Kinase Domain Mutations in Cancer: Implications for Small Molecule Drug Design Strategies
Bikker, Jack A, Brooijmans, Natasja, Wissner, Allan, Mansour, Tarek S
Published in Journal of medicinal chemistry (26.03.2009)
Published in Journal of medicinal chemistry (26.03.2009)
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Irreversible Inhibitors of the EGF Receptor May Circumvent Acquired Resistance to Gefitinib
Kwak, Eunice L., Sordella, Raffaella, Bell, Daphne W., Godin-Heymann, Nadia, Okimoto, Ross A., Brannigan, Brian W., Harris, Patricia L., Driscoll, David R., Fidias, Panos, Lynch, Thomas J., Rabindran, Sridhar K., McGinnis, John P., Wissner, Allan, Sharma, Sreenath V., Isselbacher, Kurt J., Settleman, Jeffrey, Haber, Daniel A.
Published in Proceedings of the National Academy of Sciences - PNAS (24.05.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (24.05.2005)
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Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase
RABINDRAN, Sridhar K, DISCAFANI, Carolyn M, REICH, Marvin F, RU SHEN, XIAOQING SHI, TSOU, Hwei-Ru, WANG, Yu-Fen, WISSNER, Allan, ROSFJORD, Edward C, BAXTER, Michelle, FLOYD, M. Brawner, GOLAS, Jonathan, HALLETT, William A, JOHNSON, Bernard D, NILAKANTAN, Ramaswamy, OVERBEEK, Elsebe
Published in Cancer research (Chicago, Ill.) (01.06.2004)
Published in Cancer research (Chicago, Ill.) (01.06.2004)
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Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity
Tsou, Hwei-Ru, Overbeek-Klumpers, Elsebe G, Hallett, William A, Reich, Marvin F, Floyd, M. Brawner, Johnson, Bernard D, Michalak, Ronald S, Nilakantan, Ramaswamy, Discafani, Carolyn, Golas, Jonathan, Rabindran, Sridhar K, Shen, Ru, Shi, Xiaoqing, Wang, Yu-Fen, Upeslacis, Janis, Wissner, Allan
Published in Journal of medicinal chemistry (24.02.2005)
Published in Journal of medicinal chemistry (24.02.2005)
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Combinatorial chemoprevention of intestinal neoplasia
Frost, Philip, Torrance, Christopher J, Jackson, Peta E, Montgomery, Elizabeth, Kinzler, Kenneth W, Vogelstein, Bert, Wissner, Allan, Nunes, Maria, Discafani, Carolyn M
Published in Nature medicine (01.09.2000)
Published in Nature medicine (01.09.2000)
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Synthesis and Structure−Activity Relationships of 6,7-Disubstituted 4-Anilinoquinoline-3-carbonitriles. The Design of an Orally Active, Irreversible Inhibitor of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor (EGFR) and the Human Epidermal Growth Factor Receptor-2 (HER-2)
Wissner, Allan, Overbeek, Elsebe, Reich, Marvin F, Floyd, M. Brawner, Johnson, Bernard D, Mamuya, Nellie, Rosfjord, Edward C, Discafani, Carolyn, Davis, Rachel, Shi, Xiaoqing, Rabindran, Sridhar K, Gruber, Brian C, Ye, Fei, Hallett, William A, Nilakantan, Ramaswamy, Shen, Ru, Wang, Yu-Fen, Greenberger, Lee M, Tsou, Hwei-Ru
Published in Journal of medicinal chemistry (02.01.2003)
Published in Journal of medicinal chemistry (02.01.2003)
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Journal Article
Synthesis and Src Kinase Inhibitory Activity of a Series of 4-Phenylamino-3-quinolinecarbonitriles
Boschelli, Diane H, Wang, Yanong D, Ye, Fei, Wu, Biqi, Zhang, Nan, Dutia, Minu, Powell, Dennis W, Wissner, Allan, Arndt, Kim, Weber, Jennifer M, Boschelli, Frank
Published in Journal of medicinal chemistry (01.03.2001)
Published in Journal of medicinal chemistry (01.03.2001)
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Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles
Wissner, Allan, Hamann, Philip R., Nilakantan, Ramaswamy, Greenberger, Lee M., Ye, Fei, Rapuano, Timothy A., Loganzo, Frank
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
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Imidazo[1,5- a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis
Kim, Kyung-Hee, Maderna, Andreas, Schnute, Mark E., Hegen, Martin, Mohan, Shashi, Miyashiro, Joy, Lin, Laura, Li, Evelyn, Keegan, Sean, Lussier, Jennifer, Wrocklage, Christopher, Nickerson-Nutter, Cheryl L., Wittwer, Arthur J., Soutter, Holly, Caspers, Nicole, Han, Seungil, Kurumbail, Ravi, Dunussi-Joannopoulos, Kyri, Douhan, John, Wissner, Allan
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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Dual irreversible kinase inhibitors: Quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2
Wissner, Allan, Fraser, Heidi L., Ingalls, Charles L., Dushin, Russell G., Floyd, M. Brawner, Cheung, Kinwang, Nittoli, Thomas, Ravi, Malini R., Tan, Xingzhi, Loganzo, Frank
Published in Bioorganic & medicinal chemistry (01.06.2007)
Published in Bioorganic & medicinal chemistry (01.06.2007)
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6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases with Enhanced Antitumor Activity
Tsou, Hwei-Ru, Mamuya, Nellie, Johnson, Bernard D, Reich, Marvin F, Gruber, Brian C, Ye, Fei, Nilakantan, Ramaswamy, Shen, Ru, Discafani, Carolyn, DeBlanc, Ronald, Davis, Rachel, Koehn, Frank E, Greenberger, Lee M, Wang, Yu-Fen, Wissner, Allan
Published in Journal of medicinal chemistry (16.08.2001)
Published in Journal of medicinal chemistry (16.08.2001)
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Synthesis and PKCθ inhibitory activity of a series of 4-indolylamino-5-phenyl-3-pyridinecarbonitriles
Dushin, Russell G., Nittoli, Thomas, Ingalls, Charles, Boschelli, Diane H., Cole, Derek C., Wissner, Allan, Lee, Julie, Yang, Xiaoke, Morgan, Paul, Brennan, Agnes, Chaudhary, Divya
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
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Identification, Characterization and Initial Hit-to-Lead Optimization of a Series of 4-Arylamino-3-Pyridinecarbonitrile as Protein Kinase C theta (PKCθ) Inhibitors
Cole, Derek C, Asselin, Magda, Brennan, Agnes, Czerwinski, Robert, Ellingboe, John W, Fitz, Lori, Greco, Rita, Huang, Xinyi, Joseph-McCarthy, Diane, Kelly, Michael F, Kirisits, Matthew, Lee, Julie, Li, Yuanhong, Morgan, Paul, Stock, Joseph R, Tsao, Désirée H. H, Wissner, Allan, Yang, Xiaoke, Chaudhary, Divya
Published in Journal of medicinal chemistry (09.10.2008)
Published in Journal of medicinal chemistry (09.10.2008)
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2-(Quinazolin-4-ylamino)-[1,4]benzoquinones as Covalent-Binding, Irreversible Inhibitors of the Kinase Domain of Vascular Endothelial Growth Factor Receptor-2
Wissner, Allan, Floyd, M. Brawner, Johnson, Bernard D, Fraser, Heidi, Ingalls, Charles, Nittoli, Thomas, Dushin, Russell G, Discafani, Carolyn, Nilakantan, Ramaswamy, Marini, Joseph, Ravi, Malini, Cheung, Kinwang, Tan, Xingzhi, Musto, Sylvia, Annable, Tami, Siegel, Marshall M, Loganzo, Frank
Published in Journal of medicinal chemistry (01.12.2005)
Published in Journal of medicinal chemistry (01.12.2005)
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Journal Article
Benzo[ c][2,7]naphthyridines as inhibitors of PDK-1
Kim, Kyung-Hee, Wissner, Allan, Floyd, Middleton B., Fraser, Heidi L., Wang, Yanong D., Dushin, Russell G., Hu, Yongbo, Olland, Andrea, Guo, Bing, Arndt, Kim
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1)
Nittoli, Thomas, Dushin, Russell G., Ingalls, Charles, Cheung, Katherine, Floyd, M. Brawner, Fraser, Heidi, Olland, Andrea, Hu, Yongbo, Grosu, George, Han, Xin, Arndt, Kim, Guo, Bing, Wissner, Allan
Published in European journal of medicinal chemistry (01.04.2010)
Published in European journal of medicinal chemistry (01.04.2010)
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Analogs of platelet activating factor. 7. Bis-aryl amide and bis-aryl urea receptor antagonists of PAF
Wissner, Allan, Carroll, Marion L, Johnson, Bernard D, Kerwar, Suresh S, Pickett, Walter C, Schaub, Robert E, Torley, Lawrence W, Trova, Michael P, Kohler, Constance A
Published in Journal of medicinal chemistry (01.12.1992)
Published in Journal of medicinal chemistry (01.12.1992)
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Synthesis and biological evaluation of a series of HIV-1 protease inhibitors
Trova, Michael P., Babine, Robert E., Byrn, Randal A., Casscles, Wellington T., Hastings, Richard C., Hsu, Grace C., Jirousek, Michael R., Johnson, Bernard D., Kerwar, Suresh S., Schow, Steven R., Wissner, Allan, Zhang, Nan, Wick, Michael M.
Published in Bioorganic & medicinal chemistry letters (01.08.1993)
Published in Bioorganic & medicinal chemistry letters (01.08.1993)
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Journal Article
4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile Inhibitors of Epidermal Growth Factor Receptor Kinase and Their Bioisosteric Relationship to the 4-Anilino-6,7-dialkoxyquinazoline Inhibitors
Wissner, Allan, Berger, Dan M, Boschelli, Diane H, Floyd, M. Brawner, Greenberger, Lee M, Gruber, Brian C, Johnson, Bernard D, Mamuya, Nellie, Nilakantan, Ramaswamy, Reich, Marvin F, Shen, Ru, Tsou, Hwei-Ru, Upeslacis, Erik, Wang, Yu Fen, Wu, Biqi, Ye, Fei, Zhang, Nan
Published in Journal of medicinal chemistry (24.08.2000)
Published in Journal of medicinal chemistry (24.08.2000)
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