A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors
Drilon, Alexander, Nagasubramanian, Ramamoorthy, Blake, James F, Ku, Nora, Tuch, Brian B, Ebata, Kevin, Smith, Steve, Lauriault, Veronique, Kolakowski, Gabrielle R, Brandhuber, Barbara J, Larsen, Paul D, Bouhana, Karyn S, Winski, Shannon L, Hamor, Robyn, Wu, Wen-I, Parker, Andrew, Morales, Tony H, Sullivan, Francis X, DeWolf, Walter E, Wollenberg, Lance A, Gordon, Paul R, Douglas-Lindsay, Dorothea N, Scaltriti, Maurizio, Benayed, Ryma, Raj, Sandeep, Hanusch, Bethany, Schram, Alison M, Jonsson, Philip, Berger, Michael F, Hechtman, Jaclyn F, Taylor, Barry S, Andrews, Steve, Rothenberg, S Michael, Hyman, David M
Published in Cancer discovery (01.09.2017)
Published in Cancer discovery (01.09.2017)
Get full text
Journal Article
Characterization of a Mechanism-Based Inhibitor of NAD(P)H:Quinone Oxidoreductase 1 by Biochemical, X-ray Crystallographic, and Mass Spectrometric Approaches
Winski, Shannon L, Faig, Margarita, Bianchet, Mario A, Siegel, David, Swann, Elizabeth, Fung, Kim, Duncan, Mark W, Moody, Christopher J, Amzel, L. Mario, Ross, David
Published in Biochemistry (Easton) (18.12.2001)
Published in Biochemistry (Easton) (18.12.2001)
Get full text
Journal Article
A phase I study of oral ARRY-614, a p38 MAPK/Tie2 dual inhibitor, in patients with low or intermediate-1 risk myelodysplastic syndromes
Garcia-Manero, Guillermo, Khoury, Hanna J, Jabbour, Elias, Lancet, Jeffrey, Winski, Shannon L, Cable, LouAnn, Rush, Selena, Maloney, Lara, Hogeland, Grant, Ptaszynski, Mieke, Calvo, Monica Cabrero, Bohannan, Zach, List, Alan, Kantarjian, Hagop, Komrokji, Rami
Published in Clinical cancer research (01.03.2015)
Published in Clinical cancer research (01.03.2015)
Get full text
Journal Article
Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia
Bachegowda, Lohith, Morrone, Kerry, Winski, Shannon L, Mantzaris, Ioannis, Bartenstein, Matthias, Ramachandra, Nandini, Giricz, Orsi, Sukrithan, Vineeth, Nwankwo, George, Shahnaz, Samira, Bhagat, Tushar, Bhattacharyya, Sanchari, Assal, Amer, Shastri, Aditi, Gordon-Mitchell, Shanisha, Pellagatti, Andrea, Boultwood, Jacqueline, Schinke, Carolina, Yu, Yiting, Guha, Chandan, Rizzi, James, Garrus, Jennifer, Brown, Suzy, Wollenberg, Lance, Hogeland, Grant, Wright, Dale, Munson, Mark, Rodriguez, Mareli, Gross, Stefan, Chantry, David, Zou, Yiyu, Platanias, Leonidas, Burgess, Laurence E, Pradhan, Kith, Steidl, Ulrich, Verma, Amit
Published in Cancer research (Chicago, Ill.) (15.08.2016)
Published in Cancer research (Chicago, Ill.) (15.08.2016)
Get full text
Journal Article
Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells
WINSKI, Shannon L, KOUTALOS, Yiannis, BENTLEY, David L, ROSS, David
Published in Cancer research (Chicago, Ill.) (01.03.2002)
Get full text
Published in Cancer research (Chicago, Ill.) (01.03.2002)
Journal Article
Rapid Polyubiquitination and Proteasomal Degradation of a Mutant Form of NAD(P)H:Quinone Oxidoreductase 1
Siegel, D, Anwar, A, Winski, S L, Kepa, J K, Zolman, K L, Ross, D
Published in Molecular pharmacology (01.02.2001)
Published in Molecular pharmacology (01.02.2001)
Get full text
Journal Article
OSI-930 : A novel selective inhibitor of kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models
GARTON, Andrew J, CREW, Andrew P. A, BITTNER, Mark A, KEILY, John F, BRINER, Paul, HIDDEN, Chris, SREBERNAK, Mary C, PIRRIT, Carrie, O'CONNOR, Matthew, ANNA CHAN, VULEVIC, Bojana, HENNINGER, Dwight, FRANKLIN, Maryland, HART, Karen, SENNELLO, Regina, LI, An-Hu, TAO ZHANG, RICHARDSON, Frank, EMERSON, David L, CASTELHANO, Arlindo L, ARNOLD, Lee D, GIBSON, Neil W, COOKE, Andrew R, WYNNE, Graham M, CASTALDO, Linda, KAHLER, Jennifer, WINSKI, Shannon L, FRANKS, April, BROWN, Eric N
Published in Cancer research (Chicago, Ill.) (15.01.2006)
Published in Cancer research (Chicago, Ill.) (15.01.2006)
Get full text
Journal Article
Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones
WINSKI, Shannon L, SWANN, Elizabeth, HARGREAVES, Robert H. J, DEHN, Donna L, BUTLER, John, MOODY, Christopher J, ROSS, David
Published in Biochemical pharmacology (15.06.2001)
Published in Biochemical pharmacology (15.06.2001)
Get full text
Journal Article
암을 치료하기 위한 방법 및 병용 요법
BOSHOFF CHRISTOFFEL HENDRIK, MASSACESI CRISTIAN, PATHAN NUZHAT, CESARI ROSSANO, WINSKI SHANNON L, LEE PATRICE A
Year of Publication 28.08.2020
Get full text
Year of Publication 28.08.2020
Patent
Differential Involvement of Caspases in Hydroquinone-Induced Apoptosis in Human Leukemic HL-60 and Jurkat Cells
Inayat-Hussain, Salmaan H., Winski, Shannon L., Ross, David
Published in Toxicology and applied pharmacology (01.09.2001)
Published in Toxicology and applied pharmacology (01.09.2001)
Get full text
Journal Article
Conference Proceeding
Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs)
Mulvihill, Mark J., Kan, Julie L.C., Beck, Patricia, Bittner, Mark, Cesario, Cara, Cooke, Andrew, Keane, David M., Nigro, Anthony I., Nillson, Christy, Smith, Vanessa, Srebernak, Mary, Sun, Feng-Lei, Vrkljan, Michael, Winski, Shannon L., Castelhano, Arlindo L., Emerson, David, Gibson, Neil
Published in Bioorganic & medicinal chemistry letters (15.03.2005)
Published in Bioorganic & medicinal chemistry letters (15.03.2005)
Get full text
Journal Article