The Discovery of 7‑Methyl-2-[(7-methyl[1,2,4]triazolo[1,5‑a]pyridin-6-yl)amino]-9-(tetrahydro‑2H‑pyran-4-yl)-7,9-dihydro‑8H‑purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor
Goldberg, Frederick W, Finlay, M. Raymond V, Ting, Attilla K. T, Beattie, David, Lamont, Gillian M, Fallan, Charlene, Wrigley, Gail L, Schimpl, Marianne, Howard, Martin R, Williamson, Beth, Vazquez-Chantada, Mercedes, Barratt, Derek G, Davies, Barry R, Cadogan, Elaine B, Ramos-Montoya, Antonio, Dean, Emma
Published in Journal of medicinal chemistry (09.04.2020)
Published in Journal of medicinal chemistry (09.04.2020)
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Photocatalytic Hydroaminoalkylation of Styrenes with Unprotected Primary Alkylamines
Askey, Hannah E., Grayson, James D., Tibbetts, Joshua D., Turner-Dore, Jacob C., Holmes, Jake M., Kociok-Kohn, Gabriele, Wrigley, Gail L., Cresswell, Alexander J.
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Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor
Finlay, M. Raymond V, Anderton, Mark, Ashton, Susan, Ballard, Peter, Bethel, Paul A, Box, Matthew R, Bradbury, Robert H, Brown, Simon J, Butterworth, Sam, Campbell, Andrew, Chorley, Christopher, Colclough, Nicola, Cross, Darren A. E, Currie, Gordon S, Grist, Matthew, Hassall, Lorraine, Hill, George B, James, Daniel, James, Michael, Kemmitt, Paul, Klinowska, Teresa, Lamont, Gillian, Lamont, Scott G, Martin, Nathaniel, McFarland, Heather L, Mellor, Martine J, Orme, Jonathon P, Perkins, David, Perkins, Paula, Richmond, Graham, Smith, Peter, Ward, Richard A, Waring, Michael J, Whittaker, David, Wells, Stuart, Wrigley, Gail L
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Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs
Colclough, Nicola, Chen, Kan, Johnström, Peter, Strittmatter, Nicole, Yan, Yumei, Wrigley, Gail L, Schou, Magnus, Goodwin, Richard, Varnäs, Katarina, Adua, Sally J, Zhao, Minghui, Nguyen, Don X, Maglennon, Gareth, Barton, Peter, Atkinson, James, Zhang, Lin, Janefeldt, Annika, Wilson, Joanne, Smith, Aaron, Takano, Akihiro, Arakawa, Ryosuke, Kondrashov, Mikhail, Malmquist, Jonas, Revunov, Evgeny, Vazquez-Romero, Ana, Moein, Mohammad Mahdi, Windhorst, Albert D, Karp, Natasha A, Finlay, M Raymond V, Ward, Richard A, Yates, James W T, Smith, Paul D, Farde, Lars, Cheng, Zack, Cross, Darren A E
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The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5- a ]pyridin-6-yl)amino]-9-(tetrahydro-2 H -pyran-4-yl)-7,9-dihydro-8 H -purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor
Goldberg, Frederick W, Finlay, M Raymond V, Ting, Attilla K T, Beattie, David, Lamont, Gillian M, Fallan, Charlene, Wrigley, Gail L, Schimpl, Marianne, Howard, Martin R, Williamson, Beth, Vazquez-Chantada, Mercedes, Barratt, Derek G, Davies, Barry R, Cadogan, Elaine B, Ramos-Montoya, Antonio, Dean, Emma
Published in Journal of medicinal chemistry (09.04.2020)
Published in Journal of medicinal chemistry (09.04.2020)
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Design and Synthesis of 56 Shape‐Diverse 3D Fragments
Downes, Thomas D., Jones, S. Paul, Klein, Hanna F., Wheldon, Mary C., Atobe, Masakazu, Bond, Paul S., Firth, James D., Chan, Ngai S., Waddelove, Laura, Hubbard, Roderick E., Blakemore, David C., De Fusco, Claudia, Roughley, Stephen D., Vidler, Lewis R., Whatton, Maria Ann, Woolford, Alison J.‐A., Wrigley, Gail L., O'Brien, Peter
Published in Chemistry : a European journal (22.07.2020)
Published in Chemistry : a European journal (22.07.2020)
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Quinn, Taylor R., Giblin, Kathryn A., Thomson, Clare, Boerth, Jeffrey A., Bommakanti, Gayathri, Braybrooke, Erin, Chan, Christina, Chinn, Alex J., Code, Erin, Cui, Caifeng, Fan, Yukai, Grimster, Neil P., Kohara, Keishi, Lamb, Michelle L., Ma, Lina, Mfuh, Adelphe M., Robb, Graeme R., Robbins, Kevin J., Schimpl, Marianne, Tang, Haoran, Ware, Jamie, Wrigley, Gail L., Xue, Lin, Zhang, Yun, Zhu, Huimin, Hughes, Samantha J.
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Mfuh, Adelphe M., Boerth, Jeffrey A., Bommakanti, Gayathri, Chan, Christina, Chinn, Alex J., Code, Erin, Fricke, Patrick J., Giblin, Kathryn A., Gohlke, Andrea, Hansel, Catherine, Hariparsad, Niresh, Hughes, Samantha J., Jin, Meizhong, Kantae, Vasudev, Kavanagh, Stefan L., Lamb, Michelle L., Lane, Jordan, Moore, Rachel, Puri, Taranee, Quinn, Taylor R., Reddy, Iswarya, Robb, Graeme R., Robbins, Kevin J., Gancedo Rodrigo, Miguel, Schimpl, Marianne, Singh, Baljinder, Singh, Meha, Tang, Haoran, Thomson, Clare, Walsh, Jarrod J., Ware, Jamie, Watson, Iain D. G., Ye, Min-Wei, Wrigley, Gail L., Zhang, Andrew X., Zhang, Yun, Grimster, Neil P.
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Correction to “Discovery of a Thiadiazole–Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models”
Finlay, M. Raymond V., Anderton, Mark, Bailey, Andrew, Boyd, Scott, Brookfield, Joanna, Cairnduff, Ceri, Charles, Mark, Cheasty, Anne, Critchlow, Susan E., Culshaw, Janet, Debreczeni, Judit, Ekwuru, Tennyson, Hollingsworth, Ian, Jones, Neil, Leroux, Fred, Littleson, Mairi, McCarron, Hollie, McKelvie, Jennifer, Mooney, Lorraine, Nissink, J. Willem M., Patel, Joe, Perkins, David, Powell, Steve, Quesada, Mar Jimenez, Raubo, Piotr, Sabin, Verity, Smith, James, Smith, Peter D., Stark, Andrew, Ting, Attilla, Wang, Peng, Wilson, Zena, Winter-Holt, Jon J., Wood, J. Matthew, Wrigley, Gail L., Yu, Guoqing, Zhang, Peng
Published in Journal of medicinal chemistry (13.07.2023)
Published in Journal of medicinal chemistry (13.07.2023)
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Journal Article
Discovery of a Thiadiazole–Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models
Finlay, M. Raymond V, Anderton, Mark, Bailey, Andrew, Boyd, Scott, Brookfield, Joanna, Cairnduff, Ceri, Charles, Mark, Cheasty, Anne, Critchlow, Susan E, Culshaw, Janet, Ekwuru, Tennyson, Hollingsworth, Ian, Jones, Neil, Leroux, Fred, Littleson, Mairi, McCarron, Hollie, McKelvie, Jennifer, Mooney, Lorraine, Nissink, J. Willem M, Perkins, David, Powell, Steve, Quesada, Mar Jimenez, Raubo, Piotr, Sabin, Verity, Smith, James, Smith, Peter D, Stark, Andrew, Ting, Attilla, Wang, Peng, Wilson, Zena, Winter-Holt, Jon J, Wood, J. Matthew, Wrigley, Gail L, Yu, Guoqing, Zhang, Peng
Published in Journal of medicinal chemistry (25.07.2019)
Published in Journal of medicinal chemistry (25.07.2019)
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Degorce, Sébastien L., Aagaard, Anna, Anjum, Rana, Cumming, Iain A., Diène, Coura R., Fallan, Charlene, Johnson, Tony, Leuchowius, Karl-Johan, Orton, Alexandra L., Pearson, Stuart, Robb, Graeme R., Rosen, Alan, Scarfe, Graeme B., Scott, James S., Smith, James M., Steward, Oliver R., Terstiege, Ina, Tucker, Michael J., Turner, Paul, Wilkinson, Stephen D., Wrigley, Gail L., Xue, Yafeng
Published in Bioorganic & medicinal chemistry (01.12.2020)
Published in Bioorganic & medicinal chemistry (01.12.2020)
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Boerth, Jeffrey A., Chinn, Alex J., Schimpl, Marianne, Bommakanti, Gayathri, Chan, Christina, Code, Erin L., Giblin, Kathryn A., Gohlke, Andrea, Hansel, Catherine S., Jin, Meizhong, Kavanagh, Stefan L., Lamb, Michelle L., Lane, Jordan S., Larner, Carrie J. B., Mfuh, Adelphe M., Moore, Rachel K., Puri, Taranee, Quinn, Taylor R., Ye, Minwei, Robbins, Kevin J., Gancedo-Rodrigo, Miguel, Tang, Haoran, Walsh, Jarrod, Ware, Jamie, Wrigley, Gail L., Reddy, Iswarya Karapa, Zhang, Yun, Grimster, Neil P.
Published in ACS medicinal chemistry letters (14.12.2023)
Published in ACS medicinal chemistry letters (14.12.2023)
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Jones, S. Paul, Firth, James D, Wheldon, Mary C, Atobe, Masakazu, Hubbard, Roderick E, Blakemore, David C, De Fusco, Claudia, Lucas, Simon C. C, Roughley, Stephen D, Vidler, Lewis R, Whatton, Maria Ann, Woolford, Alison J.-A, Wrigley, Gail L, O'Brien, Peter
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Published in MedChemComm (14.12.2022)
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Published in Tetrahedron letters (19.09.2012)
Published in Tetrahedron letters (19.09.2012)
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Published in Tetrahedron letters (11.12.2013)
Published in Tetrahedron letters (11.12.2013)
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ChemInform Abstract: A Novel Approach to Functionalized 5,7,8,9-Tetrahydropyrimido[4,5-b][1,4]diazepin-6-ones Using Intramolecular Palladium-Catalyzed Amidation
Carr, Greory R., Feron, James L., Johnson, Paul D., Roberts, Craig A., Rudge, David A., Simpson, Iain, Wrigley, Gail L.
Published in ChemInform (18.12.2012)
Published in ChemInform (18.12.2012)
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Design and Synthesis of 56 Shape Diverse 3-D Fragments
O'Brien, Peter, Downes, Thomas D, Jones, S Paul, Klein, Hanna F, Wheldon, Mary C, Atobe, Masakazu, Bond, Paul S, Firth, James D, Chan, Ngai S, Waddelove, Laura, Hubbard, Roderick E, Blakemore, David C, De Fusco, Claudia, Roughley, Stephen D, Vidler, Lewis R, Whatton, Maria Ann, Woolford, Alison J-A, Wrigley, Gail L
Published in Chemistry : a European journal (21.04.2020)
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Published in Chemistry : a European journal (21.04.2020)
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