Spirocyclic Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-3-hydroxy-4-(spiro[chromene-2,4′-piperidine]-4-yl) Benzamide (ADL5747)
Le Bourdonnec, Bertrand, Windh, Rolf T., Leister, Lara K., Zhou, Q. Jean, Ajello, Christopher W., Gu, Minghua, Chu, Guo-Hua, Tuthill, Paul A., Barker, William M., Koblish, Michael, Wiant, Daniel D., Graczyk, Thomas M., Belanger, Serge, Cassel, Joel A., Feschenko, Marina S., Brogdon, Bernice L., Smith, Steven A., Derelanko, Michael J., Kutz, Steve, Little, Patrick J., DeHaven, Robert N., DeHaven-Hudkins, Diane L., Dolle, Roland E.
Published in Journal of medicinal chemistry (24.09.2009)
Published in Journal of medicinal chemistry (24.09.2009)
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Potent, Orally Bioavailable Delta Opioid Receptor Agonists for the Treatment of Pain: Discovery of N,N-Diethyl-4-(5-hydroxyspiro[chromene-2,4′-piperidine]-4-yl)benzamide (ADL5859)
Bourdonnec, Bertrand Le, Windh, Rolf T, Ajello, Christopher W, Leister, Lara K, Gu, Minghua, Chu, Guo-Hua, Tuthill, Paul A, Barker, William M, Koblish, Michael, Wiant, Daniel D, Graczyk, Thomas M, Belanger, Serge, Cassel, Joel A, Feschenko, Marina S, Brogdon, Bernice L, Smith, Steven A, Christ, David D, Derelanko, Michael J, Kutz, Steve, Little, Patrick J, DeHaven, Robert N, DeHaven-Hudkins, Diane L, Dolle, Roland E
Published in Journal of medicinal chemistry (09.10.2008)
Published in Journal of medicinal chemistry (09.10.2008)
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δ-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization
Nozaki, Chihiro, Le Bourdonnec, Bertrand, Reiss, David, Windh, Rolf T, Little, Patrick J, Dolle, Roland E, Kieffer, Brigitte L, Gavériaux-Ruff, Claire
Published in The Journal of pharmacology and experimental therapeutics (01.09.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2012)
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Differential Coupling of the Sphingosine 1-Phosphate Receptors Edg-1, Edg-3, and H218/Edg-5 to the Gi, Gq, and G12 Families of Heterotrimeric G Proteins
Windh, Rolf T., Lee, Menq-Jer, Hla, Timothy, An, Songzhu, Barr, Alastair J., Manning, David R.
Published in The Journal of biological chemistry (24.09.1999)
Published in The Journal of biological chemistry (24.09.1999)
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Sphingosine 1-phosphate activates nuclear factor-kappa B through Edg receptors. Activation through Edg-3 and Edg-5, but not Edg-1, in human embryonic kidney 293 cells
Siehler, S, Wang, Y, Fan, X, Windh, R T, Manning, D R
Published in The Journal of biological chemistry (28.12.2001)
Published in The Journal of biological chemistry (28.12.2001)
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Sphingosine 1-Phosphate Activates Nuclear Factor-κB through Edg Receptors
Siehler, Sandra, Wang, Yuren, Fan, Xiaomin, Windh, Rolf T., Manning, David R.
Published in The Journal of biological chemistry (28.12.2001)
Published in The Journal of biological chemistry (28.12.2001)
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Journal Article
Sphingosine 1-Phosphate Activates Nuclear Factor-κB through Edg Receptors
Sandra Siehler, Yuren Wang, Xiaomin Fan, Rolf T. Windh, David R. Manning
Published in The Journal of biological chemistry (28.12.2001)
Published in The Journal of biological chemistry (28.12.2001)
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