An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
Tonn, George R, Wong, Simon G, Wong, Sylvia C, Johnson, Michael G, Ma, Ji, Cho, Robert, Floren, Leslie C, Kersey, Kathryn, Berry, Karen, Marcus, Andrew P, Wang, Xuemei, Van Lengerich, Bettina, Medina, Julio C, Pearson, Paul G, Wong, Bradley K
Published in Drug metabolism and disposition (01.03.2009)
Published in Drug metabolism and disposition (01.03.2009)
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Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
Wong, Simon G, Ramsden, Diane, Dallas, Shannon, Fung, Conrad, Einolf, Heidi J, Palamanda, Jairam, Chen, Liangfu, Goosen, Theunis C, Siu, Y Amy, Zhang, George, Tweedie, Donald, Hariparsad, Niresh, Jones, Barry, Yates, Phillip D
Published in Drug metabolism and disposition (01.01.2021)
Published in Drug metabolism and disposition (01.01.2021)
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Development of a mass spectrometry-based tryptophan 2, 3-dioxygenase assay using liver cytosol from multiple species
Wang, Jing, Takahashi, Ryan H., DeMent, Kevin, Gustafson, Amy, Kenny, Jane R., Wong, Simon G., Yan, Zhengyin
Published in Analytical biochemistry (01.09.2018)
Published in Analytical biochemistry (01.09.2018)
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Discovery and in Vivo Evaluation of Macrocyclic Mcl‑1 Inhibitors Featuring an α‑Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere
Rescourio, Gwenaella, Gonzalez, Ana Z, Jabri, Salman, Belmontes, Brian, Moody, Gordon, Whittington, Doug, Huang, Xin, Caenepeel, Sean, Cardozo, Mario, Cheng, Alan C, Chow, David, Dou, Hannah, Jones, Adrie, Kelly, Ron C, Li, Yihong, Lizarzaburu, Mike, Lo, Mei-Chu, Mallari, Rommel, Meleza, Cesar, Rew, Yosup, Simonovich, Scott, Sun, Daqing, Turcotte, Simon, Yan, Xuelei, Wong, Simon G, Yanez, Evelyn, Zancanella, Manuel, Houze, Jonathan, Medina, Julio C, Hughes, Paul E, Brown, Sean P
Published in Journal of medicinal chemistry (27.11.2019)
Published in Journal of medicinal chemistry (27.11.2019)
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Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme
Henne, Kirk R, Tran, Thuy B, VandenBrink, Brooke M, Rock, Dan A, Aidasani, Divesh K, Subramanian, Raju, Mason, Andrew K, Stresser, David M, Teffera, Yohannes, Wong, Simon G, Johnson, Michael G, Chen, Xiaoqi, Tonn, George R, Wong, Bradley K
Published in Drug metabolism and disposition (01.07.2012)
Published in Drug metabolism and disposition (01.07.2012)
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Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP
Johnson, Michael G., Liu, Jim (Jiwen), Li, An-Rong, van Lengerich, Bettina, Wang, Sophie, Medina, Julio C., Collins, Tassie L., Danao, Jay, Seitz, Lisa, Willee, Angela, D'Souza, Warren, Budelsky, Alison L., Fan, Peter W., Wong, Simon G. W.
Published in Bioorganic & medicinal chemistry letters (01.07.2014)
Published in Bioorganic & medicinal chemistry letters (01.07.2014)
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Bioactivation of a Novel 2-Methylindole-Containing Dual Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type-2 Cells/D-Prostanoid Receptor Antagonist Leads to Mechanism-Based CYP3A Inactivation: Glutathione Adduct Characterization and Prediction of In Vivo Drug-Drug Interaction
WONG, Simon G, FAN, Peter W, SUBRAMANIAN, Raju, TONN, George R, HENNE, Kirk R, JOHNSON, Michael G, TADANO LOHR, Michelle, WONG, Bradley K
Published in Drug metabolism and disposition (01.05.2010)
Published in Drug metabolism and disposition (01.05.2010)
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Use of recombinant human ferrochelatase as a sensitive bioassay for N-alkylprotoporphyrin IX formed after interaction of porphyrinogenic xenobiotics with rat liver microsomes
Gamble, Jeremy T, Wong, Simon GW, Dailey, Harry A, Marks, Gerald S
Published in Canadian journal of physiology and pharmacology (01.07.2000)
Published in Canadian journal of physiology and pharmacology (01.07.2000)
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An Inhibitory Metabolite Leads to Dose-and Time-Dependent Pharmacokinetics of (R)-A/-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
TONN, George R, WONG, Simon G, XUEMEI WANG, VAN LENGERICH, Bettina, MEDINA, Julio C, PEARSON, Paul G, WONG, Bradley K, WONG, Sylvia C, JOHNSON, Michael G, JI MA, CHO, Robert, FLOREN, Leslie C, KERSEY, Kathryn, BERRY, Karen, MARCUS, Andrew P
Published in Drug metabolism and disposition (2009)
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Published in Drug metabolism and disposition (2009)
Journal Article
Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD sub(2) receptors CRTH2 and DP
Johnson, Michael G, Liu, Jim, Li, An-Rong, Lengerich, Bettina van, Wang, Sophie, Medina, Julio C, Collins, Tassie L, Danao, Jay, Seitz, Lisa, Willee, Angela, D'Souza, Warren, Budelsky, Alison L, Fan, Peter W, Wong, Simon GW
Published in Bioorganic & medicinal chemistry letters (01.07.2014)
Published in Bioorganic & medicinal chemistry letters (01.07.2014)
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Neutron Reflection from 2,4-Bis(4-(N-methyl-N-octylamino)phenyl)squaraine at the Air−Water Interface and the Linear and Nonlinear Optical Properties of Its Langmuir−Blodgett and Spun-Coated Films
Ashwell, Geoffrey J, Wong, G. M. Simon, Bucknall, David G, Bahra, Gurmit S, Brown, Christopher R
Published in Langmuir (19.03.1997)
Published in Langmuir (19.03.1997)
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