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Published in Journal of medicinal chemistry (23.06.2016)
Published in Journal of medicinal chemistry (23.06.2016)
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A Dual Inhibitor of DYRK1A and GSK3β for β‐Cell Proliferation: Aminopyrazine Derivative GNF4877
Liu, Yahu A., Jin, Qihui, Ding, Qiang, Hao, Xueshi, Mo, Tingting, Yan, Shanshan, Zou, Yefen, Huang, Zhihong, Zhang, Xiaoyue, Gao, Wenqi, Wu, Tom Y.‐H., Li, Chun, Bursalaya, Badry, Di Donato, Michael, Zhang, You‐Qing, Deaton, Lisa, Shen, Weijun, Taylor, Brandon, Kamireddy, Anwesh, Harb, George, Li, Jing, Jia, Yong, Schumacher, Andrew M., Laffitte, Bryan, Glynne, Richard, Pan, Shifeng, McNamara, Peter, Molteni, Valentina, Loren, Jon
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Published in ChemMedChem (19.08.2020)
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Pancreas-Specific Delivery of β-Cell Proliferating Small Molecules
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Published in ChemMedChem (06.06.2016)
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Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6‑Azaindole Derivative GNF2133
Liu, Yahu A, Jin, Qihui, Zou, Yefen, Ding, Qiang, Yan, Shanshan, Wang, Zhicheng, Hao, Xueshi, Nguyen, Bao, Zhang, Xiaoyue, Pan, Jianfeng, Mo, Tingting, Jacobsen, Kate, Lam, Thanh, Wu, Tom Y.-H, Petrassi, H. Michael, Bursulaya, Badry, DiDonato, Michael, Gordon, W. Perry, Liu, Bo, Baaten, Janine, Hill, Robert, Nguyen-Tran, Vân, Qiu, Minhua, Zhang, You-Qing, Kamireddy, Anwesh, Espinola, Sheryll, Deaton, Lisa, Ha, Sukwon, Harb, George, Jia, Yong, Li, Jing, Shen, Weijun, Schumacher, Andrew M, Colman, Karyn, Glynne, Richard, Pan, Shifeng, McNamara, Peter, Laffitte, Bryan, Meeusen, Shelly, Molteni, Valentina, Loren, Jon
Published in Journal of medicinal chemistry (26.03.2020)
Published in Journal of medicinal chemistry (26.03.2020)
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Discovery of 5‑(3,4-Difluorophenyl)-3-(pyrazol-4-yl)-7-azaindole (GNF3809) for β‑Cell Survival in Type 1 Diabetes
Huang, Zhihong, Tremblay, Matthew S, Wu, Tom Y.-H, Ding, Qiang, Hao, Xueshi, Baaten, Janine, Hill, Robert, Liu, Bo, Meeusen, Shelly, Zou, Yefen, Yan, Shanshan, Jia, Yong, Nguyen-Tran, Van, Shen, Weijun, Bhat, Ganesh, Glynne, Richard, Laffitte, Bryan, Li, Jing, Molteni, Valentina, Liu, Yahu A
Published in ACS omega (28.02.2019)
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Rational design of small molecules as vaccine adjuvants
Wu, Tom Y-H, Singh, Manmohan, Miller, Andrew T, De Gregorio, Ennio, Doro, Francesco, D'Oro, Ugo, Skibinski, David A G, Mbow, M Lamine, Bufali, Simone, Herman, Ann E, Cortez, Alex, Li, Yongkai, Nayak, Bishnu P, Tritto, Elaine, Filippi, Christophe M, Otten, Gillis R, Brito, Luis A, Monaci, Elisabetta, Li, Chun, Aprea, Susanna, Valentini, Sara, Calabrό, Samuele, Laera, Donatello, Brunelli, Brunella, Caproni, Elena, Malyala, Padma, Panchal, Rekha G, Warren, Travis K, Bavari, Sina, O'Hagan, Derek T, Cooke, Michael P, Valiante, Nicholas M
Published in Science translational medicine (19.11.2014)
Published in Science translational medicine (19.11.2014)
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Synthetic Small Molecules That Control Stem Cell Fate
Ding, Sheng, Tom Y. H. Wu, Brinker, Achim, Peters, Eric C., Hur, Wooyoung, Gray, Nathanael S., Schultz, Peter G.
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (24.06.2003)
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Liver‐Targeted Toll‐Like Receptor 7 Agonist Combined With Entecavir Promotes a Functional Cure in the Woodchuck Model of Hepatitis B Virus
Korolowizc, Kyle E., Li, Bin, Huang, Xu, Yon, Changsuek, Rodrigo, Evelyn, Corpuz, Manny, Plouffe, David M., Kallakury, Bhaskar V., Suresh, Manasa, Wu, Tom Y.‐H., Miller, Andrew T., Menne, Stephan
Published in Hepatology communications (01.10.2019)
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A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells
Santone, Melissa, Aprea, Susanna, Wu, Tom Y H, Cooke, Michael P, Mbow, M Lamine, Valiante, Nicholas M, Rush, James S, Dougan, Stephanie, Avalos, Ana, Ploegh, Hidde, De Gregorio, Ennio, Buonsanti, Cecilia, D'Oro, Ugo
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Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1
WU, Tom Y. H, JUTEAU, Hélène, BRIDEAU, Christine, DUCHARME, Yves, FRIESEN, Richard W, GUIRAL, Sébastien, DUFRESNE, Lynn, POIRIER, Hugo, SALEM, Myriam, RIENDEAU, Denis, MANCINI, Joseph
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Solid-Phase Synthesis of 2,3,5-Trisubstituted Indoles
Wu, Tom Y. H, Ding, Sheng, Gray, Nathanael S, Schultz, Peter G
Published in Organic letters (29.11.2001)
Published in Organic letters (29.11.2001)
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Pancreas-Specific Delivery of [beta]-Cell Proliferating Small Molecules
Hao, Xueshi, Jin, Qihui, Va, Porino, Li, Chun, Shen, Weijun, Laffitte, Bryan, Wu, Tom Y-H
Published in ChemMedChem (01.06.2016)
Published in ChemMedChem (01.06.2016)
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Biarylimidazoles as inhibitors of microsomal prostaglandin E 2 synthase-1
Wu, Tom Y.H., Juteau, Hélène, Ducharme, Yves, Friesen, Richard W., Guiral, Sébastien, Dufresne, Lynn, Poirier, Hugo, Salem, Myriam, Riendeau, Denis, Mancini, Joseph, Brideau, Christine
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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Topical SMIP-7.7, a Toll–Like Receptor 7 Agonist, Protects against Genital Herpes Simplex Virus Type-2 Disease in the Guinea Pig Model of Genital Herpes
Bernstein, David I, Cardin, Rhonda D, Bravo, Fernando J, Earwood, Julie, Clark, Jennifer R, Li, Yongkai, Mishra, Pranab, Li, Chun, Nayak, Bishnu P, Miller, Andrew T, Wu, Tom Y-H, Cooke, Michael P, Valiante, Nicholas M
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Published in Antiviral chemistry & chemotherapy (01.10.2014)
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