Design, Parallel Synthesis, and Crystal Structures of Pyrazinone Antithrombotics as Selective Inhibitors of the Tissue Factor VIIa Complex
Parlow, John J, Case, Brenda L, Dice, Thomas A, Fenton, Ricky L, Hayes, Michael J, Jones, Darin E, Neumann, William L, Wood, Rhonda S, Lachance, Rhonda M, Girard, Thomas J, Nicholson, Nancy S, Clare, Michael, Stegeman, Roderick A, Stevens, Anna M, Stallings, William C, Kurumbail, Ravi G, South, Michael S
Published in Journal of medicinal chemistry (11.09.2003)
Published in Journal of medicinal chemistry (11.09.2003)
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Journal Article
Pharmacological Interruption of Acute Thrombus Formation with Minimal Hemorrhagic Complications by a Small Molecule Tissue Factor/Factor VIIa Inhibitor: Comparison to Factor Xa and Thrombin Inhibition in a Nonhuman Primate Thrombosis Model
Suleymanov, Osman D, Szalony, James A, Salyers, Anita K, LaChance, Rhonda M, Parlow, John J, South, Michael S, Wood, Rhonda S, Nicholson, Nancy S
Published in The Journal of pharmacology and experimental therapeutics (01.09.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2003)
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Journal Article
Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex
South, Michael S., Case, Brenda L., Wood, Rhonda S., Jones, Darin E., Hayes, Michael J., Girard, Thomas J., Lachance, Rhonda M., Nicholson, Nancy S., Clare, Michael, Stevens, Anna M., Stegeman, Roderick A., Stallings, William C., Kurumbail, Ravi G., Parlow, John J.
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
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Journal Article
Administration of a small molecule tissue factor/Factor VIIa inhibitor in a non-human primate thrombosis model of venous thrombosis: effects on thrombus formation and bleeding time
Szalony, James A, Suleymanov, Osman D, Salyers, Anita K, Panzer-Knodle, Susan G, Blom, Jason D, LaChance, Rhonda M, Case, Brenda L, Parlow, John J, South, Michael S, Wood, Rhonda S, Nicholson, Nancy S
Published in Thrombosis research (2003)
Published in Thrombosis research (2003)
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Journal Article
Assessment of Bleeding Propensity in Non-Human Primates by Combination of Selective Tissue Factor/VIIa Inhibition and Aspirin Compared to Warfarin and Aspirin Treatment
Salyers, Anita K., Szalony, James A., Suleymanov, Osman D., Parlow, John J., Wood, Rhonda S., South, Michael S., Nicholson, Nancy S.
Published in Pharmacology (01.02.2004)
Published in Pharmacology (01.02.2004)
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Journal Article
6-Membered unsaturated heterocyclic compounds useful for selective inhibition of the coagulation cascade
NEUMANN WILLIAM L, KUSTURIN CARRIE L, SAMPLE KIRBY R, MOORMANN ALAN E, GARLAND DANNY J, FENTON RICKY L, HAYES MICHAEL J, SNYDER JEFFERY S, SOUTH MICHAEL S, WOOD RHONDA S, HUANG WEI, SCHOLTEN JEFFREY A, SCHWEITZER BARBARA A, RUEPPEL MELVIN L, CASE BRENDA, WEBBER RONALD K, LONG SCOTT, ZENG QINGPING, PARLOW JOHN J, ABBAS ZAHEER, SALYERS ANITA, HUANG HORNGIH, NICHOLSON NANCY S, TRUJILLO JOHN, JONES DARIN E, RAHMAN HAYAT K, SULEYMANOV OSMAN D, SZALONY JIM, TOTH MIHALY V
Year of Publication 03.06.2004
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Year of Publication 03.06.2004
Patent
6-MEMBERED UNSATURATED HETEROCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE
HAYES, MICHAEL J, SNYDER, JEFFREY S, LONG, SCOTT, TOTH, MIHALY V, KUSTURIN, CARRIE L, PARLOW, JOHN J, SAMPLE, KIRBY R, ABBAS, ZAHEER, SALYERS, ANITA, NICHOLSON, NANCY S, FENTON, RICKY L, RUEPPEL, MELVIN L, GARLAND, DANNY J, TRUJILLO, JOHN, SZALONY, JIM, SOUTH, MICHAEL S, MOORMANN, ALAN E, NEUMANN, WILLIAM L, SCHWEITZER, BARBARA A, WEI, HUANG, WOOD, RHONDA S, CASE, BRENDA, ZENG, QINGPING, HAYAT, RAHMAN K, SULEYMANOV, OSMAN D, JONES, DARIN E, HUANG, HORNGIH, WEBBER, RONALD K, SCHOLTEN, JEFFREY A
Year of Publication 10.04.2003
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Year of Publication 10.04.2003
Patent
Compostos heterocìclicos insaturados de 6 membros úteis para inibição seletiva da cascata de coagulação
MIHALY V. TOTH, MELVIN L. RUEPPEL, DANNY J. GARLAND, JIM SZALONY, NANCY S. NICHOLSON, JOHN TRUJILLO, QINGPING ZENG, BRENDA CASE, WILLIAM L. NEUMANN, MICHAEL S. SOUTH, MICHAEL J. HAYES, BARBARA A. SCHWEITZER, HUANG WEI, RICKY L. FENTON, RAHMAN K. HAYAT, RHONDA S. WOOD, JOHN J. PARLOW, ZAHEER ABBAS, HORNGIH HUANG, ALAN E. MOORMANN, ANITA SALYERS, RONALD K. WEBBER, SCOTT LONG, KIRBY R. SAMPLE, JEFFREY S. SNYDER, OSMAN D. SULEYMANOV, JEFFREY A. SCHOLTEN, CARRIE L. KUSTURIN, DARIN E. JONES
Year of Publication 24.08.2004
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Year of Publication 24.08.2004
Patent