TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection
Chew, Glen M, Fujita, Tsuyoshi, Webb, Gabriela M, Burwitz, Benjamin J, Wu, Helen L, Reed, Jason S, Hammond, Katherine B, Clayton, Kiera L, Ishii, Naoto, Abdel-Mohsen, Mohamed, Liegler, Teri, Mitchell, Brooks I, Hecht, Frederick M, Ostrowski, Mario, Shikuma, Cecilia M, Hansen, Scott G, Maurer, Mark, Korman, Alan J, Deeks, Steven G, Sacha, Jonah B, Ndhlovu, Lishomwa C
Published in PLoS pathogens (01.01.2016)
Published in PLoS pathogens (01.01.2016)
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The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques
Webb, Gabriela M, Molden, Jhomary, Busman-Sahay, Kathleen, Abdulhaqq, Shaheed, Wu, Helen L, Weber, Whitney C, Bateman, Katherine B, Reed, Jason S, Northrup, Mina, Maier, Nicholas, Tanaka, Shiho, Gao, Lina, Davey, Brianna, Carpenter, Benjamin L, Axthelm, Michael K, Stanton, Jeffrey J, Smedley, Jeremy, Greene, Justin M, Safrit, Jeffrey T, Estes, Jacob D, Skinner, Pamela J, Sacha, Jonah B
Published in PLoS pathogens (12.03.2020)
Published in PLoS pathogens (12.03.2020)
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CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab
Chang, Xiao L, Wu, Helen L, Webb, Gabriela M, Tiwary, Meenakshi, Hughes, Colette, Reed, Jason S, Hwang, Joseph, Waytashek, Courtney, Boyle, Carla, Pessoa, Cleiton, Sylwester, Andrew W, Morrow, David, Belica, Karina, Fischer, Miranda, Kelly, Scott, Pourhassan, Nader, Bochart, Rachele M, Smedley, Jeremy, Recknor, Christopher P, Hansen, Scott G, Sacha, Jonah B
Published in Frontiers in immunology (19.11.2021)
Published in Frontiers in immunology (19.11.2021)
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Disruption of CCR5 signaling to treat COVID-19-associated cytokine storm: Case series of four critically ill patients treated with leronlimab
Agresti, Nicholas, Lalezari, Jacob P., Amodeo, Phillip P., Mody, Kabir, Mosher, Steven F., Seethamraju, Harish, Kelly, Scott A., Pourhassan, Nader Z., Sudduth, C. David, Bovinet, Christopher, ElSharkawi, Ahmed E., Patterson, Bruce K., Stephen, Reejis, Sacha, Jonah B., Wu, Helen L., Gross, Seth A., Dhody, Kush
Published in Journal of translational autoimmunity (Online) (01.01.2021)
Published in Journal of translational autoimmunity (Online) (01.01.2021)
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Tertiary Mutations Stabilize CD8+ T Lymphocyte Escape-Associated Compensatory Mutations following Transmission of Simian Immunodeficiency Virus
Burwitz, Benjamin J, Wu, Helen L, Reed, Jason S, Hammond, Katherine B, Newman, Laura P, Bimber, Benjamin N, Nimiyongskul, Francesca A, Leon, Enrique J, Maness, Nicholas J, Friedrich, Thomas C, Yokoyama, Masaru, Sato, Hironori, Matano, Tetsuro, O'Connor, David H, Sacha, Jonah B
Published in Journal of Virology (01.03.2014)
Published in Journal of Virology (01.03.2014)
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Journal Article
Broadly targeted CD8⁺ T cell responses restricted by major histocompatibility complex E
Hansen, Scott G., Wu, Helen L., Burwitz, Benjamin J., Hughes, Colette M., Hammond, Katherine B., Ventura, Abigail B., Reed, Jason S., Gilbride, Roxanne M., Ainslie, Emily, Morrow, David W., Ford, Julia C., Selseth, Andrea N., Pathak, Reesab, Malouli, Daniel, Legasse, Alfred W., Axthelm, Michael K., Nelson, Jay A., Gillespie, Geraldine M., Walters, Lucy C., Brackenridge, Simon, Sharpe, Hannah R., López, César A., Früh, Klaus, Korber, Bette T., McMichael, Andrew J., Gnanakaran, S., Sacha, Jonah B., Picker, Louis J.
Published in Science (American Association for the Advancement of Science) (12.02.2016)
Published in Science (American Association for the Advancement of Science) (12.02.2016)
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CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14
Patterson, Bruce K., Seethamraju, Harish, Dhody, Kush, Corley, Michael J., Kazempour, Kazem, Lalezari, Jay, Pang, Alina P.S., Sugai, Christopher, Mahyari, Eisa, Francisco, Edgar B., Pise, Amruta, Rodrigues, Hallison, Wu, Helen L., Webb, Gabriela M., Park, Byung S., Kelly, Scott, Pourhassan, Nader, Lelic, Alina, Kdouh, Lama, Herrera, Monica, Hall, Eric, Bimber, Benjamin N., Plassmeyer, Matthew, Gupta, Raavi, Alpan, Oral, O’Halloran, Jane A., Mudd, Philip A., Akalin, Enver, Ndhlovu, Lishomwa C., Sacha, Jonah B.
Published in International journal of infectious diseases (01.02.2021)
Published in International journal of infectious diseases (01.02.2021)
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Journal Article
Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques
Wu, Helen L., Busman-Sahay, Kathleen, Weber, Whitney C., Waytashek, Courtney M., Boyle, Carla D., Bateman, Katherine B., Reed, Jason S., Hwang, Joseph M., Shriver-Munsch, Christine, Swanson, Tonya, Northrup, Mina, Armantrout, Kimberly, Price, Heidi, Robertson-LeVay, Mitch, Uttke, Samantha, Kumar, Mithra R., Fray, Emily J., Taylor-Brill, Sol, Bondoc, Stephen, Agnor, Rebecca, Junell, Stephanie L., Legasse, Alfred W., Moats, Cassandra, Bochart, Rachele M., Sciurba, Joseph, Bimber, Benjamin N., Sullivan, Michelle N., Dozier, Brandy, MacAllister, Rhonda P., Hobbs, Theodore R., Martin, Lauren D., Panoskaltsis-Mortari, Angela, Colgin, Lois M.A., Siliciano, Robert F., Siliciano, Janet D., Estes, Jacob D., Smedley, Jeremy V., Axthelm, Michael K., Meyers, Gabrielle, Maziarz, Richard T., Burwitz, Benjamin J., Stanton, Jeffrey J., Sacha, Jonah B.
Published in Immunity (Cambridge, Mass.) (11.07.2023)
Published in Immunity (Cambridge, Mass.) (11.07.2023)
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Journal Article
Pandemic 1918 Influenza Virus Does Not Cause Lethal Infection in Rhesus or Cynomolgus Macaques
Chan, Mable, Tiwary, Meenakshi, Wu, Helen L., Tailor, Nikesh, Vendramelli, Robert, Audet, Jonathan, Warner, Bryce M., Tierney, Kevin, Albietz, Alix, Truong, Thang, Doan, Kaylie, Bello, Alexander, Willman, Marnie, Griffin, Bryan D., Hanley, Patrick W., Lovaglio, Jamie, Safronetz, David, Strong, Jim, Sacha, Jonah B., Kobasa, Darwyn
Published in Journal of virology (24.08.2022)
Published in Journal of virology (24.08.2022)
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Journal Article
MHC-E-Restricted CD8 + T Cells Target Hepatitis B Virus-Infected Human Hepatocytes
Burwitz, Benjamin J, Hashiguchi, Patrick K, Mansouri, Mandana, Meyer, Christine, Gilbride, Roxanne M, Biswas, Sreya, Womack, Jennie L, Reed, Jason S, Wu, Helen L, Axthelm, Michael K, Hansen, Scott G, Picker, Louis J, Früh, Klaus, Sacha, Jonah B
Published in The Journal of immunology (1950) (15.04.2020)
Published in The Journal of immunology (1950) (15.04.2020)
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The Role of MHC-E in T Cell Immunity Is Conserved among Humans, Rhesus Macaques, and Cynomolgus Macaques
Wu, Helen L, Wiseman, Roger W, Hughes, Colette M, Webb, Gabriela M, Abdulhaqq, Shaheed A, Bimber, Benjamin N, Hammond, Katherine B, Reed, Jason S, Gao, Lina, Burwitz, Benjamin J, Greene, Justin M, Ferrer, Fidel, Legasse, Alfred W, Axthelm, Michael K, Park, Byung S, Brackenridge, Simon, Maness, Nicholas J, McMichael, Andrew J, Picker, Louis J, O'Connor, David H, Hansen, Scott G, Sacha, Jonah B
Published in The Journal of immunology (1950) (01.01.2018)
Published in The Journal of immunology (1950) (01.01.2018)
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Journal Article
Cytomegalovirus-vaccine-induced unconventional T cell priming and control of SIV replication is conserved between primate species
Malouli, Daniel, Gilbride, Roxanne M, Wu, Helen L, Hwang, Joseph M, Maier, Nicholas, Hughes, Colette M, Newhouse, Daniel, Morrow, David, Ventura, Abigail B, Law, Lynn, Tisoncik-Go, Jennifer, Whitmore, Leanne, Smith, Elise, Golez, Inah, Chang, Jean, Reed, Jason S, Waytashek, Courtney, Weber, Whitney, Taher, Husam, Uebelhoer, Luke S, Womack, Jennie L, McArdle, Matthew R, Gao, Junwei, Papen, Courtney R, Lifson, Jeffrey D, Burwitz, Benjamin J, Axthelm, Michael K, Smedley, Jeremy, Früh, Klaus, Gale, Jr, Michael, Picker, Louis J, Hansen, Scott G, Sacha, Jonah B
Published in Cell host & microbe (14.09.2022)
Published in Cell host & microbe (14.09.2022)
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Journal Article
Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission
Chang, Xiao L, Webb, Gabriela M, Wu, Helen L, Greene, Justin M, Abdulhaqq, Shaheed, Bateman, Katherine B, Reed, Jason S, Pessoa, Cleiton, Weber, Whitney C, Maier, Nicholas, Chew, Glen M, Gilbride, Roxanne M, Gao, Lina, Agnor, Rebecca, Giobbi, Travis, Torgerson, Jeffrey, Siess, Don, Burnett, Nicole, Fischer, Miranda, Shiel, Oriene, Moats, Cassandra, Patterson, Bruce, Dhody, Kush, Kelly, Scott, Pourhassan, Nader, Magnani, Diogo M, Smedley, Jeremy, Bimber, Benjamin N, Haigwood, Nancy L, Hansen, Scott G, Brown, Timothy R, Ndhlovu, Lishomwa C, Sacha, Jonah B
Published in Nature communications (07.06.2021)
Published in Nature communications (07.06.2021)
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Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques
Burwitz, Benjamin J, Wettengel, Jochen M, Mück-Häusl, Martin A, Ringelhan, Marc, Ko, Chunkyu, Festag, Marvin M, Hammond, Katherine B, Northrup, Mina, Bimber, Benjamin N, Jacob, Thomas, Reed, Jason S, Norris, Reed, Park, Byung, Moller-Tank, Sven, Esser, Knud, Greene, Justin M, Wu, Helen L, Abdulhaqq, Shaheed, Webb, Gabriela, Sutton, William F, Klug, Alex, Swanson, Tonya, Legasse, Alfred W, Vu, Tania Q, Asokan, Aravind, Haigwood, Nancy L, Protzer, Ulrike, Sacha, Jonah B
Published in Nature communications (15.12.2017)
Published in Nature communications (15.12.2017)
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Journal Article
OP 2.1 CCR5 in HIV Prevention and Cure
Wu, Helen L., Webb, Gabriela M., Sacha, Jonah B.
Published in Journal of Virus Eradication (01.12.2022)
Published in Journal of Virus Eradication (01.12.2022)
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Identification and Characterization of Antigen-Specific CD8 + T Cells Using Surface-Trapped TNF-α and Single-Cell Sequencing
Abdulhaqq, Shaheed, Ventura, Abigail B, Reed, Jason S, Bashirova, Arman A, Bateman, Katherine B, McDonald, Eric, Wu, Helen L, Greene, Justin M, Schell, John B, Morrow, David, Wisskirchen, Karin, Martin, Jeffrey N, Deeks, Steven G, Carrington, Mary, Protzer, Ulrike, Früh, Klaus, Hansen, Scott G, Picker, Louis J, Sacha, Jonah B, Bimber, Benjamin N
Published in The Journal of immunology (1950) (15.12.2021)
Published in The Journal of immunology (1950) (15.12.2021)
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Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes
Burwitz, Benjamin J, Wu, Helen L, Abdulhaqq, Shaheed, Shriver-Munsch, Christine, Swanson, Tonya, Legasse, Alfred W, Hammond, Katherine B, Junell, Stephanie L, Reed, Jason S, Bimber, Benjamin N, Greene, Justin M, Webb, Gabriela M, Northrup, Mina, Laub, Wolfram, Kievit, Paul, MacAllister, Rhonda, Axthelm, Michael K, Ducore, Rebecca, Lewis, Anne, Colgin, Lois M A, Hobbs, Theodore, Martin, Lauren D, Ferguson, Betsy, Thomas, Jr, Charles R, Panoskaltsis-Mortari, Angela, Meyers, Gabrielle, Stanton, Jeffrey J, Maziarz, Richard T, Sacha, Jonah B
Published in Nature communications (10.11.2017)
Published in Nature communications (10.11.2017)
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Terumo spectra optia leukapheresis of cynomolgus macaques for hematopoietic stem cell and T cell collection
Wu, Helen L., Greene, Justin M., Swanson, Tonya, Shriver‐Munsch, Christine, Armantrout, Kimberly, Weber, Whitney C., Bateman, Katherine B., Maier, Nicholas M., Northrup, Mina, Legasse, Alfred W., Moats, Cassandra, Axthelm, Michael K., Smedley, Jeremy, Maziarz, Richard T., Martin, Lauren Drew, Hobbs, Theodore, Burwitz, Benjamin J., Sacha, Jonah B.
Published in Journal of clinical apheresis (01.02.2021)
Published in Journal of clinical apheresis (01.02.2021)
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Journal Article
Viral opportunistic infections in Mauritian cynomolgus macaques undergoing allogeneic stem cell transplantation mirror human transplant infectious disease complications
Wu, Helen L., Weber, Whitney C., Shriver‐Munsch, Christine, Swanson, Tonya, Northrup, Mina, Price, Heidi, Armantrout, Kimberly, Robertson‐LeVay, Mitchell, Reed, Jason S., Bateman, Katherine B., Mahyari, Eisa, Thomas, Archana, Junell, Stephanie L., Hobbs, Theodore R., Martin, Lauren D., MacAllister, Rhonda, Bimber, Benjamin N., Slifka, Mark K., Legasse, Alfred W., Moats, Cassandra, Axthelm, Michael K., Smedley, Jeremy, Lewis, Anne D., Colgin, Lois, Meyers, Gabrielle, Maziarz, Richard T., Burwitz, Benjamin J., Stanton, Jeffrey J., Sacha, Jonah B.
Published in Xenotransplantation (Københaven) (01.07.2020)
Published in Xenotransplantation (Københaven) (01.07.2020)
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Identification and spontaneous immune targeting of an endogenous retrovirus K envelope protein in the Indian rhesus macaque model of human disease
Wu, Helen L, Léon, Enrique J, Wallace, Lyle T, Nimiyongskul, Francesca A, Buechler, Matthew B, Newman, Laura P, Castrovinci, Philip A, Paul Johnson, R, Gifford, Robert J, Brad Jones, R, Sacha, Jonah B
Published in Retrovirology (15.01.2016)
Published in Retrovirology (15.01.2016)
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