Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1
Schnute, Mark E, McReynolds, Matthew D, Kasten, Tom, Yates, Matthew, Jerome, Gina, Rains, John W, Hall, Troii, Chrencik, Jill, Kraus, Michelle, Cronin, Ciaran N, Saabye, Matthew, Highkin, Maureen K, Broadus, Richard, Ogawa, Shinji, Cukyne, Kristin, Zawadzke, Laura E, Peterkin, Vincent, Iyanar, Kaliapan, Scholten, Jeffrey A, Wendling, Jay, Fujiwara, Hideji, Nemirovskiy, Olga, Wittwer, Arthur J, Nagiec, Marek M
Published in Biochemical journal (15.05.2012)
Published in Biochemical journal (15.05.2012)
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The advantages of describing covalent inhibitor in vitro potencies by IC50 at a fixed time point. IC50 determination of covalent inhibitors provides meaningful data to medicinal chemistry for SAR optimization
Thorarensen, Atli, Balbo, Paul, Banker, Mary E., Czerwinski, Robert M., Kuhn, Max, Maurer, Tristan S., Telliez, Jean-Baptiste, Vincent, Fabien, Wittwer, Arthur J.
Published in Bioorganic & medicinal chemistry (01.01.2021)
Published in Bioorganic & medicinal chemistry (01.01.2021)
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Reconstitution of the alternative pathway of the complement system enables rapid delineation of the mechanism of action of novel inhibitors
Goodrich, Andrew C., LeClair, Norbert P., Shillova, Nita, Morton, William D., Wittwer, Arthur J., Loyet, Kelly M., Hannoush, Rami N.
Published in The Journal of biological chemistry (01.07.2024)
Published in The Journal of biological chemistry (01.07.2024)
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Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis
Chavarria-Smith, Joseph, Chiu, Cecilia P C, Jackman, Janet K, Yin, Jianping, Zhang, Juan, Hackney, Jason A, Lin, Wei-Yu, Tyagi, Tulika, Sun, Yonglian, Tao, Janet, Dunlap, Debra, Morton, William D, Ghodge, Swapnil V, Maun, Henry R, Li, Hong, Hernandez-Barry, Hilda, Loyet, Kelly M, Chen, Emily, Liu, John, Tam, Christine, Yaspan, Brian L, Cai, Hao, Balazs, Mercedesz, Arron, Joseph R, Li, Jing, Wittwer, Arthur J, Pappu, Rajita, Austin, Cary D, Lee, Wyne P, Lazarus, Robert A, Sudhamsu, Jawahar, Koerber, James T, Yi, Tangsheng
Published in Science translational medicine (14.12.2022)
Published in Science translational medicine (14.12.2022)
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A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation
Gierse, James, Thorarensen, Atli, Beltey, Konstantine, Bradshaw-Pierce, Erica, Cortes-Burgos, Luz, Hall, Troii, Johnston, Amy, Murphy, Michael, Nemirovskiy, Olga, Ogawa, Shinji, Pegg, Lyle, Pelc, Matthew, Prinsen, Michael, Schnute, Mark, Wendling, Jay, Wene, Steve, Weinberg, Robin, Wittwer, Arthur, Zweifel, Ben, Masferrer, Jaime
Published in The Journal of pharmacology and experimental therapeutics (01.07.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2010)
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Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A (hTrkA) Inhibitors
Subramanian, Govindan, Johnson, Paul D, Zachary, Theresa, Roush, Nicole, Zhu, Yaqi, Bowen, Scott J, Janssen, Ann, Duclos, Brian A, Williams, Tracey, Javens, Christopher, Shalaly, Nancy Dekki, Molina, Daniel Martinez, Wittwer, Arthur J, Hirsch, Jeffrey L
Published in ACS chemical biology (21.06.2019)
Published in ACS chemical biology (21.06.2019)
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Imidazo[1,5- a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis
Kim, Kyung-Hee, Maderna, Andreas, Schnute, Mark E., Hegen, Martin, Mohan, Shashi, Miyashiro, Joy, Lin, Laura, Li, Evelyn, Keegan, Sean, Lussier, Jennifer, Wrocklage, Christopher, Nickerson-Nutter, Cheryl L., Wittwer, Arthur J., Soutter, Holly, Caspers, Nicole, Han, Seungil, Kurumbail, Ravi, Dunussi-Joannopoulos, Kyri, Douhan, John, Wissner, Allan
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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Aminopyrazole Carboxamide Bruton’s Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning
Schnute, Mark E, Benoit, Stephen E, Buchler, Ingrid P, Caspers, Nicole, Grapperhaus, Margaret L, Han, Seungil, Hotchandani, Rajeev, Huang, Nelson, Hughes, Robert O, Juba, Brian M, Kim, Kyung-Hee, Liu, Erica, McCarthy, Erin, Messing, Dean, Miyashiro, Joy S, Mohan, Shashi, O’Connell, Thomas N, Ohren, Jeffrey F, Parikh, Mihir D, Schmidt, Michelle, Selness, Shaun R, Springer, John R, Thanabal, Venkataraman, Trujillo, John I, Walker, Daniel P, Wan, Zhao-Kui, Withka, Jane M, Wittwer, Arthur J, Wood, Nancy L, Xing, Li, Zapf, Christoph W, Douhan, John
Published in ACS medicinal chemistry letters (10.01.2019)
Published in ACS medicinal chemistry letters (10.01.2019)
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Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors
Tortorella, Micky D., Tomasselli, Alfredo G., Mathis, Karl J., Schnute, Mark E., Woodard, Scott S., Munie, Grace, Williams, Jennifer M., Caspers, Nicole, Wittwer, Arthur J., Malfait, Anne-Marie, Shieh, Huey-Sheng
Published in The Journal of biological chemistry (04.09.2009)
Published in The Journal of biological chemistry (04.09.2009)
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Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors
Wang, Zhigang, Watt, William, Brooks, Nathan A., Harris, Melissa S., Urban, Jan, Boatman, Douglas, McMillan, Michael, Kahn, Michael, Heinrikson, Robert L., Finzel, Barry C., Wittwer, Arthur J., Blinn, James, Kamtekar, Satwik, Tomasselli, Alfredo G.
Published in Biochimica et biophysica acta (01.09.2010)
Published in Biochimica et biophysica acta (01.09.2010)
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High-performance liquid chromatography–tandem mass spectrometry assay of fatty acid amide hydrolase (FAAH) in blood: FAAH inhibition as clinical biomarker
Yapa, Udeni, Prusakiewicz, Jeffery J., Wrightstone, Ann D., Christine, Lori J., Palandra, Joe, Groeber, Elizabeth, Wittwer, Arthur J.
Published in Analytical biochemistry (15.02.2012)
Published in Analytical biochemistry (15.02.2012)
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Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis
SCHNUTE, Mark E, O'BRIEN, Patrick M, CARROLL, Jeffery N, PATT, William C, SHIEH, Huey S, COLLINS, Brandon, PAVLOVSKY, Alexander G, PALMQUIST, Katherine E, ASTON, Karl W, HITCHCOCK, Jeffrey, ROGERS, Michael D, MCDONALD, Joseph, NAHRA, Joe, JOHNSON, Adam R, MUNIE, Grace E, WITTWER, Arthur J, MAN, Chiu-Fai, SETTLE, Steven L, NEMIROVSKIY, Olga, VICKERY, Lillian E, AGAWAL, Arun, DYER, Richard D, SUNYER, Teresa, MORRIS, Mark, HOWARD ROARK, W, HANAU, Cathleen E, RUMINSKI, Peter G, SCHOLTEN, Jeffrey A, FLETCHER, Theresa R, HAMPER, Bruce C
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Substrate-Dependent Inhibition Kinetics of an Active Site-Directed Inhibitor of ADAMTS-4 (Aggrecanase 1)
Wittwer, Arthur J, Hills, Robert L, Keith, Robert H, Munie, Grace E, Arner, Elizabeth C, Anglin, Charles P, Malfait, Anne-Marie, Tortorella, Micky D
Published in Biochemistry (Easton) (29.05.2007)
Published in Biochemistry (Easton) (29.05.2007)
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Differential kinetics and inhibition of purified recombinant tyrosine kinase 2 (TYK-2) and its catalytic domain JH-1
Emmons, Thomas L, Wrightstone, Ann D, Baima, Eric T, Brown, Stacy, Sommers, Cynthia D, Hirsch, Jeffrey L, Pegg, Lyle E, Weinberg, Robin A, Fischer, H David, Wittwer, Arthur J, Tomasselli, Alfredo G
Published in Protein and peptide letters (01.05.2012)
Published in Protein and peptide letters (01.05.2012)
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Expression, purification, and characterization of TYK-2 kinase domain, a member of the Janus kinase family
Korniski, Brian, Wittwer, Arthur J., Emmons, Thomas L., Hall, Troii, Brown, Stacy, Wrightstone, Ann D., Hirsch, Jeffrey L., Gormley, Jennifer A., Weinberg, Robin A., Leone, Joseph W., Day, Jacqueline E., Chrencik, Jill E., Sommers, Cynthia D., Fischer, H. David, Tomasselli, Alfredo G.
Published in Biochemical and biophysical research communications (28.05.2010)
Published in Biochemical and biophysical research communications (28.05.2010)
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Three-dimensional structure of human cytomegalovirus protease
Shieh, Huey-Sheng, Kurumbail, Ravi G, Stevens, Anna M, Stegeman, Roderick A, Sturman, Eric J, Pak, Jina Y, Wittwer, Arthur J, Palmier, Mark O, Wiegand, Roger C, Holwerda, Barry C, Stallings, William C
Published in Nature (London) (19.09.1996)
Published in Nature (London) (19.09.1996)
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Examination of the kinetic mechanism of mitogen-activated protein kinase activated protein kinase-2
Schindler, John F, Godbey, Andrew, Hood, William F, Bolten, Suzanne L, Broadus, Richard M, Kasten, Thomas P, Cassely, Aaron J, Hirsch, Jeffery L, Merwood, Michelle A, Nagy, Mark A, Fok, Kam F, Saabye, Matthew J, Morgan, Heidi M, Compton, Robert P, Mourey, Robert J, Wittwer, Arthur J, Monahan, Joseph B
Published in Biochimica et biophysica acta (29.07.2002)
Published in Biochimica et biophysica acta (29.07.2002)
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Cell-type-specific and site-specific N-glycosylation of type I and type II human tissue plasminogen activator
Parekh, Raj B, Dwek, Raymond A, Thomas, Jerry R, Opdenakker, Ghislain, Rademacher, Thomas W, Wittwer, Arthur J, Howard, Susan C, Nelson, Rickey, Siegel, Ned R, Jennings, M, Harakas, Nikos, Feder, Joseph
Published in Biochemistry (Easton) (01.09.1989)
Published in Biochemistry (Easton) (01.09.1989)
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