Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease
Fitz, Nicholas F, Nam, Kyong Nyon, Wolfe, Cody M, Letronne, Florent, Playso, Brittany E, Iordanova, Bistra E, Kozai, Takashi D Y, Biedrzycki, Richard J, Kagan, Valerian E, Tyurina, Yulia Y, Han, Xianlin, Lefterov, Iliya, Koldamova, Radosveta
Published in Nature communications (07.06.2021)
Published in Nature communications (07.06.2021)
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Journal Article
Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice
Fitz, Nicholas F, Wolfe, Cody M, Playso, Brittany E, Biedrzycki, Richard J, Lu, Yi, Nam, Kyong Nyon, Lefterov, Iliya, Koldamova, Radosveta
Published in Molecular neurodegeneration (23.07.2020)
Published in Molecular neurodegeneration (23.07.2020)
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Journal Article
Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury
Castranio, Emilie L, Mounier, Anais, Wolfe, Cody M, Nam, Kyong Nyon, Fitz, Nicholas F, Letronne, Florent, Schug, Jonathan, Koldamova, Radosveta, Lefterov, Iliya
Published in Neurobiology of disease (01.09.2017)
Published in Neurobiology of disease (01.09.2017)
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Journal Article
Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice
Nam, Kyong Nyon, Mounier, Anais, Wolfe, Cody M, Fitz, Nicholas F, Carter, Alexis Y, Castranio, Emilie L, Kamboh, Hafsa I, Reeves, Valerie L, Wang, Jianing, Han, Xianlin, Schug, Jonathan, Lefterov, Iliya, Koldamova, Radosveta
Published in Scientific reports (27.06.2017)
Published in Scientific reports (27.06.2017)
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Journal Article
APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain
Lefterov, Iliya, Wolfe, Cody M, Fitz, Nicholas F, Nam, Kyong Nyon, Letronne, Florent, Biedrzycki, Richard J, Kofler, Julia, Han, Xianlin, Wang, Jianing, Schug, Jonathan, Koldamova, Radosveta
Published in Alzheimer's research & therapy (30.12.2019)
Published in Alzheimer's research & therapy (30.12.2019)
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Journal Article
Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice
Carter, Alexis Y, Letronne, Florent, Fitz, Nicholas F, Mounier, Anais, Wolfe, Cody M, Nam, Kyong Nyon, Reeves, Valerie L, Kamboh, Hafsa, Lefterov, Iliya, Koldamova, Radosveta
Published in PloS one (27.02.2017)
Published in PloS one (27.02.2017)
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Journal Article
Psychosis in Alzheimer's Disease Is Associated With Increased Excitatory Neuron Vulnerability and Post-transcriptional Mechanisms Altering Synaptic Protein Levels
DeChellis-Marks, Michael R, Wei, Yue, Ding, Ying, Wolfe, Cody M, Krivinko, Joshua M, MacDonald, Matthew L, Lopez, Oscar L, Sweet, Robert A, Kofler, Julia
Published in Frontiers in neurology (02.03.2022)
Published in Frontiers in neurology (02.03.2022)
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Journal Article
ABCA1 haplodeficiency affects the brain transcriptome following traumatic brain injury in mice expressing human APOE isoforms
Castranio, Emilie L, Wolfe, Cody M, Nam, Kyong Nyon, Letronne, Florent, Fitz, Nicholas F, Lefterov, Iliya, Koldamova, Radosveta
Published in Acta neuropathologica communications (26.07.2018)
Published in Acta neuropathologica communications (26.07.2018)
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Journal Article
Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice
Nam, Kyong Nyon, Wolfe, Cody M., Fitz, Nicholas F., Letronne, Florent, Castranio, Emilie L., Mounier, Anais, Schug, Jonathan, Lefterov, Iliya, Koldamova, Radosveta
Published in Biochimica et biophysica acta (01.01.2018)
Published in Biochimica et biophysica acta (01.01.2018)
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Journal Article
Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity
Mounier, Anais, Georgiev, Danko, Nam, Kyong Nyon, Fitz, Nicholas F, Castranio, Emilie L, Wolfe, Cody M, Cronican, Andrea A, Schug, Jonathan, Lefterov, Iliya, Koldamova, Radosveta
Published in The Journal of neuroscience (26.08.2015)
Published in The Journal of neuroscience (26.08.2015)
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Journal Article
HIGH-FAT DIET AFFECTS INFLAMMATION AND INCREASES TREM2 LEVEL IN APP MICE
Fitz, Nicholas F, Nam, Kyong Nyon, Wolfe, Cody M, Mounier, Anais, Schug, Jonathan, Lefterov, Iliya, Koldamova, Radosveta
Published in Alzheimer's & dementia (01.07.2016)
Published in Alzheimer's & dementia (01.07.2016)
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Journal Article
IMPACT OF APOE POLYMORPHISMS ON AMYLOID-BETA OLIGOMERIZATION AND ASSOCIATED COGNITIVE DECLINE
Fitz, Nicholas F, Carter, Alexis Y, Nam, Kyong Nyon, Castranio, Emilie L, Mounier, Anais, Wolfe, Cody M, Lefterov, Iliya, Koldamova, Radosveta
Published in Alzheimer's & dementia (01.07.2016)
Published in Alzheimer's & dementia (01.07.2016)
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Journal Article
Role of TREM2 deficiency in Alzheimer’s disease model mice expressing human APOE3 or APOE4: Molecular and cell biology/neuroinflammation
Fitz, Nicholas F., Nam, Kyong Nyon, Letronne, Florent, Wolfe, Cody M., Playso, Brittany E., Lefterov, Iliya, Koldamova, Radosveta
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
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Journal Article
P2‐100: SINGLE‐CELL TRANSCRIPTOMIC PROFILING OF TREM2 DEFICIENT MICROGLIA IN RESPONSE TO INTRACRANIAL INFUSION OF Aβ PARTICLES
Nam, Kyong Nyon, Fitz, Nicholas F., Biedrzycki, Richard J., Playso, Brittany E., Wolfe, Cody M., Lefterov, Iliya, Koldamova, Radosveta
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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Journal Article