Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand
Liu, Longbin, Prime, Michael E, Lee, Matt R, Khetarpal, Vinod, Brown, Christopher J, Johnson, Peter D, Miranda-Azpiazu, Patricia, Chen, Xuemei, Clark-Frew, Daniel, Coe, Samuel, Davis, Randall, Dickie, Anthony, Ebneth, Andreas, Esposito, Simone, Gadouleau, Elise, Gai, Xinjie, Galan, Sebastien, Green, Samantha, Greenaway, Catherine, Giles, Paul, Halldin, Christer, Hayes, Sarah, Herbst, Todd, Herrmann, Frank, Heßmann, Manuela, Jia, Zhisheng, Kiselyov, Alexander, Kotey, Adrian, Krulle, Thomas, Mangette, John E, Marston, Richard W, Menta, Sergio, Mills, Matthew R, Monteagudo, Edith, Nag, Sangram, Nibbio, Martina, Orsatti, Laura, Schaertl, Sabine, Scheich, Christoph, Sproston, Joanne, Stepanov, Vladimir, Svedberg, Marie, Takano, Akihiro, Taylor, Malcolm, Thomas, Wayne, Toth, Miklós, Vaidya, Darshan, Vanräs, Katarina, Weddell, Derek, Wigginton, Ian, Wityak, John, Mrzljak, Ladislav, Munoz-Sanjuan, Ignacio, Bard, Jonathan A, Dominguez, Celia
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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Journal Article
[C-11]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins
Liu, Longbin, Johnson, Peter D., Prime, Michael E., Khetarpal, Vinod, Lee, Matthew R., Brown, Christopher J., Chen, Xuemei, Clark-Frew, Daniel, Coe, Samuel, Conlon, Mike, Davis, Randall, Ensor, Samantha, Esposito, Simone, Moren, Anton Forsberg, Gai, Xinjie, Green, Samantha, Greenaway, Catherine, Haber, James, Halldin, Christer, Hayes, Sarah, Herbst, Todd, Herrmann, Frank, He-mann, Manuela, Hsai, Ming Min, Kotey, Adrian, Mangette, John E., Mills, Matthew R., Monteagudo, Edith, Nag, Sangram, Nibbio, Martina, Orsatti, Laura, Schaertl, Sabine, Scheich, Christoph, Sproston, Joanne, Stepanov, Vladimir, Varnas, Katarina, Varrone, Andrea, Wityak, John, Mrzljak, Ladislav, Munoz-Sanjuan, Ignacio, Bard, Jonathan A., Dominguez, Celia
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
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Bisbenzamidine isoxazoline derivatives as factor Xa inhibitors
Quan, M.L., Pruitt, J.R., Ellis, C.D., Liauw, A.Y., Galemmo, R.A., Stouten, P.F.W., Wityak, J., Knabb, R.M., Thoolen, M.J., Wong, P.C., Wexler, R.R.
Published in Bioorganic & medicinal chemistry letters (04.11.1997)
Published in Bioorganic & medicinal chemistry letters (04.11.1997)
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Discovery of N-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays
Lombardo, Louis J, Lee, Francis Y, Chen, Ping, Norris, Derek, Barrish, Joel C, Behnia, Kamelia, Castaneda, Stephen, Cornelius, Lyndon A. M, Das, Jagabandhu, Doweyko, Arthur M, Fairchild, Craig, Hunt, John T, Inigo, Ivan, Johnston, Kathy, Kamath, Amrita, Kan, David, Klei, Herbert, Marathe, Punit, Pang, Suhong, Peterson, Russell, Pitt, Sidney, Schieven, Gary L, Schmidt, Robert J, Tokarski, John, Wen, Mei-Li, Wityak, John, Borzilleri, Robert M
Published in Journal of medicinal chemistry (30.12.2004)
Published in Journal of medicinal chemistry (30.12.2004)
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Longitudinal Small-Animal PET Imaging of the zQ175 Mouse Model of Huntington Disease Shows In Vivo Changes of Molecular Targets in the Striatum and Cerebral Cortex
Häggkvist, Jenny, Tóth, Miklós, Tari, Lenke, Varnäs, Katarina, Svedberg, Marie, Forsberg, Anton, Nag, Sangram, Dominguez, Celia, Munoz-Sanjuan, Ignacio, Bard, Jonathan, Wityak, John, Varrone, Andrea, Halldin, Christer, Mrzljak, Ladislav
Published in Journal of Nuclear Medicine (01.04.2017)
Published in Journal of Nuclear Medicine (01.04.2017)
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Biaryl substituted alkylboronate esters as thrombin inhibitors
Quan, M.L., Wityak, J., Dominguez, C., Duncia, J.V., Kettner, C.A., Ellis, C.D., Liauw, A.Y., Park, J.M., Santella, J.B., Knabb, R.M., Thoolen, M.J., Weber, P.C., Wexler, R.R.
Published in Bioorganic & medicinal chemistry letters (08.07.1997)
Published in Bioorganic & medicinal chemistry letters (08.07.1997)
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M20Activation Of The Trkb Receptor Pathway Using A Novel Monoclonal Antibody Agonist: Implications For The Treatment Of Huntington's Disease
Carty, N, Schmidt, L, Bursow, G, Schwagarus, T, Graff, C, Damrath, E, Kuhlbrodt, K, Kohler, M, Koeplin, S, Salomon, K, Jaeger, S, Gemkow, M, von der Kammer, H, Wityak, J, Munoz-Sanjuan, I, Bard, J
Published in Journal of neurology, neurosurgery and psychiatry (01.09.2014)
Published in Journal of neurology, neurosurgery and psychiatry (01.09.2014)
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Journal Article
M20 Activation Of The Trkb Receptor Pathway Using A Novel Monoclonal Antibody Agonist: Implications For The Treatment Of Huntington's Disease
Carty, N., Schmidt, L., Bursow, G., Schwagarus, T., Graff, C., Damrath, E., Kuhlbrodt, K., Kohler, M., Koeplin, S., Salomon, K., Jager, S., Gemkow, M., von der Kammer, H., Wityak, J., Munoz-Sanjuan, I., Bard, J.
Published in Journal of neurology, neurosurgery and psychiatry (01.09.2014)
Published in Journal of neurology, neurosurgery and psychiatry (01.09.2014)
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N-Acylthiadiazolines, a New Class of Liver X Receptor Agonists with Selectivity for LXRβ
Molteni, Valentina, Li, Xiaolin, Nabakka, Juliet, Liang, Fang, Wityak, John, Koder, Alan, Vargas, Leo, Romeo, Russell, Mitro, Nico, Mak, Puiying A, Seidel, H. Martin, Haslam, Jennifer A, Chow, Donald, Tuntland, Tove, Spalding, Tracy A, Brock, Ansgar, Bradley, Michelle, Castrillo, Antonio, Tontonoz, Peter, Saez, Enrique
Published in Journal of medicinal chemistry (23.08.2007)
Published in Journal of medicinal chemistry (23.08.2007)
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Identification of chemokine receptor CCR4 antagonist
Purandare, Ashok V., Gao, Aiming, Wan, Honghe, Somerville, John, Burke, Christine, Seachord, Carrie, Vaccaro, Wayne, Wityak, John, Poss, Michael A.
Published in Bioorganic & medicinal chemistry letters (16.05.2005)
Published in Bioorganic & medicinal chemistry letters (16.05.2005)
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Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56(lck) inhibitors
Das, Jagabandhu, Moquin, Robert V, Lin, James, Liu, Chunjian, Doweyko, Arthur M, DeFex, Henry F, Fang, Qiong, Pang, Suhong, Pitt, Sidney, Shen, Ding Ren, Schieven, Gary L, Barrish, Joel C, Wityak, John
Published in Bioorganic & medicinal chemistry letters (04.08.2003)
Published in Bioorganic & medicinal chemistry letters (04.08.2003)
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Selective Itk Inhibitors Block T-Cell Activation and Murine Lung Inflammation
Lin, Tai-An, McIntyre, Kim W, Das, Jagabandhu, Liu, Chunjian, O'Day, Kathleen D, Penhallow, Becky, Hung, Chen-Yi, Whitney, Gena S, Shuster, David J, Yang, XiaoXia, Townsend, Robert, Postelnek, Jennifer, Spergel, Steven H, Lin, James, Moquin, Robert V, Furch, Joseph A, Kamath, Amrita V, Zhang, Hongjian, Marathe, Punit H, Perez-Villar, Juan J, Doweyko, Arthur, Killar, Loran, Dodd, John H, Barrish, Joel C, Wityak, John, Kanner, Steven B
Published in Biochemistry (Easton) (31.08.2004)
Published in Biochemistry (Easton) (31.08.2004)
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Journal Article
Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors
Das, Jagabandhu, Furch, Joseph A., Liu, Chunjian, Moquin, Robert V., Lin, James, Spergel, Steven H., McIntyre, Kim W., Shuster, David J., O’Day, Kathleen D., Penhallow, Becky, Hung, Chen-Yi, Doweyko, Arthur M., Kamath, Amrita, Zhang, Hongjian, Marathe, Punit, Kanner, Steven B., Lin, Tai-An, Dodd, John H., Barrish, Joel C., Wityak, John
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
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Journal Article
5-Cyanopyrimidine Derivatives as a Novel Class of Potent, Selective, and Orally Active Inhibitors of p38α MAP Kinase
Liu, Chunjian, Wrobleski, Stephen T, Lin, James, Ahmed, Gulzar, Metzger, Axel, Wityak, John, Gillooly, Kathleen M, Shuster, David J, McIntyre, Kim W, Pitt, Sidney, Shen, Ding Ren, Zhang, Rosemary F, Zhang, Hongjian, Doweyko, Arthur M, Diller, David, Henderson, Ian, Barrish, Joel C, Dodd, John H, Schieven, Gary L, Leftheris, Katerina
Published in Journal of medicinal chemistry (06.10.2005)
Published in Journal of medicinal chemistry (06.10.2005)
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Journal Article
Imidazoquinoxaline Src-family kinase p56(Lck) inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo[1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity
Chen, P, Doweyko, AM, Norris, D, Gu, HH, Spergel, SH, Das, J, Moquin, RV, Lin, J, Wityak, J, Iwanowicz, EJ, McIntyre, KW, Shuster, DJ, Behnia, K, Chong, S, de Fex, H, Pang, SH, Pitt, S, Shen, DR, Thrall, S, Stanley, P, Kocy, OR, Witmer, MR, Kanner, SB, Schieven, GL, Barrish, JC
Published in Journal of medicinal chemistry (26.08.2004)
Published in Journal of medicinal chemistry (26.08.2004)
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Journal Article
The Discovery of Orally Active Triaminotriazine Aniline Amides as Inhibitors of p38 MAP Kinase
Leftheris, Katerina, Ahmed, Gulzar, Chan, Ran, Dyckman, Alaric J, Hussain, Zahid, Ho, Kan, Hynes, John, Letourneau, Jeffrey, Li, Wei, Lin, Shuqun, Metzger, Axel, Moriarty, Kevin J, Riviello, Chris, Shimshock, Yvonne, Wen, James, Wityak, John, Wrobleski, Stephen T, Wu, Hong, Wu, Junjun, Desai, Madhuri, Gillooly, Kathleen M, Lin, Tsung H, Loo, Derek, McIntyre, Kim W, Pitt, Sidney, Shen, Ding Ren, Shuster, David J, Zhang, Rosemary, Diller, David, Doweyko, Arthur, Sack, John, Baldwin, Jack, Barrish, Joel, Dodd, John, Henderson, Ian, Kanner, Steve, Schieven, Gary L, Webb, Maria
Published in Journal of medicinal chemistry (02.12.2004)
Published in Journal of medicinal chemistry (02.12.2004)
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Journal Article
Imaging Mutant Huntingtin Aggregates: Development of Potential PET Ligands
Brown, CJ, Prime, M, Clark-Frew, D, Schaertl, S, Haggkvist, J, Halldin, C, Stepanov, V, Varrone, A, Varnas, K, Svedberg, M, Munoz-Sanjuan, I, Khetarpal, V, Bard, J, Wityak, J, Dominguez, C
Published in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2015)
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Published in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2015)
Conference Proceeding
Molecular design, synthesis, and structure-Activity relationships leading to the potent and selective p56(lck) inhibitor BMS-243117
Das, Jagabandhu, Lin, James, Moquin, Robert V, Shen, Zhongqi, Spergel, Steven H, Wityak, John, Doweyko, Arthur M, DeFex, Henry F, Fang, Qiong, Pang, Suhong, Pitt, Sidney, Shen, Ding Ren, Schieven, Gary L, Barrish, Joel C
Published in Bioorganic & medicinal chemistry letters (07.07.2003)
Published in Bioorganic & medicinal chemistry letters (07.07.2003)
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Journal Article
Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck)
Wityak, John, Das, Jagabandhu, Moquin, Robert V, Shen, Zhongqi, Lin, James, Chen, Ping, Doweyko, Arthur M, Pitt, Sidney, Pang, Suhong, Shen, Ding Ren, Fang, Qiong, de Fex, Henry F, Schieven, Gary L, Kanner, Steven B, Barrish, Joel C
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
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Journal Article
Discovery and SAR of 2-amino-5-[(thiomethyl)aryl]thiazoles as potent and selective Itk inhibitors
Das, Jagabandhu, Liu, Chunjian, Moquin, Robert V., Lin, James, Furch, Joseph A., Spergel, Steven H., McIntyre, Kim W., Shuster, David J., O’Day, Kathleen D., Penhallow, Becky, Hung, Chen-Yi, Kanner, Steven B., Lin, Tai-An, Dodd, John H., Barrish, Joel C., Wityak, John
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Journal Article