Model-Based Evaluation of the Impact of Formulation and Food Intake on the Complex Oral Absorption of Mavoglurant in Healthy Subjects
Wendling, Thierry, Ogungbenro, Kayode, Pigeolet, Etienne, Dumitras, Swati, Woessner, Ralph, Aarons, Leon
Published in Pharmaceutical research (01.05.2015)
Published in Pharmaceutical research (01.05.2015)
Get full text
Journal Article
Novel Bruton’s Tyrosine Kinase inhibitor remibrutinib: Drug‐drug interaction potential as a victim of CYP3A4 inhibitors based on clinical data and PBPK modeling
Huth, Felix, Schiller, Hilmar, Jin, Yi, Poller, Birk, Schuhler, Carole, Weis, Wendy, Woessner, Ralph, Drollmann, Anton, End, Peter
Published in Clinical and translational science (01.01.2022)
Published in Clinical and translational science (01.01.2022)
Get full text
Journal Article
Ligelizumab treatment for severe asthma: learnings from the clinical development programme
Trischler, Jordis, Bottoli, Ivan, Janocha, Reinhold, Heusser, Christoph, Jaumont, Xavier, Lowe, Phil, Gautier, Aurelie, Pethe, Abhijit, Woessner, Ralph, Zerwes, Hans‐Günter, Zielen, Stefan
Published in Clinical & translational immunology (2021)
Published in Clinical & translational immunology (2021)
Get full text
Journal Article
Comprehensive Assessment of Pharmacokinetics, Pharmacodynamics, and Tolerability of Ligelizumab in Healthy Volunteers and Patients with Chronic Spontaneous Urticaria to Optimize Its Subcutaneous Delivery System
Ji, Yan, Calonder, Claudio, Kirsilä, Tiina, Burciu, Alis, Tisu, Matjaz, Joubert, Yolandi, Laurent, Nathalie, Hua, Eva, Patekar, Manmath, Drollmann, Anton, Woessner, Ralph
Published in Pharmaceutics (01.09.2023)
Published in Pharmaceutics (01.09.2023)
Get full text
Journal Article
P174 - Absorption, distribution, metabolism, and excretion of tropifexor, a potent FXR agonist for the treatment of NASH, following a single oral 1 mg dose of [14C]tropifexor in healthy male subjects
Wang-Lakshman, Lydia, Miao, Zhuang, Gu, Jessie, Choudhury, Subhajit, McNamara, Elizabeth, Walles, Markus, Woessner, Ralph, Camenisch, Gian, Chen, Jin
Published in Drug metabolism and pharmacokinetics (2020)
Published in Drug metabolism and pharmacokinetics (2020)
Get full text
Journal Article
Intravenous Dosing as an Alternate Approach to Safely Achieve Supratherapeutic Exposure for Assessments of Cardiac Repolarization: A Randomized Clinical Trial with Mavoglurant (AFQ056)
Ufer, Mike, MD, PhD, Sagkriotis, Alexandros, PhD, Salunke, Atish, MPharm, Ganesan, Subramanian, PhD, Tisserant, Anne, PhD, Dodman, Angela, PhD, Voltz, Emilie, PhD, Woessner, Ralph, PhD, Jordaan, Pierre, MD, Legangneux, Eric, MD
Published in Clinical therapeutics (01.12.2016)
Published in Clinical therapeutics (01.12.2016)
Get full text
Journal Article
Cardiac safety of indacaterol in healthy subjects: a randomized, multidose, placebo- and positive-controlled, parallel-group thorough QT study
Khindri, Sanjeev, Sabo, Ronald, Harris, Stuart, Woessner, Ralph, Jennings, Simon, Drollmann, Anton F
Published in BMC pulmonary medicine (26.05.2011)
Published in BMC pulmonary medicine (26.05.2011)
Get full text
Journal Article
Treatment with anticoagulants in cerebral events (TRACE)
Woessner, Ralph, Grauer, Markus, Bianchi, Oliver, Mueller, Martin, Moersdorf, Stefan, Berlit, Peter, Goertler, Michael, Grotemeyer, Karl-Heinz, Sliwka, Ulrich, Stoll, Martin, Treib, Johannes
Published in Thrombosis and haemostasis (01.04.2004)
Published in Thrombosis and haemostasis (01.04.2004)
Get more information
Journal Article
Novel Bruton's tyrosine kinase inhibitor remibrutinib: Assessment of drug-drug interaction potential as a perpetrator of cytochrome P450 enzymes and drug transporters and the impact of covalent binding on possible drug interactions
Schiller, Hilmar, Huth, Felix, Schuhler, Carole, Drollmann, Anton, Kaul, Martin, Woessner, Ralph, Shah, Bharti, Weis, Wendy, End, Peter
Published in European journal of pharmaceutical sciences (01.05.2022)
Published in European journal of pharmaceutical sciences (01.05.2022)
Get full text
Journal Article
Secukinumab Treatment Does Not Alter the Pharmacokinetics of the Cytochrome P450 3A4 Substrate Midazolam in Patients With Moderate to Severe Psoriasis
Bruin, Gerard, Hasselberg, Anke, Koroleva, Irina, Milojevic, Julie, Calonder, Claudio, Soon, Rachel, Woessner, Ralph, Pariser, David M., Boutouyrie‐Dumont, Bruno
Published in Clinical pharmacology and therapeutics (01.12.2019)
Published in Clinical pharmacology and therapeutics (01.12.2019)
Get full text
Journal Article
Drug‐Drug Interaction Studies to Evaluate the Effect of Inhibition of UGT1A1 and CYP3A4 and Induction of CYP3A4 on the Pharmacokinetics of Tropifexor in Healthy Subjects
Chen, Jin, Stringer, Rowan, Shah, Bharti, Gu, Jessie, Zhang, Yiming, Hackling, Melissa, Prince, William, Woessner, Ralph
Published in Clinical pharmacology in drug development (01.11.2022)
Published in Clinical pharmacology in drug development (01.11.2022)
Get full text
Journal Article
Comparison of pharmacokinetics, safety and tolerability of secukinumab administered subcutaneously using different delivery systems in healthy volunteers and in psoriasis patients
Bruin, Gerard, Hockey, Hans‐Ulrich P., La Stella, Phillip, Sigurgeirsson, Bárdur, Fu, Rong, Patekar, Manmath, Charef, Pascal, Woessner, Ralph, Boutouyrie‐Dumont, Bruno
Published in British journal of clinical pharmacology (01.02.2020)
Published in British journal of clinical pharmacology (01.02.2020)
Get full text
Journal Article
Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1-mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependence of Tropifexor Metabolism
Wang-Lakshman, Lydia, Miao, Zhuang, Wang, Lai, Gu, Helen, Kagan, Mark, Gu, Jessie, McNamara, Elizabeth, Walles, Markus, Woessner, Ralph, Camenisch, Gian, Einolf, Heidi J, Chen, Jin
Published in Drug metabolism and disposition (01.07.2021)
Published in Drug metabolism and disposition (01.07.2021)
Get full text
Journal Article
Pharmacokinetics of Tropifexor, a Potent Farnesoid X Receptor Agonist, in Participants With Varying Degrees of Hepatic Impairment
Chen, Jin, Gu, Jessie, Shah, Bharti, Stringer, Rowan, Reis da Silva Torrao, Leonel, Hackling, Melissa, Nidamarthy, Prasanna Kumar, Prince, William T, Woessner, Ralph
Published in Journal of clinical pharmacology (01.04.2022)
Published in Journal of clinical pharmacology (01.04.2022)
Get more information
Journal Article
CYP3A but not P‐gp plays a relevant role in the in vivo intestinal and hepatic clearance of the delta‐specific phosphoinositide‐3 kinase inhibitor leniolisib
De Buck, Stefan, Kucher, Klaus, Hara, Hisanori, Gray, Cathy, Woessner, Ralph
Published in Biopharmaceutics & drug disposition (01.09.2018)
Published in Biopharmaceutics & drug disposition (01.09.2018)
Get full text
Journal Article
Absorption, Distribution, Metabolism, and Excretion of the Oral Prostaglandin D2 Receptor 2 Antagonist Fevipiprant (QAW039) in Healthy Volunteers and In Vitro
Pearson, David, Weiss, H Markus, Jin, Yi, Jaap van Lier, Jan, Erpenbeck, Veit J, Glaenzel, Ulrike, End, Peter, Woessner, Ralph, Eggimann, Fabian, Camenisch, Gian
Published in Drug metabolism and disposition (01.07.2017)
Published in Drug metabolism and disposition (01.07.2017)
Get full text
Journal Article
A Study to Evaluate Relative Bioavailability, Food Effect, and Pharmacodynamics of Tropifexor, a Farnesoid X Receptor Agonist, in Healthy Participants
Stringer, Rowan, Chen, Jin, Shah, Bharti, Gu, Jessie, Zhang, Yiming, Prince, William, Klickstein, Lloyd B., Woessner, Ralph
Published in Clinical pharmacology in drug development (01.02.2023)
Published in Clinical pharmacology in drug development (01.02.2023)
Get full text
Journal Article
Fevipiprant has a low risk of influencing co-medication pharmacokinetics: Impact on simvastatin and rosuvastatin in different SLCO1B1 genotypes
Poller, Birk, Woessner, Ralph, Barve, Avantika, Tillmann, Hanns-Christian, Vemula, Janardhana, Nica, Alexandra, Elbast, Walid, Schiller, Hilmar, End, Peter, Camenisch, Gian, Weiss, Markus
Published in Pulmonary pharmacology & therapeutics (01.08.2019)
Published in Pulmonary pharmacology & therapeutics (01.08.2019)
Get full text
Journal Article
Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion
Dragatin, Christian, Polus, Florine, Bodenlenz, Manfred, Calonder, Claudio, Aigner, Birgit, Tiffner, Katrin Irene, Mader, Julia Katharina, Ratzer, Maria, Woessner, Ralph, Pieber, Thomas Rudolf, Cheng, Yi, Loesche, Christian, Sinner, Frank, Bruin, Gerard
Published in Experimental dermatology (01.02.2016)
Published in Experimental dermatology (01.02.2016)
Get full text
Journal Article
Pharmacokinetics of indacaterol and mometasone furoate delivered alone or in a free or fixed dose combination in healthy subjects
Vaidya, Soniya S, Khindri, Sanjeev, Calder, Nicole, Machineni, Surendra, Hara, Hisanori, Majumdar, Tapan, Febbraro, Salvatore, Fuhr, Rainard, Woessner, Ralph
Published in Pulmonary pharmacology & therapeutics (01.04.2016)
Published in Pulmonary pharmacology & therapeutics (01.04.2016)
Get full text
Journal Article