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A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome
Wiseman, Frances K., Al-Janabi, Tamara, Hardy, John, Karmiloff-Smith, Annette, Nizetic, Dean, Tybulewicz, Victor L. J., Fisher, Elizabeth M. C., Strydom, André
Published in Nature reviews. Neuroscience (01.09.2015)
Published in Nature reviews. Neuroscience (01.09.2015)
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SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy
Kedia, Shekhar, Fertan, Emre, Wu, Yunzhao, Zhang, Yu P., Meisl, Georg, Lam, Jeff Y.L., K. Wiseman, Frances, McEwan, William A., Quaegebeur, Annelies, Spillantini, Maria Grazia, Danial, John S.H., Klenerman, David
Published in Cell chemical biology (20.02.2025)
Published in Cell chemical biology (20.02.2025)
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Rodent Modeling of Alzheimer's Disease in Down Syndrome: In vivo and ex vivo Approaches
Farrell, Clíona, Mumford, Paige, Wiseman, Frances K.
Published in Frontiers in neuroscience (07.06.2022)
Published in Frontiers in neuroscience (07.06.2022)
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The effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model
Wu, Yixing, Whittaker, Heather T., Noy, Suzanna, Cleverley, Karen, Brault, Veronique, Herault, Yann, Fisher, Elizabeth M. C., Wiseman, Frances K.
Published in PloS one (22.07.2021)
Published in PloS one (22.07.2021)
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Massively Parallel Sequencing Reveals the Complex Structure of an Irradiated Human Chromosome on a Mouse Background in the Tc1 Model of Down Syndrome
Gribble, Susan M., Wiseman, Frances K., Clayton, Stephen, Prigmore, Elena, Langley, Elizabeth, Yang, Fengtang, Maguire, Sean, Fu, Beiyuan, Rajan, Diana, Sheppard, Olivia, Scott, Carol, Hauser, Heidi, Stephens, Philip J., Stebbings, Lucy A., Ng, Bee Ling, Fitzgerald, Tomas, Quail, Michael A., Banerjee, Ruby, Rothkamm, Kai, Tybulewicz, Victor L. J., Fisher, Elizabeth M. C., Carter, Nigel P.
Published in PloS one (15.04.2013)
Published in PloS one (15.04.2013)
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Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models
Tosh, Justin L., Rhymes, Elena R., Mumford, Paige, Whittaker, Heather T., Pulford, Laura J., Noy, Sue J., Cleverley, Karen, Walker, Matthew C., Tybulewicz, Victor L. J., Wykes, Rob C., Fisher, Elizabeth M. C., Wiseman, Frances K.
Published in Scientific reports (11.03.2021)
Published in Scientific reports (11.03.2021)
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Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP
Wiseman, Frances K, Pulford, Laura J, Barkus, Chris, Liao, Fan, Portelius, Erik, Webb, Robin, Chávez-Gutiérrez, Lucia, Cleverley, Karen, Noy, Sue, Sheppard, Olivia, Collins, Toby, Powell, Caroline, Sarell, Claire J, Rickman, Matthew, Choong, Xun, Tosh, Justin L, Siganporia, Carlos, Whittaker, Heather T, Stewart, Floy, Szaruga, Maria, Murphy, Michael P, Blennow, Kaj, de Strooper, Bart, Zetterberg, Henrik, Bannerman, David, Holtzman, David M, Tybulewicz, Victor L J, Fisher, Elizabeth M C
Published in Brain (London, England : 1878) (01.08.2018)
Published in Brain (London, England : 1878) (01.08.2018)
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Endosomal structure and APP biology are not altered in a preclinical mouse cellular model of Down syndrome
Cannavo, Claudia, Cleverley, Karen, Maduro, Cheryl, Mumford, Paige, Moulding, Dale, Fisher, Elizabeth M. C., Wiseman, Frances K.
Published in PloS one (11.05.2022)
Published in PloS one (11.05.2022)
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Assessing neuroinflammation and inflammasome activity in mouse models of Down syndrome
Farrell, Clíona, Mumford, Paige, Salih, Dervis, Toomey, Christina, Fisher, Elizabeth, Wiseman, Frances K
Published in Alzheimer's & dementia (01.12.2021)
Published in Alzheimer's & dementia (01.12.2021)
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Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome–Alzheimer’s disease
Farrell, Clíona, Buhidma, Yazead, Mumford, Paige, Heywood, Wendy E., Hällqvist, Jenny, Flores-Aguilar, Lisi, Andrews, Elizabeth J., Rahimzadah, Negin, Taso, Orjona Stella, Doran, Eric, Swarup, Vivek, Head, Elizabeth, Lashley, Tammaryn, Mills, Kevin, Toomey, Christina E., Wiseman, Frances K.
Published in Acta neuropathologica (19.05.2025)
Published in Acta neuropathologica (19.05.2025)
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Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome
Chang, Pishan, Bush, Daniel, Schorge, Stephanie, Good, Mark, Canonica, Tara, Shing, Nathanael, Noy, Suzanna, Wiseman, Frances K., Burgess, Neil, Tybulewicz, Victor L.J., Walker, Matthew C., Fisher, Elizabeth M.C.
Published in Cell reports (Cambridge) (28.01.2020)
Published in Cell reports (Cambridge) (28.01.2020)
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Advocating for increased awareness and research on Down syndrome
Potier, Marie-Claude, Jonathan, Pierce, Thessa, Hilgenkamp, Fiorenza, Stagni, Marco, Emili, Frances, Wiseman, Randall, Ropper, María, Carmona-Iragui, Anne-Sophie, Rebillat, Eugenio, Barone, Marzia, Perluigi, Brian, Skotko, Shahid, Zaman, Kelly, Sullivan, Esteban, Rozen, Ann-Charlotte, Granholm-Bentley, Renata, Bartesaghi, William, Mobley, Jean-Maurice, Delabar, Mara, Dierssen, Roger, Reeves, Andre, Strydom
Published in Lancet neurology (01.04.2025)
Published in Lancet neurology (01.04.2025)
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Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer’s disease
Startin, Carla M., Ashton, Nicholas J., Hamburg, Sarah, Hithersay, Rosalyn, Wiseman, Frances K., Mok, Kin Y., Hardy, John, Lleó, Alberto, Lovestone, Simon, Parnetti, Lucilla, Zetterberg, Henrik, Hye, Abdul, Strydom, André
Published in Alzheimer's research & therapy (21.03.2019)
Published in Alzheimer's research & therapy (21.03.2019)
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Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21
Mumford, Paige, Tosh, Justin, Anderle, Silvia, Gkanatsiou Wikberg, Eleni, Lau, Gloria, Noy, Sue, Cleverley, Karen, Saito, Takashi, Saido, Takaomi C., Yu, Eugene, Brinkmalm, Gunnar, Portelius, Erik, Blennow, Kaj, Zetterberg, Henrik, Tybulewicz, Victor, Fisher, Elizabeth M.C., Wiseman, Frances K.
Published in The Journal of neuroscience (17.08.2022)
Published in The Journal of neuroscience (17.08.2022)
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Publisher Correction: Genetic dissection of down syndrome‑associated alterations in APP/amyloid‑β biology using mouse models
Tosh, Justin L., Rhymes, Elena R., Mumford, Paige, Whittaker, Heather T., Pulford, Laura J., Noy, Sue J., Cleverley, Karen, Walker, Matthew C., Tybulewicz, Victor L. J., Wykes, Rob C., Fisher, Elizabeth M. C., Wiseman, Frances K.
Published in Scientific reports (16.07.2021)
Published in Scientific reports (16.07.2021)
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Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B
Wu, Yixing, Mumford, Paige, Noy, Suzanna, Cleverley, Karen, Mrzyglod, Alicja, Luo, Dinghao, van Dalen, Floris, Verdoes, Martijn, Fisher, Elizabeth M. C., Wiseman, Frances K.
Published in Acta neuropathologica communications (14.08.2023)
Published in Acta neuropathologica communications (14.08.2023)
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Genetic mapping of APP and amyloid‐β biology modulation by trisomy 21
Mumford, Paige, Tosh, Justin, Anderle, Silvia, Gkanatsiou, Eleni, Lau, Gloria, Noy, Sue, Cleverley, Karen, Saito, Takashi, Saido, Takaomi C., Yu, Eugene Y., Brinkmalm, Gunnar, Portelius, Erik, Blennow, Kaj, Zetterberg, Henrik, Tybulewicz, Victor, Fisher, Elizabeth, Wiseman, Frances K
Published in Alzheimer's & dementia (01.06.2023)
Published in Alzheimer's & dementia (01.06.2023)
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