Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches
Rose, Nathan R, Woon, Esther C. Y, Kingham, Guy L, King, Oliver N. F, Mecinović, Jasmin, Clifton, Ian J, Ng, Stanley S, Talib-Hardy, Jobina, Oppermann, Udo, McDonough, Michael A, Schofield, Christopher J
Published in Journal of medicinal chemistry (25.02.2010)
Published in Journal of medicinal chemistry (25.02.2010)
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Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets
Perry, Gemma S, Das, Mohua, Woon, Esther C. Y
Published in Journal of medicinal chemistry (09.12.2021)
Published in Journal of medicinal chemistry (09.12.2021)
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Dynamic Combinatorial Mass Spectrometry Leads to Inhibitors of a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase
Woon, Esther C. Y, Demetriades, Marina, Bagg, Eleanor A. L, Aik, WeiShen, Krylova, Svetlana M, Ma, Jerome H. Y, Chan, MunChiang, Walport, Louise J, Wegman, David W, Dack, Kevin N, McDonough, Michael A, Krylov, Sergey N, Schofield, Christopher J
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
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Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases
Woon, Esther C. Y., Tumber, Anthony, Kawamura, Akane, Hillringhaus, Lars, Ge, Wei, Rose, Nathan R., Ma, Jerome H. Y., Chan, Mun Chiang, Walport, Louise J., Che, Ka Hing, Ng, Stanley S., Marsden, Brian D., Oppermann, Udo, McDonough, Michael A., Schofield, Christopher J.
Published in Angewandte Chemie International Edition (13.02.2012)
Published in Angewandte Chemie International Edition (13.02.2012)
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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
Chowdhury, Rasheduzzaman, Yeoh, Kar Kheng, Tian, Ya-Min, Hillringhaus, Lars, Bagg, Eleanor A, Rose, Nathan R, Leung, Ivanhoe K H, Li, Xuan S, Woon, Esther C Y, Yang, Ming, McDonough, Michael A, King, Oliver N, Clifton, Ian J, Klose, Robert J, Claridge, Timothy D W, Ratcliffe, Peter J, Schofield, Christopher J, Kawamura, Akane
Published in EMBO reports (01.05.2011)
Published in EMBO reports (01.05.2011)
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Synthesis and Evaluation of 3-(Dihydroxyboryl)benzoic Acids as d,d-Carboxypeptidase R39 Inhibitors
Inglis, Steven R, Zervosen, Astrid, Woon, Esther C. Y, Gerards, Thomas, Teller, Nathalie, Fischer, Delphine S, Luxen, André, Schofield, Christopher J
Published in Journal of medicinal chemistry (08.10.2009)
Published in Journal of medicinal chemistry (08.10.2009)
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Multiprotein Dynamic Combinatorial Chemistry: A Strategy for the Simultaneous Discovery of Subfamily‐Selective Inhibitors for Nucleic Acid Demethylases FTO and ALKBH3
Das, Mohua, Yang, Tianming, Dong, Jinghua, Prasetya, Fransisca, Xie, Yiming, Wong, Kendra H. Q., Cheong, Adeline, Woon, Esther C. Y.
Published in Chemistry, an Asian journal (04.10.2018)
Published in Chemistry, an Asian journal (04.10.2018)
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Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases
Rose, Nathan R, Woon, Esther C. Y, Tumber, Anthony, Walport, Louise J, Chowdhury, Rasheduzzaman, Li, Xuan Shirley, King, Oliver N. F, Lejeune, Clarisse, Ng, Stanley S, Krojer, Tobias, Chan, Mun Chiang, Rydzik, Anna M, Hopkinson, Richard J, Che, Ka Hing, Daniel, Michelle, Strain-Damerell, Claire, Gileadi, Carina, Kochan, Grazyna, Leung, Ivanhoe K. H, Dunford, James, Yeoh, Kar Kheng, Ratcliffe, Peter J, Burgess-Brown, Nicola, von Delft, Frank, Muller, Susanne, Marsden, Brian, Brennan, Paul E, McDonough, Michael A, Oppermann, Udo, Klose, Robert J, Schofield, Christopher J, Kawamura, Akane
Published in Journal of medicinal chemistry (26.07.2012)
Published in Journal of medicinal chemistry (26.07.2012)
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Micro cell vesicle technology (mCVT): a novel hybrid system of gene delivery for hard-to-transfect (HTT) cells
Ou, Yi-Hsuan, Zou, Shui, Goh, Wei Jiang, Chong, Suet Yen, Venkatesan, Gopalakrishnan, Wacker, Matthias G, Storm, Gerrit, Wang, Jiong-Wei, Czarny, Bertrand, Pastorin, Giorgia, Woon, Esther C. Y
Published in Nanoscale (21.09.2020)
Published in Nanoscale (21.09.2020)
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Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors
Demetriades, Marina, Leung, Ivanhoe K. H., Chowdhury, Rasheduzzaman, Chan, Mun Chiang, McDonough, Michael A., Yeoh, Kar Kheng, Tian, Ya-Min, Claridge, Timothy D. W., Ratcliffe, Peter J., Woon, Esther C. Y., Schofield, Christopher J.
Published in Angewandte Chemie International Edition (02.07.2012)
Published in Angewandte Chemie International Edition (02.07.2012)
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Journal Article
Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds
Chang, Kai-Hsuan, King, Oliver N. F., Tumber, Anthony, Woon, Esther C. Y., Heightman, Tom D., McDonough, Michael A., Schofield, Christopher J., Rose, Nathan R.
Published in ChemMedChem (02.05.2011)
Published in ChemMedChem (02.05.2011)
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5-Benzamidoisoquinolin-1-ones and 5-(ω-Carboxyalkyl)isoquinolin-1-ones as Isoform-Selective Inhibitors of Poly(ADP-ribose) Polymerase 2 (PARP-2)
Sunderland, Peter T, Woon, Esther C. Y, Dhami, Archana, Bergin, Aoife B, Mahon, Mary F, Wood, Pauline J, Jones, Louise A, Tully, Sophie R, Lloyd, Matthew D, Thompson, Andrew S, Javaid, Hashim, Martin, Niall M. B, Threadgill, Michael D
Published in Journal of medicinal chemistry (14.04.2011)
Published in Journal of medicinal chemistry (14.04.2011)
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Structure-Guided Design of Cell Wall Biosynthesis Inhibitors That Overcome β-Lactam Resistance in Staphylococcus aureus (MRSA)
Contreras-Martel, Carlos, Amoroso, Ana, Woon, Esther C. Y, Zervosen, Astrid, Inglis, Steven, Martins, Alexandre, Verlaine, Olivier, Rydzik, Anna M, Job, Viviana, Luxen, André, Joris, Bernard, Schofield, Christopher J, Dessen, Andréa
Published in ACS chemical biology (16.09.2011)
Published in ACS chemical biology (16.09.2011)
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A safe lithium mimetic for bipolar disorder
Singh, Nisha, Halliday, Amy C., Thomas, Justyn M., Kuznetsova, Olga V., Baldwin, Rhiannon, Woon, Esther C. Y., Aley, Parvinder K., Antoniadou, Ivi, Sharp, Trevor, Vasudevan, Sridhar R., Churchill, Grant C.
Published in Nature communications (01.01.2013)
Published in Nature communications (01.01.2013)
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Journal Article
Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors
Woon, Esther C. Y, Zervosen, Astrid, Sauvage, Eric, Simmons, Katie J, Živec, Matej, Inglis, Steven R, Fishwick, Colin W. G, Gobec, Stanislav, Charlier, Paulette, Luxen, André, Schofield, Christopher J
Published in ACS medicinal chemistry letters (10.03.2011)
Published in ACS medicinal chemistry letters (10.03.2011)
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Solid-Phase Synthesis of Chlorofusin Analogues
Woon, Esther C. Y, Arcieri, Mariangela, Wilderspin, Andrew F, Malkinson, John P, Searcey, Mark
Published in Journal of organic chemistry (06.07.2007)
Published in Journal of organic chemistry (06.07.2007)
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