Direct-to-Biology Accelerates PROTAC Synthesis and the Evaluation of Linker Effects on Permeability and Degradation
Hendrick, Charles E., Jorgensen, Jeff R., Chaudhry, Charu, Strambeanu, Iulia I., Brazeau, Jean-Francois, Schiffer, Jamie, Shi, Zhicai, Venable, Jennifer D., Wolkenberg, Scott E.
Published in ACS medicinal chemistry letters (14.07.2022)
Published in ACS medicinal chemistry letters (14.07.2022)
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Efficient Synthesis of Imidazoles from Aldehydes and 1,2-Diketones Using Microwave Irradiation
Wolkenberg, Scott E, Wisnoski, David D, Leister, William H, Wang, Yi, Zhao, Zhijian, Lindsley, Craig W
Published in Organic letters (29.04.2004)
Published in Organic letters (29.04.2004)
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Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT)
Harrison, Scott T, Poslusney, Michael S, Mulhearn, James J, Zhao, Zhijian, Kett, Nathan R, Schubert, Jeffrey W, Melamed, Jeffrey Y, Allison, Timothy J, Patel, Sangita B, Sanders, John M, Sharma, Sujata, Smith, Robert F, Hall, Dawn L, Robinson, Ronald G, Sachs, Nancy A, Hutson, Pete H, Wolkenberg, Scott E, Barrow, James C
Published in ACS medicinal chemistry letters (12.03.2015)
Published in ACS medicinal chemistry letters (12.03.2015)
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Intramolecular Diels−Alder and Tandem Intramolecular Diels−Alder/1,3-Dipolar Cycloaddition Reactions of 1,3,4-Oxadiazoles
Wilkie, Gordon D, Elliott, Gregory I, Blagg, Brian S. J, Wolkenberg, Scott E, Soenen, Danielle R, Miller, Michael M, Pollack, Scott, Boger, Dale L
Published in Journal of the American Chemical Society (25.09.2002)
Published in Journal of the American Chemical Society (25.09.2002)
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Trends in Hit-to-Lead Optimization Following DNA-Encoded Library Screens
Reiher, Christopher A, Schuman, David P, Simmons, Nicholas, Wolkenberg, Scott E
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors
Zhao, Zhijian, Leister, William H., O’Brien, Julie A., Lemaire, Wei, Williams, David L., Jacobson, Marlene A., Sur, Cyrille, Kinney, Gene G., Pettibone, Doug J., Tiller, Philip R., Smith, Sheri, Hartman, George D., Lindsley, Craig W., Wolkenberg, Scott E.
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
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Enabling Deoxygenative C(sp2)‑C(sp3) Cross-Coupling for Parallel Medicinal Chemistry
Liu, Wei, Mulhearn, James, Hao, Bo, Cañellas, Santiago, Last, Stefaan, Gómez, José Enrique, Jones, Alexander, De Vera, Alexander, Kumar, Kiran, Rodríguez, Raquel, Van Eynde, Lars, Strambeanu, Iulia I., Wolkenberg, Scott E.
Published in ACS medicinal chemistry letters (08.06.2023)
Published in ACS medicinal chemistry letters (08.06.2023)
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Synthesis and SAR of GlyT1 inhibitors derived from a series of N-((4-(morpholine-4-carbonyl)-1-(propylsulfonyl)piperidin-4-yl)methyl)benzamides
Zhao, Zhijian, O’Brien, Julie A., Lemaire, Wei, Williams, David L., Jacobson, Marlene A., Sur, Cyrille, Pettibone, Doug J., Tiller, Philip R., Smith, Sheri, Hartman, George D., Wolkenberg, Scott E., Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
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Benzoxazolinone aryl sulfonamides as potent, selective Nav1.7 inhibitors with in vivo efficacy in a preclinical pain model
Pero, Joseph E., Rossi, Michael A., Lehman, Hannah D.G.F., Kelly, Michael J., Mulhearn, James J., Wolkenberg, Scott E., Cato, Matthew J., Clements, Michelle K., Daley, Christopher J., Filzen, Tracey, Finger, Eleftheria N., Gregan, Yun, Henze, Darrell A., Jovanovska, Aneta, Klein, Rebecca, Kraus, Richard L., Li, Yuxing, Liang, Annie, Majercak, John M., Panigel, Jacqueline, Urban, Mark O., Wang, Jixin, Wang, Ying-Hong, Houghton, Andrea K., Layton, Mark E.
Published in Bioorganic & medicinal chemistry letters (15.06.2017)
Published in Bioorganic & medicinal chemistry letters (15.06.2017)
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Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction
Beshore, Douglas C., Adam, Gregory C., Barnard, Richard J. O., Burlein, Christine, Gallicchio, Steven N., Holloway, M. Katharine, Krosky, Daniel, Lemaire, Wei, Myers, Robert W., Patel, Sangita, Plotkin, Michael A., Powell, David A., Rada, Vanessa, Cox, Christopher D., Coleman, Paul J., Klein, Daniel J., Wolkenberg, Scott E.
Published in ACS medicinal chemistry letters (08.04.2021)
Published in ACS medicinal chemistry letters (08.04.2021)
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Design, Synthesis, and Evaluation of Novel 3,6-Diaryl-4-aminoalkoxyquinolines as Selective Agonists of Somatostatin Receptor Subtype 2
Wolkenberg, Scott E, Zhao, Zhijian, Thut, Catherine, Maxwell, Jill W, McDonald, Terrence P, Kinose, Fumi, Reilly, Michael, Lindsley, Craig W, Hartman, George D
Published in Journal of medicinal chemistry (14.04.2011)
Published in Journal of medicinal chemistry (14.04.2011)
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Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors
Zhao, Zhijian, Harrison, Scott T., Schubert, Jeffrey W., Sanders, John M., Polsky-Fisher, Stacey, Zhang, Nanyan Rena, McLoughlin, Debra, Gibson, Christopher R., Robinson, Ronald G., Sachs, Nancy A., Kandebo, Monika, Yao, Lihang, Smith, Sean M., Hutson, Pete H., Wolkenberg, Scott E., Barrow, James C.
Published in Bioorganic & medicinal chemistry letters (15.06.2016)
Published in Bioorganic & medicinal chemistry letters (15.06.2016)
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Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics
Wolkenberg, Scott E., Nolt, M. Brad, Bilodeau, Mark T., Trotter, B. Wesley, Manley, Peter J., Kett, Nathan R., Nanda, Kausik K., Wu, Zhicai, Cato, Matthew J., Kane, Stefanie A., Kiss, Laszlo, Spencer, Robert H., Wang, Jixin, Lynch, Joseph J., Regan, Christopher P., Stump, Gary L., Li, Bing, White, Rebecca, Yeh, Suzie, Dinsmore, Christopher J., Lindsley, Craig W., Hartman, George D.
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
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Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia
Lindsley, Craig W, Shipe, William D, Wolkenberg, Scott E, Theberge, Cory R, Williams, Jr, David L, Sur, Cyrille, Kinney, Gene G
Published in Current topics in medicinal chemistry (01.04.2006)
Published in Current topics in medicinal chemistry (01.04.2006)
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