mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient
Wyant, Gregory A., Abu-Remaileh, Monther, Wolfson, Rachel L., Chen, Walter W., Freinkman, Elizaveta, Danai, Laura V., Vander Heiden, Matthew G., Sabatini, David M.
Published in Cell (19.10.2017)
Published in Cell (19.10.2017)
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Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
Saxton, Robert A., Knockenhauer, Kevin E., Wolfson, Rachel L., Chantranupong, Lynne, Pacold, Michael E., Wang, Tim, Schwartz, Thomas U., Sabatini, David M.
Published in Science (American Association for the Advancement of Science) (01.01.2016)
Published in Science (American Association for the Advancement of Science) (01.01.2016)
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Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
Wang, Shuyu, Tsun, Zhi-Yang, Wolfson, Rachel L., Shen, Kuang, Wyant, Gregory A., Plovanich, Molly E., Yuan, Elizabeth D., Jones, Tony D., Chantranupong, Lynne, Comb, William, Wang, Tim, Bar-Peled, Liron, Zoncu, Roberto, Straub, Christoph, Kim, Choah, Park, Jiwon, Sabatini, Bernardo L., Sabatini, David M.
Published in Science (American Association for the Advancement of Science) (09.01.2015)
Published in Science (American Association for the Advancement of Science) (09.01.2015)
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The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
Chantranupong, Lynne, Wolfson, Rachel L, Orozco, Jose M, Saxton, Robert A, Scaria, Sonia M, Bar-Peled, Liron, Spooner, Eric, Isasa, Marta, Gygi, Steven P, Sabatini, David M
Published in Cell reports (Cambridge) (09.10.2014)
Published in Cell reports (Cambridge) (09.10.2014)
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Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival
Efeyan, Alejo, Zoncu, Roberto, Chang, Steven, Gumper, Iwona, Snitkin, Harriet, Wolfson, Rachel L., Kirak, Oktay, Sabatini, David D., Sabatini, David M.
Published in Nature (London) (31.01.2013)
Published in Nature (London) (31.01.2013)
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KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
Wolfson, Rachel L., Chantranupong, Lynne, Wyant, Gregory A., Gu, Xin, Orozco, Jose M., Shen, Kuang, Condon, Kendall J., Petri, Sabrina, Kedir, Jibril, Scaria, Sonia M., Abu-Remaileh, Monther, Frankel, Wayne N., Sabatini, David M.
Published in Nature (London) (16.03.2017)
Published in Nature (London) (16.03.2017)
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A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility
Yuskaitis, Christopher J., Jones, Brandon M., Wolfson, Rachel L., Super, Chloe E., Dhamne, Sameer C., Rotenberg, Alexander, Sabatini, David M., Sahin, Mustafa, Poduri, Annapurna
Published in Neurobiology of disease (01.03.2018)
Published in Neurobiology of disease (01.03.2018)
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Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
Okosun, Jessica, Wolfson, Rachel L, Wang, Jun, Araf, Shamzah, Wilkins, Lucy, Castellano, Brian M, Escudero-Ibarz, Leire, Al Seraihi, Ahad Fahad, Richter, Julia, Bernhart, Stephan H, Efeyan, Alejo, Iqbal, Sameena, Matthews, Janet, Clear, Andrew, Guerra-Assunção, José Afonso, Bödör, Csaba, Quentmeier, Hilmar, Mansbridge, Christopher, Johnson, Peter, Davies, Andrew, Strefford, Jonathan C, Packham, Graham, Barrans, Sharon, Jack, Andrew, Du, Ming-Qing, Calaminici, Maria, Lister, T Andrew, Auer, Rebecca, Montoto, Silvia, Gribben, John G, Siebert, Reiner, Chelala, Claude, Zoncu, Roberto, Sabatini, David M, Fitzgibbon, Jude
Published in Nature genetics (01.02.2016)
Published in Nature genetics (01.02.2016)
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DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon
Wolfson, Rachel L., Abdelaziz, Amira, Rankin, Genelle, Kushner, Sarah, Qi, Lijun, Mazor, Ofer, Choi, Seungwon, Sharma, Nikhil, Ginty, David D.
Published in Cell (03.08.2023)
Published in Cell (03.08.2023)
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Parallel ascending spinal pathways for affective touch and pain
Choi, Seungwon, Hachisuka, Junichi, Brett, Matthew A., Magee, Alexandra R., Omori, Yu, Iqbal, Noor-ul-Aine, Zhang, Dawei, DeLisle, Michelle M., Wolfson, Rachel L., Bai, Ling, Santiago, Celine, Gong, Shiaoching, Goulding, Martyn, Heintz, Nathaniel, Koerber, H. Richard, Ross, Sarah E., Ginty, David D.
Published in Nature (London) (12.11.2020)
Published in Nature (London) (12.11.2020)
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Erratum: Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
Okosun, Jessica, Wolfson, Rachel L, Wang, Jun, Araf, Shamzah, Wilkins, Lucy, Castellano, Brian M, Escudero-Ibarz, Leire, Seraihi, Ahad Fahad Al, Richter, Julia, Bernhart, Stephan H, Efeyan, Alejo, Iqbal, Sameena, Matthews, Janet, Clear, Andrew, Guerra-Assunção, José Afonso, Bödör, Csaba, Quentmeier, Hilmar, Mansbridge, Christopher, Johnson, Peter, Davies, Andrew, Strefford, Jonathan C, Packham, Graham, Barrans, Sharon, Jack, Andrew, Du, Ming-Qing, Calaminici, Maria, Lister, T Andrew, Auer, Rebecca, Montoto, Silvia, Gribben, John G, Siebert, Reiner, Chelala, Claude, Zoncu, Roberto, Sabatini, David M, Fitzgibbon, Jude
Published in Nature genetics (27.05.2016)
Published in Nature genetics (27.05.2016)
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Correction: Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
Okosun, Jessica, Wolfson, Rachel L, Wang, Jun, Araf, Shamzah, Wilkins, Lucy, Castellano, Brian M, Escudero-Ibarz, Leire, Seraihi, Ahad Fahad Al, Richter, Julia, Bernhart, Stephan H, Efeyan, Alejo, Iqbal, Sameena, Matthews, Janet, Clear, Andrew, Guerra-Assunção, José Afonso, Bödör, Csaba, Quentmeier, Hilmar, Mansbridge, Christopher, Johnson, Peter, Davies, Andrew, Strefford, Jonathan C, Packham, Graham, Barrans, Sharon, Jack, Andrew, Du, Ming-Qing, Calaminici, Maria, Lister, T Andrew, Auer, Rebecca, Montoto, Silvia, Gribben, John G, Siebert, Reiner, Chelala, Claude, Zoncu, Roberto, Sabatini, David M, Fitzgibbon, Jude
Published in Nature genetics (2016)
Published in Nature genetics (2016)
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Journal Article
Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
Okosun, Jessica, Wolfson, Rachel L, Wang, Jun, Araf, Shamzah, Wilkins, Lucy, Castellano, Brian M, Escudero-Ibarz, Leire, Seraihi, Ahad Fahad Al, Richter, Julia, Bernhart, Stephan H, Efeyan, Alejo, Iqbal, Sameena, Matthews, Janet, Clear, Andrew, Guerra-Assunção, José Afonso, Bödör, Csaba, Quentmeier, Hilmar, Mansbridge, Christopher, Johnson, Peter, Davies, Andrew, Strefford, Jonathan C, Packham, Graham, Barrans, Sharon, Jack, Andrew, Du, Ming-Qing, Calaminici, Maria, Lister, T Andrew, Auer, Rebecca, Montoto, Silvia, Gribben, John G, Siebert, Reiner, Chelala, Claude, Zoncu, Roberto, Sabatini, David M, Fitzgibbon, Jude
Published in Nature genetics (01.06.2016)
Published in Nature genetics (01.06.2016)
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Journal Article
Rag GTPase-mediated regulation of mTORC1 by nutrients is necessary for neonatal autophagy and survival
Efeyan, Alejo, Zoncu, Roberto, Chang, Steven, Gumper, Iwona, Snitkin, Harriet, Wolfson, Rachel L., Kirak, Oktay, Sabatini, David D., Sabatini, David M.
Published in Nature (London) (23.12.2012)
Published in Nature (London) (23.12.2012)
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Journal Article
Corrigendum: Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
Okosun, Jessica, Wolfson, Rachel L, Wang, Jun, Araf, Shamzah, Wilkins, Lucy, Castellano, Brian M, Escudero-Ibarz, Leire, Seraihi, Ahad Fahad Al, Richter, Julia, Bernhart, Stephan H, Efeyan, Alejo, Iqbal, Sameena, Matthews, Janet, Clear, Andrew, Guerra-Assunção, José Afonso, Bödör, Csaba, Quentmeier, Hilmar, Mansbridge, Christopher, Johnson, Peter, Davies, Andrew, Strefford, Jonathan C, Packham, Graham, Barrans, Sharon, Jack, Andrew, Du, Ming-Qing, Calaminici, Maria, Lister, T Andrew, Auer, Rebecca, Montoto, Silvia, Gribben, John G, Siebert, Reiner, Chelala, Claude, Zoncu, Roberto, Sabatini, David M, Fitzgibbon, Jude
Published in Nature genetics (27.05.2016)
Published in Nature genetics (27.05.2016)
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Journal Article
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
Wang, Shuyu, Tsun, Zhi-Yang, Wolfson, Rachel L, Shen, Kuang, Wyant, Gregory A, Plovanich, Molly E, Yuan, Elizabeth D, Jones, Tony D, Chantranupong, Lynne, Comb, William, Wang, Tim, Bar-Peled, Liron, Zoncu, Roberto, Straub, Christoph, Kim, Choah, Park, Jiwon, Sabatini, Bernardo L, Sabatini, David M
Published in Science (American Association for the Advancement of Science) (09.01.2015)
Published in Science (American Association for the Advancement of Science) (09.01.2015)
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