Place your BETs: the therapeutic potential of bromodomains
Prinjha, R.K, Witherington, J, Lee, K
Published in Trends in pharmacological sciences (Regular ed.) (01.03.2012)
Published in Trends in pharmacological sciences (Regular ed.) (01.03.2012)
Get full text
Journal Article
Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762
Chaidos, Aristeidis, Caputo, Valentina, Gouvedenou, Katerina, Liu, Binbin, Marigo, Ilaria, Chaudhry, Mohammed Suhail, Rotolo, Antonia, Tough, David F., Smithers, Nicholas N., Bassil, Anna K., Chapman, Trevor D., Harker, Nicola R., Barbash, Olena, Tummino, Peter, Al-Mahdi, Niam, Haynes, Andrea C., Cutler, Leanne, Le, BaoChau, Rahemtulla, Amin, Roberts, Irene, Kleijnen, Maurits, Witherington, Jason J., Parr, Nigel J., Prinjha, Rab K., Karadimitris, Anastasios
Published in Blood (30.01.2014)
Published in Blood (30.01.2014)
Get full text
Journal Article
Neuronal control of experimental colitis occurs via sympathetic intestinal innervation
Willemze, R. A., Welting, O., Hamersveld, H. P., Meijer, S. L., Folgering, J. H. A, Darwinkel, H., Witherington, J., Sridhar, A., Vervoordeldonk, M. J., Seppen, J., Jonge, W. J.
Published in Neurogastroenterology and motility (01.03.2018)
Published in Neurogastroenterology and motility (01.03.2018)
Get full text
Journal Article
Functional and in situ hybridization evidence that preganglionic sympathetic vasoconstrictor neurons express ghrelin receptors
Ferens, D.M, Yin, L, Bron, R, Hunne, B, Ohashi-Doi, K, Kitchener, P.D, Sanger, G.J, Witherington, J, Shimizu, Y, Furness, J.B
Published in Neuroscience (17.03.2010)
Published in Neuroscience (17.03.2010)
Get full text
Journal Article
Oral administration of a centrally acting ghrelin receptor agonist to conscious rats triggers defecation
Shafton, A. D., Sanger, G. J., Witherington, J., Brown, J. D., Muir, A., Butler, S., Abberley, L., Shimizu, Y., Furness, J. B.
Published in Neurogastroenterology and motility (01.01.2009)
Published in Neurogastroenterology and motility (01.01.2009)
Get full text
Journal Article
FRI0039 An acetyl-histone mimetic blocks inflammatory activation of rheumatoid arthritis fibroblast-like synoviocytes
Kabala, P., Grabiec, A. M., Smithers, N., Witherington, J., Tak, P. P., Prinjha, R. K., Reedquist, K. A.
Published in Annals of the rheumatic diseases (01.06.2013)
Published in Annals of the rheumatic diseases (01.06.2013)
Get full text
Journal Article
5‐hydroxyindalpine, an agonist at the putative 5‐HT1P receptor, has no activity on human recombinant monoamine receptors but accelerates distension‐induced peristalsis in mouse isolated colon
Mitchell, N. A., Pepperell, E., Ociepka, S., Brown, J. D., Witherington, J., Tuladhar, B., Sanger, G. J., Lee, K., Cellek, S.
Published in Neurogastroenterology and motility (01.07.2009)
Published in Neurogastroenterology and motility (01.07.2009)
Get full text
Journal Article
Cyclic Ketone Inhibitors of the Cysteine Protease Cathepsin K
Marquis, Robert W, Ru, Yu, Zeng, Jin, Trout, Robert E. Lee, LoCastro, Stephen M, Gribble, Andrew D, Witherington, Jason, Fenwick, Ashley E, Garnier, Benedicte, Tomaszek, Thaddeus, Tew, David, Hemling, Mark E, Quinn, Chad J, Smith, Ward W, Zhao, Baoguang, McQueney, Michael S, Janson, Cheryl A, D'Alessio, Karla, Veber, Daniel F
Published in Journal of medicinal chemistry (01.03.2001)
Published in Journal of medicinal chemistry (01.03.2001)
Get full text
Journal Article
5-Aryl-pyrazolo[3,4- b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)
Witherington, Jason, Bordas, Vincent, Garland, Stephen L, Hickey, Deirdre M.B, Ife, Robert J, Liddle, John, Saunders, Martin, Smith, David G, Ward, Robert W
Published in Bioorganic & medicinal chemistry letters (05.05.2003)
Published in Bioorganic & medicinal chemistry letters (05.05.2003)
Get full text
Journal Article
6-Aryl-pyrazolo[3,4- b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)
Witherington, Jason, Bordas, Vincent, Gaiba, Alessandra, Garton, Neil S., Naylor, Antoinette, Rawlings, Anthony D., Slingsby, Brian P., Smith, David G., Takle, Andrew K., Ward, Robert W.
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Get full text
Journal Article
6-Heteroaryl-pyrazolo[3,4- b]pyridines: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)
Witherington, Jason, Bordas, Vincent, Gaiba, Alessandra, Naylor, Antoinette, Rawlings, Anthony D., Slingsby, Brian P., Smith, David G., Takle, Andrew K., Ward, Robert W.
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Get full text
Journal Article
CCR2: Characterization of the Antagonist Binding Site from a Combined Receptor Modeling/Mutagenesis Approach
Berkhout, Theo A, Blaney, Frank E, Bridges, Angela M, Cooper, David G, Forbes, Ian T, Gribble, Andrew D, Groot, Pieter H. E, Hardy, Adam, Ife, Robert J, Kaur, Rejbinder, Moores, Kitty E, Shillito, Helen, Willetts, Jennifer, Witherington, Jason
Published in Journal of medicinal chemistry (11.09.2003)
Published in Journal of medicinal chemistry (11.09.2003)
Get full text
Journal Article
Complementary stereoselective conjugate addition reactions on indolo[2,3-a]quinolizine templates
Allin, Steven M., Khera, Jagjit S., Thomas, Christopher I., Witherington, Jason, Doyle, Kevin, Elsegood, Mark R.J., Edgar, Mark
Published in Tetrahedron letters (20.03.2006)
Published in Tetrahedron letters (20.03.2006)
Get full text
Journal Article