Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans[S]
Takahashi, Shogo, Fukami, Tatsuki, Masuo, Yusuke, Brocker, Chad N., Xie, Cen, Krausz, Kristopher W., Wolf, C. Roland, Henderson, Colin J., Gonzalez, Frank J.
Published in Journal of lipid research (01.12.2016)
Published in Journal of lipid research (01.12.2016)
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Journal Article
Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy
MacLeod, A Kenneth, Lin, De, Huang, Jeffrey T-J, McLaughlin, Lesley A, Henderson, Colin J, Wolf, C Roland
Published in Clinical cancer research (01.05.2018)
Published in Clinical cancer research (01.05.2018)
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Journal Article
Quantifying ERK activity in response to inhibition of the BRAFV600E-MEK-ERK cascade using mathematical modelling
Hamis, Sara J., Kapelyukh, Yury, McLaren, Aileen, Henderson, Colin J., Roland Wolf, C., Chaplain, Mark A. J.
Published in British journal of cancer (23.11.2021)
Published in British journal of cancer (23.11.2021)
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Journal Article
Aryl hydrocarbon receptor is required for optimal B‐cell proliferation
Villa, Matteo, Gialitakis, Manolis, Tolaini, Mauro, Ahlfors, Helena, Henderson, Colin J, Wolf, C Roland, Brink, Robert, Stockinger, Brigitta
Published in The EMBO journal (04.01.2017)
Published in The EMBO journal (04.01.2017)
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Journal Article
Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer
MacLeod, A Kenneth, Acosta-Jimenez, Lourdes, Coates, Philip J, McMahon, Michael, Carey, Frank A, Honda, Tadashi, Henderson, Colin J, Wolf, C Roland
Published in British journal of cancer (06.12.2016)
Published in British journal of cancer (06.12.2016)
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Journal Article
Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha
Wang, Xiu Jun, Hayes, John D, Henderson, Colin J, Wolf, C. Roland
Published in Proceedings of the National Academy of Sciences - PNAS (04.12.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (04.12.2007)
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Journal Article
Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR
Braeuning, Albert, Gavrilov, Alina, Brown, Susan, Wolf, C Roland, Henderson, Colin J, Schwarz, Michael
Published in Toxicological sciences (01.08.2014)
Published in Toxicological sciences (01.08.2014)
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Journal Article
Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of Nrf2 by cancer chemotherapeutic agents
XIU JUN WANG, HAYES, John D, WOLF, C. Roland
Published in Cancer research (Chicago, Ill.) (15.11.2006)
Published in Cancer research (Chicago, Ill.) (15.11.2006)
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Journal Article
In Vivo Regulation of Human Glutathione Transferase GSTP by Chemopreventive Agents
HENDERSON, Colin J, MCLAREN, Aileen W, WOLF, C. Roland
Published in Cancer research (Chicago, Ill.) (15.08.2014)
Published in Cancer research (Chicago, Ill.) (15.08.2014)
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Journal Article
Constitutive androstane receptor 1 is constitutively bound to chromatin and 'primed' for transactivation in hepatocytes
McMahon, Michael, Ding, Shaohong, Jimenez, Lourdes Acosta, Terranova, Remi, Gerard, Marie-Apolline, Vitobello, Antonio, Moggs, Jonathan, Henderson, Colin J, Wolf, C Roland
Published in Molecular pharmacology (01.01.2019)
Published in Molecular pharmacology (01.01.2019)
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Journal Article
NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology
Riddick, David S, Ding, Xinxin, Wolf, C Roland, Porter, Todd D, Pandey, Amit V, Zhang, Qing-Yu, Gu, Jun, Finn, Robert D, Ronseaux, Sebastien, McLaughlin, Lesley A, Henderson, Colin J, Zou, Ling, Flück, Christa E
Published in Drug metabolism and disposition (01.01.2013)
Published in Drug metabolism and disposition (01.01.2013)
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Journal Article
Generation and utility of genetically humanized mouse models
Scheer, Nico, Snaith, Mike, Wolf, C. Roland, Seibler, Jost
Published in Drug discovery today (01.12.2013)
Published in Drug discovery today (01.12.2013)
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Journal Article
A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response
Scheer, Nico, Ross, Jillian, Rode, Anja, Zevnik, Branko, Niehaves, Sandra, Faust, Nicole, Wolf, C Roland
Published in The Journal of clinical investigation (01.09.2008)
Published in The Journal of clinical investigation (01.09.2008)
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Journal Article
Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel haem oxygenase 1 reporter mouse
McMahon, Michael, Ding, Shaohong, Acosta‐Jimenez, Lourdes P., Frangova, Tania G., Henderson, Colin J., Wolf, C. Roland
Published in The Journal of physiology (01.01.2018)
Published in The Journal of physiology (01.01.2018)
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Journal Article
Potential of in vivo stress reporter models to reduce animal use and provide mechanistic insights in toxicity studies [version 1; peer review: 2 approved]
Iñesta Vaquera, Francisco, Ferro, Febe, McMahon, Michael, Henderson, Colin J., Wolf, C. Roland
Published in F1000 research (2022)
Published in F1000 research (2022)
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Journal Article
Improving the predictive power of xenograft and syngeneic anti-tumour studies using mice humanised for pathways of drug metabolism [version 2; peer review: 2 approved]
Henderson, Colin J., McLaren, Aileen W., Kapelyukh, Yury, Wolf, C. Roland
Published in F1000 research (01.01.2022)
Published in F1000 research (01.01.2022)
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Journal Article
Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line
Hasegawa, Maki, Kapelyukh, Yury, Tahara, Harunobu, Seibler, Jost, Rode, Anja, Krueger, Sylvia, Lee, Dongtao N, Wolf, C Roland, Scheer, Nico
Published in Molecular pharmacology (01.09.2011)
Published in Molecular pharmacology (01.09.2011)
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