SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging
Rut, Wioletta, Groborz, Katarzyna, Zhang, Linlin, Sun, Xinyuanyuan, Zmudzinski, Mikolaj, Pawlik, Bartlomiej, Wang, Xinyu, Jochmans, Dirk, Neyts, Johan, Młynarski, Wojciech, Hilgenfeld, Rolf, Drag, Marcin
Published in Nature chemical biology (01.02.2021)
Published in Nature chemical biology (01.02.2021)
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Journal Article
Investigation of the P1′ and P2′ sites of IQF substrates and their selectivity toward 20S proteasome subunits
Gladysz, Radoslaw, Malek, Natalia, Rut, Wioletta, Drag, Marcin
Published in Biological chemistry (23.02.2023)
Published in Biological chemistry (23.02.2023)
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Journal Article
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design
Rut, Wioletta, Lv, Zongyang, Zmudzinski, Mikolaj, Patchett, Stephanie, Nayak, Digant, Snipas, Scott J, El Oualid, Farid, Huang, Tony T, Bekes, Miklos, Drag, Marcin, Olsen, Shaun K
Published in Science advances (16.10.2020)
Published in Science advances (16.10.2020)
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Journal Article
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Rut, Wioletta, Zmudzinski, Mikolaj, Snipas, Scott J, Bekes, Miklos, Huang, Tony T, Drag, Marcin
Published in Chemical Science (21.06.2020)
Published in Chemical Science (21.06.2020)
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Journal Article
Web Resource
Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes
Poreba, Marcin, Rut, Wioletta, Vizovisek, Matej, Groborz, Katarzyna, Kasperkiewicz, Paulina, Finlay, Darren, Vuori, Kristiina, Turk, Dusan, Turk, Boris, Salvesen, Guy S., Drag, Marcin
Published in Chemical science (Cambridge) (2018)
Published in Chemical science (Cambridge) (2018)
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Journal Article
Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin
Mahoney, Matthew W., Helander, Jonathan, Kooner, Anoopjit S., Norman, Mariah, Damalanka, Vishnu C., De Bona, Paolo, Kasperkiewicz, Paulina, Rut, Wioletta, Poreba, Marcin, Kashipathy, Maithri M., Battaile, Kevin P., Lovell, Scott, O'Donoghue, Anthony J., Craik, Charles S., Drag, Marcin, Janetka, James W.
Published in Protein science (01.08.2024)
Published in Protein science (01.08.2024)
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Journal Article
Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase
Zmudzinski, Mikolaj, Rut, Wioletta, Olech, Kamila, Granda, Jarosław, Giurg, Mirosław, Burda-Grabowska, Małgorzata, Kaleta, Rafał, Zgarbova, Michala, Kasprzyk, Renata, Zhang, Linlin, Sun, Xinyuanyuan, Lv, Zongyang, Nayak, Digant, Kesik-Brodacka, Malgorzata, Olsen, Shaun K., Weber, Jan, Hilgenfeld, Rolf, Jemielity, Jacek, Drag, Marcin
Published in Scientific reports (06.06.2023)
Published in Scientific reports (06.06.2023)
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Journal Article
Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery
Kryštůfek, Robin, Šácha, Pavel, Starková, Jana, Brynda, Jiří, Hradilek, Martin, Tloušt’ová, Eva, Grzymska, Justyna, Rut, Wioletta, Boucher, Michael J, Drąg, Marcin, Majer, Pavel, Hájek, Miroslav, Řezáčová, Pavlína, Madhani, Hiten D, Craik, Charles S, Konvalinka, Jan
Published in Journal of medicinal chemistry (27.05.2021)
Published in Journal of medicinal chemistry (27.05.2021)
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Journal Article
Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts
Strub, Daniel Jan, Talma, Michał, Strub, Maria, Rut, Wioletta, Zmudzinski, Mikolaj, Brud, Władysław, Neyts, Johan, Vangeel, Laura, Zhang, Linlin, Sun, Xinyuanyuan, Lv, Zongyang, Nayak, Digant, Olsen, Shaun K., Hilgenfeld, Rolf, Jochmans, Dirk, Drąg, Marcin
Published in Scientific reports (20.08.2022)
Published in Scientific reports (20.08.2022)
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Journal Article
Small Molecule Active Site Directed Tools for Studying Human Caspapses
Poreba, Marcin, Szalek, Aleksandra, Kasperkiewicz, Paulina, Wioletta Rut, Salvesen, Guy S, Drag, Marcin
Published in Chemical reviews (25.11.2015)
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Published in Chemical reviews (25.11.2015)
Journal Article
Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase
Modak, Joyanta K., Rut, Wioletta, Wijeyewickrema, Lakshmi C., Pike, Robert N., Drag, Marcin, Roujeinikova, Anna
Published in Biochimie (01.02.2016)
Published in Biochimie (01.02.2016)
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Journal Article
Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe
Cogo, Francesco, Poreba, Marcin, Rut, Wioletta, Groborz, Katarzyna, Smyth, Peter, Johnston, Michael C, Williams, Richard, Longley, Daniel B, Burden, Roberta E, Salvesen, Guy S, Drag, Marcin, Scott, Christopher J
Published in Nanoscale (03.01.2019)
Published in Nanoscale (03.01.2019)
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Journal Article
Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections
Reinke, Patrick Y. A., de Souza, Edmarcia Elisa, Günther, Sebastian, Falke, Sven, Lieske, Julia, Ewert, Wiebke, Loboda, Jure, Herrmann, Alexander, Rahmani Mashhour, Aida, Karničar, Katarina, Usenik, Aleksandra, Lindič, Nataša, Sekirnik, Andreja, Botosso, Viviane Fongaro, Santelli, Gláucia Maria Machado, Kapronezai, Josana, de Araújo, Marcelo Valdemir, Silva-Pereira, Taiana Tainá, Filho, Antônio Francisco de Souza, Tavares, Mariana Silva, Flórez-Álvarez, Lizdany, de Oliveira, Danielle Bruna Leal, Durigon, Edison Luiz, Giaretta, Paula Roberta, Heinemann, Marcos Bryan, Hauser, Maurice, Seychell, Brandon, Böhler, Hendrik, Rut, Wioletta, Drag, Marcin, Beck, Tobias, Cox, Russell, Chapman, Henry N., Betzel, Christian, Brehm, Wolfgang, Hinrichs, Winfried, Ebert, Gregor, Latham, Sharissa L., Guimarães, Ana Marcia de Sá, Turk, Dusan, Wrenger, Carsten, Meents, Alke
Published in Communications biology (18.10.2023)
Published in Communications biology (18.10.2023)
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Journal Article
SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme
Békés, Miklós, Rut, Wioletta, Kasperkiewicz, Paulina, Mulder, Monique P C, Ovaa, Huib, Drag, Marcin, Lima, Christopher D, Huang, Tony T
Published in Biochemical journal (01.06.2015)
Published in Biochemical journal (01.06.2015)
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Journal Article
Profiling of coronaviral M pro and enteroviral 3C pro specificity provides a framework for the development of broad-spectrum antiviral compounds
Rut, Wioletta, Groborz, Katarzyna, Sun, Xinyuanyuan, Hilgenfeld, Rolf, Drag, Marcin
Published in Protein science (01.09.2024)
Published in Protein science (01.09.2024)
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Journal Article