New quinoline NK3 receptor antagonists with CNS activity
SMITH, Paul W, WYMAN, Paul A, COGGON, Sara, MURKITT, Graham, SEARLE, Kirsten, THOMAS, David R, WATSON, Jeannette M, MARTIN, William, ZINING WU, DAWSON, Lee A, LOVELL, Peter, GOODACRE, Caroline, SERAFINOWSKA, Halina T, VONG, Antonio, HARRINGTON, Frank, FLYNN, Sean, BRADLEY, Daniel M, PORTER, Rod
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Get full text
Journal Article
The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists
JOHNSON, Dale J, FORBES, Ian T, MURKITT, Graham S, LUCAS, Adam J, MOOKHERJEE, Claudette R, WATSON, Jeannette M, GARTLON, Jane E, BRADFORD, Andrea M, BROWN, Fiona, WATSON, Steve P, GARZYA, Vincenzo, STEVENSON, Graeme I, WALKER, Graham R, MUDHAR, Harminder S, FLYNN, Sean T, WYMAN, Paul A, SMITH, Paul W
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
Get full text
Journal Article
Studies on a series of potent, orally bioavailable, 5-HT1 receptor ligands—Part II
Ward, Simon E., Eddershaw, Peter, Flynn, Sean T., Gordon, Laurie, Lovell, Peter J., Moore, Susan H., Scott, Claire M., Smith, Paul W., Thewlis, Kevin M., Wyman, Paul A.
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
Get full text
Journal Article
Studies on a series of potent, orally bioavailable, 5-HT(1) receptor ligands--part II
Ward, Simon E, Eddershaw, Peter, Flynn, Sean T, Gordon, Laurie, Lovell, Peter J, Moore, Susan H, Scott, Claire M, Smith, Paul W, Thewlis, Kevin M, Wyman, Paul A
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
Get full text
Journal Article
(1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 receptor antagonist derived from metoclopramide
Gaster, Laramie M, Jennings, Andrew J, Joiner, Graham F, King, Frank D, Mulholland, Keith R, Rahman, Shirley K, Starr, Susannah, Wyman, Paul A, Wardle, Kay A
Published in Journal of medicinal chemistry (01.12.1993)
Published in Journal of medicinal chemistry (01.12.1993)
Get full text
Journal Article
Biarylcarbamoylindolines Are Novel and Selective 5-HT2C Receptor Inverse Agonists: Identification of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a Potential Antidepressant/Anxiolytic Agent
Bromidge, Steven M, Dabbs, Steven, Davies, David T, Davies, Susannah, Duckworth, D. Malcolm, Forbes, Ian T, Gaster, Laramie M, Ham, Peter, Jones, Graham E, King, Frank D, Mulholland, Keith R, Saunders, Damian V, Wyman, Paul A, Blaney, Frank E, Clarke, Stephen E, Blackburn, Thomas P, Holland, Vicky, Kennett, Guy A, Lightowler, Sean, Middlemiss, Derek N, Trail, Brenda, Riley, Graham J, Wood, Martyn D
Published in Journal of medicinal chemistry (23.03.2000)
Published in Journal of medicinal chemistry (23.03.2000)
Get full text
Journal Article
Identification of a potent and selective 5-HT1B receptor antagonist
WYMAN, Paul A, MARSHALL, Howard R, FLYNN, Sean T, KING, Ron J, THOMPSON, Mervyn, SMITH, Paul W, HADLEY, Michael S, PRICE, Gary W, SCOTT, Claire M, DAWSON, Lee A
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Get full text
Journal Article
Novel and Selective 5-HT2C/2B Receptor Antagonists as Potential Anxiolytic Agents: Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling of Substituted 1-(3-Pyridylcarbamoyl)indolines
Bromidge, Steven M, Dabbs, Steven, Davies, David T, Duckworth, D. Malcolm, Forbes, Ian T, Ham, Peter, Jones, Graham E, King, Frank D, Saunders, Damian V, Starr, Susannah, Thewlis, Kevin M, Wyman, Paul A, Blaney, Frank E, Naylor, Christopher B, Bailey, Fiona, Blackburn, Thomas P, Holland, Vicky, Kennett, Guy A, Riley, Graham J, Wood, Martyn D
Published in Journal of medicinal chemistry (07.05.1998)
Published in Journal of medicinal chemistry (07.05.1998)
Get full text
Journal Article
Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands
Jenkins, Sarah M, Wadsworth, Harry J, Bromidge, Steven, Orlek, Barry S, Wyman, Paul A, Riley, Graham J, Hawkins, Julie
Published in Journal of medicinal chemistry (01.06.1992)
Published in Journal of medicinal chemistry (01.06.1992)
Get full text
Journal Article
The Discovery and Development of 5-HT-terminal Autoreceptor Antagonists
Clitherow, John W, King, Frank D, Middlemiss, Derek N, Wyman, Paul A
Published in Progress in Medicinal Chemistry (2003)
Published in Progress in Medicinal Chemistry (2003)
Get full text
Book Chapter
Journal Article
N-[(1-Butyl-4-piperidinyl)methyl]-3,4- dihydro-2H-[1,3]oxazino[3,2-a]indole- 10-carboxamide hydrochloride: the first potent and selective 5-HT4 receptor antagonist amide with oral activity
Gaster, Laramie M, Joiner, Graham F, King, Frank D, Wyman, Paul A, Sutton, Jonathan M, Bingham, Sharon, Ellis, Elizabeth S, Sanger, Gareth J, Wardle, Kay A
Published in Journal of medicinal chemistry (01.11.1995)
Published in Journal of medicinal chemistry (01.11.1995)
Get full text
Journal Article
The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M 1 agonists
Johnson, Dale J., Forbes, Ian T., Watson, Steve P., Garzya, Vincenzo, Stevenson, Graeme I., Walker, Graham R., Mudhar, Harminder S., Flynn, Sean T., Wyman, Paul A., Smith, Paul W., Murkitt, Graham S., Lucas, Adam J., Mookherjee, Claudette R., Watson, Jeannette M., Gartlon, Jane E., Bradford, Andrea M., Brown, Fiona
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
Get full text
Journal Article
7-Aroyl-2,3-dihydrobenzo[b]furan-3-carboxylic acids and 7-benzoyl-2,3-dihydrobenzo[b]thiophene-3-carboxylic acids as analgesic agents
Boyle, Elizabeth A, Mangan, Frank R, Markwell, Roger E, Smith, Stephen A, Thomson, Michael J, Ward, Robert W, Wyman, Paul A
Published in Journal of medicinal chemistry (01.06.1986)
Published in Journal of medicinal chemistry (01.06.1986)
Get full text
Journal Article
Studies on a series of potent, orally bioavailable, 5-HT 1 receptor ligands—Part II
Ward, Simon E., Eddershaw, Peter, Flynn, Sean T., Gordon, Laurie, Lovell, Peter J., Moore, Susan H., Scott, Claire M., Smith, Paul W., Thewlis, Kevin M., Wyman, Paul A.
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
Get full text
Journal Article
Studies on a series of potent, orally bioavailable, 5.HT1receptor ligands-Part II
WARD, Simon E, EDDERSHAW, Peter, FLYNN, Sean T, GORDON, Laurie, LOVELL, Peter J, MOORE, Susan H, SCOTT, Claire M, SMITH, Paul W, THEWLIS, Kevin M, WYMAN, Paul A
Published in Bioorganic & medicinal chemistry letters (2009)
Get full text
Published in Bioorganic & medicinal chemistry letters (2009)
Journal Article
The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M sub(1) agonists
Johnson, Dale J, bes, Ian T, Watson, Steve P, Garzya, Vincenzo, Stevenson, Graeme I, Walker, Graham R, Mudhar, Harminder S, Flynn, Sean T, Wyman, Paul A, Smith, Paul W, Murkitt, Graham S, Lucas, Adam J, Mookherjee, Claudette R, Watson, Jeannette M, Gartlon, Jane E, Bradford, Andrea M, Brown, Fiona
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
Get full text
Journal Article
The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core
Harrington, Paul E., St. Jean, David J., Clarine, Jeffrey, Coulter, Thomas S., Croghan, Michael, Davenport, Adam, Davis, James, Ghiron, Chiara, Hutchinson, Jonathan, Kelly, Michael G., Lott, Fred, Lu, Jenny Ying-Lin, Martin, David, Morony, Sean, Poon, Steve F., Portero-Larragueta, Elena, Reagan, Jeff D., Regal, Kelly A., Tasker, Andrew, Wang, Minghan, Yang, Yuhua, Yao, Guomin, Zeng, Qingping, Henley, Charles, Fotsch, Christopher
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
Get full text
Journal Article
New quinoline NK 3 receptor antagonists with CNS activity
Smith, Paul W., Wyman, Paul A., Lovell, Peter, Goodacre, Caroline, Serafinowska, Halina T., Vong, Antonio, Harrington, Frank, Flynn, Sean, Bradley, Daniel M., Porter, Rod, Coggon, Sara, Murkitt, Graham, Searle, Kirsten, Thomas, David R., Watson, Jeannette M., Martin, William, Wu, Zining, Dawson, Lee A.
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
Get full text
Journal Article
Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent
Bromidge, S M, Dabbs, S, Davies, D T, Davies, S, Duckworth, D M, Forbes, I T, Gaster, L M, Ham, P, Jones, G E, King, F D, Mulholland, K R, Saunders, D V, Wyman, P A, Blaney, F E, Clarke, S E, Blackburn, T P, Holland, V, Kennett, G A, Lightowler, S, Middlemiss, D N, Trail, B, Riley, G J, Wood, M D
Published in Journal of medicinal chemistry (23.03.2000)
Published in Journal of medicinal chemistry (23.03.2000)
Get full text
Journal Article
Identification of a potent and selective 5-HT 1B receptor antagonist
Wyman, Paul A., Marshall, Howard R., Flynn, Sean T., King, Ron J., Thompson, Mervyn, Smith, Paul W., Hadley, Michael S., Price, Gary W., Scott, Claire M., Dawson, Lee A.
Published in Bioorganic & medicinal chemistry letters (2005)
Published in Bioorganic & medicinal chemistry letters (2005)
Get full text
Journal Article