Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies
Moilanen, Anu-Maarit, Riikonen, Reetta, Oksala, Riikka, Ravanti, Laura, Aho, Eija, Wohlfahrt, Gerd, Nykänen, Pirjo S., Törmäkangas, Olli P., Palvimo, Jorma J., Kallio, Pekka J.
Published in Scientific reports (03.07.2015)
Published in Scientific reports (03.07.2015)
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Journal Article
A vertebrate model for the study of lipid binding/transfer protein function: Conservation of OSBP-related proteins between zebrafish and human
Zhou, You, Wohlfahrt, Gerd, Paavola, Jere, Olkkonen, Vesa M.
Published in Biochemical and biophysical research communications (11.04.2014)
Published in Biochemical and biophysical research communications (11.04.2014)
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Journal Article
The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket
Suchanek, Monika, Hynynen, Riikka, Wohlfahrt, Gerd, Lehto, Markku, Johansson, Marie, Saarinen, Hannu, Radzikowska, Anna, Thiele, Christoph, Olkkonen, Vesa M
Published in Biochemical journal (01.08.2007)
Published in Biochemical journal (01.08.2007)
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Journal Article
Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors
Goswami, Rajeev, Mukherjee, Subhendu, Wohlfahrt, Gerd, Ghadiyaram, Chakshusmathi, Nagaraj, Jwala, Chandra, Beeram Ravi, Sistla, Ramesh K, Satyam, Leena K, Samiulla, Dodheri S, Moilanen, Anu, Subramanya, Hosahalli S, Ramachandra, Murali
Published in ACS medicinal chemistry letters (12.12.2013)
Published in ACS medicinal chemistry letters (12.12.2013)
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Journal Article
Novel small molecule inhibitors for prostate-specific antigen
Koistinen, Hannu, Wohlfahrt, Gerd, Mattsson, Johanna M., Wu, Ping, Lahdenperä, Juhani, Stenman, Ulf-Håkan
Published in The Prostate (01.08.2008)
Published in The Prostate (01.08.2008)
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Journal Article
Faulty Epithelial Polarity Genes and Cancer
Tervonen, Topi A., Partanen, Johanna I., Saarikoski, Sirkku T., Myllynen, Mikko, Marques, Elsa, Paasonen, Katriina, Moilanen, Anu, Wohlfahrt, Gerd, Kovanen, Panu E., Klefstrom, Juha
Published in Advances in Cancer Research (2011)
Published in Advances in Cancer Research (2011)
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Book Chapter
Journal Article
Analysis of the Munc18b-Syntaxin Binding Interface
Kauppi, Maria, Wohlfahrt, Gerd, Olkkonen, Vesa M.
Published in The Journal of biological chemistry (01.11.2002)
Published in The Journal of biological chemistry (01.11.2002)
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Journal Article
First-in-Class Small Molecule to Inhibit CYP11A1 and Steroid Hormone Biosynthesis
Karimaa, Mari, Riikonen, Reetta, Kettunen, Henna, Taavitsainen, Päivi, Ramela, Meri, Chrusciel, Marcin, Karlsson, Stefan, Rummakko, Petteri, Simola, Outi, Wohlfahrt, Gerd, Hakulinen, Pasi, Vuorela, Annamari, Joensuu, Heikki, Utriainen, Tapio, Fizazi, Karim, Oksala, Riikka
Published in Molecular cancer therapeutics (02.12.2022)
Published in Molecular cancer therapeutics (02.12.2022)
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Journal Article
Abstract 1250: ODM-208, a novel, small-molecule CYP11A1 inhibitor, demonstrates strong inhibition of steroid biosynthesis and antitumor activity in castration-resistant prostate cancer (CRPC) model
Karimaa, Mari, Kettunen, Henna, Ramela, Meri, Mansikka-Savolainen, Suvi, Chrusciel, Marcin, Simola, Outi, Taavitsainen, Päivi, Wohlfahrt, Gerd, Rummakko, Petteri, Vuorela, Annamari, Fizazi, Karim, Oksala, Riikka
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21
Göricke, Fabian, Vu, Victoria, Smith, Leanna, Scheib, Ulrike, Böhm, Raphael, Akkilic, Namik, Wohlfahrt, Gerd, Weiske, Jörg, Bömer, Ulf, Brzezinka, Krzysztof, Lindner, Niels, Lienau, Philip, Gradl, Stefan, Beck, Hartmut, Brown, Peter J., Santhakumar, Vijayaratnam, Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Schmees, Norbert, Petersen, Kirstin
Published in Journal of medicinal chemistry (09.03.2023)
Published in Journal of medicinal chemistry (09.03.2023)
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Journal Article
TEAD 억제제
RUMMAKKO PETTERI, WOHLFAHRT GERD, NOUTSIAS DIMITRIS, DIN BELLE DAVID, PIETIKAINEN PEKKA, SIPILA JULIUS, AHLMARK MARKO
Year of Publication 22.12.2023
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Year of Publication 22.12.2023
Patent
ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity
Holmström, Tim H, Moilanen, Anu-Maarit, Ikonen, Tarja, Björkman, Mari L, Linnanen, Tero, Wohlfahrt, Gerd, Karlsson, Stefan, Oksala, Riikka, Korjamo, Timo, Samajdar, Susanta, Rajagopalan, Srinivasan, Chelur, Shekar, Narayanan, Kishore, Ramachandra, Raghuveer K, Mani, Jiju, Nair, Rashmi, Gowda, Nagaraj, Anthony, Thomas, Dhodheri, Samiulla, Mukherjee, Subhendu, Ujjinamatada, Ravi K, Srinivas, Nanduri, Ramachandra, Murali, Kallio, Pekka J
Published in Molecular cancer therapeutics (01.01.2019)
Published in Molecular cancer therapeutics (01.01.2019)
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Journal Article
Abstract 1143: Evaluation of AU-18069, a novel small molecule CBP/p300 bromodomain inhibitor for the treatment of cancers
Abbineni, Chandrasekhar, Thiyagarajan, Saravanan, Senaiar, Ramesh S, Mukherjee, Subhendu, Jaleel, Mahaboobi, Marappan, Sivapriya, N R, Raghavendra, Renukappa, Girish Aggunda, B, Aravind A, R, Naveen Kumar, Reddy, Venkata Siva, Babu, Asha, Srinivas, Akhila, Yadlapalli, Prasad, Gore, Suraj T, Hemasankar, Pathange, Dey, Mamon, S, Samiulla D, Naik, Chandranath D, Antony, Thomas, Nellore, Kavitha, Chelur, Shekar, Daginakatte, Girish, Myllymäki, Mikko, Wohlfahrt, Gerd, Ramachandra, Murali, Samajdar, Susanta
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Discovery and characterization of ORM‐11372, a novel inhibitor of the sodium‐calcium exchanger with positive inotropic activity
Otsomaa, Leena, Levijoki, Jouko, Wohlfahrt, Gerd, Chapman, Hugh, Koivisto, Ari‐Pekka, Syrjänen, Kaisa, Koskelainen, Tuula, Peltokorpi, Saara‐Elisa, Finckenberg, Piet, Heikkilä, Aira, Abi‐Gerges, Najah, Ghetti, Andre, Miller, Paul E., Page, Guy, Mervaala, Eero, Nagy, Norbert, Kohajda, Zsófia, Jost, Norbert, Virág, László, Varró, András, Papp, Julius Gy
Published in British journal of pharmacology (01.12.2020)
Published in British journal of pharmacology (01.12.2020)
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Journal Article