Search Results - "Wonacott, Alan" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate

Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate

by Slater, Martin J, Amphlett, Elizabeth M, Andrews, David M, Bravi, Gianpaolo, Burton, George, Cheasty, Anne G, Corfield, John A, Ellis, Malcolm R, Fenwick, Rebecca H, Fernandes, Stephanie, Guidetti, Rossella, Haigh, David, Hartley, C. David, Howes, Peter D, Jackson, Deborah L, Jarvest, Richard L, Lovegrove, Victoria L. H, Medhurst, Katrina J, Parry, Nigel R, Price, Helen, Shah, Pritom, Singh, Onkar M. P, Stocker, Richard, Thommes, Pia, Wilkinson, Claire, Wonacott, Alan
Published in Journal of medicinal chemistry (08.03.2007)

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Dihydropyrancarboxamides Related to Zanamivir: A New Series of Inhibitors of Influenza Virus Sialidases. 2. Crystallographic and Molecular Modeling Study of Complexes of 4-Amino-4H-pyran-6-carboxamides and Sialidase from Influenza Virus Types A and B

Dihydropyrancarboxamides Related to Zanamivir: A New Series of Inhibitors of Influenza Virus Sialidases. 2. Crystallographic and Molecular Modeling Study of Complexes of 4-Amino-4H-pyran-6-carboxamides and Sialidase from Influenza Virus Types A and B

by Taylor, Neil R, Cleasby, Anne, Singh, Onkar, Skarzynski, Tadeusz, Wonacott, Alan J, Smith, Paul W, Sollis, Steven L, Howes, Peter D, Cherry, Peter C, Bethell, Richard, Colman, Peter, Varghese, Jose
Published in Journal of medicinal chemistry (12.03.1998)

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Discovery of Further Pyrrolidine trans-Lactams as Inhibitors of Human Neutrophil Elastase (HNE) with Potential as Development Candidates and the Crystal Structure of HNE Complexed with an Inhibitor (GW475151)

Discovery of Further Pyrrolidine trans-Lactams as Inhibitors of Human Neutrophil Elastase (HNE) with Potential as Development Candidates and the Crystal Structure of HNE Complexed with an Inhibitor (GW475151)

by Macdonald, Simon J. F, Dowle, Michael D, Harrison, Lee A, Clarke, Geoffrey D. E, Inglis, Graham G. A, Johnson, Martin R, Shah, Pritom, Smith, Robin A, Amour, Augustin, Fleetwood, Gill, Humphreys, Davina C, Molloy, Christopher R, Dixon, Mary, Godward, Rosalind E, Wonacott, Alan J, Singh, Onkar M. P, Hodgson, Simon T, Hardy, George W
Published in Journal of medicinal chemistry (29.08.2002)

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Crystal structure of the Ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA

Crystal structure of the Ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA

by Jovine, Luca, Hainzl, Tobias, Oubridge, Chris, Scott, William G, Li, Jade, Sixma, Titia K, Wonacott, Alan, Skarzynski, Tadeusz, Nagai, Kiyoshi
Published in Structure (London) (15.05.2000)

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Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides

Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides

by WYATT, Paul G, COOMBER, Barry A, EVANS, Derek N, JACK, Torquil I, FULTON, Heather E, WONACOTT, Alan J, COLMAN, Peter, VARGHESE, Jose
Published in Bioorganic & medicinal chemistry letters (12.03.2001)

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Novel Natural Product 5,5-trans-Lactone Inhibitors of Human α-Thrombin: Mechanism of Action and Structural Studies

Novel Natural Product 5,5-trans-Lactone Inhibitors of Human α-Thrombin: Mechanism of Action and Structural Studies

by Weir, Malcolm P, Bethell, Susanne S, Cleasby, Anne, Campbell, Callum J, Dennis, Richard J, Dix, Clive J, Finch, Harry, Jhoti, Harren, Mooney, Christopher J, Patel, Shila, Tang, Chi-Man, Ward, Malcolm, Wonacott, Alan J, Wharton, Christopher W
Published in Biochemistry (Easton) (12.05.1998)

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4-Acetylamino-3-(imidazol-1-yl)-benzoic acids as novel inhibitors of influenza sialidase

4-Acetylamino-3-(imidazol-1-yl)-benzoic acids as novel inhibitors of influenza sialidase

by Howes, Peter D, Cleasby, Anne, Evans, Derek N, Feilden, Helen, Smith, Paul W, Sollis, Steven L, Taylor, Neil, Wonacott, Alan J
Published in European journal of medicinal chemistry (01.03.1999)

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X-ray Crystal Structure of Human Dopamine Sulfotransferase, SULT1A3

X-ray Crystal Structure of Human Dopamine Sulfotransferase, SULT1A3

by Dajani, Rana, Cleasby, Anne, Neu, Margarete, Wonacott, Alan J., Jhoti, Harren, Hood, Alan M., Modi, Sandeep, Hersey, Anne, Taskinen, Jyrki, Cooke, Robert M., Manchee, Gary R., Coughtrie, Michael W.H.
Published in The Journal of biological chemistry (01.12.1999)

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X-ray crystal structure of human dopamine sulfotransferase, SULT1A3. Molecular modeling and quantitative structure-activity relationship analysis demonstrate a molecular basis for sulfotransferase substrate specificity

X-ray crystal structure of human dopamine sulfotransferase, SULT1A3. Molecular modeling and quantitative structure-activity relationship analysis demonstrate a molecular basis for sulfotransferase substrate specificity

by Dajani, R, Cleasby, A, Neu, M, Wonacott, A J, Jhoti, H, Hood, A M, Modi, S, Hersey, A, Taskinen, J, Cooke, R M, Manchee, G R, Coughtrie, M W
Published in The Journal of biological chemistry (31.12.1999)

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The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X‐ray crystallography

The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X‐ray crystallography

by Lewis, R. J., Singh, O. M., Smith, C. V., Skarzynski, T., Maxwell, A., Wonacott, A. J., Wigley, D. B.
Published in The EMBO journal (15.03.1996)

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Structure of UDP- N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP- N-acetylglucosamine and the drug fosfomycin

Structure of UDP- N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP- N-acetylglucosamine and the drug fosfomycin

by Skarzynski, Tadeusz, Mistry, Anil, Wonacott, Alan, Hutchinson, Susan E, Kelly, Valerie A, Duncan, Kenneth
Published in Structure (London) (15.12.1996)

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The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin

The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin

by Tsai, Francis T.F., Singh, Onkar M.P., Skarzynski, Tadeusz, Wonacott, Alan J., Weston, Simon, Tucker, Alec, Pauptit, Richard A., Breeze, Alexander L., Poyser, J. Philip, O'Brien, Ronan, Ladbury, John E., Wigley, Dale B.
Published in Proteins, structure, function, and bioinformatics (01.05.1997)

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Crystallization of Lysyl Transfer Ribonucleic Acid Synthetase from Yeast

Crystallization of Lysyl Transfer Ribonucleic Acid Synthetase from Yeast

by Rymo, Lars, Lagerkvist, Ulf, Wonacott, Alan
Published in The Journal of biological chemistry (10.09.1970)

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X-ray and spectrophotometric studies of the binding of proflavin to the S1 specificity pocket of human α-thrombin

X-ray and spectrophotometric studies of the binding of proflavin to the S1 specificity pocket of human α-thrombin

by Conti, Elena, Rivetti, Claudio, Wonacott, Alan, Brick, Peter
Published in FEBS letters (27.03.1998)

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Novel inhibitors of influenza sialidases related to GG167 structure-activity, crystallographic and Molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides

Novel inhibitors of influenza sialidases related to GG167 structure-activity, crystallographic and Molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides

by Smith, Paul W., Sollis, Steven L., Howes, Peter D., Cherry, Peter C., Cobley, Kevin N., Taylor, Helen, Whittington, Andrew R., Scicinski, Jan, Bethell, Richard C., Taylor, Neil, Skarzynski, Tadeusz, Cleasby, Anne, Singh, Oncar, Wonacott, Alan, Varghese, Jose, Colman, Peter
Published in Bioorganic & medicinal chemistry letters (17.12.1996)

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Crystal Structures of Thrombin Complexed to a Novel Series of Synthetic Inhibitors Containing a 5,5-trans-Lactone Template

Crystal Structures of Thrombin Complexed to a Novel Series of Synthetic Inhibitors Containing a 5,5-trans-Lactone Template

by Jhoti, Harren, Cleasby, Anne, Reid, Scott, Thomas, Pam J, Weir, Malcolm, Wonacott, Alan
Published in Biochemistry (Easton) (22.06.1999)

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Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4 H-pyran-2-carboxylic acid-6-propylamides

Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4 H-pyran-2-carboxylic acid-6-propylamides

by Wyatt, Paul G, Coomber, Barry A, Evans, Derek N, Jack, Torquil I, Fulton, Heather E, Wonacott, Alan J, Colman, Peter, Varghese, Jose
Published in Bioorganic & medicinal chemistry letters (2001)

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Coenzyme-induced conformational changes in glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus

Coenzyme-induced conformational changes in glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus

by Skarżyński, Tadeusz, Wonacott, Alan J.
Published in Journal of molecular biology (20.10.1988)

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Crystallization of Inhibitor Complexes of an N-Terminal 24 kDa Fragment of the DNA Gyrase B Protein

Crystallization of Inhibitor Complexes of an N-Terminal 24 kDa Fragment of the DNA Gyrase B Protein

by Lewis, Richard J., Singh, Onkar M.P., Smith, Clare V., Maxwell, Anthony, Skarzynski, Tadeusz, Wonacott, Alan J., Wigley, Dale B.
Published in Journal of molecular biology (05.08.1994)

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X-ray Crystallographic Studies of a Series of Penicillin-Derived Asymmetric Inhibitors of HIV-1 Protease

X-ray Crystallographic Studies of a Series of Penicillin-Derived Asymmetric Inhibitors of HIV-1 Protease

by Jhoti, Harren, Singh, Onkar M. P, Weir, Malcolm P, Cooke, Robert, Murray-Rust, Peter, Wonacott, Alan
Published in Biochemistry (Easton) (01.07.1994)

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