A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma
Hall, Peter E, Lewis, Rachel, Syed, Nelofer, Shaffer, Richard, Evanson, Jane, Ellis, Stephen, Williams, Matthew, Feng, Xiaoxing, Johnston, Amanda, Thomson, Jim A, Harris, Fiona P, Jena, Raj, Matys, Tomasz, Jefferies, Sarah, Smith, Kate, Wu, Bor-Wen, Bomalaski, John S, Crook, Timothy, O'Neill, Kevin, Paraskevopoulos, Dimitris, Khadeir, Ramsay S, Sheaff, Michael, Pacey, Simon, Plowman, Piers N, Szlosarek, Peter W
Published in Clinical cancer research (01.05.2019)
Published in Clinical cancer research (01.05.2019)
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Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging
ALLEN, Michael D, PHUONG LUONG, LATTANZIO, Laura, CHMIELEWSKA-KASSASSIR, Malgorzata, TOMLINSON, Ian, ROYLANCE, Rebecca, WHITAKER, Hayley C, WARREN, Anne Y, NEAL, David, FREZZA, Christian, BELTRAN, Luis, JONES, Louise J, HUDSON, Chantelle, CHELALA, Claude, WU, Bor-Wen, BOMALASKI, John S, JACKSON, Robert C, LU, Yong-Jie, CROOK, Tim, LEMOINE, Nicholas R, MATHER, Stephen, FOSTER, Julie, SOSABOWSKI, Jane, LEYTON, Julius, AVRIL, Norbert, LI, Chien-Feng, SZLOSAREK, Peter W, DELAGE, Barbara, GHAZALY, Essam, CUTTS, Rosalind, MING YUAN, SYED, Nelofer, LO NIGRO, Cristiana
Published in Cancer research (Chicago, Ill.) (01.02.2014)
Published in Cancer research (Chicago, Ill.) (01.02.2014)
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Phase 1b study of pegylated arginine deiminase (ADI-PEG 20) plus Pembrolizumab in advanced solid cancers
Chang, Kwang-Yu, Chiang, Nai-Jung, Wu, Shang-Yin, Yen, Chia-Jui, Chen, Shang-Hung, Yeh, Yu-Min, Li, Chien-Feng, Feng, Xiaoxing, Wu, Katherine, Johnston, Amanda, Bomalaski, John S., Wu, Bor-Wen, Gao, Jianjun, Subudhi, Sumit K., Kaseb, Ahmed O., Blando, Jorge M., Yadav, Shalini S., Szlosarek, Peter W., Chen, Li-Tzong
Published in Oncoimmunology (01.01.2021)
Published in Oncoimmunology (01.01.2021)
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Phase 1 Dose-Escalation Study of Pegylated Arginine Deiminase, Cisplatin, and Pemetrexed in Patients With Argininosuccinate Synthetase 1-Deficient Thoracic Cancers
Beddowes, Emma, Spicer, James, Chan, Pui Ying, Khadeir, Ramsay, Corbacho, Javier Garcia, Repana, Dimitra, Steele, Jeremy P, Schmid, Peter, Szyszko, Teresa, Cook, Gary, Diaz, Monica, Feng, Xiaoxing, Johnston, Amanda, Thomson, Jim, Sheaff, Michael, Wu, Bor-Wen, Bomalaski, John, Pacey, Simon, Szlosarek, Peter W
Published in Journal of clinical oncology (01.06.2017)
Published in Journal of clinical oncology (01.06.2017)
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Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial
Szlosarek, Peter W, Steele, Jeremy P, Nolan, Luke, Gilligan, David, Taylor, Paul, Spicer, James, Lind, Michael, Mitra, Sankhasuvra, Shamash, Jonathan, Phillips, Melissa M, Luong, Phuong, Payne, Sarah, Hillman, Paul, Ellis, Stephen, Szyszko, Teresa, Dancey, Gairin, Butcher, Lee, Beck, Stephan, Avril, Norbert E, Thomson, Jim, Johnston, Amanda, Tomsa, Marianne, Lawrence, Cheryl, Schmid, Peter, Crook, Timothy, Wu, Bor-Wen, Bomalaski, John S, Lemoine, Nicholas, Sheaff, Michael T, Rudd, Robin M, Fennell, Dean, Hackshaw, Allan
Published in JAMA oncology (01.01.2017)
Published in JAMA oncology (01.01.2017)
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Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma
Ott, Patrick A., Carvajal, Richard D., Pandit-Taskar, Neeta, Jungbluth, Achim A., Hoffman, Eric W., Wu, Bor-Wen, Bomalaski, John S., Venhaus, Ralph, Pan, Linda, Old, Lloyd J., Pavlick, Anna C., Wolchok, Jedd D.
Published in Investigational new drugs (01.04.2013)
Published in Investigational new drugs (01.04.2013)
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Structure-Based Design and Synthesis of Substituted 2-Butanols as Nonpeptidic Inhibitors of HIV Protease: Secondary Amide Series
Reich, Siegfried H, Melnick, Michael, Pino, Mark J, Fuhry, Mary Ann M, Trippe, Anthony J, Appelt, Krzysztof, Davies, Jay F, Wu, Bor-Wen, Musick, Linda
Published in Journal of medicinal chemistry (05.07.1996)
Published in Journal of medicinal chemistry (05.07.1996)
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Bis Tertiary Amide Inhibitors of the HIV-1 Protease Generated via Protein Structure-Based Iterative Design
Melnick, Michael, Reich, Siegfried H, Lewis, Kathy K, Mitchell, Lennert J, Nguyen, Dzuy, Trippe, Anthony J, Dawson, Heather, Davies, Jay F, Appelt, Krzysztof, Wu, Bor-Wen, Musick, Linda, Gehlhaar, Dan K, Webber, Stephanie, Shetty, Bhasker, Kosa, Maha, Kahil, Deborah, Andrada, Dominic
Published in Journal of medicinal chemistry (05.07.1996)
Published in Journal of medicinal chemistry (05.07.1996)
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Crystal-Structure-Based Design and Synthesis of Novel C-Terminal Inhibitors of HIV Protease
Varney, Michael D, Appelt, Krzysztof, Kalish, Vince, Reddy, M. Rami, Tatlock, John, Palmer, Cindy L, Romines, William H, Wu, Bor-Wen, Musick, Linda
Published in Journal of medicinal chemistry (01.07.1994)
Published in Journal of medicinal chemistry (01.07.1994)
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A phase II study of ADI-PEG 20 in combination with gemcitabine and docetaxel for the treatment of soft tissue sarcoma
Van Tine, Brian Andrew, Bui, Nam, Prudner, Bethany, Bomalaski, John S., Wu, Bor-Wen, Chawla, Sant P., Ganjoo, Kristen N., Oppelt, Peter John, Hirbe, Angela C.
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Phase 1 study of pegargiminase combined with cisplatin and pemetrexed in patients with ASS1-deficient uveal melanoma
Chan, Pui Ying, Phillips, Melissa Mary, Khadeir, Ramsay, Ellis, Stephen, Thomson, Jim, Johnston, Amanda, Feng, Xiaoxing, Wu, Bor-Wen, Bomalaski, John S., Sheaff, Michael, Szlosarek, Peter Wojciech
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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A phase Ib study of ADI-PEG 20 plus pembrolizumab in advanced solid cancers
Chang, Kwang-Yu, Chiang, Nai-Jung, Yen, Chia-Jui, Wu, Shang-Yin, Chen, Shang-Hung, Johnston, Amanda, Bomalaski, John S., Wu, Bor-Wen, Chen, Li-Tzong
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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Abstract B33: Expansion study of pegylated arginine deiminase (ADI-PEG20), pemetrexed, and cisplatin in patients with ASS1-deficient non-squamous non-small cell lung cancer (TRAP)
Phillips, Melissa, Szyszko, Teresa, Hall, Peter, Rashid, Sukaina, Khadeir, Ramsay, Lim, Louise, Steele, Jeremy, Conibear, John, Wells, Paula, Ellis, Stephen, Feng, Xiaoxing, Thomson, Jim, Johnston, Amanda, Wu, Bor-Wen, Bomalaski, John, Pacey, Simon, Cook, Gary, Szlosarek, Peter
Published in Clinical cancer research (01.09.2018)
Published in Clinical cancer research (01.09.2018)
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Protein Structure-Based Design of Potent Orally Bioavailable, Nonpeptide Inhibitors of Human Immunodeficiency Virus Protease
Reich, Siegfried H., Melnick, Michael, Davies, Jay F., Appelt, Kryzysztof, Lewis, Kathy K., Fuhry, Mary Ann, Pino, Mark, Trippe, Anthony J., Nguyen, Dzuy, Dawson, Heather, Wu, Bor-Wen, Musick, Linda, Kosa, Maha, Kahil, Deborah, Webber, Stephanie, Gehlhaar, Dan K., Andrada, Dominic, Shetty, Bhasker
Published in Proceedings of the National Academy of Sciences - PNAS (11.04.1995)
Published in Proceedings of the National Academy of Sciences - PNAS (11.04.1995)
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A phase I expansion study of pegargiminase, cisplatin, and pemetrexed in argininosuccinate synthetase 1-negative recurrent high grade gliomas (HGGs)
Hall, Peter Edward, Lewis, Rachel, Syed, Nelofer, Shaffer, Richard, Evanson, Jane, Ellis, Stephen, Williams, Matthew, Feng, Xiaoxing, Johnston, Amanda, Thomson, Jim, Harris, Fiona, Jena, Raj, Khadeir, Ramsay, Wu, Bor-Wen, Bomalaski, John S., Crook, Timothy, Sheaff, Michael, Pacey, Simon, Plowman, Nick, Szlosarek, Peter Wojciech
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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Structure-based drug design of nonpeptidic P2 substituents for HIV-1 protease inhibitors
Kalish, Vincent J., Tatlock, John H., Davies, Jay F., Kaldor, Stephen W., Dressman, Bruce A., Reich, Siegfried, Pino, Mark, Nyugen, Dzuy, Appelt, Krzysztof, Musick, Linda, Wu, Bor-wen
Published in Bioorganic & medicinal chemistry letters (06.04.1995)
Published in Bioorganic & medicinal chemistry letters (06.04.1995)
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18-FLT-PET/CT as an imaging biomarker in patients with ASS1-deficient thoracic cancers treated with ADI-PEG20, pemetrexed and cisplatin
Szlosarek, Peter Wojciech, Szyszko, Teresa, Pacey, Simon, Spicer, James F., Phillips, Melissa, Steele, Jeremy P. C., Barba, Adalberto, Diaz, Monica, Johnston, Amanda, Wu, Bor-Wen, Bomalaski, John S., Cook, Gary J. R.
Published in Journal of clinical oncology (20.05.2016)
Published in Journal of clinical oncology (20.05.2016)
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A PHASE I EXPANSION STUDY OF PEGARGIMINASE, CISPLATIN AND PEMETREXED IN ARGININOSUCCINATE SYNTHETASE 1-NEGATIVE RECURRENT HIGH GRADE GLIOMAS (HGGS)
Hall, Peter, Lewis, Rachel, Syed, Nelofer, Shaffer, Richard, Evanson, Jane, Ellis, Stephen, Williams, Matthew, Feng, Xiaoxing, Johnston, Amanda, Thomson, Jim, Harris, Fiona, Jena, Raj, Jefferies, Sarah, Khadeir, Ramsay, Wu, Bor-Wen, Bomalaski, John, Crook, Timothy, Sheaff, Michael, Pacey, Simon, Plowman, Nick, Szlosarek, Peter
Published in Neuro-oncology (Charlottesville, Va.) (03.10.2018)
Published in Neuro-oncology (Charlottesville, Va.) (03.10.2018)
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