blood‐brain barrier permeability
Liao, XueMei, Hong, Yuan, Mao, Yu, Chen, Na, Wang, Qian, Wang, Zhe, Zhang, LeDuo, Wang, Li, Shi, Chen, Shi, WeiJun, Ge, Hui, Li, AnDi, Li, Xin, Xia, GuangXin, Liu, YanJun
Published in Cancer science (01.05.2020)
Published in Cancer science (01.05.2020)
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A new triterpenoid from Teucrium viscidum
Hao, Xincai, Zhang, Jinwen, Xia, Guangxin, Xue, Yongbo, Luo, Zengwei, Si, Yanyan, Yao, Guangmin, Zhang, Yonghui
Published in Molecules (Basel, Switzerland) (21.01.2013)
Published in Molecules (Basel, Switzerland) (21.01.2013)
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Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting EGFR
Wu, Jianwei, Chen, Wenteng, Xia, Guangxin, Zhang, Jing, Shao, Jiaan, Tan, Biqin, Zhang, Chunchun, Yu, Wanwan, Weng, Qinjie, Liu, Haiyan, Hu, Miao, Deng, Hailin, Hao, Yu, Shen, Jingkang, Yu, Yongping
Published in ACS medicinal chemistry letters (10.10.2013)
Published in ACS medicinal chemistry letters (10.10.2013)
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Potent and novel 11β-HSD1 inhibitors identified from shape and docking based virtual screening
Xia, Guangxin, Xue, Mengzhu, Liu, Lin, Yu, Jianxin, Liu, Haiyan, Li, Ping, Wang, Jianfa, Li, Yanlian, Xiong, Bing, Shen, Jingkang
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
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Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2- e]purin-4(3 H)-one derivatives
Xia, Guangxin, Li, Jianfeng, Peng, Aiming, Lai, Shunan, Zhang, Shujun, Shen, Jingshan, Liu, Zhonghua, Chen, Xinjian, Ji, Ruyun
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
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Synthesis and evaluation of homocamptothecin antibody-drug conjugates for cancer treatment
Li, Yalong, Cheng, Zhiyang, Zhou, Wei, Wang, Lei, Li, Xiaomei, Xia, Guangxin, Lu, Wei, Zhu, Shulei
Published in European journal of medicinal chemistry (05.12.2024)
Published in European journal of medicinal chemistry (05.12.2024)
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Association of serum albumin to globulin ratio with outcomes in acute ischemic stroke
Wang, Anxin, Zhang, Yijun, Xia, Guangxin, Tian, Xue, Zuo, Yingting, Chen, Pan, Wang, Yongjun, Meng, Xia, Han, Xinsheng
Published in CNS neuroscience & therapeutics (01.05.2023)
Published in CNS neuroscience & therapeutics (01.05.2023)
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Numerical study of point spread function of a fast neutron radiography system based on scintillating-fiber array
Zhang, FaQing, Li, ZhengHong, Yang, JianLun, Ye, Fan, Wang, Zhen, Xia, GuangXin, Ying, ChunTong, Liu, GuangJun
Published in Science China. Physics, mechanics & astronomy (01.12.2007)
Published in Science China. Physics, mechanics & astronomy (01.12.2007)
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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SPH3127: A Phase I, Randomized, Double-Blind, Placebo-Controlled Trial
Jing, Shan, Xu, Ranchi, Yang, Kexu, Liu, Wenfang, Zhang, Leduo, Ke, Ying, Xia, Guangxin, Lin, Yang
Published in Clinical therapeutics (01.04.2021)
Published in Clinical therapeutics (01.04.2021)
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SPH7854, a gut-limited RORγt antagonist, ameliorates TNBS-induced experimental colitis in rat
Xiang, Zhijun, Zhang, Bingbin, Cao, Shuangyi, Cao, Long, Li, Lingwen, huang, Dehua, Li, Qian, Chen, Yuxiang, Gong, Xuelian, Zhang, Xiaohong, Li, Ruizhi, Wu, Jinmiao, Peng, Yayuan, Huo, Guoyong, Xu, Lixia, Zhang, Zhihui, Li, Di, Xia, Guangxin
Published in International immunopharmacology (25.10.2024)
Published in International immunopharmacology (25.10.2024)
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Discovery of SPH5030, a Selective, Potent, and Irreversible Tyrosine Kinase Inhibitor for HER2-Amplified and HER2-Mutant Cancer Treatment
Li, Di, Tu, Yuanxiang, Jin, Kaijun, Duan, Lingjun, Hong, Yuan, Xu, Jia, Chen, Na, Zhang, Zhihui, Zuo, Hongjian, Gong, Wanchun, Zhang, Jing, Wang, Qian, Qian, Hai, Wang, Xuenan, Ke, Ying, Xia, Guangxin
Published in Journal of medicinal chemistry (14.04.2022)
Published in Journal of medicinal chemistry (14.04.2022)
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Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor
Iijima, Daisuke, Sugama, Hiroshi, Takahashi, Yoichi, Hirai, Miki, Togashi, Yuko, Xie, Jianshu, Shen, Jingkang, Ke, Ying, Akatsuka, Hidenori, Kawaguchi, Takayuki, Takedomi, Kei, Kashima, Akiko, Nishio, Masashi, Inui, Yosuke, Yoneda, Hikaru, Xia, Guangxin, Iijima, Toru
Published in Journal of medicinal chemistry (25.08.2022)
Published in Journal of medicinal chemistry (25.08.2022)
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Discovery and optimization of a series of imidazo[4,5-b]pyrazine derivatives as highly potent and exquisitely selective inhibitors of the mesenchymal–epithelial transition factor (c-Met) protein kinase
Zhao, Fei, Zhang, Jing, Zhang, Leduo, Hao, Yu, Shi, Chen, Xia, Guangxin, Yu, Jianxin, Liu, Yanjun
Published in Bioorganic & medicinal chemistry (15.09.2016)
Published in Bioorganic & medicinal chemistry (15.09.2016)
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Evaluation of preclinical safety profile of SPH3127, a direct renin inhibitor, after 28-day repeated oral administration in Sprague-Dawley rats and cynomolgus monkeys
Mao, Yu, zhang, Leduo, Li, Hua, Li, Xin, Liu, Yanjun, Xia, Guangxin
Published in Regulatory toxicology and pharmacology (01.12.2019)
Published in Regulatory toxicology and pharmacology (01.12.2019)
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Discovery of novel triazoles containing benzyloxy phenyl isoxazole side chain with potent and broad-spectrum antifungal activity
Chi, Xiaochen, Xie, Fei, Li, Liping, Hao, Yumeng, Wu, Hao, Li, Xianru, Xia, Guangxin, Yan, Lan, Zhang, Dazhi, Jiang, Yuanying, Ni, Tingjunhong
Published in Bioorganic chemistry (01.08.2023)
Published in Bioorganic chemistry (01.08.2023)
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Discovery of a novel series of imidazo[1′,2’:1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors
Shi, Chen, Wang, Qian, Liao, Xuemei, Ge, Hui, Huo, Guoyong, Zhang, Leduo, Chen, Na, Zhai, Xiong, Hong, Yuan, Wang, Li, Wang, Zhe, Shi, Weijun, Mao, Yu, Yu, Jianxin, Ke, Ying, Xia, Guangxin
Published in European journal of medicinal chemistry (01.05.2020)
Published in European journal of medicinal chemistry (01.05.2020)
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Discovery of 6-(2-(dimethylamino)ethyl)-N-(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole-6-yl)pyrimidin-2-yl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-amine as a highly potent cyclin-dependent kinase 4/6 inhibitor for treatment of cancer
Shi, Chen, Wang, Qian, Liao, Xuemei, Ge, Hui, Huo, Guoyong, Zhang, Leduo, Chen, Na, Zhai, Xiong, Hong, Yuan, Wang, Li, Han, Yanan, Xiao, Wenbo, Wang, Zhe, Shi, Weijun, Mao, Yu, Yu, Jianxin, Xia, Guangxin, Liu, Yanjun
Published in European journal of medicinal chemistry (15.09.2019)
Published in European journal of medicinal chemistry (15.09.2019)
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Design, synthesis, and pharmacological evaluation of quinazoline derivatives as novel and potent pan-JAK inhibitors
Xiang, Jinbao, Wang, Yuji, Wang, Wanhe, Yu, Jianxin, Zheng, Lianyou, Hong, Yuan, Shi, Lingling, Zhang, Chunling, Chen, Na, Xu, Jia, Gong, Xuelian, Zhang, Zhuoqi, Cui, Hongming, Zhou, Qian, Zhang, Dapeng, Liu, Yanjun, Ke, Ying, Shen, Jingkang, Xia, Guangxin, Bai, Xu
Published in Bioorganic chemistry (01.11.2023)
Published in Bioorganic chemistry (01.11.2023)
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