GP369, an FGFR2-IIIb-Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 Signaling
AILIN BAI, MEETZE, Kristan, JINWEI JIANG, LERNER, Lorena, GYURIS, Jeno, ZHIGANG WENG, VO, Nhi Y, KOLLIPARA, Sriram, MAZSA, Elizabeth K, WINSTON, William M, WEILER, Solly, POLING, Laura L, TING CHEN, ISMAIL, Nesreen S
Published in Cancer research (Chicago, Ill.) (01.10.2010)
Published in Cancer research (Chicago, Ill.) (01.10.2010)
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Characterization of ASP8374, a fully-human, antagonistic anti-TIGIT monoclonal antibody
Shirasuna, Kenna, Koelsch, Gerald, Seidel-Dugan, Cynthia, Salmeron, Andres, Steiner, Philipp, Winston, William M, Brodkin, Heather R, Nirschl, Christopher J, Abbott, Sandra, Kinugasa, Fumitaka, Sugahara, Shingo, Ohori, Makoto, Takeuchi, Masahiro, Hicklin, Daniel J, Yoshida, Taku
Published in Cancer treatment and research communications (2021)
Published in Cancer treatment and research communications (2021)
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Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models
Meetze, Kristan, Vincent, Sylvie, Tyler, Steven, Mazsa, Elizabeth K, Delpero, Andrea R, Bottega, Steve, McIntosh, Donna, Nicoletti, Richard, Winston, William M, Weiler, Solly, Feng, Bin, Gyuris, Jeno, Weng, Zhigang
Published in Clinical cancer research (01.03.2015)
Published in Clinical cancer research (01.03.2015)
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Discovery of a Conditionally Activated IL-2 that Promotes Antitumor Immunity and Induces Tumor Regression
Nirschl, Christopher J, Brodkin, Heather R, Hicklin, Daniel J, Ismail, Nesreen, Morris, Kristin, Seidel-Dugan, Cynthia, Steiner, Philipp, Steuert, Zoe, Sullivan, Jenna M, Tyagi, Ethika, Winston, William M, Salmeron, Andres
Published in Cancer immunology research (03.05.2022)
Published in Cancer immunology research (03.05.2022)
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mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity
Nirschl, Christopher J, Brodkin, Heather R, Domonkos, Celesztina, Dwyer, Connor J, Hicklin, Daniel J, Ismail, Nesreen, Seidel-Dugan, Cynthia, Steiner, Philipp, Steuert, Zoe, Sullivan, Jenna M, Winston, William M, Salmeron, Andres
Published in Cancer immunology research (05.07.2023)
Published in Cancer immunology research (05.07.2023)
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1059 Spatial analysis of tumor infiltrating lymphocyte populations in syngeneic mouse tumor models after treatment with IL-12 (mWTX-330) and IL-2 (WTX-124) INDUKINETM molecules
Nirschl, Christopher J, Brodkin, Heather R, Hicklin, Daniel J, Seidel-Dugan, Cynthia, Steuert, Zoe, Winston, William M, Salmeron, Andres
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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1058 Optimal antitumor immunity triggered by WTX-124, a clinical stage conditionally activated INDUKINETM molecule that releases fully potent IL-2 in the tumor microenvironment
Nirschl, Christopher J, Brodkin, Heather R, Hicklin, Daniel J, Ismail, Nesreen, Lewis, Yuka, Seidel-Dugan, Cynthia, Steuert, Zoe, Sullivan, Jenna M, Winston, William M, Salmeron, Andres
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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252 The combination of ACT and INDUKINE therapy leads to improved antitumor immunity in solid tumors
Dwyer, Connor J, Brodkin, Heather R, Donovan, Olivia G, Economides, Kyriakos, Hicklin, Daniel J, LePrevost, Julie, Morris, Kristin, Seidel-Dugan, Cynthia, Winston, William M, Salmeron, Andres
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
1075 Development of WTX-712, a conditionally active IL-21 INDUKINETM molecule for the treatment of cancer
Sullivan, Jenna M, Aderhold, Pam, Brodkin, Heather R, Nagy-Domonkos, Celesztina, Economides, Kyriakos, Hicklin, Daniel J, Ismail, Nesreen, Seidel-Dugan, Cynthia, Winston, William M, Salmeron, Andres
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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23814, an Inhibitory Antibody of Ligand-Mediated Notch1 Activation, Modulates Angiogenesis and Inhibits Tumor Growth without Gastrointestinal Toxicity
Proia, Theresa, Jiang, Feng, Bell, Alisa, Nicoletti, Richard, Kong, Lingxin, Kreuter, Kelly, Poling, Laura, Winston, William M, Flaherty, Meghan, Weiler, Solly, Perino, Samantha, O'Hagan, Ronan, Lin, Jie, Gyuris, Jeno, Okamura, Heidi
Published in Molecular cancer therapeutics (01.08.2015)
Published in Molecular cancer therapeutics (01.08.2015)
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Journal Article
ANTI-GDF15 ANTIBODIES
CHIU MARIA ISABEL, LIU QING, ABBOTT SANDRA, BAI AILIN, CHEN TING, GYURIS JENO, TAO NIANJUN, WEILER SOLLY, WINSTON WILLIAM M, LERNER LORENA, POLING LAURA, WENG ZHIGANG
Year of Publication 02.09.2015
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Year of Publication 02.09.2015
Patent
ANTI-FGFR2 ANTIBODIES
BAI AILIN, WINSTON WILLIAM M. JR, CHEN TING, GYURIS JENO, WEILER SOLLY, MEETZE KRISTAN, WENG ZHIGANG
Year of Publication 19.06.2013
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Year of Publication 19.06.2013
Patent
Abstract 1829: Generation of IL-21 INDUKINETM molecules for the treatment of cancer
Sullivan, Jenna M., Aderhold, Pamela A., Brodkin, Heather R., Economides, Kyriakos, Hicklin, Daniel J., Ismail, Nesreen, Lewis, Yuka, Seidel-Dugan, Cynthia, Spencer, Cierra, Winston, William M., Salmeron, Andres
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 1817: WTX-613, (JZP898) a selectively activated IFNα INDUKINE™ molecule, reprograms the tumor microenvironment and generates robust anti-tumor immunity as a monotherapy and in combination with checkpoint inhibitors
Nirschl, Christopher J., Brodkin, Heather R., Domonkos, Celesztina, Economides, Kyriakos, Hicklin, Daniel J., Ismail, Nesreen, Seidel-Dugan, Cynthia, Steiner, Philipp, Steuert, Zoe, Winston, William M., Salmeron, Andres
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 4078: WTX-712, a conditionally active IL-21 INDUKINETM molecule, induces a strong anti-tumor phenotype through a differentiated mechanism
Sullivan, Jenna M., Aderhold, Pamela A., Brodkin, Heather R., Nagy-Domonkos, Celesztina, Economides, Kyriakos, Hicklin, Daniel J., Ismail, Nesreen, Lewis, Yuka, Seidel-Dugan, Cynthia, Winston, William M., Salmeron, Andres
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 4074: Discovery of WTX-518, an IL-18 pro-drug that is conditionally activated within the tumor microenvironment and induces regressions in mouse tumor models
Morris, Kristin R., Brodkin, Heather, Economides, Kyriakos, Hicklin, Daniel J., LePrevost, Julie, Nagy-Domonkos, Celesztina, Nirschl, Christopher, Salmeron, Andres, Seidel-Dugan, Cynthia, Spencer, Cierra, Steuert, Zoe, Winston, William M.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract A074: Discovery of WTX-330, a clinical stage conditionally activated IL-12 INDUKINETM therapeutic with potent antitumor activity in murine syngeneic tumor models resistant to checkpoint blockade
Nirschl, Christopher J, Brodkin, Heather R, Chopra, Sameer S, Dwyer, Connor J, Hicklin, Daniel J, Isaacs, Randi, Ismail, Nesreen, Seidel-Dugan, Cynthia, Steuert, Zoe, Sullivan, Jenna M, Winston, William M, Salmeron, Andres
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Abstract 2054: WTX-124 is a novel IL-2 pro-drug that is conditionally activated in tumors and drives anti-tumor immunity by activating tumor infiltrating CD8+ T cells
Nirschl, Christopher J., Brodkin, Heather R., Hicklin, Daniel J., Ismail, Nesreen, Morris, Kristin, Salmeron, Andres, Seidel-Dugan, Cynthia, Steiner, Philipp, Steuert, Zoe, Sullivan, Jenna M., Winston, William M.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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