The Case for Development of 11-Aza-artemisinins for Malaria
Harmse, Rozanne, Wong, Ho Ning, Smit, Frans, Haynes, Richard K, N'Da, David D
Published in Current medicinal chemistry (01.01.2015)
Published in Current medicinal chemistry (01.01.2015)
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Interactions between Artemisinins and other Antimalarial Drugs in Relation to the Cofactor Model-A Unifying Proposal for Drug Action
Haynes, Richard K., Cheu, Kwan-Wing, Chan, Ho-Wai, Wong, Ho-Ning, Li, Ka-Yan, Tang, Maggie Mei-Ki, Chen, Min-Jiao, Guo, Zu-Feng, Guo, Zhi-Hong, Sinniah, Kumar, Witte, Amanda B., Coghi, Paolo, Monti, Diego
Published in ChemMedChem (01.12.2012)
Published in ChemMedChem (01.12.2012)
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Facile Oxidation of Leucomethylene Blue and Dihydroflavins by Artemisinins: Relationship with Flavoenzyme Function and Antimalarial Mechanism of Action
Haynes, Richard K., Chan, Wing-Chi, Wong, Ho-Ning, Li, Ka-Yan, Wu, Wai-Keung, Fan, Kit-Man, Sung, Herman H. Y., Williams, Ian D., Prosperi, Davide, Melato, Sergio, Coghi, Paolo, Monti, Diego
Published in ChemMedChem (02.08.2010)
Published in ChemMedChem (02.08.2010)
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Journal Article
Synthesis of Artemiside and Its Effects in Combination with Conventional Drugs against Severe Murine Malaria
JIN GUO, GUIGUEMDE, Armand W, BENTURA-MARCIANO, Annael, CLARK, Julie, HAYNES, Richard K, CHAN, Wing-Chi, WONG, Ho-Ning, HUNT, Nicholas H, KIPLIN GUY, R, GOLENSER, Jacob
Published in Antimicrobial Agents and Chemotherapy (01.01.2012)
Published in Antimicrobial Agents and Chemotherapy (01.01.2012)
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Journal Article
Artesunate and Dihydroartemisinin (DHA): Unusual Decomposition Products Formed under Mild Conditions and Comments on the Fitness of DHA as an Antimalarial Drug
Haynes, Richard K., Chan, Ho-Wai, Lung, Chung-Man, Ng, Nga-Chun, Wong, Ho-Ning, Shek, Lai Yung, Williams, Ian D., Cartwright, Anthony, Gomes, Melba F.
Published in ChemMedChem (08.10.2007)
Published in ChemMedChem (08.10.2007)
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Journal Article
Artemisone Uptake in Plasmodium falciparum-Infected Erythrocytes
POOLEY, Sophie, FATIH, Farrah A, KRISHNA, Sanjeev, GERISCH, Michael, HAYNES, Richard K, WONG, Ho-Ning, STAINES, Henry M
Published in Antimicrobial Agents and Chemotherapy (01.02.2011)
Published in Antimicrobial Agents and Chemotherapy (01.02.2011)
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Journal Article
A Partial Convergence in Action of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal with Verapamil, and an Insight into the Antimalarial Activity of Chloroquine
Haynes, Richard K., Cheu, Kwan-Wing, Li, Ka-Yan, Tang, Maggie Mei-Ki, Wong, Ho-Ning, Chen, Min-Jiao, Guo, Zu-Feng, Guo, Zhi-Hong, Coghi, Paolo, Monti, Diego
Published in ChemMedChem (05.09.2011)
Published in ChemMedChem (05.09.2011)
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The evaluation of the anti-cancer drug elesclomol that forms a redox-active copper chelate as a potential anti-tubercular drug
Ngwane, Andile H, Petersen, Ray-Dean, Baker, Bienyameen, Wiid, Ian, Wong, Ho Ning, Haynes, Richard K
Published in IUBMB life (01.05.2019)
Published in IUBMB life (01.05.2019)
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Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse model
Müller, Joachim, Aguado-Martínez, Adriana, Manser, Vera, Wong, Ho Ning, Haynes, Richard K, Hemphill, Andrew
Published in Veterinary research (Paris) (17.02.2016)
Published in Veterinary research (Paris) (17.02.2016)
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Journal Article
Preparation of N-Sulfonyl- and N-Carbonyl-11-Azaartemisinins with Greatly Enhanced Thermal Stabilities: in vitro Antimalarial Activities
Haynes, Richard K., Wong, Ho-Ning, Lee, Kin-Wo, Lung, Chung-Man, Shek, Lai Yung, Williams, Ian D., Croft, Simon L., Vivas, Livia, Rattray, Lauren, Stewart, Lindsay, Wong, Vincent K. W., Ko, Ben C. B.
Published in ChemMedChem (08.10.2007)
Published in ChemMedChem (08.10.2007)
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Journal Article
Efficacies and ADME properties of redox active methylene blue and phenoxazine analogues for use in new antimalarial triple drug combinations with amino-artemisinins
Watson, Daniel J, Laing, Lizahn, Petzer, Jacobus P, Wong, Ho Ning, Parkinson, Christopher J, Wiesner, Lubbe, Haynes, Richard K
Published in Frontiers in pharmacology (08.01.2024)
Published in Frontiers in pharmacology (08.01.2024)
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Journal Article
Anti-Melanoma Activities of Artemisone and Prenylated Amino-Artemisinins in Combination With Known Anticancer Drugs
Wong, Ho Ning, Lewies, Angélique, Haigh, Michaela, Viljoen, Joe M., Wentzel, Johannes F., Haynes, Richard K., du Plessis, Lissinda H.
Published in Frontiers in pharmacology (29.09.2020)
Published in Frontiers in pharmacology (29.09.2020)
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Journal Article
Facile Preparation of N -Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities
Wu, Yuet, Parapini, Silvia, Williams, Ian D, Misiano, Paola, Wong, Ho Ning, Taramelli, Donatella, Basilico, Nicoletta, Haynes, Richard K
Published in Molecules (Basel, Switzerland) (13.07.2018)
Published in Molecules (Basel, Switzerland) (13.07.2018)
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Journal Article
Antimalarial and antitumour activities of the steroidal quinone-methide celastrol and its combinations with artemiside, artemisone and methylene blue
Ng, Jerome P. L., Han, Yu, Yang, Li Jun, Birkholtz, Lyn-Marie, Coertzen, Dina, Wong, Ho Ning, Haynes, Richard K., Coghi, Paolo, Wong, Vincent Kam Wai
Published in Frontiers in pharmacology (02.09.2022)
Published in Frontiers in pharmacology (02.09.2022)
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Journal Article
The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside
Gibhard, Liezl, Coertzen, Dina, Reader, Janette, van der Watt, Mariëtte E, Birkholtz, Lyn-Marie, Wong, Ho Ning, Batty, Kevin T, Haynes, Richard K, Wiesner, Lubbe
Published in Pharmaceutics (03.12.2021)
Published in Pharmaceutics (03.12.2021)
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Journal Article
Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies–Activities Against Blood Stage P. falciparum Including PfKI3 C580Y Mutants and Liver Stage P. berghei Parasites
Wong, Ho Ning, Padín-Irizarry, Vivian, van der Watt, Mariëtte E., Reader, Janette, Liebenberg, Wilna, Wiesner, Lubbe, Smith, Peter, Eribez, Korina, Winzeler, Elizabeth A., Kyle, Dennis E., Birkholtz, Lyn-Marie, Coertzen, Dina, Haynes, Richard K.
Published in Frontiers in chemistry (10.01.2020)
Published in Frontiers in chemistry (10.01.2020)
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Elimination of Schistosoma mansoni in infected mice by slow release of artemisone
Gold, Daniel, Alian, Mohammed, Domb, Avraham, Karawani, Yara, Jbarien, Maysa, Chollet, Jacques, Haynes, Richard K., Wong, Ho Ning, Buchholz, Viola, Greiner, Andreas, Golenser, Jacob
Published in International journal for parasitology -- drugs and drug resistance (01.08.2017)
Published in International journal for parasitology -- drugs and drug resistance (01.08.2017)
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Journal Article
Cover Picture: Artemisone-A Highly Active Antimalarial Drug of the Artemisinin Class (Angew. Chem. Int. Ed. 13/2006)
Haynes, Richard K., Fugmann, Burkhard, Stetter, Jörg, Rieckmann, Karl, Heilmann, Hans-Dietrich, Chan, Ho-Wai, Cheung, Man-Ki, Lam, Wai-Lun, Wong, Ho-Ning, Croft, Simon L., Vivas, Livia, Rattray, Lauren, Stewart, Lindsay, Peters, Wallace, Robinson, Brian L., Edstein, Michael D., Kotecka, Barbara, Kyle, Dennis E., Beckermann, Bernhard, Gerisch, Michael, Radtke, Martin, Schmuck, Gabriele, Steinke, Wolfram, Wollborn, Ute, Schmeer, Karl, Römer, Axel
Published in Angewandte Chemie International Edition (20.03.2006)
Published in Angewandte Chemie International Edition (20.03.2006)
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Toward New Transmission-Blocking Combination Therapies: Pharmacokinetics of 10-Amino-Artemisinins and 11-Aza-Artemisinin and Comparison with Dihydroartemisinin and Artemether
Watson, Daniel J, Laing, Lizahn, Gibhard, Liezl, Wong, Ho Ning, Haynes, Richard K, Wiesner, Lubbe
Published in Antimicrobial agents and chemotherapy (16.07.2021)
Published in Antimicrobial agents and chemotherapy (16.07.2021)
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Journal Article
Evaluation and optimization of synthetic routes from dihydroartemisinin to the alkylamino-artemisinins artemiside and artemisone: A test of N-glycosylation methodologies on a lipophilic peroxide
Chan, Wing Chi, Wai Chan, Dennis Ho, Lee, Kin Wo, Tin, Wing Shan, Wong, Ho Ning, Haynes, Richard K.
Published in Tetrahedron (20.09.2018)
Published in Tetrahedron (20.09.2018)
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