Roscovitine and purvalanol A effectively reverse anthracycline resistance mediated by the activity of aldo-keto reductase 1C3 (AKR1C3): A promising therapeutic target for cancer treatment
Novotná, Eva, Büküm, Neslihan, Hofman, Jakub, Flaxová, Michaela, Kouklíková, Etela, Louvarová, Dagmar, Wsól, Vladimír
Published in Biochemical pharmacology (01.10.2018)
Published in Biochemical pharmacology (01.10.2018)
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Isocitrate dehydrogenase 2 inhibitor enasidenib synergizes daunorubicin cytotoxicity by targeting aldo-keto reductase 1C3 and ATP-binding cassette transporters
Morell, Anselm, Budagaga, Youssif, Vagiannis, Dimitrios, Zhang, Yu, Laštovičková, Lenka, Novotná, Eva, Haddad, Andrew, Haddad, Melodie, Portillo, Ramon, Hofman, Jakub, Wsól, Vladimír
Published in Archives of toxicology (01.12.2022)
Published in Archives of toxicology (01.12.2022)
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Interactions of antileukemic drugs with daunorubicin reductases: could reductases affect the clinical efficacy of daunorubicin chemoregimens?
Novotná, Eva, Morell, Anselm, Büküm, Neslihan, Hofman, Jakub, Danielisová, Petra, Wsól, Vladimír
Published in Archives of toxicology (01.09.2020)
Published in Archives of toxicology (01.09.2020)
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In vitro metabolism of fenofibric acid by carbonyl reducing enzymes
Malátková, Petra, Kanavi, Matthildi, Nobilis, Milan, Wsól, Vladimír
Published in Chemico-biological interactions (25.10.2016)
Published in Chemico-biological interactions (25.10.2016)
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Bruton’s Tyrosine Kinase Inhibitor Zanubrutinib Effectively Modulates Cancer Resistance by Inhibiting Anthracycline Metabolism and Efflux
Čermáková, Lucie, Hofman, Jakub, Laštovičková, Lenka, Havlíčková, Lucie, Špringrová, Ivona, Novotná, Eva, Wsól, Vladimír
Published in Pharmaceutics (21.09.2022)
Published in Pharmaceutics (21.09.2022)
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The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man
Malátková, Petra, Havlíková, Lucie, Wsól, Vladimír
Published in Chemico-biological interactions (05.09.2014)
Published in Chemico-biological interactions (05.09.2014)
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Bruton's Tyrosine Kinase Inhibitors Ibrutinib and Acalabrutinib Counteract Anthracycline Resistance in Cancer Cells Expressing AKR1C3
Morell, Anselm, Čermáková, Lucie, Novotná, Eva, Laštovičková, Lenka, Haddad, Melodie, Haddad, Andrew, Portillo, Ramon, Wsól, Vladimír
Published in Cancers (11.12.2020)
Published in Cancers (11.12.2020)
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Inhibition of AKR1B10-mediated metabolism of daunorubicin as a novel off-target effect for the Bcr-Abl tyrosine kinase inhibitor dasatinib
Büküm, Neslihan, Novotná, Eva, Morell, Anselm, Želazková, Jana, Laštovičková, Lenka, Čermáková, Lucie, Portillo, Ramon, Solich, Petr, Wsól, Vladimír
Published in Biochemical pharmacology (01.10.2021)
Published in Biochemical pharmacology (01.10.2021)
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Olaparib Synergizes the Anticancer Activity of Daunorubicin via Interaction with AKR1C3
Tavares, Tássia S., Hofman, Jakub, Lekešová, Alžběta, Želazková, Jana, Wsól, Vladimír
Published in Cancers (01.11.2020)
Published in Cancers (01.11.2020)
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