The Target Residence Time of Antihistamines Determines Their Antagonism of the G Protein-Coupled Histamine H1 Receptor
Bosma, Reggie, Witt, Gesa, Vaas, Lea A I, Josimovic, Ivana, Gribbon, Philip, Vischer, Henry F, Gul, Sheraz, Leurs, Rob
Published in Frontiers in pharmacology (25.09.2017)
Published in Frontiers in pharmacology (25.09.2017)
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Electronic laboratory notebooks in a public–private partnership
Vaas, Lea A.I, Witt, Gesa, Windshügel, Björn, Bosin, Andrea, Serra, Giovanni, Bruengger, Adrian, Winterhalter, Mathias, Gribbon, Philip, Levy-Petelinkar, Cindy J, Kohler, Manfred
Published in PeerJ. Computer science (19.09.2016)
Published in PeerJ. Computer science (19.09.2016)
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Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1
Pöhner, Ina, Quotadamo, Antonio, Panecka-Hofman, Joanna, Luciani, Rosaria, Santucci, Matteo, Linciano, Pasquale, Landi, Giacomo, Di Pisa, Flavio, Dello Iacono, Lucia, Pozzi, Cecilia, Mangani, Stefano, Gul, Sheraz, Witt, Gesa, Ellinger, Bernhard, Kuzikov, Maria, Santarem, Nuno, Cordeiro-da-Silva, Anabela, Costi, Maria P., Venturelli, Alberto, Wade, Rebecca C.
Published in Journal of medicinal chemistry (14.07.2022)
Published in Journal of medicinal chemistry (14.07.2022)
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The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents
Linciano, Pasquale, Pozzi, Cecilia, Tassone, Giusy, Landi, Giacomo, Mangani, Stefano, Santucci, Matteo, Luciani, Rosaria, Ferrari, Stefania, Santarem, Nuno, Tagliazucchi, Lorenzo, Cordeiro-da-Silva, Anabela, Tonelli, Michele, Tondi, Donatella, Bertarini, Laura, Gul, Sheraz, Witt, Gesa, Moraes, Carolina B., Costantino, Luca, Costi, Maria Paola
Published in European journal of medicinal chemistry (15.01.2024)
Published in European journal of medicinal chemistry (15.01.2024)
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Selection of data sets for FAIRification in drug discovery and development: Which, why, and how?
Alharbi, Ebtisam, Gadiya, Yojana, Henderson, David, Zaliani, Andrea, Delfin-Rossaro, Alejandra, Cambon-Thomsen, Anne, Kohler, Manfred, Witt, Gesa, Welter, Danielle, Juty, Nick, Jay, Caroline, Engkvist, Ola, Goble, Carole, Reilly, Dorothy S, Satagopam, Venkata, Ioannidis, Vassilios, Gu, Wei, Gribbon, Philip
Published in Drug discovery today (01.08.2022)
Published in Drug discovery today (01.08.2022)
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Selection of data sets for FAIRification in drug discovery and development: Which, why, and how?
Alharbi, Ebtisam, Gadiya, Yojana, Henderson, David, Zaliani, Andrea, Delfin-Rossaro, Alejandra, Cambon-Thomsen, Anne, Kohler, Manfred, Witt, Gesa, Welter, Danielle, Juty, Nick, Jay, Caroline, Engkvist, Ola, Goble, Carole, Reilly, Dorothy S., Satagopam, Venkata, Ioannidis, Vassilios, Gu, Wei, Gribbon, Philip
Published in Drug discovery today (01.08.2022)
Published in Drug discovery today (01.08.2022)
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α‑Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease
Moreno-Cinos, Carlos, Sassetti, Elisa, Salado, Irene G, Witt, Gesa, Benramdane, Siham, Reinhardt, Laura, Cruz, Cristina D, Joossens, Jurgen, Van der Veken, Pieter, Brötz-Oesterhelt, Heike, Tammela, Päivi, Winterhalter, Mathias, Gribbon, Philip, Windshügel, Björn, Augustyns, Koen
Published in Journal of medicinal chemistry (24.01.2019)
Published in Journal of medicinal chemistry (24.01.2019)
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Enhancement of Benzothiazoles as Pteridine Reductase‑1 Inhibitors for the Treatment of Trypanosomatidic Infections
Linciano, Pasquale, Pozzi, Cecilia, Iacono, Lucia dello, di Pisa, Flavio, Landi, Giacomo, Bonucci, Alessio, Gul, Sheraz, Kuzikov, Maria, Ellinger, Bernhard, Witt, Gesa, Santarem, Nuno, Baptista, Catarina, Franco, Caio, Moraes, Carolina B, Müller, Wolfgang, Wittig, Ulrike, Luciani, Rosaria, Sesenna, Antony, Quotadamo, Antonio, Ferrari, Stefania, Pöhner, Ina, Cordeiro-da-Silva, Anabela, Mangani, Stefano, Costantino, Luca, Costi, Maria Paola
Published in Journal of medicinal chemistry (25.04.2019)
Published in Journal of medicinal chemistry (25.04.2019)
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SASC: A simple approach to synthetic cohorts for generating longitudinal observational patient cohorts from COVID-19 clinical data
Khorchani, Takoua, Gadiya, Yojana, Witt, Gesa, Lanzillotta, Delia, Claussen, Carsten, Zaliani, Andrea
Published in Patterns (New York, N.Y.) (08.04.2022)
Published in Patterns (New York, N.Y.) (08.04.2022)
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Droplet-based vitrification of adherent human induced pluripotent stem cells on alginate microcarrier influenced by adhesion time and matrix elasticity
Meiser, Ina, Majer, Julia, Katsen-Globa, Alisa, Schulz, André, Schmidt, Katharina, Stracke, Frank, Koutsouraki, Eirini, Witt, Gesa, Keminer, Oliver, Pless, Ole, Gardner, John, Claussen, Carsten, Gribbon, Philip, Neubauer, Julia C., Zimmermann, Heiko
Published in Cryobiology (01.12.2021)
Published in Cryobiology (01.12.2021)
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Aryl thiosemicarbazones for the treatment of trypanosomatidic infections
Linciano, Pasquale, Moraes, Carolina B., Alcantara, Laura M., Franco, Caio H., Pascoalino, Bruno, Freitas-Junior, Lucio H., Macedo, Sara, Santarem, Nuno, Cordeiro-da-Silva, Anabela, Gul, Sheraz, Witt, Gesa, Kuzikov, Maria, Ellinger, Bernhard, Ferrari, Stefania, Luciani, Rosaria, Quotadamo, Antonio, Costantino, Luca, Costi, Maria Paola
Published in European journal of medicinal chemistry (25.02.2018)
Published in European journal of medicinal chemistry (25.02.2018)
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Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign
Linciano, Pasquale, Cullia, Gregorio, Borsari, Chiara, Santucci, Matteo, Ferrari, Stefania, Witt, Gesa, Gul, Sheraz, Kuzikov, Maria, Ellinger, Bernhard, Santarém, Nuno, Cordeiro da Silva, Anabela, Conti, Paola, Bolognesi, Maria Laura, Roberti, Marinella, Prati, Federica, Bartoccini, Francesca, Retini, Michele, Piersanti, Giovanni, Cavalli, Andrea, Goldoni, Luca, Bertozzi, Sine Mandrup, Bertozzi, Fabio, Brambilla, Enzo, Rizzo, Vincenzo, Piomelli, Daniele, Pinto, Andrea, Bandiera, Tiziano, Costi, Maria Paola
Published in European journal of medicinal chemistry (01.03.2020)
Published in European journal of medicinal chemistry (01.03.2020)
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Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics
Borsari, Chiara, Jiménez-Antón, María Dolores, Eick, Julia, Bifeld, Eugenia, Torrado, Juan José, Olías-Molero, Ana Isabel, Corral, María Jesús, Santarem, Nuno, Baptista, Catarina, Severi, Leda, Gul, Sheraz, Wolf, Markus, Kuzikov, Maria, Ellinger, Bernhard, Reinshagen, Jeanette, Witt, Gesa, Linciano, Pasquale, Tait, Annalisa, Costantino, Luca, Luciani, Rosaria, Tejera Nevado, Paloma, Zander-Dinse, Dorothea, Franco, Caio H., Ferrari, Stefania, Moraes, Carolina B., Cordeiro-da-Silva, Anabela, Ponterini, Glauco, Clos, Joachim, Alunda, José María, Costi, Maria Paola
Published in European journal of medicinal chemistry (01.12.2019)
Published in European journal of medicinal chemistry (01.12.2019)
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Journal Article
Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity
Uliassi, Elisa, Fiorani, Giulia, Krauth-Siegel, R. Luise, Bergamini, Christian, Fato, Romana, Bianchini, Giulia, Carlos Menéndez, J., Molina, Maria Teresa, López-Montero, Eulogio, Falchi, Federico, Cavalli, Andrea, Gul, Sheraz, Kuzikov, Maria, Ellinger, Bernhard, Witt, Gesa, Moraes, Carolina B., Freitas-Junior, Lucio H., Borsari, Chiara, Costi, Maria Paola, Bolognesi, Maria Laura
Published in European journal of medicinal chemistry (01.12.2017)
Published in European journal of medicinal chemistry (01.12.2017)
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Journal Article
Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs
Borsari, Chiara, Luciani, Rosaria, Pozzi, Cecilia, Poehner, Ina, Henrich, Stefan, Trande, Matteo, Cordeiro-da-Silva, Anabela, Santarem, Nuno, Baptista, Catarina, Tait, Annalisa, Di Pisa, Flavio, Dello Iacono, Lucia, Landi, Giacomo, Gul, Sheraz, Wolf, Markus, Kuzikov, Maria, Ellinger, Bernhard, Reinshagen, Jeanette, Witt, Gesa, Gribbon, Philip, Kohler, Manfred, Keminer, Oliver, Behrens, Birte, Costantino, Luca, Tejera Nevado, Paloma, Bifeld, Eugenia, Eick, Julia, Clos, Joachim, Torrado, Juan, Jiménez-Antón, María D, Corral, María J, Alunda, José Ma, Pellati, Federica, Wade, Rebecca C, Ferrari, Stefania, Mangani, Stefano, Costi, Maria Paola
Published in Journal of medicinal chemistry (25.08.2016)
Published in Journal of medicinal chemistry (25.08.2016)
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In vitro and in silico analysis of the effects of D 2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations
de Witte, Wilhelmus E A, Versfelt, Joost W, Kuzikov, Maria, Rolland, Solene, Georgi, Victoria, Gribbon, Philip, Gul, Sheraz, Huntjens, Dymphy, van der Graaf, Piet Hein, Danhof, Meindert, Fernández-Montalván, Amaury, Witt, Gesa, de Lange, Elizabeth C M
Published in British journal of pharmacology (01.11.2018)
Published in British journal of pharmacology (01.11.2018)
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In vitro and in silico analysis of the effects of D2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations
Witte, Wilhelmus E A, Versfelt, Joost W, Kuzikov, Maria, Rolland, Solene, Georgi, Victoria, Gribbon, Philip, Gul, Sheraz, Huntjens, Dymphy, Graaf, Piet Hein, Danhof, Meindert, Fernández‐Montalván, Amaury, Witt, Gesa, Lange, Elizabeth C M
Published in British journal of pharmacology (01.11.2018)
Published in British journal of pharmacology (01.11.2018)
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An automated and high-throughput-screening compatible pluripotent stem cell-based test platform for developmental and reproductive toxicity assessment of small molecule compounds
Witt, Gesa, Keminer, Oliver, Leu, Jennifer, Tandon, Rashmi, Meiser, Ina, Willing, Anne, Winschel, Ingo, Abt, Jana-Christin, Brändl, Björn, Sébastien, Isabelle, Friese, Manuel A., Müller, Franz-Josef, Neubauer, Julia C., Claussen, Carsten, Zimmermann, Heiko, Gribbon, Philip, Pless, Ole
Published in Cell biology and toxicology (01.04.2021)
Published in Cell biology and toxicology (01.04.2021)
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Journal Article
Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds
Borsari, Chiara, Santarem, Nuno, Torrado, Juan, Olías, Ana Isabel, Corral, María Jesús, Baptista, Catarina, Gul, Sheraz, Wolf, Markus, Kuzikov, Maria, Ellinger, Bernhard, Witt, Gesa, Gribbon, Philip, Reinshagen, Jeanette, Linciano, Pasquale, Tait, Annalisa, Costantino, Luca, Freitas-Junior, Lucio H., Moraes, Carolina B., Bruno dos Santos, Pascoalino, Alcântara, Laura Maria, Franco, Caio Haddad, Bertolacini, Claudia Danielli, Fontana, Vanessa, Tejera Nevado, Paloma, Clos, Joachim, Alunda, José María, Cordeiro-da-Silva, Anabela, Ferrari, Stefania, Costi, Maria Paola
Published in European journal of medicinal chemistry (27.01.2017)
Published in European journal of medicinal chemistry (27.01.2017)
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Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase‑1 Inhibitors
Landi, Giacomo, Linciano, Pasquale, Borsari, Chiara, Bertolacini, Claudia P, Moraes, Carolina B, Cordeiro-da-Silva, Anabela, Gul, Sheraz, Witt, Gesa, Kuzikov, Maria, Costi, Maria Paola, Pozzi, Cecilia, Mangani, Stefano
Published in ACS infectious diseases (12.07.2019)
Published in ACS infectious diseases (12.07.2019)
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