COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice
Zheng, Jian, Wong, Lok-Yin Roy, Li, Kun, Verma, Abhishek Kumar, Ortiz, Miguel E., Wohlford-Lenane, Christine, Leidinger, Mariah R., Knudson, C. Michael, Meyerholz, David K., McCray, Paul B., Perlman, Stanley
Published in Nature (London) (28.01.2021)
Published in Nature (London) (28.01.2021)
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Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment
Sun, Jing, Zhuang, Zhen, Zheng, Jian, Li, Kun, Wong, Roy Lok-Yin, Liu, Donglan, Huang, Jicheng, He, Jiangping, Zhu, Airu, Zhao, Jingxian, Li, Xiaobo, Xi, Yin, Chen, Rongchang, Alshukairi, Abeer N., Chen, Zhao, Zhang, Zhaoyong, Chen, Chunke, Huang, Xiaofang, Li, Fang, Lai, Xiaomin, Chen, Dingbin, Wen, Liyan, Zhuo, Jianfen, Zhang, Yanjun, Wang, Yanqun, Huang, Shuxiang, Dai, Jun, Shi, Yongxia, Zheng, Kui, Leidinger, Mariah R., Chen, Jiekai, Li, Yimin, Zhong, Nanshan, Meyerholz, David K., McCray, Paul B., Perlman, Stanley, Zhao, Jincun
Published in Cell (06.08.2020)
Published in Cell (06.08.2020)
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Omicron subvariant BA.5 efficiently infects lung cells
Hoffmann, Markus, Wong, Lok-Yin Roy, Arora, Prerna, Zhang, Lu, Rocha, Cheila, Odle, Abby, Nehlmeier, Inga, Kempf, Amy, Richter, Anja, Halwe, Nico Joel, Schön, Jacob, Ulrich, Lorenz, Hoffmann, Donata, Beer, Martin, Drosten, Christian, Perlman, Stanley, Pöhlmann, Stefan
Published in Nature communications (13.06.2023)
Published in Nature communications (13.06.2023)
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Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning
Lei, Ruipeng, Qing, Enya, Odle, Abby, Yuan, Meng, Gunawardene, Chaminda D., Tan, Timothy J. C., So, Natalie, Ouyang, Wenhao O., Wilson, Ian A., Gallagher, Tom, Perlman, Stanley, Wu, Nicholas C., Wong, Lok-Yin Roy
Published in Nature communications (14.05.2024)
Published in Nature communications (14.05.2024)
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Journal Article
Identification of Lysine Acetylation Sites on MERS-CoV Replicase pp1ab
Zhu, Lin, Fung, Sin-Yee, Xie, Guangshan, Wong, Lok-Yin Roy, Jin, Dong-Yan, Cai, Zongwei
Published in Molecular & cellular proteomics (01.08.2020)
Published in Molecular & cellular proteomics (01.08.2020)
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Journal Article
SARS-CoV-2-specific immunoglobulin Y antibodies are protective in infected mice
El-Kafrawy, Sherif A, Odle, Abby, Abbas, Aymn T, Hassan, Ahmed M, Abdel-Dayem, Umama A, Qureshi, Arooj K, Wong, Lok-Yin Roy, Zheng, Jian, Meyerholz, David K, Perlman, Stanley, Zumla, Alimuddin, Azhar, Esam I
Published in PLoS pathogens (01.09.2022)
Published in PLoS pathogens (01.09.2022)
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Contrasting roles of MERS-CoV and SARS-CoV-2 internal proteins in pathogenesis in mice
Wong, Lok-Yin Roy, Odle, Abby, Luhmann, Emma, Wu, Douglas C, Wang, Yiquan, Teo, Qi Wen, Ptak, Celeste, Sariol, Alan, Lowery, Shea, Mack, Matthias, Meyerholz, David K, Wu, Nicholas C, Radoshevich, Lilliana, Perlman, Stanley
Published in mBio (19.12.2023)
Published in mBio (19.12.2023)
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Intranasal Immunization with a Vaccinia Virus Vaccine Vector Expressing Pre-Fusion Stabilized SARS-CoV-2 Spike Fully Protected Mice against Lethal Challenge with the Heavily Mutated Mouse-Adapted SARS2-N501YMA30 Strain of SARS-CoV-2
Kibler, Karen V., Szczerba, Mateusz, Lake, Douglas, Roeder, Alexa J., Rahman, Masmudur, Hogue, Brenda G., Roy Wong, Lok-Yin, Perlman, Stanley, Li, Yize, Jacobs, Bertram L.
Published in Vaccines (Basel) (23.07.2022)
Published in Vaccines (Basel) (23.07.2022)
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SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
Halfmann, Peter J., Iida, Shun, Iwatsuki-Horimoto, Kiyoko, Maemura, Tadashi, Kiso, Maki, Scheaffer, Suzanne M., Darling, Tamarand L., Joshi, Astha, Loeber, Samantha, Singh, Gagandeep, Foster, Stephanie L., Ying, Baoling, Case, James Brett, Chong, Zhenlu, Whitener, Bradley, Moliva, Juan, Floyd, Katharine, Ujie, Michiko, Nakajima, Noriko, Ito, Mutsumi, Wright, Ryan, Uraki, Ryuta, Warang, Prajakta, Gagne, Matthew, Li, Rong, Sakai-Tagawa, Yuko, Liu, Yanan, Larson, Deanna, Osorio, Jorge E., Hernandez-Ortiz, Juan P., Henry, Amy R., Ciuoderis, Karl, Florek, Kelsey R., Patel, Mit, Odle, Abby, Wong, Lok-Yin Roy, Bateman, Allen C., Wang, Zhongde, Edara, Venkata-Viswanadh, Franks, John, Jeevan, Trushar, Fabrizio, Thomas, DeBeauchamp, Jennifer, Kercher, Lisa, Seiler, Patrick, Gonzalez-Reiche, Ana Silvia, Sordillo, Emilia Mia, Chang, Lauren A., van Bakel, Harm, Simon, Viviana, Douek, Daniel C., Sullivan, Nancy J., Thackray, Larissa B., Ueki, Hiroshi, Yamayoshi, Seiya, Imai, Masaki, Perlman, Stanley, Webby, Richard J., Seder, Robert A., Suthar, Mehul S., García-Sastre, Adolfo, Schotsaert, Michael, Suzuki, Tadaki, Boon, Adrianus C. M., Diamond, Michael S., Kawaoka, Yoshihiro
Published in Nature (London) (24.03.2022)
Published in Nature (London) (24.03.2022)
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Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3
Lui, Pak-Yin, Wong, Lok-Yin Roy, Fung, Cheuk-Lai, Siu, Kam-Leung, Yeung, Man-Lung, Yuen, Kit-San, Chan, Chi-Ping, Woo, Patrick Chiu-Yat, Yuen, Kwok-Yung, Jin, Dong-Yan
Published in Emerging microbes & infections (20.04.2016)
Published in Emerging microbes & infections (20.04.2016)
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Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19
Wong, Lok-Yin Roy, Zheng, Jian, Wilhelmsen, Kevin, Li, Kun, Ortiz, Miguel E., Schnicker, Nicholas J., Thurman, Andrew, Pezzulo, Alejandro A., Szachowicz, Peter J., Li, Pengfei, Pan, Ruangang, Klumpp, Klaus, Aswad, Fred, Rebo, Justin, Narumiya, Shuh, Murakami, Makoto, Zuniga, Sonia, Sola, Isabel, Enjuanes, Luis, Meyerholz, David K., Fortney, Kristen, McCray, Paul B., Perlman, Stanley
Published in Nature (London) (05.05.2022)
Published in Nature (London) (05.05.2022)
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Journal Article
Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection
Dampalla, Chamandi S., Zheng, Jian, Perera, Krishani Dinali, Wong, Lok-Yin Roy, Meyerholz, David K., Nguyen, Harry Nhat, Kashipathy, Maithri M., Battaile, Kevin P., Lovell, Scott, Kim, Yunjeong, Perlman, Stanley, Groutas, William C., Chang, Kyeong-Ok
Published in Proceedings of the National Academy of Sciences - PNAS (20.07.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (20.07.2021)
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