Targeting the Mycobacterium ulcerans cytochrome bc 1 :aa 3 for the treatment of Buruli ulcer
Scherr, Nicole, Bieri, Raphael, Thomas, Sangeeta S, Chauffour, Aurélie, Nitin Pal Kalia, Schneide, Paul, Ruf, Marie-Thérèse, Lamelas, Araceli, Manimekalai, Malathy S S, Grüber, Gerhard, Ishii, Norihisa, Suzuki, Koichi, Tanner, Marcel, Moraski, Garrett C, Miller, Marvin J, Witschel, Matthias, Jarlier, Vincent, Pluschke, Gerd, Pethe, Kevin
Published in Nature communications (01.12.2018)
Published in Nature communications (01.12.2018)
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Journal Article
Inhibition of acyl‐ACP thioesterase as site of action of the commercial herbicides cumyluron, oxaziclomefone, bromobutide, methyldymron and tebutam
Johnen, Philipp, Zimmermann, Sophie, Betz, Michael, Hendriks, Janneke, Zimmermann, Alexandra, Marnet, Martina, De, Inessa, Zimmermann, Gunther, Kibat, Christine, Cornaciu, Irina, Mariaule, Vincent, Pica, Andrea, Clavel, Damien, Márquez, José Antonio, Witschel, Matthias
Published in Pest management science (01.08.2022)
Published in Pest management science (01.08.2022)
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Journal Article
A new herbicidal site of action: Cinmethylin binds to acyl-ACP thioesterase and inhibits plant fatty acid biosynthesis
Campe, Ruth, Hollenbach, Eva, Kämmerer, Lara, Hendriks, Janneke, Höffken, Hans Wolfgang, Kraus, Helmut, Lerchl, Jens, Mietzner, Thomas, Tresch, Stefan, Witschel, Matthias, Hutzler, Johannes
Published in Pesticide biochemistry and physiology (01.06.2018)
Published in Pesticide biochemistry and physiology (01.06.2018)
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Journal Article
An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery
Najer, Adrian, Wu, Dalin, Nussbaumer, Martin G, Schwertz, Geoffrey, Schwab, Anatol, Witschel, Matthias C, Schäfer, Anja, Diederich, François, Rottmann, Matthias, Palivan, Cornelia G, Beck, Hans-Peter, Meier, Wolfgang
Published in Nanoscale (21.08.2016)
Published in Nanoscale (21.08.2016)
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Journal Article
Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease
Witschel, Matthias, Rottmann, Matthias, Kaiser, Marcel, Brun, Reto
Published in PLoS neglected tropical diseases (01.10.2012)
Published in PLoS neglected tropical diseases (01.10.2012)
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Journal Article
Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X‑ray Cocrystal Structures
Schwertz, Geoffrey, Witschel, Matthias C, Rottmann, Matthias, Bonnert, Roger, Leartsakulpanich, Ubolsree, Chitnumsub, Penchit, Jaruwat, Aritsara, Ittarat, Wanwipa, Schäfer, Anja, Aponte, Raphael A, Charman, Susan A, White, Karen L, Kundu, Abhijit, Sadhukhan, Surajit, Lloyd, Mel, Freiberg, Gail M, Srikumaran, Myron, Siggel, Marc, Zwyssig, Adrian, Chaiyen, Pimchai, Diederich, François
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
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Journal Article
Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold
Schwertz, Geoffrey, Witschel, Matthias C., Rottmann, Matthias, Leartsakulpanich, Ubolsree, Chitnumsub, Penchit, Jaruwat, Aritsara, Amornwatcharapong, Watcharee, Ittarat, Wanwipa, Schäfer, Anja, Aponte, Raphael A., Trapp, Nils, Chaiyen, Pimchai, Diederich, François
Published in ChemMedChem (08.05.2018)
Published in ChemMedChem (08.05.2018)
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Journal Article
Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT): Cocrystal Structures of Pyrazolopyrans with Potent Blood- and Liver-Stage Activities
Witschel, Matthias C, Rottmann, Matthias, Schwab, Anatol, Leartsakulpanich, Ubolsree, Chitnumsub, Penchit, Seet, Michael, Tonazzi, Sandro, Schwertz, Geoffrey, Stelzer, Frank, Mietzner, Thomas, McNamara, Case, Thater, Frank, Freymond, Céline, Jaruwat, Aritsara, Pinthong, Chatchadaporn, Riangrungroj, Pinpunya, Oufir, Mouhssin, Hamburger, Matthias, Mäser, Pascal, Sanz-Alonso, Laura M, Charman, Susan, Wittlin, Sergio, Yuthavong, Yongyuth, Chaiyen, Pimchai, Diederich, François
Published in Journal of medicinal chemistry (09.04.2015)
Published in Journal of medicinal chemistry (09.04.2015)
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Journal Article
Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands
Schwab, Anatol, Illarionov, Boris, Frank, Annika, Kunfermann, Andrea, Seet, Michael, Bacher, Adelbert, Witschel, Matthias C, Fischer, Markus, Groll, Michael, Diederich, François
Published in ACS chemical biology (18.08.2017)
Published in ACS chemical biology (18.08.2017)
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Journal Article
Conformational Aspects in the Design of Inhibitors for Serine Hydroxymethyltransferase (SHMT): Biphenyl, Aryl Sulfonamide, and Aryl Sulfone Motifs
Schwertz, Geoffrey, Frei, Michelle S., Witschel, Matthias C., Rottmann, Matthias, Leartsakulpanich, Ubolsree, Chitnumsub, Penchit, Jaruwat, Aritsara, Ittarat, Wanwipa, Schäfer, Anja, Aponte, Raphael A., Trapp, Nils, Mark, Kerstin, Chaiyen, Pimchai, Diederich, François
Published in Chemistry : a European journal (12.10.2017)
Published in Chemistry : a European journal (12.10.2017)
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Journal Article
Deorphaning Pyrrolopyrazines as Potent Multi-Target Antimalarial Agents
Reker, Daniel, Seet, Michael, Pillong, Max, Koch, Christian P., Schneider, Petra, Witschel, Matthias C., Rottmann, Matthias, Freymond, Céline, Brun, Reto, Schweizer, Bernd, Illarionov, Boris, Bacher, Adelbert, Fischer, Markus, Diederich, François, Schneider, Gisbert
Published in Angewandte Chemie International Edition (01.07.2014)
Published in Angewandte Chemie International Edition (01.07.2014)
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Journal Article
Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD
Kunfermann, Andrea, Witschel, Matthias, Illarionov, Boris, Martin, René, Rottmann, Matthias, Höffken, H. Wolfgang, Seet, Michael, Eisenreich, Wolfgang, Knölker, Hans-Joachim, Fischer, Markus, Bacher, Adelbert, Groll, Michael, Diederich, François
Published in Angewandte Chemie International Edition (17.02.2014)
Published in Angewandte Chemie International Edition (17.02.2014)
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Journal Article
In search of new herbicidal inhibitors of the non‐mevalonate pathway
Witschel, Matthias, Röhl, Franz, Niggeweg, Ricarda, Newton, Trevor
Published in Pest management science (01.05.2013)
Published in Pest management science (01.05.2013)
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Journal Article
Inhibitors of the Herbicidal Target IspD: Allosteric Site Binding
Witschel, Matthias C., Höffken, H. Wolfgang, Seet, Michael, Parra, Liliana, Mietzner, Thomas, Thater, Frank, Niggeweg, Ricarda, Röhl, Franz, Illarionov, Boris, Rohdich, Felix, Kaiser, Johannes, Fischer, Markus, Bacher, Adelbert, Diederich, François
Published in Angewandte Chemie International Edition (16.08.2011)
Published in Angewandte Chemie International Edition (16.08.2011)
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Journal Article
Screening of Antifungal Azole Drugs and Agrochemicals with an Adapted alamarBlue-Based Assay Demonstrates Antibacterial Activity of Croconazole against Mycobacterium ulcerans
Scherr, Nicole, Röltgen, Katharina, Witschel, Matthias, Pluschke, Gerd
Published in Antimicrobial Agents and Chemotherapy (01.12.2012)
Published in Antimicrobial Agents and Chemotherapy (01.12.2012)
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Journal Article
Novel bioassay for the discovery of inhibitors of the 2-C-methyl-D-erythritol 4-phosphate (MEP) and terpenoid pathways leading to carotenoid biosynthesis
Corniani, Natália, Velini, Edivaldo D, Silva, Ferdinando M L, Nanayakkara, N P Dhammika, Witschel, Matthias, Dayan, Franck E
Published in PloS one (31.07.2014)
Published in PloS one (31.07.2014)
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Journal Article
Identification of 1,3-Diiminoisoindoline Carbohydrazides as Potential Antimalarial Candidates
Mombelli, Paolo, Witschel, Matthias C., van Zijl, Anthoni W., Geist, Julie G., Rottmann, Matthias, Freymond, Céline, Röhl, Franz, Kaiser, Marcel, Illarionova, Victoria, Fischer, Markus, Siepe, Isabella, Schweizer, W. Bernd, Brun, Reto, Diederich, François
Published in ChemMedChem (02.01.2012)
Published in ChemMedChem (02.01.2012)
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Journal Article