RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist
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Published in PloS one (31.12.2013)
Published in PloS one (31.12.2013)
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RVX-208: A Small Molecule That Increases Apolipoprotein A-I and High-Density Lipoprotein Cholesterol In Vitro and In Vivo
BAILEY, Dana, JAHAGIRDAR, Ravi, KRIMBOU, Larbi, WONG, Norman C. W, GENEST, Jacques, GORDON, Allan, HAFIANE, Anouar, CAMPBELL, Steven, CHATUR, Safia, WAGNER, Gregory S, HANSEN, Henrik C, CHIACCHIA, Fabrizio S, JOHANSSON, Jan
Published in Journal of the American College of Cardiology (08.06.2010)
Published in Journal of the American College of Cardiology (08.06.2010)
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Relation of insulin treatment for type 2 diabetes to the risk of major adverse cardiovascular events after acute coronary syndrome: an analysis of the BETonMACE randomized clinical trial
Schwartz, Gregory G, Nicholls, Stephen J, Toth, Peter P, Sweeney, Michael, Halliday, Christopher, Johansson, Jan O, Wong, Norman C W, Kulikowski, Ewelina, Kalantar-Zadeh, Kamyar, Ginsberg, Henry N, Ray, Kausik K
Published in Cardiovascular diabetology (22.06.2021)
Published in Cardiovascular diabetology (22.06.2021)
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Complement Is an Essential Component of the Immune Response to Adeno-Associated Virus Vectors
ZAISS, Anne K, COTTER, Matthew J, WHITE, Lindsay R, CLARK, Sharon A, WONG, Norman C. W, HOLERS, V. Michael, BARTLETT, Jeffrey S, MURUVE, Daniel A
Published in Journal of Virology (01.03.2008)
Published in Journal of Virology (01.03.2008)
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Hyperglycemia suppresses hepatic scavenger receptor class B type I expression
Murao, Koji, Yu, Xiao, Imachi, Hitomi, Cao, Wen M, Chen, Ke, Matsumoto, Kensuke, Nishiuchi, Takamasa, Wong, Norman C. W, Ishida, Toshihiko
Published in American journal of physiology: endocrinology and metabolism (01.01.2008)
Published in American journal of physiology: endocrinology and metabolism (01.01.2008)
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A mutant high-density lipoprotein receptor inhibits proliferation of human breast cancer cells
CAO, Wen M, MURAO, Koji, IMACHI, Hitomi, XIAO YU, ABE, Hiroshi, YAMAUCHI, Akira, NIIMI, Michio, MIYAUCHI, Akira, WONG, Norman C. W, ISHIDA, Toshihiko
Published in Cancer research (Chicago, Ill.) (15.02.2004)
Published in Cancer research (Chicago, Ill.) (15.02.2004)
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Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism
Tsujikawa, Laura M, Fu, Li, Das, Shovon, Halliday, Christopher, Rakai, Brooke D, Stotz, Stephanie C, Sarsons, Christopher D, Gilham, Dean, Daze, Emily, Wasiak, Sylwia, Studer, Deborah, Rinker, Kristina D, Sweeney, Michael, Johansson, Jan O, Wong, Norman C W, Kulikowski, Ewelina
Published in Clinical epigenetics (12.07.2019)
Published in Clinical epigenetics (12.07.2019)
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Induction of apolipoprotein A-I gene expression by glucagon-like peptide-1 and exendin-4 in hepatocytes but not intestinal cells
Chehade, Joe M, Alcalde, Rosalyn, Naem, Emad, Mooradian, Arshag D, Wong, Norman C.W, Haas, Michael J
Published in Metabolism, clinical and experimental (01.02.2013)
Published in Metabolism, clinical and experimental (01.02.2013)
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RVX-297, a BET Bromodomain Inhibitor, Has Therapeutic Effects in Preclinical Models of Acute Inflammation and Autoimmune Disease
Jahagirdar, Ravi, Attwell, Sarah, Marusic, Suzana, Bendele, Alison, Shenoy, Narmada, McLure, Kevin G, Gilham, Dean, Norek, Karen, Hansen, Henrik C, Yu, Raymond, Tobin, Jennifer, Wagner, Gregory S, Young, Peter R, Wong, Norman C W, Kulikowski, Ewelina
Published in Molecular pharmacology (01.12.2017)
Published in Molecular pharmacology (01.12.2017)
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The Effect of Bromodomain and Extra-Terminal Inhibitor Apabetalone on Attenuated Coronary Atherosclerotic Plaque: Insights from the ASSURE Trial
Shishikura, Daisuke, Kataoka, Yu, Honda, Satoshi, Takata, Kohei, Kim, Susan W., Andrews, Jordan, Psaltis, Peter J., Sweeney, Michael, Kulikowski, Ewelina, Johansson, Jan, Wong, Norman C. W., Nicholls, Stephen J.
Published in American journal of cardiovascular drugs : drugs, devices, and other interventions (01.02.2019)
Published in American journal of cardiovascular drugs : drugs, devices, and other interventions (01.02.2019)
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BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes
Wasiak, Sylwia, Dzobo, Kim E, Rakai, Brooke D, Kaiser, Yannick, Versloot, Miranda, Bahjat, Mahnoush, Stotz, Stephanie C, Fu, Li, Sweeney, Michael, Johansson, Jan O, Wong, Norman C W, Stroes, Erik S G, Kroon, Jeffrey, Kulikowski, Ewelina
Published in Clinical epigenetics (11.11.2020)
Published in Clinical epigenetics (11.11.2020)
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Pancreatic Glucokinase Is Activated by Insulin-Like Growth Factor-I
Yoshida, Kazuya, Murao, Koji, Imachi, Hitomi, Cao, Wen M, Yu, Xiao, Li, Junhua, Ahmed, Rania A. M, Kitanaka, Noriko, Wong, Norman C. W, Unterman, Terry G, Magnuson, Mark A, Ishida, Toshihiko
Published in Endocrinology (Philadelphia) (01.06.2007)
Published in Endocrinology (Philadelphia) (01.06.2007)
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Cognitive Effects of the BET Protein Inhibitor Apabetalone: A Prespecified Montreal Cognitive Assessment Analysis Nested in the BETonMACE Randomized Controlled Trial
Cummings, Jeffrey, Schwartz, Gregory G., Nicholls, Stephen J., Khan, Aziz, Halliday, Chris, Toth, Peter P., Sweeney, Michael, Johansson, Jan O., Wong, Norman C.W., Kulikowski, Ewelina, Kalantar-Zadeh, Kamyar, Lebioda, Kenneth, Ginsberg, Henry N., Winblad, Bengt, Zetterberg, Henrik, Ray, Kausik K.
Published in Journal of Alzheimer's disease (01.01.2021)
Published in Journal of Alzheimer's disease (01.01.2021)
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Insulin Induction of Apolipoprotein AI, Role of Sp1
Lam, Johnny K, Matsubara, Shuji, Mihara, Koichiro, Zheng, Xi-long, Mooradian, Arshag D, Wong, Norman C. W
Published in Biochemistry (Easton) (11.03.2003)
Published in Biochemistry (Easton) (11.03.2003)
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Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro
Gilham, Dean, Smith, Audrey L, Fu, Li, Moore, Dalia Y, Muralidharan, Abenaya, Reid, St Patrick M, Stotz, Stephanie C, Johansson, Jan O, Sweeney, Michael, Wong, Norman C W, Kulikowski, Ewelina, El-Gamal, Dalia
Published in Biomedicines (18.04.2021)
Published in Biomedicines (18.04.2021)
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Regulation of Scavenger Receptor Class BI Gene Expression by Angiotensin II in Vascular Endothelial Cells
Yu, Xiao, Murao, Koji, Imachi, Hitomi, Cao, Wen-Ming, Li, Junhua, Matsumoto, Kensuke, Nishiuchi, Takamasa, Ahmed, Rania A.M, Wong, Norman C.W, Kosaka, Hiroaki, Unterman, Terry G, Ishida, Toshihiko
Published in Hypertension (Dallas, Tex. 1979) (01.06.2007)
Published in Hypertension (Dallas, Tex. 1979) (01.06.2007)
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The BET inhibitor apabetalone decreases neuroendothelial proinflammatory activation in vitro and in a mouse model of systemic inflammation
Wasiak, Sylwia, Fu, Li, Daze, Emily, Gilham, Dean, Rakai, Brooke D., Stotz, Stephanie C., Tsujikawa, Laura M., Sarsons, Chris D., Studer, Deborah, Rinker, Kristina D., Jahagirdar, Ravi, Wong, Norman C. W., Sweeney, Michael, Johansson, Jan O., Kulikowski, Ewelina
Published in Translational neuroscience (01.01.2023)
Published in Translational neuroscience (01.01.2023)
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Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease
Sweeney, Michael, Johansson, Jan O., Wong, Norman C. W., Kulikowski, Ewelina, Fu, Li, Rakai, Brooke D., Stotz, Stephanie C., Halliday, Christopher, Tsujikawa, Laura M., Daze, Emily, Gilham, Dean, Wasiak, Sylwia, Jahagirdar, Ravi
Published in Cardiovascular therapeutics (2020)
Published in Cardiovascular therapeutics (2020)
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