Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
Bilican, Bilada, Serio, Andrea, Barmada, Sami J, Nishimura, Agnes Lumi, Sullivan, Gareth J, Carrasco, Monica, Phatnani, Hemali P, Puddifoot, Clare A, Story, David, Fletcher, Judy, Park, In-Hyun, Friedman, Brad A, Daley, George Q, Wyllie, David J. A, Hardingham, Giles E, Wilmut, Ian, Finkbeiner, Steven, Maniatis, Tom, Shaw, Christopher E, Chandran, Siddharthan
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (10.04.2012)
Get full text
Journal Article
Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome
Asiminas, Antonis, Jackson, Adam D, Louros, Susana R, Till, Sally M, Spano, Teresa, Dando, Owen, Bear, Mark F, Chattarji, Sumantra, Hardingham, Giles E, Osterweil, Emily K, Wyllie, David J A, Wood, Emma R, Kind, Peter C
Published in Science translational medicine (29.05.2019)
Published in Science translational medicine (29.05.2019)
Get more information
Journal Article
Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction
Perkins, Emma M, Burr, Karen, Banerjee, Poulomi, Mehta, Arpan R, Dando, Owen, Selvaraj, Bhuvaneish T, Suminaite, Daumante, Nanda, Jyoti, Henstridge, Christopher M, Gillingwater, Thomas H, Hardingham, Giles E, Wyllie, David J A, Chandran, Siddharthan, Livesey, Matthew R
Published in Molecular neurodegeneration (04.03.2021)
Published in Molecular neurodegeneration (04.03.2021)
Get full text
Journal Article
Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells
Bilican, Bilada, Livesey, Matthew R, Haghi, Ghazal, Qiu, Jing, Burr, Karen, Siller, Rick, Hardingham, Giles E, Wyllie, David J A, Chandran, Siddharthan
Published in PloS one (17.01.2014)
Published in PloS one (17.01.2014)
Get full text
Journal Article
Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity
Patani, Rickie, Compston, Alastair, Puddifoot, Clare A, Wyllie, David J A, Hardingham, Giles E, Allen, Nicholas D, Chandran, Siddharthan
Published in PloS one (06.10.2009)
Published in PloS one (06.10.2009)
Get full text
Journal Article
Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder
Simões de Oliveira, Laura, O'Leary, Heather E, Nawaz, Sarfaraz, Loureiro, Rita, Davenport, Elizabeth C, Baxter, Paul, Louros, Susana R, Dando, Owen, Perkins, Emma, Peltier, Julien, Trost, Matthias, Osterweil, Emily K, Hardingham, Giles E, Cousin, Michael A, Chattarji, Sumantra, Booker, Sam A, Benke, Tim A, Wyllie, David J A, Kind, Peter C
Published in Molecular autism (14.06.2024)
Published in Molecular autism (14.06.2024)
Get full text
Journal Article
The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults
Martel, Marc-André, Ryan, Tomás J., Bell, Karen F.S., Fowler, Jill H., McMahon, Aoife, Al-Mubarak, Bashayer, Komiyama, Noboru H., Horsburgh, Karen, Kind, Peter C., Grant, Seth G.N., Wyllie, David J.A., Hardingham, Giles E.
Published in Neuron (Cambridge, Mass.) (10.05.2012)
Published in Neuron (Cambridge, Mass.) (10.05.2012)
Get full text
Journal Article
Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns
Das Sharma, Shreya, Pal, Rakhi, Reddy, Bharath Kumar, Selvaraj, Bhuvaneish T, Raj, Nisha, Samaga, Krishna Kumar, Srinivasan, Durga J, Ornelas, Loren, Sareen, Dhruv, Livesey, Matthew R, Bassell, Gary J, Svendsen, Clive N, Kind, Peter C, Chandran, Siddharthan, Chattarji, Sumantra, Wyllie, David J A
Published in Molecular autism (19.06.2020)
Published in Molecular autism (19.06.2020)
Get full text
Journal Article
Imbalance of flight–freeze responses and their cellular correlates in the Nlgn3−/y rat model of autism
Anstey, Natasha J, Kapgal, Vijayakumar, Tiwari, Shashank, Watson, Thomas C, Toft, Anna K. H, Dando, Owen R, Inkpen, Felicity H, Baxter, Paul S, KoziÄ, Zrinko, Jackson, Adam D, He, Xin, Nawaz, Mohammad Sarfaraz, Kayenaat, Aiman, Bhattacharya, Aditi, Wyllie, David J. A, Chattarji, Sumantra, Wood, Emma R, Hardt, Oliver, Kind, Peter C
Published in Molecular autism (18.07.2022)
Published in Molecular autism (18.07.2022)
Get full text
Journal Article
Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
Hasel, Philip, Dando, Owen, Jiwaji, Zoeb, Baxter, Paul, Todd, Alison C., Heron, Samuel, Márkus, Nóra M., McQueen, Jamie, Hampton, David W., Torvell, Megan, Tiwari, Sachin S., McKay, Sean, Eraso-Pichot, Abel, Zorzano, Antonio, Masgrau, Roser, Galea, Elena, Chandran, Siddharthan, Wyllie, David J. A., Simpson, T. Ian, Hardingham, Giles E.
Published in Nature communications (02.05.2017)
Published in Nature communications (02.05.2017)
Get full text
Journal Article
Subunit-Specific Agonist Activity at NR2A-, NR2B-, NR2C-, and NR2D-Containing N-Methyl-d-aspartate Glutamate Receptors
Erreger, Kevin, Geballe, Matthew T, Kristensen, Anders, Chen, Philip E, Hansen, Kasper B, Lee, C Justin, Yuan, Hongjie, Le, Phuong, Lyuboslavsky, Polina N, Micale, Nicola, Jørgensen, Lars, Clausen, Rasmus P, Wyllie, David J A, Snyder, James P, Traynelis, Stephen F
Published in Molecular pharmacology (01.10.2007)
Published in Molecular pharmacology (01.10.2007)
Get full text
Journal Article
Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals
Qiu, Jing, Tan, Yan-Wei, Hagenston, Anna M., Martel, Marc-Andre, Kneisel, Niclas, Skehel, Paul A., Wyllie, David J. A., Bading, Hilmar, Hardingham, Giles E.
Published in Nature communications (18.06.2013)
Published in Nature communications (18.06.2013)
Get full text
Journal Article
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity
Selvaraj, Bhuvaneish T., Livesey, Matthew R., Zhao, Chen, Gregory, Jenna M., James, Owain T., Cleary, Elaine M., Chouhan, Amit K., Gane, Angus B., Perkins, Emma M., Dando, Owen, Lillico, Simon G., Lee, Youn-Bok, Nishimura, Agnes L., Poreci, Urjana, Thankamony, Sai, Pray, Meryll, Vasistha, Navneet A., Magnani, Dario, Borooah, Shyamanga, Burr, Karen, Story, David, McCampbell, Alexander, Shaw, Christopher E., Kind, Peter C., Aitman, Timothy J., Whitelaw, C. Bruce A., Wilmut, Ian, Smith, Colin, Miles, Gareth B., Hardingham, Giles E., Wyllie, David J. A., Chandran, Siddharthan
Published in Nature communications (24.01.2018)
Published in Nature communications (24.01.2018)
Get full text
Journal Article
Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes
Chen, Philip E., Geballe, Matthew T., Katz, Elyse, Erreger, Kevin, Livesey, Matthew R., O'Toole, Kate K., Le, Phuong, Lee, C. Justin, Snyder, James P., Traynelis, Stephen F., Wyllie, David J. A.
Published in The Journal of physiology (01.01.2008)
Published in The Journal of physiology (01.01.2008)
Get full text
Journal Article
Altered dendritic spine function and integration in a mouse model of fragile X syndrome
Booker, Sam A., Domanski, Aleksander P. F., Dando, Owen R., Jackson, Adam D., Isaac, John T. R., Hardingham, Giles E., Wyllie, David J. A., Kind, Peter C.
Published in Nature communications (23.10.2019)
Published in Nature communications (23.10.2019)
Get full text
Journal Article