Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance
McCubrey, James A., Steelman, Linda S., Chappell, William H., Abrams, Stephen L., Wong, Ellis W.T., Chang, Fumin, Lehmann, Brian, Terrian, David M., Milella, Michele, Tafuri, Agostino, Stivala, Franca, Libra, Massimo, Basecke, Jorg, Evangelisti, Camilla, Martelli, Alberto M., Franklin, Richard A.
Published in Biochimica et biophysica acta (01.08.2007)
Published in Biochimica et biophysica acta (01.08.2007)
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The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy
Abrams, Stephen L., Steelman, Linda S., Shelton, John G., Wong, Ellis W.T., Chappell, William H., Bäsecke, Jörg, Stivala, Franca, Donia, Marco, Nicoletti, Ferdinando, Libra, Massimo, Martelli, Alberto M., McCubrey, James A
Published in Cell cycle (Georgetown, Tex.) (01.05.2010)
Published in Cell cycle (Georgetown, Tex.) (01.05.2010)
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Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells
Steelman, Linda S., Navolanic, Patrick, Chappell, William H., Abrams, Stephen L., Wong, Ellis W.T., Martelli, Alberto M., Cocco, Lucio, Stivala, Franca, Libra, Massimo, Nicoletti, Ferdinando, Drobot, Lyudmyla B., Franklin, Richard A., McCubrey, James A.
Published in Cell cycle (Georgetown, Tex.) (01.09.2011)
Published in Cell cycle (Georgetown, Tex.) (01.09.2011)
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Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors
Steelman, L S, Navolanic, P M, Sokolosky, M L, Taylor, J R, Lehmann, B D, Chappell, W H, Abrams, S L, Wong, E W T, Stadelman, K M, Terrian, D M, Leslie, N R, Martelli, A M, Stivala, F, Libra, M, Franklin, R A, McCubrey, J A
Published in Oncogene (03.07.2008)
Published in Oncogene (03.07.2008)
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Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance
McCubrey, James A, Steelman, Linda S, Franklin, Richard A, Abrams, Steven L, Chappell, William H, Wong, Ellis W T, Lehmann, Brian D, Terrian, David M, Basecke, Jorg, Stivala, Franca, Libra, Massimo, Evangelisti, Camilla, Martelli, Alberto M
Published in Advances in enzyme regulation (2007)
Published in Advances in enzyme regulation (2007)
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Journal Article
Dominant Role of Raf/MEK/ERK Signaling in Hematopoietic Cell Cycle Progression, Prevention of Apoptosis and Drug Resistance
McCubrey, James A., Abrams, Steven L., Steelman, Linda S., Wong, Ellis W.T., Chappell, William H., Basecke, Jorg, Stivala, Franca, Libra, Massimo, Milella, Michele, Tafuri, Agostino, Troppmair, Jacob, Konopleva, Marina, Andreeff, Michael, Evangelisti, Camilla, Martelli, Alberto M.
Published in Blood (16.11.2006)
Published in Blood (16.11.2006)
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Journal Article
Key Roles of the Raf-1 and Akt in Drug Resistance, Cell Cycle Progression and the Prevention of Apoptosis in Hematopoietic Cells
Abrams, Steven L., Steelman, Linda S., Shelton, John G., Chappell, William H., Wong, Ellis W.T., Bertrand, Fred E., McCubrey, James A.
Published in Blood (16.11.2005)
Published in Blood (16.11.2005)
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Journal Article
Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy
McCubrey, James A, Sokolosky, Melissa L, Lehmann, Brian D, Taylor, Jackson R, Navolanic, Patrick M, Chappell, William H, Abrams, Stephen L, Stadelman, Kristin M, Wong, Ellis W T, Misaghian, Negin, Horn, Stefan, Bäsecke, Jörg, Libra, Massimo, Stivala, Franca, Ligresti, Giovanni, Tafuri, Agostino, Milella, Michele, Zarzycki, Marek, Dzugaj, Andrzej, Chiarini, Francesca, Evangelisti, Camilla, Martelli, Alberto M, Terrian, David M, Franklin, Richard A, Steelman, Linda S
Published in Advances in enzyme regulation (2008)
Published in Advances in enzyme regulation (2008)
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Journal Article